The extracellular matrix (ECM) is an intricate network that provides structural and anchoring support to cells in order to stabilize cell morphology and tissue architecture. The ECM also controls many aspects of the cell's dynamic behavior and fate through its ongoing, bidirectional interaction with cells. These interactions between the cell and components of the surrounding ECM are implicated in several biological processes, including development and adult tissue repair in response to injury, throughout the lifespan of multiple species. The present review gives an overview of the growing evidence that cell-matrix interactions play a pivotal role in the aging process. The focus of the first part of the article is on recent studies using cell-derived decellularized ECM, which strongly suggest that age-related changes in the ECM induce cellular senescence, a well-recognized hallmark of aging. This is followed by a review of findings from genetic studies indicating that changes in genes involved in cell-ECM adhesion and matrix-mediated intracellular signaling cascades affect longevity. Finally, mention is made of novel data proposing an intricate interplay between cell-matrix interactions and the renin-angiotensin system that may have a significant impact on mammalian arterial stiffness with age.
The role of the cell-matrix interface in aging and its interaction with the renin-angiotensin system in the aged vasculature.
Published 2019 in Mechanisms of Ageing and Development
ABSTRACT
PUBLICATION RECORD
- Publication year
2019
- Venue
Mechanisms of Ageing and Development
- Publication date
2019-01-01
- Fields of study
Biology, Medicine
- Identifiers
- External record
- Source metadata
Semantic Scholar, PubMed
CITATION MAP
EXTRACTION MAP
CLAIMS
CONCEPTS
- aging process
The progressive biological changes associated with advancing age in cells, tissues, and organisms.
Aliases: aging
- arterial stiffness
Reduced elasticity of arterial walls that affects vascular function and increases with vascular aging.
- cell-derived decellularized ecm
Extracellular matrix material produced by removing cells from a cell-generated matrix for experimental use.
Aliases: decellularized ECM
- cell-ecm adhesion
The set of molecular attachment processes that connect cells to the surrounding extracellular matrix.
Aliases: cell-matrix adhesion
- cell-matrix interactions
Bidirectional functional interactions between cells and the surrounding extracellular matrix.
Aliases: cell-matrix interface
- cellular senescence
A stable state of proliferative arrest and altered cell function used here as a hallmark of aging.
- extracellular matrix
The network of extracellular macromolecules that surrounds cells and provides structural and biochemical support in tissues.
Aliases: ECM
- longevity
The length of life or lifespan outcome considered in genetic studies of aging-related traits.
- matrix-mediated intracellular signaling cascades
Intracellular signaling pathways triggered or modulated by interactions with the extracellular matrix.
Aliases: ECM-mediated signaling
- renin-angiotensin system
A hormone and signaling system that regulates vascular tone, fluid balance, and blood pressure.
Aliases: RAS
REFERENCES
CITED BY
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