Antiretroviral Therapy for Prevention of Tuberculosis in Adults with HIV: A Systematic Review and Meta-Analysis

In a systematic review and meta-analysis, Amitabh Suthar and colleagues investigate the association between antiretroviral therapy and the reduction in the incidence of tuberculosis in adults with HIV infection.

• Publication year

  2012

• Venue

  PLoS Medicine

• Publication date

  2012-07-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1371/journal.pmed.1001270PMID 22911011PMCID 3404110
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta-Analyses

  2014cited by this paper
• Antiretroviral therapy for prevention of HIV transmission in HIV-discordant couples (Review)

  2013cited by this paper
• Interventions to improve the performance of HIV health systems for treatment-as-prevention in sub-Saharan Africa: the experimental evidence.

  2012cited by this paper
• Impact of antiretroviral therapy on tuberculosis incidence among HIV-positive patients in high-income countries.

  2012cited by this paper
• Community-based multi-disease prevention campaigns for controlling human immunodeficiency virus-associated tuberculosis [Perspectives].

  2012cited by this paper
• Comprar Modern Epidemiology | Timothy L. Lash | 9781451190052 | Lippincott Williams & Wilkins

  2012cited by this paper
• Stable Incidence of HIV Diagnoses Among Danish MSM Despite Increased Engagement in Unsafe Sex

  2012cited by this paper
• Global tuberculosis control 2010

  2012cited by this paper
• Immunodeficiency at the start of ART: Global view

  2012cited by this paper
• Update on World Health Organization HIV drug resistance prevention and assessment strategy: 2004-2011.

  2012cited by this paper
• Community-based intervention to increase HIV testing and case detection in people aged 16-32 years in Tanzania, Zimbabwe, and Thailand (NIMH Project Accept, HPTN 043): a randomised study.

  2011cited by this paper
• Timing of antiretroviral therapy for HIV-1 infection and tuberculosis.

  2011cited by this paper
• Tuberculosis in Patients Receiving Antiretroviral Treatment: Incidence, Risk Factors, and Prevention Strategies

  2011cited by this paper
• 6-month versus 36-month isoniazid preventive treatment for tuberculosis in adults with HIV infection in Botswana: a randomised, double-blind, placebo-controlled trial.

  2011cited by this paper
• Antiretroviral therapy for prevention of HIV transmission in HIV-discordant couples.

  2011cited by this paper
• Timing of HAART initiation and clinical outcomes in human immunodeficiency virus type 1 seroconverters.

  2011cited by this paper
• Risk factors for tuberculosis after highly active antiretroviral therapy initiation in the United States and Canada: implications for tuberculosis screening.

  2011cited by this paper
• Development of a Standardized Screening Rule for Tuberculosis in People Living with HIV in Resource-Constrained Settings: Individual Participant Data Meta-analysis of Observational Studies

  2011cited by this paper
• Book Review: Sustainability and Equity: A Better Future for All

  2011cited by this paper
• Tuberculosis in HIV programmes in lower-income countries: practices and risk factors.

  2011cited by this paper
• Prevention of HIV-1 infection with early antiretroviral therapy

  2011influential reference
• Antiretroviral therapy and the control of HIV-associated tuberculosis. Will ART do it?

  2011cited by this paper
• Antiretroviral Therapy and TB Notification Rates in a High HIV Prevalence South African Community

  2011cited by this paper
• When to Initiate Combined Antiretroviral Therapy to Reduce Mortality and AIDS-Defining Illness in HIV-Infected Persons in Developed Countries

  2011cited by this paper
• Earlier versus later start of antiretroviral therapy in HIV-infected adults with tuberculosis.

  2011cited by this paper
• Antiretroviral Therapy in Prevention of HIV and TB: Update on Current Research Efforts

  2011cited by this paper
• Reduced tuberculosis case notification associated with scaling up antiretroviral treatment in rural Malawi.

  2011cited by this paper
• The HIV-associated tuberculosis epidemic--when will we act?

  2010cited by this paper
• A consistent log-linear relationship between tuberculosis incidence and body mass index.

  2010cited by this paper
• Association of isoniazid preventive therapy with lower early mortality in individuals on antiretroviral therapy in a workplace programme

  2010influential reference
• Cochrane Handbook for Systematic Reviews of Interventions

  2010cited by this paper
• Tuberculosis control and elimination 2010-50: cure, care, and social development.

  2010influential reference
• Decreases in Community Viral Load Are Accompanied by Reductions in New HIV Infections in San Francisco

  2010cited by this paper
• Tuberculosis during the first year of antiretroviral therapy in a South African cohort using an intensive pretreatment screening strategy

  2010cited by this paper
• Early versus standard antiretroviral therapy for HIV-infected adults in Haiti.

  2010influential reference
• Antiretroviral therapy for tuberculosis control in nine African countries

  2010cited by this paper
• Incidence of tuberculosis after HAART initiation in a cohort of HIV-positive patients in Burkina Faso.

  2010cited by this paper
• The Population Dynamics and Control of Tuberculosis

  2010cited by this paper
• Tuberculosis and human immunodeficiency virus co-infections and their predictors at a hospital-based HIV/AIDS clinic in Uganda.

  2010cited by this paper
• Antiretrovirals and isoniazid preventive therapy in the prevention of HIV-associated tuberculosis in settings with limited health-care resources.

  2010cited by this paper
• Treatment of latent tuberculosis infection in HIV infected persons.

  2010cited by this paper
• Body mass index and risk of tuberculosis and death

  2010cited by this paper
• Association of highly active antiretroviral therapy coverage, population viral load, and yearly new HIV diagnoses in British Columbia, Canada: a population-based study.

  2010cited by this paper
• Rapid Implementation of an Integrated Large-Scale HIV Counseling and Testing, Malaria, and Diarrhea Prevention Campaign in Rural Kenya

  2010cited by this paper
• Timing of initiation of antiretroviral drugs during tuberculosis therapy.

  2010cited by this paper
• Universal voluntary HIV testing with immediate antiretroviral therapy as a strategy for elimination of HIV transmission: a mathematical model.

  2009cited by this paper
• The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration

  2009cited by this paper
• Timing of initiation of antiretroviral therapy in AIDS-free HIV-1-infected patients: a collaborative analysis of 18 HIV cohort studies

  2009cited by this paper
• Epidemiological benefits of more-effective tuberculosis vaccines, drugs, and diagnostics

  2009influential reference
• Clinical Prognostic Value of RNA Viral Load and CD4 Cell Counts during Untreated HIV-1 Infection—A Quantitative Review

  2009cited by this paper
• Trends in tuberculosis incidence and their determinants in 134 countries.

  2009cited by this paper
• Risk and prognostic significance of tuberculosis in patients from The TREAT Asia HIV Observational Database

  2009influential reference
• Short-term and long-term risk of tuberculosis associated with CD4 cell recovery during antiretroviral therapy in South Africa

  2009cited by this paper
• Isoniazid preventive therapy, HAART and tuberculosis risk in HIV-infected adults in South Africa: a prospective cohort

  2009influential reference
• Initiation of HAART at Higher CD4 Cell Counts Is Associated With a Lower Frequency of Antiretroviral Drug Resistance Mutations at Virologic Failure

  2009cited by this paper
• Effect of early versus deferred antiretroviral therapy for HIV on survival.

  2009cited by this paper
• Towards universal access: scaling up priority HIV/AIDS interventions in the health sector. Progress report 2009

  2009cited by this paper
• Duration from seroconversion to eligibility for antiretroviral therapy and from ART eligibility to death in adult HIV-infected patients from low and middle-income countries: collaborative analysis of prospective studies

  2008cited by this paper
• Immune reconstitution and "unmasking" of tuberculosis during antiretroviral therapy.

  2008cited by this paper
• Tuberculosis incidence and risk factors among patients living with HIV/AIDS in public health service institutions in Brasilia, Federal District.

  2008cited by this paper
• The impact of antiretroviral therapy and isoniazid preventive therapy on tuberculosis incidence in HIV-infected patients in Rio de Janeiro, Brazil

  2007influential reference
• Tuberculosis after initiation of antiretroviral therapy in low-income and high-income countries.

  2007cited by this paper
• Statistical design of THRio: a phased implementation clinic-randomized study of a tuberculosis preventive therapy intervention

  2007influential reference
• Impact of Antiretroviral Therapy on the Incidence of Tuberculosis: The Brazilian Experience, 1995–2001

  2007influential reference
• Antiretroviral therapy for HIV infection in adults and adolescents: recommendations for a public health approach. 2006 revision.

  2006cited by this paper
• The WHO public-health approach to antiretroviral treatment against HIV in resource-limited settings.

  2006cited by this paper
• HIV infection, antiretroviral therapy, and CD4+ cell count distributions in African populations.

  2006cited by this paper
• Factors associated with the development of opportunistic infections in HIV-1-infected adults with high CD4+ cell counts: a EuroSIDA study.

  2006cited by this paper
• Antiretroviral therapy at a district hospital in Ethiopia prevents death and tuberculosis in a cohort of HIV patients

  2006influential reference
• Risk factors for active tuberculosis after antiretroviral treatment initiation in Abidjan.

  2005cited by this paper
• Incidence of Tuberculosis among HIV-infected patients receiving highly active antiretroviral therapy in Europe and North America.

  2005cited by this paper
• Treatment of latent tuberculosis infection in HIV infected persons.

  2004cited by this paper
• Measuring inconsistency in meta-analyses

  2003cited by this paper
• Reduced risk of tuberculosis among Brazilian patients with advanced human immunodeficiency virus infection treated with highly active antiretroviral therapy.

  2002cited by this paper
• Quantifying heterogeneity in a meta‐analysis

  2002cited by this paper
• Interventions to reduce tuberculosis mortality and transmission in low- and middle-income countries.

  2002cited by this paper
• Effect of highly active antiretroviral therapy on incidence of tuberculosis in South Africa: a cohort study.

  2002influential reference
• Human Development Report

  2001cited by this paper
• Publication and related bias in meta-analysis: power of statistical tests and prevalence in the literature.

  2000cited by this paper
• Will DOTS do it? A reappraisal of tuberculosis control in countries with high rates of HIV infection.

  1999cited by this paper
• Will DOTS do it? A reappraisal of tuberculosis control in countries with high rates of HIV infection.

  1999influential reference
• The Handbook of Research Synthesis

  1995cited by this paper
• The Handbook of Research Synthesis

  1994cited by this paper
• Tuberculosis preventive therapy in HIV-infected individuals. A Joint Statement of the WHO Tuberculosis Programme and the Global Programme on AIDS, and the International Union Against Tuberculosis and Lung Disease (IUATLD).

  1993cited by this paper
• Diagnostic standards and classification of tuberculosis.

  1991cited by this paper
• American Thoracic Society. Diagnostic standards and classification of tuberculosis.

  1990cited by this paper
• [Modern epidemiology].

  1971cited by this paper

• The Dynamics of Human Cytomegalovirus Markers in Tuberculosis Disease Among People With Human Immunodeficiency Virus on Long-term Antiretroviral Therapy: A Nested Case-Control Study

  2026cites this paper
• Analysis of factors influencing latent tuberculosis infection screening using QuantiFERON-TB Gold In-Tube in people living with HIV/AIDS

  2026cites this paper
• Breakthrough Tuberculosis in a Large Cohort of People Living With HIV on Preventive Treatment.

  2026cites this paper
• Tuberculosis after TB Preventive Therapy in Persons Living with HIV Recently Initiating Antiretroviral Therapy, Mozambique

  2026cites this paper
• The impact of treatment accessibility on HIV-TB co-infection: a comparative fractional-order modeling approach

  2026cites this paper
• Concurrent TB and HIV therapies control TB reactivation during co-infection but not chronic immune activation

  2025cites this paper
• Pulmonary Tuberculosis-Associated Morbidity in Africa: A Systematic Review

  2025cites this paper
• Incidence of opportunistic diseases after the "treat all" strategy: 10 years cohort for HIV.

  2025cites this paper
• Temporal trends in tuberculosis and time from enrolment in care to antiretroviral therapy initiation: A multicountry cohort study from Latin America

  2025cites this paper
• Frequency of tuberculosis symptoms at repeat visits amongst adults attending for HIV care in Gauteng province, South Africa

  2025cites this paper
• Incidence and risk factors for tuberculosis at a rural HIV clinic in Uganda, 2012–2019; A retrospective cohort study

  2025cites this paper
• Potential pediatric tuberculosis incidence and deaths resulting from interruption in programmes supported by international health aid, 2025-2034: a mathematical modelling study

  2025cites this paper
• Tuberculosis and HIV coinfection: progress and challenges towards reducing incidence and mortality.

  2025cites this paper
• Sociodemographic determinants of multidrug-resistant tuberculosis in Lesotho: A case-control study

  2025cites this paper
• Antiretroviral treatment does not prevent extrapulmonary tuberculosis during SIV/Mtb co-infection in macaques

  2025cites this paper
• The delivery of new tuberculosis vaccines to people living with HIV – when to vaccinate?

  2025influential citation
• Causes of Admissions and Outcome in Adults Living with HIV/Aids in the Buea Regional Hospital: A 5-Year Retrospective Review

  2025cites this paper
• The Role of Type I Interferons in Tuberculosis and in Tuberculosis-Risk-Associated Comorbidities

  2025cites this paper
• Trends in prevalent TB among persons enrolling for HIV care before and after ‘Test and Treat’ across East-Africa

  2025cites this paper
• Impact of increasing CD4 count threshold eligibility for antiretroviral therapy initiation on advanced HIV disease and tuberculosis prevalence and incidence in South Africa: an interrupted time series analysis

  2025cites this paper
• Potential paediatric tuberculosis incidence and deaths resulting from interruption in programmes supported by international health aid, 2025-34: a mathematical modelling study.

  2025cites this paper
• Concurrent TB and HIV therapies effectively control clinical reactivation of TB during co-infection but fail to eliminate chronic immune activation

  2024cites this paper
• Tuberculosis immune reconstitution syndrome (TB-IRIS) followed by recurring lymphadenitis up to 8 years post-antituberculous treatment

  2024cites this paper
• TB diagnoses and mortality in hospitalized people living with HIV in South Africa.

  2024cites this paper
• Health and economic impacts of Vaccae vaccination incorporating active case finding in India and South Africa: a modelling study

  2024cites this paper
• Risk of tuberculosis after achieving HIV virological suppression on antiretroviral therapy: a Danish nationwide prospective cohort study.

  2024cites this paper
• HIV replication and tuberculosis risk among people living with HIV in Europe: A multicohort analysis, 1983–2015

  2024cites this paper
• Factors associated with uptake of isoniazid preventive therapy among children living with HIV in Mwanza region, Tanzania: a cross-sectional study

  2024cites this paper
• Tuberculosis Preventive Treatment in High TB-Burden Settings: A State-of-the-Art Review

  2024cites this paper
• Africa Health Research Institute (AHRI) Household Contact study: a study protocol, statistical analysis and modelling plan

  2024cites this paper
• Association of SARS-CoV-2 Seropositivity with Persistent Immune Activation in HIV/Tuberculosis Co-Infected Patients

  2024cites this paper
• Dynamics of Matricellular Protein Levels in Blood Predict Recovery in Patients with Human Immunodeficiency Virus-Tuberculosis Coinfection

  2024cites this paper
• Population-wide active case finding as a strategy to end TB

  2024cites this paper
• Risk of tuberculosis after initiation of antiretroviral therapy among persons with HIV in Europe.

  2024cites this paper
• HIV-Associated Tuberculosis.

  2024cites this paper
• The impact of alternative delivery strategies for novel tuberculosis vaccines in low-income and middle-income countries: a modelling study

  2023cites this paper
• Preventing tuberculosis with community-based care in an HIV-endemic setting: a modeling analysis

  2023cites this paper
• The Impact of Credit and Liquidity Risk on Bank Performance

  2023cites this paper
• Chapitre 10: Le traitement de la tuberculose active chez les populations particulières

  2023cites this paper
• Estimated rates of progression to tuberculosis disease for persons infected with Mycobacterium tuberculosis in the United States

  2023cites this paper
• Screening for tuberculosis infection and effectiveness of preventive treatment among people with HIV in low-incidence settings

  2023cites this paper
• Tuberculosis testing patterns in South Africa to identify groups that would benefit from increased investigation

  2023cites this paper
• Isoniazid preventive therapy completion and factors associated with non-completion among patients on antiretroviral therapy at Kisenyi Health Centre IV, Kampala, Uganda

  2023cites this paper
• Undernutrition as a risk factor for tuberculosis disease

  2023cites this paper
• Joint Modeling of Longitudinal Outcome and Competing Risks: Application to HIV/AIDS Data

  2023cites this paper
• Models of integration of TB and HIV services and factors associated with perceived quality of TB-HIV integrated service delivery in O. R Tambo District, South Africa

  2023cites this paper
• Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome—An Extempore Game of Misfiring with Defense Arsenals

  2023cites this paper
• Impact of micro- and macronutrient status on the incidence of tuberculosis: An examination of an African cohort initiating antiretroviral therapy

  2023cites this paper
• Assessing risk factors for latent and active tuberculosis among persons living with HIV in Florida: A comparison of self-reports and medical records

  2022cites this paper
• Differential Expression of miRNA-192 is a Potential Biomarker for HIV Associated Immune Recovery Uveitis

  2022cites this paper
• Phenotypic profile of Mycobacterium tuberculosis-specific CD4 T cell responses in HIV-positive patients who develop Tuberculosis-associated Immune Reconstitution Inflammatory Syndrome

  2022cites this paper
• The contribution of late HIV diagnosis on the occurrence of HIV-associated tuberculosis

  2022cites this paper
• Isoniazid Adherence Reduces Mortality and Incident Tuberculosis at 96 Weeks Among Adults Initiating Antiretroviral Therapy With Advanced Human Immunodeficiency Virus in Multiple High-Burden Settings

  2022cites this paper
• Predicting the risk of active pulmonary tuberculosis in people living with HIV: development and validation of a nomogram

  2022cites this paper
• Modeling the trajectory of CD4 cell count and its effect on the risk of AIDS progression and TB infection among HIV-infected patients using a joint model of competing risks and longitudinal ordinal data

  2022cites this paper
• Evaluating agreement between bodies of evidence from randomized controlled trials and cohort studies in medical research: a meta-epidemiological study

  2022cites this paper
• Impact of saturated treatments on HIV-TB dual epidemic as a consequence of COVID-19: optimal control with awareness and treatment

  2022cites this paper
• An empirical evaluation of the impact scenario of pooling bodies of evidence from randomized controlled trials and cohort studies in medical research

  2022cites this paper
• Incidence of active tuberculosis among people living with HIV receiving long‐term antiretroviral therapy in high TB/HIV burden settings in Thailand: implication for tuberculosis preventive therapy

  2022cites this paper
• Medical Care for Tuberculosis-HIV-Coinfected Patients in Russia with Respect to a Changeable Patients’ Structure

  2022cites this paper
• Incidence and factors associated with active tuberculosis among people living with HIV after long-term antiretroviral therapy in Thailand: a competing risk model

  2022cites this paper
• The impact of alternative delivery strategies for novel tuberculosis vaccines in low- and middle-income countries: a modelling study

  2022cites this paper
• Mortality and survival of tuberculosis coinfected patients living with AIDS in São Paulo, Brazil: a 12-year cohort study

  2022cites this paper
• Landscape of TB Infection and Prevention among People Living with HIV

  2022cites this paper
• Sputnik V protection from COVID-19 in people living with HIV under antiretroviral therapy

  2022cites this paper
• High­dose oral and intravenous rifampicin for the treatment of tuberculous meningitis in predominantly Human Immunodeficiency Virus (HIV)­positive Ugandan adults: a phase II open­label randomized controlled trial

  2022cites this paper
• Testing and Treating Mycobacterium tuberculosis Infection.

  2022cites this paper
• Phenotypic Profile of Mycobacterium tuberculosis-Specific CD4 T-Cell Responses in People With Advanced Human Immunodeficiency Virus Who Develop Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome

  2022cites this paper
• 1 Isoniazid preventive therapy completion and factors 2 associated with non-completion among patients on 3 antiretroviral therapy at Kisenyi Health Centre IV,

  2022cites this paper
• Re-evaluating the health impact and cost-effectiveness of tuberculosis preventive treatment for modern HIV cohorts on antiretroviral therapy: a modelling analysis using data from Tanzania

  2022cites this paper
• Analysis of HIV prevalence, tuberculosis and their combinations in the territory of Chechen Republic

  2022cites this paper
• Chapter 10: Treatment of active tuberculosis in special populations

  2022cites this paper
• Utility of the lateral flow urine lipoarabinomannan tuberculosis assay in patients with advanced HIV disease at antiretroviral therapy centres in Mumbai, India

  2022cites this paper
• Transmission modeling to infer tuberculosis incidence prevalence and mortality in settings with generalized HIV epidemics

  2022cites this paper
• Isoniazid preventive therapy plus antiretroviral therapy for the prevention of tuberculosis: a systematic review and meta-analysis of individual participant data.

  2021cites this paper
• Isoniazid or rifampicin preventive therapy with and without screening for subclinical TB: a modeling analysis

  2021cites this paper
• Tuberculosis incidence and mortality in people living with HIV: A Danish nationwide cohort study.

  2021cites this paper
• Impact of Isoniazid Preventive Therapy on Tuberculosis incidence among people living with HIV: A secondary data analysis using Inverse Probability Weighting of individuals attending HIV care and treatment clinics in Tanzania

  2021cites this paper
• HIV treatment and worker absenteeism: Quasi-experimental evidence from a large-scale health program in South Africa.

  2021cites this paper
• Association of Urinary Interferon Gamma Protein-10 Levels and Low Levels of Cluster of Differentiation 4 Serum in Patients with Tuberculosis-Human Immunodeficiency Virus Coinfection

  2021cites this paper
• Validation of a host blood transcriptomic biomarker for pulmonary tuberculosis in people living with HIV: a prospective diagnostic and prognostic accuracy study

  2021cites this paper
• Life-expectancy with HIV in Latin America and the Caribbean.

  2021cites this paper
• Assessment of the tuberculosis case-finding and prevention cascade among people living with HIV in Zambia – 2018: a cross-sectional cluster survey

  2021cites this paper
• HIV-associated tuberculosis

  2021cites this paper
• Incidence and predictors of tuberculosis among HIV patients after initiation of antiretroviral treatment in Ethiopia: a systematic review and meta-analysis

  2021cites this paper
• Incidence Rate and Risk Factors for Tuberculosis among People Living with HIV: A 2015–2017 Cohort from Tashkent, Uzbekistan

  2021cites this paper
• High-Dose Oral and Intravenous Rifampicin for the Treatment of Tuberculous Meningitis in Predominantly Human Immunodeficiency Virus (HIV)-Positive Ugandan Adults: A Phase II Open-Label Randomized Controlled Trial

  2021cites this paper
• COVID-19 promoting the development of active tuberculosis in a patient with latent tuberculosis infection: A case report

  2021cites this paper
• Early innate and adaptive immune perturbations determine long-term severity of chronic virus and Mycobacterium tuberculosis coinfection.

  2021cites this paper
• Determinants of Multi-drug resistant Tuberculosis in four treatment centers of Eastern Amhara, Ethiopia: A case-control study.

  2021cites this paper
• Current Advances in the Development of Drug and Vaccine for Tuberculosis Prevention and Treatment

  2020cites this paper
• Mortality Among People With HIV Treated for Tuberculosis Based on Positive, Negative, or No Bacteriologic Test Results for Tuberculosis: The IeDEA Consortium

  2020cites this paper
• Ending Tuberculosis by 2030 -pipe dream or reality?

  2020cites this paper
• Pre-Pregnancy Hypertension Among Women in Rural and Urban Areas of the United States.

  2020cites this paper
• LSHTM Research Online

  2020cites this paper
• Effectiveness of isoniazid preventive therapy to reduce tuberculosis incidence in the context of antiretroviral therapy.

  2020cites this paper
• New opportunities in tuberculosis prevention: implications for people living with HIV

  2020cites this paper
• Early Initiation of ARV Therapy Among TB–HIV Patients in Indonesia Prolongs Survival Rates!

  2020influential citation
• Public Health Action International Union Against Tuberculosis and Lung Disease Health solutions for the poor

  2020cites this paper
• Nutrition in HIV and Tuberculosis

  2020cites this paper