Regional Heterogeneity of D2-Receptor Signaling in the Dorsal Striatum and Nucleus Accumbens.

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Neuron

• Publication date

  2018-05-02

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.neuron.2018.03.038PMID 29656874PMCID PMC6048973
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Firing

  2020cited by this paper
• Dopamine Secretion Is Mediated by Sparse Active Zone-like Release Sites.

  2018cited by this paper
• CONTACT FOR REAGENT AND RESOURCE SHARING

  2018cited by this paper
• Distinctive Modulation of Dopamine Release in the Nucleus Accumbens Shell Mediated by Dopamine and Acetylcholine Receptors

  2017cited by this paper
• Arresting the Development of Addiction: The Role of β-Arrestin 2 in Drug Abuse

  2017cited by this paper
• Distinct cortical and striatal actions of a β-arrestin–biased dopamine D2 receptor ligand reveal unique antipsychotic-like properties

  2016cited by this paper
• Nicotinic and opioid receptor regulation of striatal dopamine D2-receptor mediated transmission

  2016cited by this paper
• Striatal dopamine neurotransmission: regulation of release and uptake.

  2016cited by this paper
• Highly Selective Dopamine D3 Receptor (D3R) Antagonists and Partial Agonists Based on Eticlopride and the D3R Crystal Structure: New Leads for Opioid Dependence Treatment.

  2016influential reference
• Dopamine Regulation of Lateral Inhibition between Striatal Neurons Gates the Stimulant Actions of Cocaine.

  2016cited by this paper
• Fluorescent false neurotransmitter reveals functionally silent dopamine vesicle clusters in the striatum

  2016cited by this paper
• Spontaneous Synaptic Activation of Muscarinic Receptors by Striatal Cholinergic Neuron Firing.

  2016influential reference
• Distinct profiles of functional discrimination among G proteins determine the actions of G protein–coupled receptors

  2015cited by this paper
• RGS Redundancy and Implications in GPCR-GIRK Signaling.

  2015cited by this paper
• Using Bioluminescence Resonance Energy Transfer (BRET) to Characterize Agonist‐Induced Arrestin Recruitment to Modified and Unmodified G Protein‐Coupled Receptors

  2015influential reference
• Elevated Mitochondrial Bioenergetics and Axonal Arborization Size Are Key Contributors to the Vulnerability of Dopamine Neurons.

  2015influential reference
• Role of G Protein–Coupled Receptor Kinases 2 and 3 in μ-Opioid Receptor Desensitization and Internalization

  2015cited by this paper
• Enkephalin Disinhibits Mu Opioid Receptor-Rich Striatal Patches via Delta Opioid Receptors.

  2015cited by this paper
• Phasic dopamine release drives rapid activation of striatal D2-receptors.

  2014influential reference
• Neurocircuitry of drug reward.

  2014cited by this paper
• The Timing of Dopamine- and Noradrenaline-Mediated Transmission Reflects Underlying Differences in the Extent of Spillover and Pooling

  2014cited by this paper
• RGS7/Gβ5/R7BP complex regulates synaptic plasticity and memory by modulating hippocampal GABABR-GIRK signaling

  2014cited by this paper
• Decoding spatial and temporal features of neuronal cAMP/PKA signaling with FRET biosensors

  2014cited by this paper
• Chronic Cocaine Dampens Dopamine Signaling during Cocaine Intoxication and Unbalances D1 over D2 Receptor Signaling

  2013cited by this paper
• Cocaine-induced adaptations in D1 and D2 accumbens projection neurons (a dichotomy not necessarily synonymous with direct and indirect pathways).

  2013cited by this paper
• Strengthening the accumbal indirect pathway promotes resilience to compulsive cocaine use

  2013cited by this paper
• Striatal dopamine release is triggered by synchronized activity in cholinergic interneurons.

  2012cited by this paper
• Distribution and compartmental organization of GABAergic medium-sized spiny neurons in the mouse nucleus accumbens

  2012cited by this paper
• Regulators of G protein signaling RGS7 and RGS11 determine the onset of the light response in ON bipolar neurons

  2012influential reference
• The Complex of G Protein Regulator RGS9-2 and Gβ5 Controls Sensitization and Signaling Kinetics of Type 5 Adenylyl Cyclase in the Striatum

  2012cited by this paper
• Molecular determinants of selectivity and efficacy at the dopamine D3 receptor.

  2012cited by this paper
• The Striatal Balancing Act in Drug Addiction: Distinct Roles of Direct and Indirect Pathway Medium Spiny Neurons

  2011cited by this paper
• Control of Striatal Signaling by G Protein Regulators

  2011cited by this paper
• G protein Gαo is essential for vomeronasal function and aggressive behavior in mice

  2011cited by this paper
• Modulation of striatal projection systems by dopamine.

  2011cited by this paper
• Dopamine release in the basal ganglia.

  2011influential reference
• Dopamine Receptor Subtypes in Reward and Relapse

  2010cited by this paper
• Gβ5 recruits R7 RGS proteins to GIRK channels to regulate the timing of neuronal inhibitory signaling

  2010cited by this paper
• Dopamine signaling in the nucleus accumbens of animals self-administering drugs of abuse.

  2010cited by this paper
• Physiology and pharmacology of striatal neurons.

  2009cited by this paper
• Imaging dopamine's role in drug abuse and addiction.

  2009cited by this paper
• Differential Dopaminergic Modulation of Neostriatal Synaptic Connections of Striatopallidal Axon Collaterals

  2009cited by this paper
• Changes in Striatal Signaling Induce Remodeling of RGS Complexes Containing Gβ5 and R7BP Subunits

  2009cited by this paper
• The Time Course of Dopamine Transmission in the Ventral Tegmental Area

  2009cited by this paper
• Controls of Tonic and Phasic Dopamine Transmission in the Dorsal and Ventral Striatum

  2009influential reference
• Novel tools for use in bioluminescence resonance energy transfer (BRET) assays.

  2009cited by this paper
• Allosteric communication between protomers of dopamine Class A GPCR dimers modulates activation

  2009cited by this paper
• Recurrent Collateral Connections of Striatal Medium Spiny Neurons Are Disrupted in Models of Parkinson's Disease

  2008cited by this paper
• Protean Agonism at the Dopamine D2 Receptor: (S)-3-(3-Hydroxyphenyl)-N-propylpiperidine Is an Agonist for Activation of Go1 but an Antagonist/Inverse Agonist for Gi1,Gi2, and Gi3

  2007influential reference
• Differential ability of D1 and D2 dopamine receptor agonists to induce and modulate expression and reinstatement of cocaine place preference in rats

  2007cited by this paper
• Genome-wide atlas of gene expression in the adult mouse brain

  2007influential reference
• PET imaging of dopamine D2 receptors during chronic cocaine self-administration in monkeys

  2006cited by this paper
• Relationship between axonal collateralization and neuronal degeneration in basal ganglia.

  2006influential reference
• Behavioral sensitization to binge-pattern cocaine administration is not associated with changes in protein levels of four major G-proteins.

  2005cited by this paper
• Cocaine-induced alterations in dopamine receptor signaling: implications for reinforcement and reinstatement.

  2005cited by this paper
• Subsecond dopamine release promotes cocaine seeking

  2003cited by this paper
• Functional coupling of the human dopamine D2 receptor with G alpha i1, G alpha i2, G alpha i3 and G alpha o G proteins: evidence for agonist regulation of G protein selectivity.

  2003influential reference
• Functional coupling of the human dopamine D2 receptor with Gαi1, Gαi2, Gαi3 and Gαo G proteins: evidence for agonist regulation of G protein selectivity

  2003influential reference
• Time window of autoreceptor‐mediated inhibition of limbic and striatal dopamine release

  2002cited by this paper
• Functional Domains in Dorsal Striatum of the Nonhuman Primate Are Defined by the Dynamic Behavior of Dopamine

  2002influential reference
• Striatonigrostriatal Pathways in Primates Form an Ascending Spiral from the Shell to the Dorsolateral Striatum

  2000cited by this paper
• GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins.

  2000cited by this paper
• Slowed recovery of rod photoresponse in mice lacking the GTPase accelerating protein RGS9-1

  2000influential reference
• RGS9: A regulator of G‐protein signalling with specific expression in rat and mouse striatum

  1998cited by this paper
• Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter

  1996cited by this paper
• Comparison of Dopamine Uptake in the Basolateral Amygdaloid Nucleus, Caudate‐Putamen, and Nucleus Accumbens of the Rat

  1995influential reference
• Different kinetics govern dopaminergic transmission in the amygdala, prefrontal cortex, and striatum: an in vivo voltammetric study

  1994cited by this paper
• Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics

  1990cited by this paper
• Dopamine high-affinity transport site topography in rat brain: major differences between dorsal and ventral striatum.

  1990cited by this paper
• Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.

  1988cited by this paper
• Diffusion and uptake of dopamine in rat caudate and nucleus accumbens compared using fast cyclic voltammetry.

  1988cited by this paper
• Intracellular recordings from rat nucleus accumbens neurons in vitro.

  1986cited by this paper
• Direct in vivo monitoring of dopamine released from two striatal compartments in the rat.

  1983cited by this paper
• The fronto-striatal projection in the cat and monkey and its relationship to inhomogeneities established by acetylcholinesterase histochemistry.

  1981cited by this paper
• Fine structure and synaptic connections of the common spiny neuron of the rat neostriatum: A study employing intracellular injection of horseradish peroxidase

  1980cited by this paper
• Fine structure and synaptic connections of the common spiny neuron of the rat neostriatum: a study employing intracellular inject of horseradish peroxidase.

  1980cited by this paper
• Supporting Online Material Materials and Methods Som Text Figs. S1 to S8 References Cell Type–specific Loss of Bdnf Signaling Mimics Optogenetic Control of Cocaine Reward

  year unknowncited by this paper
• Neuroscience and Biobehavioral Reviews Review from the Ventral to the Dorsal Striatum: Devolving Views of Their Roles in Drug Addiction

  year unknowninfluential reference

• Correlation of repetitive behaviors in deer mice with striatal mRNA expression of endogenous opioids and mu, delta, kappa, and dopamine receptors.

  2025cites this paper
• Functional neuroanatomy of dopaminergic arousal systems: implications for the wake-promoting effect of psychostimulants, with particular reference to modafinil

  2025cites this paper
• Dopaminergic Inhibition of the Inwardly Rectifying Potassium Current in Direct Pathway Medium Spiny Neurons in Normal and Parkinsonian Striatum

  2025cites this paper
• Scopolamine-Induced Amnesia in Zebrafish: Behavioral Characterization and Pharmacological Reversal

  2025cites this paper
• New insights into axonal regulators of dopamine transmission in health and disease.

  2025cites this paper
• Temporal fMRI Dynamics Map Dopamine Physiology

  2025cites this paper
• Separable dorsal raphe dopamine projections mimic the facets of a loneliness-like state

  2025cites this paper
• Comparison of the function of two novel human dopamine D2 receptor variants identifies a likely mechanism for their pathogenicity.

  2024cites this paper
• Cocaine-Induced Remodeling of the Rat Brain Peptidome: Quantitative Mass Spectrometry Reveals Anatomically Specific Patterns of Cocaine-Regulated Peptide Changes.

  2024cites this paper
• Three paradoxes related to the mode of action of pramipexole: The path from D2/D3 dopamine receptor stimulation to modification of dopamine-modulated functions

  2024cites this paper
• Dopamine D1–D5 Receptors in Brain Nuclei: Implications for Health and Disease

  2024cites this paper
• Study on inhibitory effect of GC-miR-143 inhibitor nanoparticles on D2 receptor-mediated neurological behavioral damage in lacunar infarction

  2023cites this paper
• Integrative multi-dimensional characterization of striatal projection neuron heterogeneity in adult brain

  2023cites this paper
• Divergent properties and independent regulation of striatal dopamine and GABA co-transmission

  2022cites this paper
• Gait Abnormalities and Aberrant D2 Receptor Expression and Signaling in Mice Carrying the Human Pathogenic Mutation DRD2I212F

  2022cites this paper
• Dopamine Receptors: Is It Possible to Become a Therapeutic Target for Depression?

  2022cites this paper
• Gait Abnormalities and Aberrant D2 Receptor Expression and Signaling in a Mouse Model of the Human Pathogenic Mutation DRD2I212F

  2022cites this paper
• Serotonin receptors contribute to dopamine depression of lateral inhibition in the nucleus accumbens

  2022cites this paper
• Accumbens D2-MSN hyperactivity drives antipsychotic-induced behavioral supersensitivity

  2021cites this paper
• Gαo is a major determinant of cAMP signaling in the pathophysiology of movement disorders

  2021cites this paper
• NOX1/NADPH Oxidase Promotes Synaptic Facilitation Induced by Repeated D2 Receptor Stimulation: Involvement in Behavioral Repetition

  2021cites this paper
• Loss of nigral excitation of cholinergic interneurons contributes to parkinsonian motor impairments.

  2021cites this paper
• A photoswitchable GPCR-based opsin for presynaptic silencing

  2021cites this paper
• Spatial and temporal scales of dopamine transmission

  2021cites this paper
• Roles of the Functional Interaction between Brain Cholinergic and Dopaminergic Systems in the Pathogenesis and Treatment of Schizophrenia and Parkinson’s Disease

  2021cites this paper
• Signaling-Biased and Constitutively Active Dopamine D2 Receptor Variant.

  2021cites this paper
• A photoswitchable GPCR-based opsin for presynaptic inhibition.

  2021cites this paper
• Subregion-specific effects on striatal neurotransmission and dopamine-signaling by acute and repeated amphetamine exposure.

  2021cites this paper
• Subregion-Specific Regulation of Dopamine D1 Receptor Signaling in the Striatum: Implication for L-DOPA-Induced Dyskinesia

  2021cites this paper
• The Biology and Pathobiology of Glutamatergic, Cholinergic, and Dopaminergic Signaling in the Aging Brain

  2021cites this paper
• Cocaine shifts dopamine D2 receptor sensitivity to gate conditioned behaviors.

  2021cites this paper
• Heterogenous electrophysiological responses of functionally distinct striatal subregions to circadian and sleep-related homeostatic processes.

  2021cites this paper
• Separable Dorsal Raphe Dopamine Projections Mediate Sociability and Valence

  2021cites this paper
• Chiral Cyclic Aliphatic Linkers as Building Blocks for Selective Dopamine D2 or D3 Receptor Agonists.

  2021cites this paper
• Quantum Dots: Applications in Biology

  2020cites this paper
• Neuronal signature of an antipsychotic response

  2020cites this paper
• Molecular and functional architecture of striatal dopamine release sites

  2020cites this paper
• Labeling Neuronal Proteins with Quantum Dots for Single-Molecule Imaging.

  2020cites this paper
• Functional and molecular heterogeneity of D2R neurons along dorsal ventral axis in the striatum

  2020cites this paper
• Double dissociation between actions of dopamine D1 and D2 receptors of the ventral and dorsolateral striatum to produce reinstatement of cocaine seeking behavior.

  2020cites this paper
• Dopamine Receptor Subtypes, Physiology and Pharmacology: New Ligands and Concepts in Schizophrenia

  2020cites this paper
• Region-specific effects of acute haloperidol in the human midbrain, striatum and cortex.

  2020cites this paper
• In Situ Regulated Dopamine Transporter Trafficking: There’s No Place Like Home

  2020cites this paper
• GPCR and Alcohol-Related Behaviors in Genetically Modified Mice

  2020cites this paper
• Current strategies toward safer mu opioid receptor drugs for pain management

  2019cites this paper
• Disentangling the diverse roles of dopamine D2 receptors in striatal function and behavior

  2019cites this paper
• Schizophrenia, Dopamine and the Striatum: From Biology to Symptoms

  2019cites this paper
• Cholinergic Transmission at Muscarinic Synapses in the Striatum Is Driven Equally by Cortical and Thalamic Inputs

  2019cites this paper
• Imaging striatal dopamine release using a nongenetically encoded near infrared fluorescent catecholamine nanosensor

  2019cites this paper
• Striatum-related functional activation during reward- versus punishment-based learning in psychosis risk

  2019cites this paper
• Role of RGS12 in the differential regulation of kappa opioid receptor-dependent signaling and behavior

  2019cites this paper
• Dopamine and the Temporal Dependence of Learning and Memory

  2019cites this paper
• Histamine H3 receptor activation reduces the impairment in prepulse inhibition (PPI) of the acoustic startle response and Akt phosphorylation induced by MK-801 (dizocilpine), antagonist at N-Methyl-d-Aspartate (NMDA) receptors.

  2019cites this paper
• Accumbal Adenosine A2A Receptors Enhance Cognitive Flexibility by Facilitating Strategy Shifting

  2019cites this paper
• Mechanisms and regulation of dopamine release.

  2019cites this paper
• Genetic tools to study complexity of striatal function

  2019cites this paper
• Emerging Roles of Striatal Dopamine D2 Receptors in Motivated Behaviour: Implications for Psychiatric Disorders.

  2019cites this paper
• Arrestin recruitment to dopamine D2 receptor mediates locomotion but not incentive motivation

  2018cites this paper
• Parkinson's Disease-Linked LRRK2-G2019S Mutation Alters Synaptic Plasticity and Promotes Resilience to Chronic Social Stress in Young Adulthood

  2018cites this paper
• Deconstructing value-based decision making via temporally selective manipulation of neural activity: Insights from rodent models

  2018cites this paper
• Dopamine Is Differentially Encoded by D2 Receptors in Striatal Subregions.

  2018cites this paper
• Combining Optical Approaches with Human Inducible Pluripotent Stem Cells in G Protein-Coupled Receptor Drug Screening and Development

  2018cites this paper