The cytoplasmic dynein transport machinery and its many cargoes

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Nature reviews. Molecular cell biology

• Publication date

  2018-04-16

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/s41580-018-0004-3PMID 29662141PMCID PMC6457270
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Author contributions

  2019cited by this paper
• The matrix revisited.

  2018cited by this paper
• A conserved interaction of the dynein light intermediate chain with dynein-dynactin effectors necessary for processivity

  2018cited by this paper
• New splicing variants of mitochondrial Rho GTPase-1 (Miro1) transport peroxisomes

  2018cited by this paper
• Lissencephaly-1 is a context-dependent regulator of the human dynein complex

  2017cited by this paper
• Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility

  2017cited by this paper
• The human cytoplasmic dynein interactome reveals novel activators of motility

  2017influential reference
• Cryo-EM shows how dynactin recruits two dyneins for faster movement

  2017cited by this paper
• Hitchhiking: A Non-Canonical Mode of Microtubule-Based Transport.

  2017cited by this paper
• LRGUK1 is part of a multiprotein complex required for manchette function and male fertility

  2017cited by this paper
• NuMA Targets Dynein to Microtubule Minus-Ends at Mitosis

  2017cited by this paper
• Cryo-EM Reveals How Human Cytoplasmic Dynein Is Auto-inhibited and Activated

  2017influential reference
• Differential effects of the dynein-regulatory factor Lissencephaly-1 on processive dynein-dynactin motility

  2017cited by this paper
• Molecular mechanism of dynein recruitment to kinetochores by the Rod–Zw10–Zwilch complex and Spindly

  2017cited by this paper
• Molecular mechanism of dynein recruitment to kinetochores by the Rod–Zw10–Zwilch complex and Spindly

  2017cited by this paper
• Dynactin has two antagonistic regulatory domains and exerts opposing effects on dynein motility

  2017cited by this paper
• NuMA recruits dynein activity to microtubule minus-ends at mitosis

  2017cited by this paper
• Lis1 has two opposing modes of regulating cytoplasmic dynein

  2017cited by this paper
• Comparative analysis of axonal transport markers in primary mammalian neurons.

  2016cited by this paper
• Assembly and activation of dynein–dynactin by the cargo adaptor protein Hook3

  2016cited by this paper
• Regulation of centriolar satellite integrity and its physiology

  2016cited by this paper
• How dynein and dynactin transport cargos: a structural perspective.

  2016cited by this paper
• Why do peroxisomes associate with the cytoskeleton?

  2016cited by this paper
• Rab5 and its effector FHF contribute to neuronal polarity through dynein-dependent retrieval of somatodendritic proteins from the axon

  2016cited by this paper
• Mechanisms and functions of lysosome positioning

  2016cited by this paper
• Membrane Tethering Complexes in the Endosomal System

  2016cited by this paper
• Hook Adaptors Induce Unidirectional Processive Motility by Enhancing the Dynein-Dynactin Interaction*

  2016cited by this paper
• Compartment-Specific Regulation of Autophagy in Primary Neurons

  2016cited by this paper
• Axonal autophagosomes recruit dynein for retrograde transport through fusion with late endosomes

  2015cited by this paper
• Microtubule-dependent transport and dynamics of vimentin intermediate filaments

  2015cited by this paper
• The structure of the dynactin complex and its interaction with dynein

  2015cited by this paper
• Proteomic Analysis of Dynein-Interacting Proteins in Amyotrophic Lateral Sclerosis Synaptosomes Reveals Alterations in the RNA-Binding Protein Staufen1*

  2015cited by this paper
• Intermediate Filaments Play a Pivotal Role in Regulating Cell Architecture and Function*

  2015cited by this paper
• Mechanism and regulation of cytoplasmic dynein.

  2015cited by this paper
• Membrane-Coupled mRNA Trafficking in Fungi.

  2015cited by this paper
• The Ciliopathy Protein CC2D2A Associates with NINL and Functions in RAB8-MICAL3-Regulated Vesicle Trafficking

  2015cited by this paper
• Moving and positioning the nucleus in skeletal muscle – one step at a time

  2015cited by this paper
• NINL and DZANK1 Co-function in Vesicle Transport and Are Essential for Photoreceptor Development in Zebrafish

  2015cited by this paper
• Peroxisomes move by hitchhiking on early endosomes using the novel linker protein PxdA

  2015cited by this paper
• Peroxisomes, lipid droplets, and endoplasmic reticulum “hitchhike” on motile early endosomes

  2015influential reference
• The Arf and Rab11 effector FIP3 acts synergistically with ASAP1 to direct Rabin8 in ciliary receptor targeting

  2015cited by this paper
• Interplay between kinesin-1 and cortical dynein during axonal outgrowth and microtubule organization in Drosophila neurons

  2015cited by this paper
• HkRP3 Is a Microtubule-Binding Protein Regulating Lytic Granule Clustering and NK Cell Killing

  2015cited by this paper
• Axonal autophagosomes recruit dynein for retrograde transport through fusion with late endosomes

  2015cited by this paper
• LC3 binding to the scaffolding protein JIP1 regulates processive dynein-driven transport of autophagosomes.

  2014cited by this paper
• HookA is a novel dynein–early endosome linker critical for cargo movement in vivo

  2014cited by this paper
• Signalling endosomes in axonal transport: travel updates on the molecular highway.

  2014cited by this paper
• Toward a Comprehensive Map of the Effectors of Rab GTPases

  2014cited by this paper
• Bicaudal d family adaptor proteins control the velocity of Dynein-based movements.

  2014cited by this paper
• Structure of human cytoplasmic dynein-2 primed for its powerstroke

  2014cited by this paper
• mRNA localization in the Drosophila germline

  2014cited by this paper
• Bidirectional cargo transport: moving beyond tug of war

  2014cited by this paper
• Orchestration of cell surface proteins by Rab11.

  2014cited by this paper
• Autoinhibition and cooperative activation mechanisms of cytoplasmic dynein

  2014cited by this paper
• Early endosome motility spatially organizes polysome distribution

  2014cited by this paper
• FHIP and FTS proteins are critical for dynein-mediated transport of early endosomes in Aspergillus

  2014cited by this paper
• Hook is an adapter that coordinates kinesin-3 and dynein cargo attachment on early endosomes

  2014cited by this paper
• A PIK3C3–Ankyrin-B–Dynactin pathway promotes axonal growth and multiorganelle transport

  2014cited by this paper
• Local translation in neuronal processes—in vivo tests of a “heretical hypothesis”

  2014cited by this paper
• Function and regulation of dynein in mitotic chromosome segregation

  2014cited by this paper
• Long-distance axonal transport of AAV9 is driven by dynein and kinesin-2 and is trafficked in a highly motile Rab7-positive compartment.

  2014cited by this paper
• Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes

  2014cited by this paper
• A Ras-like domain in the light intermediate chain bridges the dynein motor to a cargo-binding region

  2014influential reference
• Dynamic Imaging of the Hepatitis C Virus NS5A Protein during a Productive Infection

  2014cited by this paper
• Interaction of SQSTM1 with the motor protein dynein – SQSTM1 is required for normal dynein function and trafficking

  2014cited by this paper
• Influenza A virus uses the aggresome processing machinery for host cell entry

  2014cited by this paper
• In vitro reconstitution of a highly processive recombinant human dynein complex

  2014cited by this paper
• Translocating myonuclei have distinct leading and lagging edges that require Kinesin and Dynein

  2014cited by this paper
• The Regulation of Autophagosome Dynamics by Huntingtin and HAP1 Is Disrupted by Expression of Mutant Huntingtin, Leading to Defective Cargo Degradation

  2014influential reference
• Transport along the dendritic endoplasmic reticulum mediates the trafficking of GABAB receptors

  2014cited by this paper
• Rab11 facilitates cross-talk between autophagy and endosomal pathway through regulation of Hook localization

  2014cited by this paper
• RILP interacts with HOPS complex via VPS41 subunit to regulate endocytic trafficking

  2014cited by this paper
• Circovirus Transport Proceeds via Direct Interaction of the Cytoplasmic Dynein IC1 Subunit with the Viral Capsid Protein

  2014cited by this paper
• PKA-dependent dynein switching from lysosomes to adenovirus: A novel form of host–virus competition

  2014influential reference
• Involvement of Microtubular Network and Its Motors in Productive Endocytic Trafficking of Mouse Polyomavirus

  2014cited by this paper
• TRAK/Milton motor-adaptor proteins steer mitochondrial trafficking to axons and dendrites.

  2013cited by this paper
• Microtubule-dependent endosomal sorting of clathrin-independent cargo by Hook1

  2013cited by this paper
• JNK-Interacting Protein 3 Mediates the Retrograde Transport of Activated c-Jun N-Terminal Kinase and Lysosomes

  2013cited by this paper
• Late endosomal transport and tethering are coupled processes controlled by RILP and the cholesterol sensor ORP1L

  2013cited by this paper
• Dynein recruitment to nuclear pores activates apical nuclear migration and mitotic entry in brain progenitor cells.

  2013cited by this paper
• Mitochondrial trafficking in neurons.

  2013cited by this paper
• Dynamic Recruitment of CDK5RAP2 to Centrosomes Requires Its Association with Dynein

  2013cited by this paper
• SQSTM1/p62 Interacts with HDAC6 and Regulates Deacetylase Activity

  2013cited by this paper
• Reovirus Cell Entry Requires Functional Microtubules

  2013cited by this paper
• Mechanisms of spindle positioning

  2013cited by this paper
• Dynein and Dynactin Leverage Their Bivalent Character to Form a High-Affinity Interaction

  2013cited by this paper
• 14-3-3 protein targets misfolded chaperone-associated proteins to aggresomes

  2013cited by this paper
• Teamwork in microtubule motors.

  2013cited by this paper
• The herpesvirus VP1/2 protein is an effector of dynein-mediated capsid transport and neuroinvasion.

  2013cited by this paper
• Mutations in cytoplasmic dynein and its regulators cause malformations of cortical development and neurodegenerative diseases.

  2013cited by this paper
• JIP1 regulates the directionality of APP axonal transport by coordinating kinesin and dynein motors

  2013cited by this paper
• Nudel/NudE and Lis1 promote dynein and dynactin interaction in the context of spindle morphogenesis

  2013cited by this paper
• The biophysics and cell biology of lipid droplets

  2013cited by this paper
• Endosomal transport of septin mRNA and protein indicates local translation on endosomes and is required for correct septin filamentation

  2013cited by this paper
• BICD2, dynactin, and LIS1 cooperate in regulating dynein recruitment to cellular structures

  2012cited by this paper
• Cortical dynein controls microtubule dynamics to generate pulling forces that position microtubule asters.

  2012cited by this paper
• The 2.8 Å crystal structure of the dynein motor domain

  2012cited by this paper
• Lis1 is an initiation factor for dynein-driven organelle transport

  2012cited by this paper
• Lis1 Acts as a “Clutch” between the ATPase and Microtubule-Binding Domains of the Dynein Motor

  2012cited by this paper
• Golgin160 recruits the dynein motor to position the Golgi apparatus.

  2012cited by this paper

• A nucleotide code governs Lis1's ability to relieve dynein autoinhibition.

  2026cites this paper
• Longitudinal Peripheral Blood Transcriptomics Reveal Novel Signatures During Cardiac Allograft Rejection

  2026cites this paper
• Kinesin-1 trans-synaptically regulates synaptic localization of SARM1 for asymmetric neuron diversification

  2026cites this paper
• Microtubule inner proteins in apicomplexan parasites

  2026cites this paper
• The Rab5 effector Rabankyrin-5 mediates endosomal fusion and trafficking of human papillomavirus during early entry.

  2026cites this paper
• Kinesin-1 conformational dynamics are controlled by a cargo-sensitive TPR switch

  2026cites this paper
• Loss and gain of motor protein function cause microtubule bundle damage in Drosophila axons.

  2026cites this paper
• Dynein upsizes under load.

  2026cites this paper
• The cytoskeleton regulates cytoophidium dynamics in Drosophila ovaries.

  2026cites this paper
• Proteomic Landscape of Sweat Glands in Neuronal Intranuclear Inclusion Disease Reveals a Pathogenic Triad of Abnormal Autophagy, Mitochondrial Dysfunction, and a Failed Oxidative Stress Response

  2026cites this paper
• Lipid Droplet‐Localized Spindle Apparatus Coiled‐Coil Protein 1 Regulates Lipid Droplet Distribution

  2026cites this paper
• Roles of microtubules and LIS1 in dynein transport machinery assembly.

  2026cites this paper
• Occludin acts as a dynein adaptor regulating permeability and collateral angiogenesis.

  2025cites this paper
• Multi-omics analysis of placental metabolomics and transcriptomics datasets reveals comprehensive insights into the pathophysiology of preeclampsia.

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• Driving cancer: Motor and adaptor protein dysregulation in endocytic receptor signalling.

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• Advances in networking droplets

  2025cites this paper
• The mechanochemical cycle of reactive full-length human dynein 1

  2025cites this paper
• Effect of Dync1h1 on Phototransduction Protein Transport and the Development and Maintenance of Photoreceptor Cells in Zebrafish

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• Cytoskeleton Regulates Cytoophidium Dynamics in Drosophila Ovaries

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• Glaucomatous retinal ganglion cells: death and protection.

  2025cites this paper
• Mitochondria transported by Kinesin 3 prevent localized calcium spiking to inhibit caspase-dependent specialized cell death

  2025cites this paper
• Dominant spinal muscular atrophy linked mutations in the cargo binding domain of BICD2 result in altered interactomes and dynein hyperactivity

  2025cites this paper
• The Hitchdock Domain in Kinesin-2 Tail Enables Adaptor Assembly and Cargo Binding

  2025cites this paper
• Sec61β, a subunit of the Sec61 complex at the endoplasmic reticulum, coordinates with Ocnus in regulating Drosophila spermatogenesis.

  2025cites this paper
• Enzyme-mediated proximity labeling reveals the co-translational targeting of DLGAP5 mRNA to the centrosome during mitosis

  2025cites this paper
• The KASH protein UNC-83 differentially regulates kinesin-1 activity to control developmental stage-specific nuclear migration

  2025cites this paper
• Fat traffic control: S-acylation in axonal transport

  2025cites this paper
• Active fluctuations of cytoplasmic actomyosin networks facilitate dynein-driven transport

  2025cites this paper
• Interfacial Interactions between Neural Tracing Lectin–Gold Nanoparticle Conjugate and Cell Membrane Glycoproteins

  2025cites this paper
• COP9 signalosome and PRMT5 methylosome complexes are essential regulators of Lis1-dynein-based transport.

  2025cites this paper
• Enhanced Processivity and Collective Force Production of Kinesin-1 at Low Radial Forces

  2025cites this paper
• Main Manuscript for Many dynein teams collectively generate high forces during the transport of large organelles.

  2025cites this paper
• Non-cell autonomous autophagy in amyotrophic lateral sclerosis: A new promising target?

  2025cites this paper
• Histone lactylation regulates DOCK4 to control heat nociception and supports Dynein-mediated Nav1.7 trafficking

  2025cites this paper
• NMR approaches to identify transient structure and interactions of intrinsically disordered dynein intermediate chain.

  2025cites this paper
• CDR2 is a dynein adaptor recruited by kinectin to regulate ER sheet organization.

  2025cites this paper
• Retrotransposon 3S18 forms self-protective aggregates and prolongs mid-oogenesis.

  2025cites this paper
• Morphological map of under- and overexpression of genes in human cells

  2025cites this paper
• Cryo-EM captures early intermediate steps in dynein activation by LIS1

  2025cites this paper
• Bi-allelic deleterious variants in SNAPIN, which encodes a retrograde dynein adaptor, cause a prenatal-onset neurodevelopmental disorder.

  2025cites this paper
• Alpha-centractin is a novel substrate of SETD3 methyltransferase in vitro

  2025cites this paper
• NuMA and Ninein: Dynein Cargo-Adaptors Without a Classical Cargo

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• Dominant spinal muscular atrophy linked mutations in the cargo binding domain of BICD2 result in altered interactomes and dynein hyperactivity

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• A bacteriophage tubulin forms microtubule-like assemblies with nine protofilaments.

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• Different mechanisms link gain and loss of kinesin functions to axonal degeneration

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• HIV-1 binds dynein directly to hijack microtubule transport machinery

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• Exploration of the interaction between dynein intermediate chain and dynactin p150Glued reveals a novel binding Interface

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