Cerebrospinal fluid markers of extracellular matrix remodelling, synaptic plasticity and neuroinflammation before and after cranial radiotherapy

Advances in the treatment of brain tumours have increased the number of long‐term survivors, but at the cost of side effects following cranial radiotherapy ranging from neurocognitive deficits to outright tissue necrosis. At present, there are no tools reflecting the molecular mechanisms underlying such side effects, and thus no means to evaluate interventional effects after cranial radiotherapy. Therefore, fluid biomarkers are of great clinical interest.

• Publication year

  2018

• Venue

  Journal of Internal Medicine

• Publication date

  2018-04-17

• Fields of study

  Medicine, Environmental Science

• Identifiers
  DOI 10.1111/joim.12763PMID 29664192
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Secreted amyloid precursor protein‐alpha can restore novel object location memory and hippocampal LTP in aged rats

  2017cited by this paper
• Repeated Measures Correlation

  2017cited by this paper
• Radiation Dose-Dependent Hippocampal Atrophy Detected With Longitudinal Volumetric Magnetic Resonance Imaging.

  2017cited by this paper
• Mechanisms of radiotherapy-associated cognitive disability in patients with brain tumours

  2017cited by this paper
• Serum concentrations of the axonal injury marker neurofilament light protein are not influenced by blood-brain barrier permeability.

  2017cited by this paper
• Dose-Dependent Cortical Thinning After Partial Brain Irradiation in High-Grade Glioma.

  2016cited by this paper
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  2016cited by this paper
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  2016cited by this paper
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  2016cited by this paper
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  2016cited by this paper
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  2016cited by this paper
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  2016cited by this paper
• SNAP-25, a Known Presynaptic Protein with Emerging Postsynaptic Functions

  2016cited by this paper
• In Sickness and in Health: Perineuronal Nets and Synaptic Plasticity in Psychiatric Disorders

  2015cited by this paper
• Persistent changes in neuronal structure and synaptic plasticity caused by proton irradiation

  2015cited by this paper
• Neurogranin and YKL-40: independent markers of synaptic degeneration and neuroinflammation in Alzheimer’s disease

  2015cited by this paper
• Fibronectin is a potential cerebrospinal fluid and serum epilepsy biomarker.

  2015cited by this paper
• Neurogranin regulates CaM dynamics at dendritic spines

  2015cited by this paper
• Chondroitin Sulfate Proteoglycans: Structure-Function Relationship with Implication in Neural Development and Brain Disorders

  2014cited by this paper
• Neurochemical evidence of potential neurotoxicity after prophylactic cranial irradiation.

  2014cited by this paper
• Growth associated protein (GAP-43): cloning and the development of a sensitive ELISA for neurological disorders.

  2014cited by this paper
• Hippocampal proteoglycans brevican and versican are linked to spatial memory of Sprague–Dawley rats in the morris water maze

  2014cited by this paper
• Different reactions to irradiation in the juvenile and adult hippocampus

  2014cited by this paper
• SNAP-25 is a promising novel cerebrospinal fluid biomarker for synapse degeneration in Alzheimer’s disease

  2014cited by this paper
• Regulation of Cellular Processes by Interleukin‐16 in Homeostasis and Cancer

  2014cited by this paper
• Amyloid precursor protein and neural development

  2014cited by this paper
• Acute function of secreted amyloid precursor protein fragment APPsα in synaptic plasticity

  2014cited by this paper
• The principle of membrane fusion in the cell (Nobel lecture).

  2014cited by this paper
• LTP requires a unique postsynaptic SNARE fusion machinery.

  2013cited by this paper
• Absence of CCL2 is sufficient to restore hippocampal neurogenesis following cranial irradiation.

  2013cited by this paper
• Synaptotagmin‐1 promotes the formation of axonal filopodia and branches along the developing axons of forebrain neurons

  2013cited by this paper
• SNAP-25 regulates spine formation through postsynaptic binding to p140Cap

  2013cited by this paper
• In vivo single branch axotomy induces GAP-43–dependent sprouting and synaptic remodeling in cerebellar cortex

  2013cited by this paper
• Cranial irradiation compromises neuronal architecture in the hippocampus

  2013cited by this paper
• Brevican: a key proteoglycan in the perisynaptic extracellular matrix of the brain.

  2012cited by this paper
• Whole Brain Radiation-Induced Cognitive Impairment: Pathophysiological Mechanisms and Therapeutic Targets

  2012cited by this paper
• Association between schizophrenia and common variation in neurocan (NCAN), a genetic risk factor for bipolar disorder.

  2012cited by this paper
• Cerebrospinal Fluid Matrix Metalloproteinases Are Elevated in Cerebral Adrenoleukodystrophy and Correlate with MRI Severity and Neurologic Dysfunction

  2012cited by this paper
• Irradiation alters MMP-2/TIMP-2 system and collagen type IV degradation in brain.

  2012cited by this paper
• The role of brevican in glioma: promoting tumor cell motility in vitro and in vivo

  2012cited by this paper
• Extracellular matrix and perineuronal nets in CNS repair

  2011cited by this paper
• Functions of the APP gene family in the nervous system: insights from mouse models

  2011cited by this paper
• Phase III trial of prophylactic cranial irradiation compared with observation in patients with locally advanced non-small-cell lung cancer: neurocognitive and quality-of-life analysis.

  2011cited by this paper
• Extracellular matrix molecules, their receptors, and secreted proteases in synaptic plasticity

  2011cited by this paper
• Neurocan contributes to the molecular heterogeneity of the perinodal ECM.

  2010cited by this paper
• Abnormal post‐translational and extracellular processing of brevican in plaque‐bearing mice over‐expressing APPsw

  2010cited by this paper
• Cognitive function before and after intensity-modulated radiation therapy in patients with nasopharyngeal carcinoma: a prospective study.

  2010cited by this paper
• Extracellular matrix-glial abnormalities in the amygdala and entorhinal cortex of subjects diagnosed with schizophrenia.

  2010cited by this paper
• Blockade of IL‐15 activity inhibits microglial activation through the NFκB, p38, and ERK1/2 pathways, reducing cytokine and chemokine release

  2010cited by this paper
• Irradiation induces regionally specific alterations in pro-inflammatory environments in rat brain

  2010cited by this paper
• Cognitive and radiological effects of radiotherapy in patients with low-grade glioma: long-term follow-up.

  2009cited by this paper
• Brevican distinctively assembles extracellular components at the large diameter nodes of Ranvier in the CNS

  2009cited by this paper
• Prophylactic cranial irradiation in extensive disease small-cell lung cancer: short-term health-related quality of life and patient reported symptoms: results of an international Phase III randomized controlled trial by the EORTC Radiation Oncology and Lung Cancer Groups.

  2009cited by this paper
• Transient Inflammation in Neurogenic Regions after Irradiation of the Developing Brain

  2009cited by this paper
• N-terminal acetylation of the neuronal protein SNAP-25 is revealed by the SMI81 monoclonal antibody.

  2009cited by this paper
• Neural precursor cells and central nervous system radiation sensitivity.

  2009cited by this paper
• Voluntary running rescues adult hippocampal neurogenesis after irradiation of the young mouse brain

  2008cited by this paper
• Extracellular matrix of the central nervous system: from neglect to challenge

  2008cited by this paper
• O3‐02–06: Elevated cerebrospinal fluid BACE1 activity in incipient Alzheimer's disease

  2008cited by this paper
• Matrix metalloproteinases and proteoglycans in axonal regeneration.

  2007cited by this paper
• IL-15/IL-15 receptor biology: a guided tour through an expanding universe.

  2006cited by this paper
• Role of the Neurogranin Concentrated in Spines in the Induction of Long-Term Potentiation

  2006cited by this paper
• From the authors

  2005cited by this paper
• Radiation injury and neurogenesis

  2003cited by this paper
• The Cerebrospinal Fluid Levels of Tau, Growth-Associated Protein-43 and Soluble Amyloid Precursor Protein Correlate in Alzheimer’s Disease, Reflecting a Common Pathophysiological Process

  2001cited by this paper
• Glial Tumor Invasion: A Role for the Upregulation and Cleavage of BEHAB/Brevican

  2001cited by this paper
• Neurocan Is Upregulated in Injured Brain and in Cytokine-Treated Astrocytes

  2000cited by this paper
• Molecular interactions of neural chondroitin sulfate proteoglycans in the brain development.

  2000cited by this paper
• Brevican Is Degraded by Matrix Metalloproteinases and Aggrecanase-1 (ADAMTS4) at Different Sites*

  2000cited by this paper
• CSF levels of tau, β-amyloid1–42 and GAP-43 in frontotemporal dementia, other types of dementia and normal aging

  2000cited by this paper
• Intracranial injury acutely induces the expression of the secreted isoform of the CNS-specific hyaluronan-binding protein BEHAB/brevican.

  1999cited by this paper
• Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission. Prophylactic Cranial Irradiation Overview Collaborative Group.

  1999cited by this paper
• B-50, the growth associated protein-43: modulation of cell morphology and communication in the nervous system

  1997cited by this paper
• Calculating correlation coefficients with repeated observations: Part 1--Correlation within subjects.

  1995cited by this paper
• Statistics notes: Calculating correlation coefficients with repeated observations: Part 1—correlation within subjects

  1995cited by this paper
• Synaptotagmin: a calcium sensor on the synaptic vesicle surface.

  1992cited by this paper
• Long-term sequelae after pediatric brain tumors: their effect on disability and quality of life.

  1990cited by this paper
• A protein induced during nerve growth (GAP-43) is a major component of growth-cone membranes

  1986cited by this paper
• Changes in axonally transported proteins during axon regeneration in toad retinal ganglion cells

  1981cited by this paper
• “Mini-mental state”: A practical method for grading the cognitive state of patients for the clinician

  1975cited by this paper

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  2025cites this paper
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  2025cites this paper
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  2025cites this paper
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  2024cites this paper
• CSF biomarkers of neurotoxicity in childhood cancer survivors after cranial radiotherapy or surgery

  2024cites this paper
• Soluble Proteoglycans and Proteoglycan Fragments as Biomarkers of Pathological Extracellular Matrix Remodeling

  2024cites this paper
• Endo‐lysosomal protein concentrations in CSF from patients with frontotemporal dementia caused by CHMP2B mutation

  2023cites this paper
• Radiotherapy-induced tumor physical microenvironment remodeling to overcome immunotherapy resistance1.

  2023cites this paper
• Proteins Involved in Synaptic Plasticity Are Downregulated in the Cerebrospinal Fluid of Infants With Clinical Sepsis Complicated by Neuroinflammation

  2022influential citation
• Early plasma biomarker dynamic profiles are associated with acute ischemic stroke outcomes

  2022cites this paper
• Targeting Epithelial-to-Mesenchymal Transition in Radioresistance: Crosslinked Mechanisms and Strategies

  2022cites this paper
• Brevican and Neurocan Cleavage Products in the Cerebrospinal Fluid - Differential Occurrence in ALS, Epilepsy and Small Vessel Disease

  2022cites this paper
• Quantification of SNAP-25 with mass spectrometry and Simoa: a method comparison in Alzheimer’s disease

  2022cites this paper
• Radiation Effects on Brain Extracellular Matrix

  2020cites this paper
• Dissection of synaptic pathways through the CSF biomarkers for predicting Alzheimer disease

  2020cites this paper
• CSF synaptic protein concentrations are raised in those with atypical Alzheimer’s disease but not frontotemporal dementia

  2019cites this paper
• Combretastatin A4 Nanodrug‐Induced MMP9 Amplification Boosts Tumor‐Selective Release of Doxorubicin Prodrug

  2019cites this paper
• Chronic disturbance in the thalamus following cranial irradiation to the developing mouse brain

  2019cites this paper
• Expression and secretion of synaptic proteins during stem cell differentiation to cortical neurons

  2018cites this paper