Persistent changes in neuronal structure and synaptic plasticity caused by proton irradiation

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Brain Structure and Function

• Publication date

  2015-03-01

• Fields of study

  Biology, Medicine, Physics, Environmental Science

• Identifiers
  DOI 10.1007/s00429-014-0709-9PMID 24446074PMCID PMC4105336
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2013influential reference
• Clinical perspective on oxidative stress in sporadic amyotrophic lateral sclerosis.

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  2009influential reference
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