Length-dependent Ca2+ activation in cardiac muscle: some remaining questions

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Journal of Muscle Research and Cell Motility

• Publication date

  2005-10-05

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1007/s10974-005-9011-zPMID 16205841
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Single particle analysis of relaxed and activated muscle thin filaments.

  2005cited by this paper
• Titin-based modulation of active tension and interfilament lattice spacing in skinned rat cardiac muscle

  2005influential reference
• Phosphorylation of Titin Modulates Passive Stiffness of Cardiac Muscle in a Titin Isoform-dependent Manner

  2005cited by this paper
• Titin isoform-dependent effect of calcium on passive myocardial tension.

  2004cited by this paper
• Interfilament spacing, Ca2+ sensitivity, and Ca2+ binding in skinned bovine cardiac muscle

  2004cited by this paper
• Switching of troponin I: Ca(2+) and myosin-induced activation of heart muscle.

  2004cited by this paper
• Response of equatorial x-ray reflections and stiffness to altered sarcomere length and myofilament lattice spacing in relaxed skinned cardiac muscle.

  2004influential reference
• Cardiac length dependence of force and force redevelopment kinetics with altered cross-bridge cycling.

  2004cited by this paper
• Approaches to modeling crossbridges and calcium-dependent activation in cardiac muscle.

  2004cited by this paper
• Basal myosin light chain phosphorylation is a determinant of Ca2+ sensitivity of force and activation dependence of the kinetics of myocardial force development.

  2004cited by this paper
• X-ray diffraction from a left ventricular wall of rat heart.

  2004cited by this paper
• Increased Ca2+-sensitivity of the contractile apparatus in end-stage human heart failure results from altered phosphorylation of contractile proteins.

  2003cited by this paper
• Titin Isoform Variance and Length Dependence of Activation in Skinned Bovine Cardiac Muscle

  2003influential reference
• Troponin I in the murine myocardium: influence on length-dependent activation and interfilament spacing.

  2003cited by this paper
• Titin: properties and family relationships

  2003cited by this paper
• Length dependence of cardiac myofilament Ca(2+) sensitivity in the presence of substitute nucleoside triphosphates.

  2002cited by this paper
• Molecular Control Mechanisms in Striated Muscle Contraction

  2002cited by this paper
• Protein Kinase A Phosphorylates Titin’s Cardiac-Specific N2B Domain and Reduces Passive Tension in Rat Cardiac Myocytes

  2002cited by this paper
• Frank-Starling law of the heart and the cellular mechanisms of length-dependent activation

  2002cited by this paper
• The Frank -Starling Relationship: Cellular and Molecular Mechanisms

  2002cited by this paper
• Length‐dependent activation in three striated muscle types of the rat

  2002cited by this paper
• Myofilament Calcium Sensitivity in Skinned Rat Cardiac Trabeculae: Role of Interfilament Spacing

  2002cited by this paper
• Cardiac titin: an adjustable multi‐functional spring

  2002cited by this paper
• Thin filament near‐neighbour regulatory unit interactions affect rabbit skeletal muscle steady‐state force‐Ca2+ relations

  2002cited by this paper
• Influence of length on force and activation-dependent changes in troponin c structure in skinned cardiac and fast skeletal muscle.

  2001cited by this paper
• Length Dependence of Tension Generation in Rat Skinned Cardiac Muscle: Role of Titin in the Frank-Starling Mechanism of the Heart

  2001cited by this paper
• Calcium, cross-bridges, and the Frank-Starling relationship.

  2001cited by this paper
• Ca2+ - and cross-bridge-dependent changes in N- and C-terminal structure of troponin C in rat cardiac muscle.

  2001influential reference
• Titin-Based Modulation of Calcium Sensitivity of Active Tension in Mouse Skinned Cardiac Myocytes

  2001influential reference
• Acidosis or inorganic phosphate enhances the length dependence of tension in rat skinned cardiac muscle

  2001cited by this paper
• Structural and functional studies of titin's fn3 modules reveal conserved surface patterns and binding to myosin S1--a possible role in the Frank-Starling mechanism of the heart.

  2001cited by this paper
• Regulation of contraction in striated muscle.

  2000influential reference
• Effect of protein kinase A on calcium sensitivity of force and its sarcomere length dependence in human cardiomyocytes.

  2000cited by this paper
• Myofilament lattice spacing as a function of sarcomere length in isolated rat myocardium.

  2000cited by this paper
• Effects of MgADP on length dependence of tension generation in skinned rat cardiac muscle.

  2000influential reference
• Attenuation of length dependence of calcium activation in myofilaments of transgenic mouse hearts expressing slow skeletal troponin I

  2000cited by this paper
• Tropomyosin and actin isoforms modulate the localization of tropomyosin strands on actin filaments.

  2000cited by this paper
• Length-dependence of cross-bridge mediated activation of the cardiac thin filament.

  2000influential reference
• Effect of troponin I phosphorylation by protein kinase A on length-dependence of tension activation in skinned cardiac muscle fibers.

  2000influential reference
• Length modulation of active force in rat cardiac myocytes: is titin the sensor?

  1999cited by this paper
• Effect of ionic strength on length-dependent Ca(2+) activation in skinned cardiac muscle.

  1999cited by this paper
• The filament lattice of striated muscle.

  1998cited by this paper
• Effects of in vivo-like activation frequency on the length-dependent force generation of skeletal muscle fibre bundles

  1998cited by this paper
• Changes in interfilament spacing mimic the effects of myosin regulatory light chain phosphorylation in rabbit psoas fibers.

  1998cited by this paper
• Strong binding of myosin modulates length-dependent Ca2+ activation of rat ventricular myocytes.

  1998cited by this paper
• Length dependence of Ca(2+)-tension relationship in aequorin-injected ferret papillary muscles.

  1997cited by this paper
• Force enhancement without changes in cross-bridge turnover kinetics: the effect of EMD 57033.

  1997cited by this paper
• Steric-model for activation of muscle thin filaments.

  1997cited by this paper
• Resting tension participates in the modulation of active tension in isolated guinea pig ventricular myocytes.

  1997cited by this paper
• Ca2+ Binding to Troponin C in Skinned Skeletal Muscle Fibers Assessed with Caged Ca2+ and a Ca2+ Fluorophore

  1997cited by this paper
• Sarcomere length versus interfilament spacing as determinants of cardiac myofilament Ca2+ sensitivity and Ca2+ binding.

  1996cited by this paper
• Myosin light chain phosphorylation affects the structure of rabbit skeletal muscle thick filaments.

  1996influential reference
• Myosin head orientation and mobility during isometric contraction: effects of osmotic compression.

  1996cited by this paper
• The effect of muscle length on intracellular calcium and force in single fibres from mouse skeletal muscle.

  1996cited by this paper
• CGP-48506 increases contractility of ventricular myocytes and myofilaments by effects on actin-myosin reaction.

  1996cited by this paper
• Osmotic compression of single cardiac myocytes eliminates the reduction in Ca2+ sensitivity of tension at short sarcomere length.

  1995cited by this paper
• Myosin binding-induced cooperative activation of the thin filament in cardiac myocytes and skeletal muscle fibers.

  1995influential reference
• Characterization of the equilibrium between blocked and closed states of muscle thin filaments.

  1995cited by this paper
• Osmotic compression of skinned cardiac and skeletal muscle bundles: effects on force generation, Ca2+ sensitivity and Ca2+ binding.

  1995cited by this paper
• Mechanical Modulation of the Ca2+ Regulatory Protein Complex in Cardiac Muscle

  1995cited by this paper
• Length, force, and Ca(2+)-troponin C affinity in cardiac and slow skeletal muscle.

  1994cited by this paper
• The regulatory switch of the muscle thin filament: Ca2+ or myosin heads?

  1994cited by this paper
• Myofilament Ca2+ sensitivity in intact versus skinned rat ventricular muscle.

  1994cited by this paper
• The effect of lattice spacing change on cross-bridge kinetics in chemically skinned rabbit psoas muscle fibers. I. Proportionality between the lattice spacing and the fiber width.

  1993cited by this paper
• Regulation of the interaction between actin and myosin subfragment 1: evidence for three states of the thin filament.

  1993cited by this paper
• Alterations in intracellular calcium and tension of activated ferret papillary muscle in response to step length changes.

  1993cited by this paper
• Parallel inhibition of active force and relaxed fiber stiffness in skeletal muscle by caldesmon: implications for the pathway to force generation.

  1991cited by this paper
• Force, length, and Ca(2+)-troponin C affinity in skeletal muscle.

  1991cited by this paper
• Hysteresis and the length dependence of calcium sensitivity in chemically skinned rat cardiac muscle.

  1988cited by this paper
• Length and myofilament spacing-dependent changes in calcium sensitivity of skeletal fibres: effects of pH and ionic strength

  1988cited by this paper
• Bound calcium and force development in skinned cardiac muscle bundles: effect of sarcomere length.

  1988cited by this paper
• Calcium concentration in the myoplasm of skinned ferret ventricular muscle following changes in muscle length.

  1988cited by this paper
• Sensitization of Dog and Guinea Pig Heart Myofilaments to Ca2+Activation and the Inotropic Effect of Pimobendan: Comparison With Milrinone

  1988cited by this paper
• Effect of length and cross-bridge attachment on Ca2+ binding to cardiac troponin C.

  1987cited by this paper
• Evidence for a force-dependent component of calcium binding to cardiac troponin C.

  1987cited by this paper
• Comparison between the Sarcomere Length‐Force Relations of Intact and Skinned Trabeculae from Rat Right Ventricle: Influence of Calcium Concentrations on These Relations

  1986cited by this paper
• Tension development and calcium sensitivity in skinned muscle fibres of the frog

  1985cited by this paper
• The cellular basis of the length-tension relation in cardiac muscle.

  1985cited by this paper
• Equatorial x-ray diffraction from single skinned rabbit psoas fibers at various degrees of activation. Changes in intensities and lattice spacing.

  1985cited by this paper
• Length dependence of changes in sarcoplasmic calcium concentration and myofibrillar calcium sensitivity in striated muscle fibres

  1984cited by this paper
• X-ray diffraction evidence for cross-bridge formation in relaxed muscle fibers at various ionic strengths.

  1984cited by this paper
• Calcium‐ and length‐dependent force production in rat ventricular muscle

  1982cited by this paper
• The effects of muscle length on intracellular calcium transients in mammalian cardiac muscle.

  1982cited by this paper
• Influence of osmotic compression on calcium activation and tension in skinned muscle fibers of the rabbit

  1981cited by this paper
• Myoplasmic free calcium concentration reached during the twitch of an intact isolated cardiac cell and during calcium-induced release of calcium from the sarcoplasmic reticulum of a skinned cardiac cell from the adult rat or rabbit ventricle

  1981cited by this paper
• Tension Development and Sarcomere Length in Rat Cardiac Trabeculae: Evidence of Length‐Dependent Activation

  1980cited by this paper
• Myofilament-generated tension oscillations during partial calcium activation and activation dependence of the sarcomere length-tension relation of skinned cardiac cells

  1978cited by this paper
• Swelling of skinned muscle fibers of the frog. Experimental observations.

  1977cited by this paper
• Length‐Dependent Activation: Its Effect on the Length‐Tension Relation in Cat Ventricular Muscle

  1977cited by this paper
• A reexamination of the influence of muscle length on myocardial performance.

  1977cited by this paper
• The contribution of activation processes to the length–tension relation of cardiac muscle

  1974cited by this paper
• The relations between sarcomere length and characteristics of isometric twitch contractions of frog sartorius muscle

  1972cited by this paper
• Cooperation within actin filament in vertebrate skeletal muscle.

  1972cited by this paper
• Netherlands: Proposals for Reforming University Science

  1972cited by this paper
• Stretch-induced increase in activation of skinned muscle fibres by calcium.

  1972cited by this paper
• The variation in isometric tension with sarcomere length in vertebrate muscle fibres

  1966cited by this paper

• Nanometer scale difference in myofilament lattice structure of muscle alters muscle function in a spatially explicit model

  2025cites this paper
• CARDIAC MYOSIN BINDING PROTEIN-C ACTS AS A TUNABLE LOAD SENSOR TO REGULATE AFTERLOAD DEPENDENCE OF VENTRICULAR FUNCTION.

  2025cites this paper
• Nanometer scale difference in myofilament lattice structure of muscle alter muscle function in a spatially explicit model

  2024cites this paper
• Functional control of myosin motors in the cardiac cycle

  2024cites this paper
• Sarcomere length affects Ca2+ sensitivity of contraction in ischemic but not non-ischemic myocardium

  2023influential citation
• Optimized Conditions for the Long-Term Maintenance of Precision-Cut Murine Myocardium in Biomimetic Tissue Culture

  2023cites this paper
• Cardiac Sarcomere Signaling in Health and Disease

  2022cites this paper
• Muscle active force-length curve explained by an electrophysical model of interfilament spacing.

  2022cites this paper
• The regulatory light chain mediates inactivation of myosin motors during active shortening of cardiac muscle

  2021cites this paper
• Cardiac MyBP-C phosphorylation regulates the Frank–Starling relationship in murine hearts

  2021influential citation
• The effect of variable troponin C mutation thin filament incorporation on cardiac muscle twitch contractions.

  2021cites this paper
• Stress-dependent activation of myosin in the heart requires thin filament activation and thick filament mechanosensing

  2021cites this paper
• Nanometer-scale structure differences in the myofilament lattice spacing of two cockroach leg muscles correspond to their different functions

  2020cites this paper
• Eliminating the First Inactive State and Stabilizing the Active State of the Cardiac Regulatory System Alters Behavior in Solution and in Ordered Systems.

  2020cites this paper
• Regulation of Myofilament Contractile Function in Human Donor and Failing Hearts

  2019cites this paper
• Metabolic Cardiomyopathy in Paediatric Practice

  2019cites this paper
• Метаболическая кардиомиопатия в практике педиатра

  2019cites this paper
• Metabolic cardiomyopathy in pediatrics.

  2019cites this paper
• A nanometer difference in myofilament lattice spacing of two cockroach leg muscles explains their different functions

  2019cites this paper
• Inter-filament spacing mediates calcium binding to troponin: A simple geometric-mechanistic model explains the shift of force-length maxima with muscle activation.

  2018cites this paper
• Sarcomere length–dependent effects on Ca2+-troponin regulation in myocardium expressing compliant titin

  2018cites this paper
• Functional significance of C-terminal mobile domain of cardiac troponin I.

  2017cites this paper
• Hill equation and Hatze's muscle activation dynamics complement each other: enhanced pharmacological and physiological interpretability of modelled activity-pCa curves.

  2017cites this paper
• A model of cardiac contraction based on novel measurements of tension development in human cardiomyocytes.

  2017cites this paper
• Leg Lifting in HFrEF, Frank-Starling, and Mitral Regurgitation.

  2017cites this paper
• The continuing evolution of cardiac troponin I biomarker analysis: from protein to proteoform

  2017cites this paper
• The effect of cardiomyopathy mutation (R97L) in mouse cardiac troponin T on the muscle length-mediated recruitment of crossbridges is modified divergently by α- and β-myosin heavy chain.

  2016cites this paper
• The molecular basis of the Frank-Starling relationship

  2016cites this paper
• Molecule specific effects of PKA-mediated phosphorylation on rat isolated heart and cardiac myofibrillar function.

  2016cites this paper
• Effects of myosin light chain phosphorylation on length-dependent myosin kinetics in skinned rat myocardium.

  2016cites this paper
• Cooperativity in mechano-calcium feedbacks in the myocardium: Some conceptual discrepancies and overcoming inconsistency within the framework of a mathematical model

  2016cites this paper
• Excitation model of pacemaker cardiomyocytes of cardiac conduction system

  2015cites this paper
• ON PATHOPHYSIOLOGICAL ASPECTS OF ELECTROTHERAPY OF THE HEART

  2015cites this paper
• Mathematical modeling of the role of cooperativity between contractile and regulatory proteins in the mechano-calcium feedbacks in myocardium

  2015cites this paper
• Molecular genetics and pathogenesis of cardiomyopathy

  2015cites this paper
• Myosin MgADP release rate decreases at longer sarcomere length to prolong myosin attachment time in skinned rat myocardium.

  2015cites this paper
• Investigations of Molecular Mechanisms of Actin–Myosin Interactions in Cardiac Muscle

  2015cites this paper
• Mechanics of Vascular Smooth Muscle.

  2015cites this paper
• Attenuated sarcomere lengthening of the aged murine left ventricle observed using two-photon fluorescence microscopy.

  2015cites this paper
• An action potential-driven model of soleus muscle activation dynamics for locomotor-like movements

  2015cites this paper
• Troponin I phosphorylation in human myocardium in health and disease

  2014cites this paper
• Mechanoelectric feedback does not contribute to the Frank-Starling relation in the rat and guinea pig heart

  2014cites this paper
• The Role of Endogenous Peptides (Apelin, Adrenomedullin) in the Regulation of Cardiac Contractility

  2014cites this paper
• Titin-mediated control of cardiac myofibrillar function.

  2014cites this paper
• Length-dependent activation is modulated by cardiac troponin I bisphosphorylation at Ser23 and Ser24 but not by Thr143 phosphorylation.

  2014cites this paper
• Phosphorylation of protein kinase C sites Ser42/44 decreases Ca(2+)-sensitivity and blunts enhanced length-dependent activation in response to protein kinase A in human cardiomyocytes.

  2014cites this paper
• Advances in Fiber Diffraction of Macromolecular Assembles

  2014cites this paper
• Engineering troponin C with altered Ca2+ binding properties to study mechanisms of enhanced contraction of cardiac muscle from healthy and infarcted hearts

  2013influential citation
• Impact of titin isoform on length dependent activation and cross-bridge cycling kinetics in rat skeletal muscle.

  2013cites this paper
• N‐terminal phosphorylation of cardiac troponin‐I reduces length‐dependent calcium sensitivity of contraction in cardiac muscle

  2013influential citation
• The length–tension curve in muscle depends on lattice spacing

  2013cites this paper
• Deletion of 1-43 amino acids in cardiac myosin essential light chain blunts length dependency of Ca(2+) sensitivity and cross-bridge detachment kinetics.

  2013cites this paper
• Enhanced Ca2+ binding of cardiac troponin reduces sarcomere length dependence of contractile activation independently of strong crossbridges.

  2012influential citation
• Passive Cardiac Properties and Titin Expression in Dilated Cardiomyopathy

  2012cites this paper
• Finite Element Estimation of Protein-Ligand Association Rates with Post-Encounter Effects: Applications to Calcium binding in Troponin C and SERCA.

  2012cites this paper
• The interaction of Ca2+ with sarcomeric proteins: role in function and dysfunction of the heart

  2012cites this paper
• The interaction of Ca2+ with sarcomeric proteins: role in function and dysfunction of the heart.

  2012cites this paper
• The Mutations Associated with Dilated Cardiomyopathy

  2012cites this paper
• The interdependence of Ca2+ activation, sarcomere length, and power output in the heart

  2011cites this paper
• Thick-filament strain and interfilament spacing in passive muscle: effect of titin-based passive tension.

  2011cites this paper
• Molecular mechanism of actin-myosin motor in muscle

  2011cites this paper
• Myosin head orientation: a structural determinant for the Frank-Starling relationship.

  2011cites this paper
• Adaptive control of cardiac contraction to changes in loading: from theory of sarcomere dynamics to whole-heart function

  2011cites this paper
• Cardiomyopathy, Sarcomeropathy, and Z-diskopathy

  2011cites this paper
• Contribution of genetic factors to the pathogenesis of dilated cardiomyopathy: the cause of dilated cardiomyopathy: genetic or acquired? (genetic-side).

  2011cites this paper
• Electromechanical coupling in the cardiac myocyte; stretch-arrhythmia feedback

  2011cites this paper
• Theory of cardiac sarcomere contraction and the adaptive control of cardiac function to changes in demands

  2010cites this paper
• Axial and Radial Forces of Cross-Bridges Depend on Lattice Spacing

  2010cites this paper
• Comparative Biomechanics of Thick Filaments and Thin Filaments with Functional Consequences for Muscle Contraction

  2010cites this paper
• Molecular basis of hereditary cardiomyopathy: abnormalities in calcium sensitivity, stretch response, stress response and beyond

  2010cites this paper
• Analysing force–pCa curves

  2010cites this paper
• Length dependence of force generation exhibit similarities between rat cardiac myocytes and skeletal muscle fibres

  2010cites this paper
• Myofilament length dependent activation.

  2010cites this paper
• Effects of cardiac myosin binding protein-C on the regulation of interaction of cardiac myosin with thin filament in an in vitro motility assay.

  2010cites this paper
• The Role of Endogenous Peptides ( Apelin , Adrenomedullin ) in the Regulation of Cardiac

  2010cites this paper
• The effect of heat stress, dehydration and exercise on global left ventricular function and mechanics in healthy humans

  2010cites this paper
• Sarcomere length dependence of power output is increased after PKA treatment in rat cardiac myocytes.

  2009cites this paper
• Insight into the actin-myosin motor from x-ray diffraction on muscle.

  2009cites this paper
• Differences between cardiac and skeletal troponin interaction with the thin filament probed by troponin exchange in skeletal myofibrils.

  2009cites this paper
• The external work-pressure time integral relationships and the afterload dependence of Frank-Starling mechanism.

  2009cites this paper
• Myosin regulatory light chain phosphorylation and its role in active mechanics and force generation of the heart

  2009cites this paper
• Characterization of secophalloidin-induced force loss in cardiac myofibrils

  2009cites this paper
• Cooperative cross-bridge activation of thin filaments contributes to the Frank-Starling mechanism in cardiac muscle.

  2009cites this paper
• Length-dependent activation and auto-oscillation in skeletal myofibrils at partial activation by Ca2+.

  2008cites this paper
• Molecular etiology and pathogenesis of hereditary cardiomyopathy.

  2008cites this paper
• Familial hypertrophic cardiomyopathy-related cardiac troponin C mutation L29Q affects Ca2+ binding and myofilament contractility.

  2008cites this paper
• Mathematical Modeling of Mechanically Modulated Rhythm Disturbances in Homogeneous and Heterogeneous Myocardium with Attenuated Activity of Na+–K+ Pump

  2008cites this paper
• Sarcomere mechanics in uniform and non-uniform cardiac muscle: a link between pump function and arrhythmias.

  2008cites this paper
• Calcium cycling and signaling in cardiac myocytes.

  2008cites this paper
• Cardiac function and modulation of sarcomeric function by length.

  2008cites this paper
• Understanding muscle from its length

  2007cites this paper
• Rate of tension redevelopment is not modulated by sarcomere length in permeabilized human, murine, and porcine cardiomyocytes.

  2007cites this paper
• Effects of sustained length-dependent activation on in situ cross-bridge dynamics in rat hearts.

  2007cites this paper
• Nonlinear Force-Length Relationship in the ADP-Induced Contraction of Skeletal Myofibrils

  2007cites this paper
• Sarcomere length dependence of rat skinned cardiac myocyte mechanical properties: dependence on myosin heavy chain

  2007cites this paper
• Regulation of muscle contraction by Ca2+ and ADP: focusing on the auto-oscillation (SPOC).

  2007cites this paper
• A Model Based Analysis of Steady-State versus Dynamic Elements in the Relationship between Calcium and Force

  2007cites this paper
• Force Measurements of Human Embryonic Stem Cell‐Derived Cardiomyocytes in an In Vitro Transplantation Model

  2007cites this paper
• The effects of force inhibition by sodium vanadate on cross-bridge binding, force redevelopment, and Ca2+ activation in cardiac muscle.

  2007cites this paper
• Interfilament spacing is preserved during sarcomere length isometric contractions in rat cardiac trabeculae.

  2007cites this paper