Compartmentalization of the plasma membrane.

The compartmentalization of the plasma membrane is essential for cells to perform specialized biochemical functions, in particular those responsible for intracellular and intercellular signaling pathways. Study of membrane compartmentalization requires state-of-the-art imaging tools that can reveal dynamics of individual molecules with high spatial and temporal resolution. In addition, quantitative analyses are employed to identify transient changes in molecule dynamics. In this review, membrane compartments are classified as stable domains, transient compartments, or nanodomains where proteins aggregate. Interestingly, in most cases, the cortical cytoskeleton plays important roles. Recent studies of the membrane-cytoskeleton interface are providing new insights about membrane organization involving a scale-free self-similar fractal structure and cytoskeleton active processes coupled to membrane dynamics.

• Publication year

  2018

• Venue

  Current Opinion in Cell Biology

• Publication date

  2018-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.ceb.2018.04.002PMID 29656224
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Super-Resolution Microscopy Reveals the Native Ultrastructure of the Erythrocyte Cytoskeleton.

  2018cited by this paper
• The actin cytoskeleton of the mouse sperm flagellum is organized in a helical structure

  2018cited by this paper
• Elucidating distinct ion channel populations on the surface of hippocampal neurons via single-particle tracking recurrence analysis.

  2017cited by this paper
• Unraveling intermittent features in single-particle trajectories by a local convex hull method.

  2017cited by this paper
• Detection of transition times from single-particle-tracking trajectories.

  2017cited by this paper
• Ergodicity breaking on the neuronal surface emerges from random switching between diffusive states

  2017cited by this paper
• TAOK2 Kinase Mediates PSD95 Stability and Dendritic Spine Maturation through Septin7 Phosphorylation.

  2017cited by this paper
• Plasma Membrane is Compartmentalized by a Self-Similar Cortical Actin Meshwork

  2017cited by this paper
• Actomyosin dynamics drive local membrane component organization in an in vitro active composite layer

  2016cited by this paper
• The actin cytoskeleton modulates the activation of iNKT cells by segregating CD1d nanoclusters on antigen-presenting cells

  2016cited by this paper
• Nanoscopic compartmentalization of membrane protein motion at the axon initial segment

  2016cited by this paper
• Control of lipid domain organization by a biomimetic contractile actomyosin cortex

  2016cited by this paper
• Systems-level approach to uncovering diffusive states and their transitions from single-particle trajectories.

  2016cited by this paper
• ErbB 1 dimerization is promoted by domain co-confinement and stabilized by ligand-binding

  2016cited by this paper
• Confined diffusion of transmembrane proteins and lipids induced by the same actin meshwork lining the plasma membrane

  2016cited by this paper
• Dendritic Spines as Tunable Regulators of Synaptic Signals

  2016cited by this paper
• Excitable RhoA dynamics drive pulsed contractions in the early C. elegans embryo

  2016cited by this paper
• Single-Molecule Imaging of Nav1.6 on the Surface of Hippocampal Neurons Reveals Somatic Nanoclusters.

  2016cited by this paper
• Preferential Targeting of Nav1.6 Voltage-Gated Na+ Channels to the Axon Initial Segment during Development

  2015cited by this paper
• Diffusion of GPI-anchored proteins is influenced by the activity of dynamic cortical actin

  2015cited by this paper
• Mechanisms underlying anomalous diffusion in the plasma membrane.

  2015cited by this paper
• A review of progress in single particle tracking: from methods to biophysical insights

  2015cited by this paper
• Cortical actin networks induce spatio-temporal confinement of phospholipids in the plasma membrane – a minimally invasive investigation by STED-FCS

  2015cited by this paper
• Dynamin regulates metaphase furrow formation and plasma membrane compartmentalization in the syncytial Drosophila embryo

  2015cited by this paper
• Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution

  2014cited by this paper
• A lipid bound actin meshwork organizes liquid phase separation in model membranes

  2014cited by this paper
• Anomalous diffusion models and their properties: non-stationarity, non-ergodicity, and ageing at the centenary of single particle tracking.

  2014cited by this paper
• Mapping the energy and diffusion landscapes of membrane proteins at the cell surface using high-density single-molecule imaging and Bayesian inference: application to the multiscale dynamics of glycine receptors in the neuronal membrane.

  2014cited by this paper
• High-density single-particle tracking: quantifying molecule organization and dynamics at the nanoscale

  2014cited by this paper
• Analysis of the local organization and dynamics of cellular actin networks

  2013cited by this paper
• FCS in STED microscopy: studying the nanoscale of lipid membrane dynamics.

  2013cited by this paper
• Actin, Spectrin, and Associated Proteins Form a Periodic Cytoskeletal Structure in Axons

  2013cited by this paper
• Extracting intracellular diffusive states and transition rates from single-molecule tracking data

  2013cited by this paper
• Analysis of turnover dynamics of the submembranous actin cortex

  2013cited by this paper
• Visualization of plasma membrane compartmentalization by high-speed quantum dot tracking.

  2013cited by this paper
• Actin mediates the nanoscale membrane organization of the clustered membrane protein influenza hemagglutinin.

  2013cited by this paper
• New insights into the regulation and cellular functions of the ARP2/3 complex

  2012cited by this paper
• Active remodeling of cortical actin regulates spatiotemporal organization of cell surface molecules.

  2012cited by this paper
• Size of cell-surface Kv2.1 domains is governed by growth fluctuations.

  2012cited by this paper
• ErbB1 dimerization is promoted by domain co-confinement and stabilized by ligand-binding

  2011cited by this paper
• Detecting nanodomains in living cell membrane by fluorescence correlation spectroscopy.

  2011cited by this paper
• Ergodic and nonergodic processes coexist in the plasma membrane as observed by single-molecule tracking

  2011cited by this paper
• PALM and STORM: Unlocking live‐cell super‐resolution

  2011cited by this paper
• The Membrane Skeleton Controls Diffusion Dynamics and Signaling through the B Cell Receptor

  2010cited by this paper
• Ankyrin G restricts ion channel diffusion at the axonal initial segment before the establishment of the diffusion barrier

  2010cited by this paper
• Dynamic superresolution imaging of endogenous proteins on living cells at ultra-high density.

  2010cited by this paper
• Probing cellular events, one quantum dot at a time

  2010cited by this paper
• Both MHC class II and its GPI-anchored form undergo hop diffusion as observed by single-molecule tracking.

  2008cited by this paper
• High-density mapping of single-molecule trajectories with photoactivated localization microscopy

  2008cited by this paper
• AnkyrinG is required for maintenance of the axon initial segment and neuronal polarity

  2008cited by this paper
• Actin restricts FcɛRI diffusion and facilitates antigen-induced receptor immobilization

  2008cited by this paper
• Three-dimensional reconstruction of the membrane skeleton at the plasma membrane interface by electron tomography

  2006cited by this paper
• Quantitative characterization of changes in dynamical behavior for single-particle tracking studies.

  2006cited by this paper
• STED microscopy reveals that synaptotagmin remains clustered after synaptic vesicle exocytosis

  2006cited by this paper
• Cortical organization by the septin cytoskeleton is essential for structural and mechanical integrity of mammalian spermatozoa.

  2005cited by this paper
• Endocytotic elimination and domain-selective tethering constitute a potential mechanism of protein segregation at the axonal initial segment

  2004cited by this paper
• Accumulation of anchored proteins forms membrane diffusion barriers during neuronal polarization

  2003cited by this paper
• Phospholipids undergo hop diffusion in compartmentalized cell membrane

  2002cited by this paper
• A diffusion barrier maintains distribution of membrane proteins in polarized neurons

  1999cited by this paper

• Genetic architecture of drought resilience in barley (Hordeum vulgare L.) revealed by genome-wide association study

  2026cites this paper
• Lipid bilayer-mediated spatiotemporal correlation between near-wall confined motion of micro-carriers.

  2025cites this paper
• Five key challenges for the plasma membrane insertion of nicotinic acetylcholine receptors in cellular model systems.

  2025cites this paper
• Molecular Dynamics Study of Plasma Membrane Electroporation Under Bipolar Pulses.

  2025cites this paper
• Confinement energy landscape classification reveals membrane receptor nano-organization mechanisms.

  2024cites this paper
• A novel single-color FRET biosensor for Rho-kinase activity reveals calcium-dependent activation of RhoA and ROCK

  2024cites this paper
• Mechanosensitive membrane domains regulate calcium entry in arterial endothelial cells to protect against inflammation

  2024cites this paper
• Initiation of lumen formation from junctions via differential actomyosin contractility regulated by dynamic recruitment of Rasip1

  2024cites this paper
• A Novel Single-Color FRET Sensor for Rho-Kinase Reveals Calcium-Dependent Activation of RhoA and ROCK

  2024cites this paper
• Super-resolution microscopy methods to study membrane pores in situ.

  2024cites this paper
• Local time statistics and permeable barrier crossing: From Poisson to birth-death diffusion equations

  2024cites this paper
• An agent-based approach for modelling and simulation of glycoprotein VI receptor diffusion, localisation and dimerisation in platelet lipid rafts

  2023cites this paper
• Rafting on the Evidence for Lipid Raft-like Domains as Hubs Triggering Environmental Toxicants’ Cellular Effects

  2023cites this paper
• Implications of different membrane compartmentalization models in particle-based in silico studies

  2023cites this paper
• Mechanism of tension propagation in cell membranes

  2023cites this paper
• Mitochondrial Dynamics: Working with the Cytoskeleton and Intracellular Organelles to Mediate Mechanotransduction

  2023cites this paper
• Quantitative classification of energy landscapes inferred from single nanoparticle tracking of membrane receptors inside nanodomains reveals confinement functional and molecular features

  2023cites this paper
• Physics of mechanotransduction by Piezo ion channels

  2022cites this paper
• High Electrochemiluminescence from Ru(bpy)3 2+ Embedded Metal–Organic Frameworks to Visualize Single Molecule Movement at the Cellular Membrane

  2022cites this paper
• Harnessing Split‐Inteins as a Tool for the Selective Modification of Surface Receptors in Live Cells

  2022cites this paper
• Cancer as a Channelopathy—Appreciation of Complimentary Pathways Provides a Different Perspective for Developing Treatments

  2022cites this paper
• Myosin-dependent partitioning of junctional Prickle2 toward the anterior vertex during planar polarization of Xenopus neuroectoderm

  2022cites this paper
• Morphological profiling by high-throughput single-cell biophysical fractometry

  2022cites this paper
• 1,3 Dialkylated Imidazolium Ionic Liquid Causes Interdigitated Domains in a Phospholipid Membrane.

  2022cites this paper
• Cholesterol Oxidation Modulates the Formation of Liquid-Ordered Domains in Model Membranes

  2021cites this paper
• Mass spectrometry and the cellular surfaceome.

  2021cites this paper
• Microscopic Interactions of Melatonin, Serotonin and Tryptophan with Zwitterionic Phospholipid Membranes

  2021cites this paper
• Cell mechanics and signalisation: SARS-CoV-2 hijacks membrane liquid crystals and cytoskeletal fractal topology

  2021cites this paper
• A deep learning-based approach to model anomalous diffusion of membrane proteins: The case of the nicotinic acetylcholine receptor

  2021cites this paper
• Membrane transport inspired hydrolysis of non-activated esters at near physiological pH.

  2021cites this paper
• Identification of electroporation sites in the complex lipid organization of the plasma membrane

  2021cites this paper
• The scientific principles and technological determinants of haemodialysis membranes

  2021cites this paper
• Membrane Compartmentalization and Scaffold Proteins in Leukocyte Migration

  2020cites this paper
• PLRP2 selectively localizes synaptic membrane proteins via acyl-chain remodeling of phospholipids.

  2020cites this paper
• Organization of Protein Tyrosine Kinase-7 on Cell Membranes Characterized by Aptamer Probe-Based STORM Imaging.

  2020cites this paper
• Modulation and Dynamics of Cell Membrane Heterogeneities.

  2020cites this paper
• Influence of Cholesterol on the Orientation of the Farnesylated GTP-Bound KRas-4B Binding with Anionic Model Membranes

  2020cites this paper
• Membrane Nanodomains

  2020cites this paper
• PLRP2 selectively localizes synaptic membrane proteins via acyl-chain remodeling of phospholipids

  2020cites this paper
• High-Precision Protein-Tracking With Interferometric Scattering Microscopy

  2020influential citation
• Molecular Crowding and Diffusion-Capture in Synapses

  2020cites this paper
• Getting around the cell: physical transport in the intracellular world

  2020cites this paper
• Sperm Differentiation: The Role of Trafficking of Proteins

  2020cites this paper
• Correlative dual-color dSTORM/AFM reveals protein clusters at the cytoplasmic side of human bronchial epithelium membranes.

  2020cites this paper
• Plant electrome: the electrical dimension of plant life

  2019cites this paper
• From diffusion in compartmentalized media to non-Gaussian random walks

  2019cites this paper
• Plant electrome: the electrical dimension of plant life

  2019cites this paper
• A stochastic model of ion channel cluster formation in the plasma membrane

  2019cites this paper
• The Lateral Organization and Mobility of Plasma Membrane Components.

  2019cites this paper
• Real-time observation of dynamic heterogeneity of gold nanorods on plasma membrane with darkfield microscopy

  2019cites this paper
• Biomolecule displacement by Brownian step

  2019cites this paper
• Actin Cytoskeleton and Membrane Interactions: Role in GPCR Function and Organization

  2019cites this paper
• The disordered boundary of the cell: emerging properties of membrane-bound intrinsically disordered proteins

  2019cites this paper
• Nanoscale organization of tetraspanins during HIV-1 budding by correlative dSTORM/AFM.

  2019cites this paper
• Identifying diffusive motions in single-particle trajectories on the plasma membrane via fractional time-series models.

  2019cites this paper
• Temporal dependence of shifts in mu opioid receptor mobility at the cell surface after agonist binding observed by single-particle tracking

  2018cites this paper
• The actin cytoskeleton of the mouse sperm flagellum is organized in a helical structure

  2018cites this paper
• Dynamic pattern generation in cell membranes: Current insights into membrane organization.

  2018cites this paper
• Interleaflet and Substrate Coupling in Phospholipid Bilayers

  2018cites this paper
• Roles of membrane lipids in the organization of epithelial cells: Old and new problems

  2018cites this paper
• Permeability of immobile rings of membrane inclusions to in-plane flow.

  2018cites this paper
• Senomic view of the cell: Senome versus Genome

  2018cites this paper
• A synthetic biology platform for the reconstitution and mechanistic dissection of LINC complex assembly

  2018cites this paper
• Recurrence statistics for anomalous diffusion regime change detection

  2018cites this paper