Multi-stage Differentiation Defines Melanoma Subtypes with Differential Vulnerability to Drug-Induced Iron-Dependent Oxidative Stress.

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Cancer Cell

• Publication date

  2018-05-14

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.ccell.2018.03.017PMID 29657129PMCID PMC5953834
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

  2017cited by this paper
• Targeted agents and immunotherapies: optimizing outcomes in melanoma

  2017cited by this paper
• Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance

  2017cited by this paper
• Adaptive resistance of melanoma cells to RAF inhibition via reversible induction of a slowly dividing de‐differentiated state

  2017cited by this paper
• Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

  2017cited by this paper
• Abstract 1006: Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

  2017influential reference
• Sequential transcriptional waves direct the differentiation of newborn neurons in the mouse neocortex

  2016cited by this paper
• Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

  2016cited by this paper
• Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

  2016cited by this paper
• Diverse drug-resistance mechanisms can emerge from drug-tolerant cancer persister cells

  2016cited by this paper
• A Landscape of Pharmacogenomic Interactions in Cancer

  2016cited by this paper
• Combination therapy with BRAF and MEK inhibitors for melanoma: latest evidence and place in therapy

  2016cited by this paper
• JUN dependency in distinct early and late BRAF inhibition adaptation states of melanoma

  2016cited by this paper
• Phenotype Switching in Melanoma: Implications for Progression and Therapy

  2015cited by this paper
• Non-genomic and Immune Evolution of Melanoma Acquiring MAPKi Resistance.

  2015influential reference
• Genome-Wide DNA Methylation Analysis in Melanoma Reveals the Importance of CpG Methylation in MITF Regulation.

  2015cited by this paper
• Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset.

  2015influential reference
• Combining Dependent P-values with an Empirical Adaptation of Brown’s Method

  2015influential reference
• HISAT: a fast spliced aligner with low memory requirements

  2015influential reference
• Oxidative stress inhibits distant metastasis by human melanoma cells

  2015cited by this paper
• MITF and c-Jun antagonism interconnects melanoma dedifferentiation with pro-inflammatory cytokine responsiveness and myeloid cell recruitment

  2015cited by this paper
• Co-clinical assessment identifies patterns of BRAF inhibitor resistance in melanoma.

  2015cited by this paper
• Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma

  2014cited by this paper
• HTSeq—a Python framework to work with high-throughput sequencing data

  2014influential reference
• A melanoma cell state distinction influences sensitivity to MAPK pathway inhibitors.

  2014influential reference
• Regulation of ferroptotic cancer cell death by GPX4.

  2014influential reference
• Melanocytes as Instigators and Victims of Oxidative Stress

  2014cited by this paper
• Identification of a ZEB2-MITF-ZEB1 transcriptional network that controls melanogenesis and melanoma progression

  2014cited by this paper
• IFN-γ signaling maintains skin pigmentation homeostasis through regulation of melanosome maturation

  2014cited by this paper
• Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma

  2014cited by this paper
• PGC1α expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress.

  2013cited by this paper
• Modeling neural crest induction, melanocyte specification, and disease-related pigmentation defects in hESCs and patient-specific iPSCs.

  2013cited by this paper
• TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

  2013influential reference
• Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray

  2013cited by this paper
• A switch in the expression of embryonic EMT-inducers drives the development of malignant melanoma.

  2013cited by this paper
• Transcription factors: from enhancer binding to developmental control

  2012cited by this paper
• Removing technical variability in RNA-seq data using conditional quantile normalization

  2012cited by this paper
• Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

  2012influential reference
• Colocalization of Inflammatory Response with B7-H1 Expression in Human Melanocytic Lesions Supports an Adaptive Resistance Mechanism of Immune Escape

  2012cited by this paper
• Sox10 promotes the formation and maintenance of giant congenital naevi and melanoma

  2012cited by this paper
• Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiation

  2012influential reference
• Relief of profound feedback inhibition of mitogenic signaling by RAF inhibitors attenuates their activity in BRAFV600E melanomas.

  2012cited by this paper
• Ferroptosis: an iron-dependent form of nonapoptotic cell death.

  2012influential reference
• Top scoring pairs for feature selection in machine learning and applications to cancer outcome prediction

  2011cited by this paper
• Selective killing of cancer cells with a small molecule targeting stress response to ROS

  2011cited by this paper
• RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)

  2011cited by this paper
• Recovery of phospho-ERK activity allows melanoma cells to escape from BRAF inhibitor therapy

  2010cited by this paper
• Tumor-initiated inflammation overrides protective adaptive immunity in an induced melanoma model in mice.

  2010cited by this paper
• Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation

  2010influential reference
• ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking

  2010cited by this paper
• Differential sensitivity of melanoma cell lines with BRAFV600E mutation to the specific Raf inhibitor PLX4032

  2010influential reference
• MiTF regulates cellular response to reactive oxygen species through transcriptional regulation of APE-1/Ref-1.

  2009cited by this paper
• The human keratins: biology and pathology

  2008cited by this paper
• Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells.

  2008cited by this paper
• Statistical Significance of Clustering for High-Dimension, Low–Sample Size Data

  2008cited by this paper
• Novel MITF targets identified using a two‐step DNA microarray strategy

  2008cited by this paper
• A gene regulatory network orchestrates neural crest formation

  2008cited by this paper
• Subclass Mapping: Identifying Common Subtypes in Independent Disease Data Sets

  2007cited by this paper
• RAS–RAF–MEK-dependent oxidative cell death involving voltage-dependent anion channels

  2007cited by this paper
• Metastatic potential of melanomas defined by specific gene expression profiles with no BRAF signature.

  2006influential reference
• The Microphthalmia-Associated Transcription Factor Mitf Interacts with β-Catenin To Determine Target Gene Expression

  2006cited by this paper
• Consensus Clustering: A Resampling-Based Method for Class Discovery and Visualization of Gene Expression Microarray Data

  2003cited by this paper
• Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade

  2002cited by this paper
• In silico prediction of protein-protein interactions in human macrophages

  2001cited by this paper
• Recognition of shared melanoma antigens in association with major HLA-A alleles by tumor infiltrating T lymphocytes from 123 patients with melanoma.

  2000cited by this paper
• Independent regulation of growth and SMAD-mediated transcription by transforming growth factor beta in human melanoma cells.

  1999cited by this paper

• Ferroptosis reshapes the tumor immune microenvironment: molecular mechanisms, immune regulation, and therapeutic synergistic strategies

  2026cites this paper
• Clonal dynamics shaped by diverse drug-tolerant persister states in melanoma resistance.

  2026cites this paper
• Chromatin architecture and physical constriction cooperate in phenotype switching and cancer cell dissemination

  2026cites this paper
• Melanin as a Redox Hub: Linking Energy Flow to Genome Stability and Immune Control.

  2026cites this paper
• NF1 Loss Remodels Tumor Niches for Immune Evasion

  2026cites this paper
• Opposing roles of DGAT-mediated lipid droplet biogenesis in the regulation of ferroptosis sensitivity.

  2026cites this paper
• Targeting ferroptosis in cancer: from mechanistic insights to therapeutic approaches

  2026cites this paper
• Biopsy RNA-seq captures TROP-2–linked migration and clonal resistance to forecast aggressiveness in metastatic melanoma

  2026cites this paper
• A comprehensive review of mechanisms underlying resistance to immune checkpoint inhibitors

  2026cites this paper
• Cell adhesion molecules as emerging regulators of ferroptosis: mechanisms and therapeutic opportunities in cancer

  2026cites this paper
• Translating ferroptosis into oncology: challenges, opportunities and future directions.

  2026cites this paper
• Nanomagnetic Hyperthermia Sensitizes Gemcitabine Chemosensitivity in Pancreatic Cancer by Inhibiting HSPB1 to Amplify ACSL4-Mediated Ferroptosis.

  2026cites this paper
• Identification of MITF-regulated transcript isoforms of ubiquitously expressed genes.

  2026cites this paper
• Iron, copper and disulfide dysregulation: molecular crossroads of metabolic cell death in melanoma progression

  2025cites this paper
• BDH2-driven lysosome-to-mitochondria iron transfer shapes ferroptosis vulnerability of the melanoma cell states

  2025cites this paper
• A critical role of FAK signaling in Rac1-driven melanoma cell resistance to MAPK pathway inhibition

  2025cites this paper
• SOX10 Regulates Melanoma Metastasis Through the IRF1‐ITGA3/EphA2‐FAK Pathway

  2025cites this paper
• Exo-miR-1911-5p regulates ferroptosis to promote macrophages M2 polarization-mediated gastric cancer cisplatin resistance via MYB/AKR1B10/ACC

  2025cites this paper
• Prospects for ferroptosis therapies in cancer

  2025influential citation
• Travelling Waves in Gene Expression: A Mathematical Model of Cell-State Dynamics in Melanoma

  2025cites this paper
• A new perspective on iron-dependent cell death: PRDX-1-mediated ferroptosis in tumor cells

  2025cites this paper
• Iron overload enhances the susceptibility to cysteine deprivation-induced ferroptosis in non-small cell lung cancer cells

  2025cites this paper
• Dual targeting of BRAFV600E and ferroptosis results in synergistic anticancer activity via iron overload and enhanced oxidative stress

  2025cites this paper
• Integration of scRNA-seq and ST-seq identifies hyperproliferative RRM2+ cells features and therapeutic targets in gastric cancer

  2025cites this paper
• Elevated Transglutaminase-2 in SOX10-Deficient Melanoma Promotes Tumor Onset and Decreases Intratumoral CD4+ T Cells.

  2025cites this paper
• Role of CNNM4 in the progression of cholangiocarcinoma: implications for ferroptosis and therapeutic potential

  2025cites this paper
• Ferroptosis in Cancer and Inflammatory Diseases: Mechanisms and Therapeutic Implications

  2025cites this paper
• Elevated NR2F1 underlies the persistence of invasive disease after treatment of BRAF-mutant melanoma

  2025cites this paper
• SLC25A10 promotes cisplatin resistance by inhibiting ferroptosis in cervical cancer

  2025cites this paper
• MC1R contributes to ferroptosis resistance and tumor aggressiveness in colorectal cancer by activating Notch signaling

  2025cites this paper
• Identification of HCAR1 as a ferroptosis-related biomarker of gastric cancer based on a novel ferroptosis-related prognostic model and in vitro experiments.

  2025cites this paper
• Applications of gene pair methods in clinical research: advancing precision medicine

  2025cites this paper
• Redirecting resistance evolution in BRAFV600 melanoma by inhibition of the peroxiredoxin-thioredoxin system

  2025cites this paper
• Mechanisms of ferroptosis sensitization and resistance.

  2025cites this paper
• NF1 Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in NF1-Mutant Melanoma

  2025cites this paper
• Exploring the underlying molecular connections: a bioinformatics approach to link melanoma and Parkinson’s disease

  2025cites this paper
• p52-ZER6/DAZAP1 axis promotes ferroptosis resistance and colorectal cancer progression via regulating SLC7A11 mRNA stabilization

  2025cites this paper
• Fatty acid uptake activates an AXL–CAV1–β-catenin axis to drive melanoma progression

  2025influential citation
• BRAFV600E‐PROTAC versus inhibitors in melanoma cells: Deep transcriptomic characterization

  2025cites this paper
• Transcriptional reprogramming triggered by neonatal UV radiation or Lkb1 loss prevents BRAFV600E-induced growth arrest in melanocytes

  2025cites this paper
• Radiation-induced ferroptosis via liposomal delivery of 7-Dehydrocholesterol

  2025cites this paper
• Deubiquitination by USP7 Stabilizes JunD and Activates AIFM2 (FSP1) to Inhibit Ferroptosis in Melanoma.

  2025cites this paper
• Metabolic buffering suppresses phenotype switching in cancer

  2025cites this paper
• Dysregulation of Labile Iron Predisposes Chemotherapy Resistant Cancer Cells to Ferroptosis

  2025cites this paper
• NSD2 and miRNAs as Key Regulators of Melanoma Response to Romidepsin and Interferon‐α2b Treatment

  2025influential citation
• Ferroptosis-related genes mediate tumor microenvironment and prognosis in triple-negative breast cancer via integrated RNA-seq analysis

  2025cites this paper
• Two are better than one: A case study of the biferrocenyl-thymidine "click" conjugate biFcT as novel ferroptosis-inducing agent in lung cancer cells.

  2025cites this paper
• Spatial determinants of tumor cell dedifferentiation and plasticity in primary cutaneous melanoma

  2025cites this paper
• Cascade-enhanced persistent luminescence for monitoring iron metabolism during ferroptosis-based therapy.

  2025cites this paper
• Combinatorial therapy regimens targeting preclinical models of melanoma resistant to immune checkpoint blockade

  2025cites this paper
• Ferroptosis in cancer: revealing the multifaceted functions of mitochondria

  2025cites this paper
• Plasticity and Functional Heterogeneity of Cancer-Associated Fibroblasts.

  2025cites this paper
• A novel patient-derived cutaneous melanoma cell line reveals key features of metastatic melanoma

  2025cites this paper
• Emerging Roles of Ferroptosis in Skin Pathophysiology.

  2025cites this paper
• Mechanical confinement governs phenotypic plasticity in melanoma

  2025cites this paper
• Mature and migratory dendritic cells promote immune infiltration and response to anti-PD-1 checkpoint blockade in metastatic melanoma

  2025cites this paper
• Defining the Role of Integrins in Melanoblast Migration In Vivo.

  2025cites this paper
• Regulatory Mechanisms of SPARC Overexpression in Melanoma Progression

  2025cites this paper
• Ozonated olive oil inhibits melanoma proliferation by inducing ferroptosis

  2025cites this paper
• Comprehensive Analysis of BRCA1/2 mutations, "BRCAness" and PARP inhibitors in Melanoma.

  2025cites this paper
• Editorial: Modulation of ferroptosis via metabolic and signaling pathways: therapeutic opportunities across malignancies and degenerative diseases

  2025cites this paper
• Decoding ferroptosis for cancer therapy

  2025cites this paper
• Prexasertib exerts a synergistic effect on the antitumor activity of Lenvatinib through ALOX15-mediated ferroptosis in hepatocellular carcinoma.

  2025cites this paper
• Interaction of lncRNA LENT with DHX36 regulates translation and suppresses autophagy in melanoma

  2025cites this paper
• Roles of selenium-containing glutathione peroxidases and thioredoxin reductases in the regulation of processes associated with glioblastoma progression.

  2025cites this paper
• Mitochondrial Regulation of Ferroptosis in Cancer Cells

  2025cites this paper
• Ferritin as an Effective Prognostic Factor and Potential Cancer Biomarker

  2025cites this paper
• Global trends and emerging insights in BRAF and MEK inhibitor resistance in melanoma: a bibliometric analysis

  2025cites this paper
• High-Glucose-Induced Metabolic and Redox Alterations Are Distinctly Modulated by Various Antidiabetic Agents and Interventions Against FABP5/7, MITF and ANGPTL4 in Melanoma A375 Cells

  2025cites this paper
• Single‐cell transcriptomics and epigenomics point to CD58‐CD2 interaction in controlling primary melanoma growth and immunity

  2025cites this paper
• Selective abrogation of S6K2 identifies lipid homeostasis as a survival vulnerability in MAPK inhibitor-resistant NRAS-mutant melanoma.

  2025cites this paper
• Profiling Serum Oxylipin Metabolites Across Melanoma Subtypes and Immunotherapy Responders

  2025cites this paper
• Integrated multi-omics profiling reveals the role of the DNA methylation landscape in shaping biological heterogeneity and clinical behaviour of metastatic melanoma

  2025influential citation
• Bioinformatics-based Prognosis Effect of Ferroptosis-related Genes on Gastric Cancer

  2025cites this paper
• Defined cellular reprogramming of androgen receptor-active prostate cancer to neuroendocrine prostate cancer

  2025cites this paper
• Multieffect Specific Nanovesicles for Homing Resistant Tumors and Overcoming Osimertinib‐Acquired Resistance in NSCLC

  2025cites this paper
• Arginine Deprivation Induces Quiescence and Confers Vulnerability to Ferroptosis in Colorectal Cancer

  2025cites this paper
• Harnessing ferroptosis for precision oncology: challenges and prospects

  2025cites this paper
• Decoding melanoma's cellular mosaic to unlock immunotherapy potential.

  2025cites this paper
• LRP2 Expression in Melanoma Is Associated With a Transitory Cell State, Increased T Cell Infiltration, and Is Upregulated by IFNy Signaling

  2025influential citation
• From mechanisms to medicine: Ferroptosis as a Therapeutic target in liver disorders

  2025cites this paper
• ZEB1 transcription factor induces tumor cell PD-L1 expression in melanoma

  2025cites this paper
• Dual role of interferon-gamma in the response of melanoma patients to immunotherapy with immune checkpoint inhibitors

  2025cites this paper
• Unravelling the antitumor mechanism of Ocoxin through cancer cell genomics

  2025cites this paper
• NUPR1 Promotes Radioresistance in Colorectal Cancer Cells by Inhibiting Ferroptosis

  2025cites this paper
• Tissue inhibitor of metalloproteinase 1 promotes ferroptosis and suppresses prostate cancer metastasis

  2025cites this paper
• Neural crest-associated gene FOXD1 induces an immunosuppressive microenvironment by regulating myeloid-derived suppressor cells in melanoma

  2025cites this paper
• Male-specific lethal 1 (MSL1) promotes Erastin-induced ferroptosis in colon cancer cells by regulating the KCTD12-SLC7A11 axis

  2025cites this paper
• The intersection of ferroptosis and non-coding RNAs: a novel approach to ovarian cancer

  2025cites this paper
• Identification of a novel signature derived from ferroptosis-related genes to predict prognosis, immune landscape and chemotherapeutic sensitivity in head and neck squamous cell carcinoma.

  2025cites this paper
• Ferrous Fumarate-Encapsulated Nanoformulation Triggering a Domino Effect for Enhanced Ferroptosis Therapy.

  2025cites this paper
• MCSP+ metastasis founder cells activate immunosuppression early in human melanoma metastatic colonization

  2025influential citation
• SENP5 promotes endometrial cancer cell growth by regulating β-catenin deSUMOylation to enhance GPX4-resistance to ferroptosis

  2025cites this paper
• The epigenetic regulator TRIM24 controls melanoma cell dedifferentiation and resistance to treatment in melanoma

  2025cites this paper
• Multi-omics-based subtyping of melanoma suggests distinct immune and targeted therapy strategies

  2025cites this paper
• GPNMB marks a quiescent cell population in melanoma and promotes metastasis formation

  2025cites this paper
• Receptor tyrosine kinase inhibitor tivozanib regulates cell state plasticity and restores MITF dependency in BRAF wild-type melanoma

  2025cites this paper
• Integrated Analysis of Single-Cell and Bulk RNA-Seq Data reveals that Ferroptosis-Related Genes Mediated the Tumor Microenvironment predicts Prognosis, and guides Drug Selection in Triple-Negative Breast Cancer

  2025cites this paper
• COP1 Deficiency in BRAFV600E Melanomas Confers Resistance to Inhibitors of the MAPK Pathway

  2025cites this paper
• Ferroptosis: A Targetable Vulnerability for Melanoma Treatment.

  2025cites this paper