Structural characterization of muropeptides from Chlamydia trachomatis peptidoglycan by mass spectrometry resolves “chlamydial anomaly”

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2015-08-19

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1073/pnas.1514026112PMID 26290580PMCID PMC4577195
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Discovery of chlamydial peptidoglycan reveals bacteria with murein sacculi but without FtsZ

  2013influential reference
• A new metabolic cell wall labeling method reveals peptidoglycan in Chlamydia trachomatis

  2013cited by this paper
• Biochemical characterisation of the chlamydial MurF ligase, and possible sequence of the chlamydial peptidoglycan pentapeptide stem

  2012influential reference
• Cutting Edge: Primary Innate Immune Cells Respond Efficiently to Polymeric Peptidoglycan, but Not to Peptidoglycan Monomers

  2011cited by this paper
• The NOD/RIP2 Pathway Is Essential for Host Defenses Against Chlamydophila pneumoniae Lung Infection

  2009cited by this paper
• Functional and Biochemical Analysis of the Chlamydia trachomatis Ligase MurE

  2009cited by this paper
• Increased NOD2-mediated recognition of N-glycolyl muramyl dipeptide

  2009cited by this paper
• Activation of innate immune antiviral response by NOD2

  2009cited by this paper
• Chlamydiae as symbionts in eukaryotes.

  2008cited by this paper
• The Cytosolic Pattern Recognition Receptor NOD1 Induces Inflammatory Interleukin-8 during Chlamydia trachomatis Infection

  2008cited by this paper
• Stimulation of the cytosolic receptor for peptidoglycan, Nod1, by infection with Chlamydia trachomatis or Chlamydia muridarum

  2006cited by this paper
• l,l-diaminopimelate aminotransferase, a trans-kingdom enzyme shared by Chlamydia and plants for synthesis of diaminopimelate/lysine

  2006cited by this paper
• Frequency of Spontaneous Mutations That Confer Antibiotic Resistance in Chlamydia spp

  2005cited by this paper
• Nod1-Mediated Endothelial Cell Activation by Chlamydophila pneumoniae

  2005cited by this paper
• Identification of the namH Gene, Encoding the Hydroxylase Responsible for the N-Glycolylation of the Mycobacterial Peptidoglycan*

  2005cited by this paper
• Chlamydia and Gonorrhea Co-occurrence in a High School Population

  2004cited by this paper
• Information-dependent acquisition-mediated LC-MS/MS screening procedure with semiquantitative potential.

  2004cited by this paper
• Prevalence of chlamydial and gonococcal infections among young adults in the United States.

  2004cited by this paper
• Functional and Biochemical Analysis of Chlamydia trachomatis MurC, an Enzyme Displaying UDP-N-Acetylmuramate:Amino Acid Ligase Activity

  2003cited by this paper
• Nod1 Detects a Unique Muropeptide from Gram-Negative Bacterial Peptidoglycan

  2003cited by this paper
• Host Recognition of Bacterial Muramyl Dipeptide Mediated through NOD2

  2003cited by this paper
• Nod2 Is a General Sensor of Peptidoglycan through Muramyl Dipeptide (MDP) Detection*

  2003cited by this paper
• Peptidoglycan Molecular Requirements Allowing Detection by Nod1 and Nod2*

  2003cited by this paper
• Gonorrhea Prevalence and Coinfection With Chlamydia in Women in the United States, 2000

  2003cited by this paper
• Comparison of the UDP-N-Acetylmuramate:l-Alanine Ligase Enzymes from Mycobacterium tuberculosis andMycobacterium leprae

  2000cited by this paper
• Lack of Cell Wall Peptidoglycan versus Penicillin Sensitivity: New Insights into the Chlamydial Anomaly

  1999cited by this paper
• Antibiotics, peptidoglycan synthesis and genomics: the chlamydial anomaly revisited.

  1998influential reference
• Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis.

  1998influential reference
• Kinetic and crystallographic studies of Escherichia coli UDP‐N‐acetylmuramate:L‐alanine ligase

  1996cited by this paper
• Disulfide cross-linked envelope proteins: the functional equivalent of peptidoglycan in chlamydiae?

  1996cited by this paper
• Why is Chlamydia sensitive to penicillin in the absence of peptidoglycan?

  1993cited by this paper
• Muramic acid is not detectable in Chlamydia psittaci or Chlamydia trachomatis by gas chromatography-mass spectrometry

  1990cited by this paper
• 5 Analysis of the Chemical Composition and Primary Structure of Murein

  1985cited by this paper
• Chlamydia trachomatis has penicillin-binding proteins but not detectable muramic acid

  1982cited by this paper
• A search for the bacterial mucopeptide component, muramic acid, in Chlamydia.

  1974cited by this paper
• Peptidoglycan Types of Bacterial Cell Walls and Their Taxonomic Implications

  1973cited by this paper
• Purification and properties of uridine diphosphate N-acetylmuramate: L-alanine ligase.

  1973cited by this paper
• Peptidoglycan types of bacterial cell walls and their taxonomic implications

  1972cited by this paper
• Effect of Penicillin on the Multiplication of Meningopneumonitis Organisms (Chlamydia psittaci)

  1968cited by this paper
• INHIBITION OF THE GROWTH OF AGENTS OF THE PSITTACOSIS GROUP BY d-CYCLOSERINE AND ITS SPECIFIC REVERSAL BY d-ALANINE

  1963cited by this paper

• Chlamydia trachomatis restricts signaling through NOD2 until late in the pathogen’s developmental cycle

  2025cites this paper
• Antimicrobial Susceptibility Testing in Chlamydia trachomatis: The Current State of Evidence and a Call for More National Surveillance Studies

  2025cites this paper
• A nucleus-encoded dynamin-like protein controls endosymbiont division in the trypanosomatid Angomonas deanei.

  2025cites this paper
• A Review on the Extraction, Structural Characterization, Function, and Applications of Peptidoglycan.

  2025cites this paper
• Bacterial muropeptides promote OXPHOS and suppress mitochondrial stress in mammals

  2024cites this paper
• The second messenger signaling molecule cyclic di-AMP drives developmental cycle progression in Chlamydia trachomatis

  2024cites this paper
• The MraY Inhibitor Muraymycin D2 and Its Derivatives Induce Enlarged Cells in Obligate Intracellular Chlamydia and Wolbachia and Break the Persistence Phenotype in Chlamydia

  2024cites this paper
• Vitamin D effects on Chlamydia trachomatis infection: a case-control and experimental study

  2024cites this paper
• A closer look at ligand specificity for cellular activation of NOD2 with synthetic muramyl dipeptide analogues.

  2024cites this paper
• Irradiated whole cell Chlamydia vaccine confers significant protection in a murine genital tract challenge model

  2024cites this paper
• Aberrant Bodies: An Alternative Metabolic Homeostasis Allowing Survivability?

  2024cites this paper
• Plasticity in the cell division processes of obligate intracellular bacteria

  2023cites this paper
• Bacterial muropeptides promote OXPHOS and suppress mitochondrial stress in normal and human mitochondrial disease models

  2023cites this paper
• Origin and Evolution of Pseudomurein Biosynthetic Gene Clusters

  2022cites this paper
• Plant peptidoglycan precursor biosynthesis: Conservation between moss chloroplasts and Gram-negative bacteria

  2022cites this paper
• Bacterial peptidoglycan muropeptides benefit mitochondrial homeostasis and animal physiology by acting as ATP synthase agonists.

  2022cites this paper
• Peptidoglycan editing in non-proliferating intracellular Salmonella as source of interference with immune signaling

  2022cites this paper
• Peptidoglycan from Akkermansia muciniphila Muc  T: chemical structure and immunostimulatory properties of muropeptides.

  2022cites this paper
• Dissecting Metabolism of Leaf Nodules in Ardisia crenata and Psychotria punctata

  2021cites this paper
• Persistence Alters the Interaction between Chlamydia trachomatis and Its Host Cell

  2021cites this paper
• Discovery of a Diverse Set of Bacteria That Build Their Cell Walls without the Canonical Peptidoglycan Polymerase aPBP

  2021cites this paper
• Localized Peptidoglycan Biosynthesis in Chlamydia trachomatis Conforms to the Polarized Division and Cell Size Reduction Developmental Models

  2021cites this paper
• Penicillin-binding proteins regulate multiple steps in the polarized cell division process of Chlamydia

  2020cites this paper
• Competing Substrates for the Bifunctional Diaminopimelic Acid Epimerase/Glutamate Racemase Modulate Peptidoglycan Synthesis in Chlamydia trachomatis

  2020cites this paper
• Structural and ligand binding analyses of the periplasmic sensor domain of RsbU in Chlamydia trachomatis support a role in TCA cycle regulation

  2020cites this paper
• Chlamydia trachomatis Oligopeptide Transporter Performs Dual Functions of Oligopeptide Transport and Peptidoglycan Recycling

  2020cites this paper
• NOD1 and NOD2 Activation by Diverse Stimuli: a Possible Role for Sensing Pathogen-Induced Endoplasmic Reticulum Stress

  2020cites this paper
• Building peptidoglycan inside eukaryotic cells: A view from symbiotic and pathogenic bacteria

  2020cites this paper
• NOD1/NOD2 and RIP2 Regulate Endoplasmic Reticulum Stress-Induced Inflammation during Chlamydia Infection

  2020influential citation
• Division without Binary Fission: Cell Division in the FtsZ-Less Chlamydia

  2020cites this paper
• Fosmidomycin, an inhibitor of isoprenoid synthesis, induces persistence in Chlamydia by inhibiting peptidoglycan assembly

  2019cites this paper
• The novel shapeshifting bacterial phylum Saltatorellota

  2019cites this paper
• Immunobiology of monocytes and macrophages during Chlamydia trachomatis infection.

  2019cites this paper
• Peptidoglycan.

  2019cites this paper
• Genetics and Molecular Dynamics of L,L-Diaminopimelate Aminotransferase (DapL): an Enzyme Involved in Lysine and Peptidoglycan Biosynthesis

  2019cites this paper
• Clear Victory for Chlamydia: The Subversion of Host Innate Immunity

  2019cites this paper
• A SpoIID Homolog Cleaves Glycan Strands at the Chlamydial Division Septum

  2019cites this paper
• Structure of the peptidoglycan polymerase RodA resolved by evolutionary coupling analysis

  2018cites this paper
• Chlamydia trachomatis dapF Encodes a Bifunctional Enzyme Capable of Both d-Glutamate Racemase and Diaminopimelate Epimerase Activities

  2018cites this paper
• Development of a Chlamydia trachomatis vaccine for urogenital infections: novel tools and new strategies point to bright future prospects

  2018cites this paper
• Chlamydia Persistence: A Survival Strategy to Evade Antimicrobial Effects in-vitro and in-vivo

  2018cites this paper
• Deconstructing the Chlamydial Cell Wall.

  2018cites this paper
• Chlamydia trachomatis regulates innate immune barrier integrity and mediates cytokine and antimicrobial responses in human uterine ECC‐1 epithelial cells

  2017cites this paper
• Peptidoglycan in obligate intracellular bacteria

  2017influential citation
• Productive and Penicillin-Stressed Chlamydia pecorum Infection Induces Nuclear Factor Kappa B Activation and Interleukin-6 Secretion In Vitro

  2017cites this paper
• Three Novel Species with Peptidoglycan Cell Walls form the New Genus Lacunisphaera gen. nov. in the Family Opitutaceae of the Verrucomicrobial Subdivision 4

  2017cites this paper
• Simkania negevensis, an insight into the biology and clinical importance of a novel member of the Chlamydiales order

  2017cites this paper
• Chlamydiales, Anaplasma and Bartonella: persistence and immune escape of intracellular bacteria.

  2017cites this paper
• Bacillus anthracis Peptidoglycan Integrity Is Disrupted by the Chemokine CXCL10 through the FtsE/X Complex

  2017influential citation
• Overview of Clostridium difficile Infection: Life Cycle, Epidemiology, Antimicrobial Resistance and Treatment

  2017cites this paper
• Novel Planctomycetes and Verrucomicrobia associated with aquatic phototrophs

  2017cites this paper
• Molecular recognition of muramyl dipeptide by Nod2 and its implications in Crohn's disease and innate immunity

  2017cites this paper
• Biochemical Characterization of the Activity and Control of the Autolysins Involved in Flagella Assembly in Gram-Negative Bacteria

  2017cites this paper
• Metabolic adaptation of Chlamydia trachomatis to mammalian host cells

  2017influential citation
• Evidence for a peptidoglycan‐like structure in Orientia tsutsugamushi

  2017cites this paper
• Bacterial Cell Division: Nonmodels Poised to Take the Spotlight.

  2017cites this paper
• SEDS proteins are a widespread family of bacterial cell wall polymerases

  2016cites this paper
• Chlamydial Antibiotic Resistance and Treatment Failure in Veterinary and Human Medicine

  2016cites this paper
• Defining the mechanism behind the self-association of therapeutic monoclonal antibodies using mass spectrometric techniques

  2016cites this paper
• Molecular characterization of the polymorphic membrane proteins of Chlamydia psittaci

  2016cites this paper
• Sensing the enemy, containing the threat: cell-autonomous immunity to Chlamydia trachomatis.

  2016cites this paper
• Chlamydia cell biology and pathogenesis

  2016cites this paper
• Pathogenic Chlamydia Lack a Classical Sacculus but Synthesize a Narrow, Mid-cell Peptidoglycan Ring, Regulated by MreB, for Cell Division

  2016influential citation
• Identification and Partial Characterization of a Novel UDP-N-Acetylenolpyruvoylglucosamine Reductase/UDP-N-Acetylmuramate:l-Alanine Ligase Fusion Enzyme from Verrucomicrobium spinosum DSM 4136T

  2016cites this paper
• Glycosyltransferases and Transpeptidases/Penicillin-Binding Proteins: Valuable Targets for New Antibacterials

  2016cites this paper
• Sensing the enemy, containing the threat: cell-autonomous immunity to Chlamydia trachomatis.

  2016cites this paper
• The role of NOD1 and NOD2 in host defense against chlamydial infection.

  2016cites this paper
• Lipid Requirements for the Enzymatic Activity of MraY Translocases and in Vitro Reconstitution of the Lipid II Synthesis Pathway*

  2015cites this paper