Sensing the enemy, containing the threat: cell-autonomous immunity to Chlamydia trachomatis.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  FEMS Microbiology Reviews

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 27476078
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Structural requirements

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  2017cited by this paper
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  2016cited by this paper
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  2016cited by this paper
• Interferon-Inducible GTPases in Host Resistance, Inflammation and Disease.

  2016influential reference
• TLR2, TLR4 and TLR9 genotypes and haplotypes in the susceptibility to and clinical course of Chlamydia trachomatis infections in Dutch women.

  2016influential reference
• Bacterial Outer Membrane Vesicles Mediate Cytosolic Localization of LPS and Caspase-11 Activation.

  2016cited by this paper
• A Noncanonical Autophagy Pathway Restricts Toxoplasma gondii Growth in a Strain-Specific Manner in IFN-γ-Activated Human Cells

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• The DNA Sensor AIM2 Maintains Intestinal Homeostasis via Regulation of Epithelial Antimicrobial Host Defense.

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• Inflammasomes Coordinate Pyroptosis and Natural Killer Cell Cytotoxicity to Clear Infection by a Ubiquitous Environmental Bacterium.

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  2015cited by this paper
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  2015cited by this paper
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• IRGM governs the core autophagy machinery to conduct antimicrobial defense.

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• Inflammasomes: mechanism of action, role in disease, and therapeutics

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  2015influential reference
• Mutational Analysis of the Chlamydia muridarum Plasticity Zone

  2015cited by this paper
• Epithelial cell contributions to intestinal immunity.

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  2014cited by this paper
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  2014influential reference
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  2014influential reference
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  2014influential reference
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  2013cited by this paper
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  2011influential reference
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  2010influential reference

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  2023cites this paper
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• TLR4/CD14/MD2 Revealed as the Limited Toll-like Receptor Complex for Chlamydia trachomatis-Induced NF-κB Signaling

  2022cites this paper
• Interactions of Autophagy and the Immune System in Health and Diseases

  2022cites this paper
• Regulation of chlamydial colonization by IFNγ delivered via distinct cells.

  2022cites this paper
• The bacterial effector GarD shields Chlamydia trachomatis inclusions from RNF213-mediated ubiquitylation and destruction.

  2022cites this paper
• How did we get here? Insights into mechanisms of immunity-related GTPase targeting to intracellular pathogens.

  2022cites this paper
• Towards a Deeper Understanding of Chlamydia trachomatis Pathogenetic Mechanisms: Editorial to the Special Issue “Chlamydia trachomatis Pathogenicity and Disease”

  2022cites this paper
• Immunopathogenesis of genital Chlamydia infection: insights from mouse models.

  2021influential citation
• Chlamydia trachomatis: Cell biology, immunology and vaccination.

  2021cites this paper
• Host Cell Amplification of Nutritional Stress Contributes To Persistence in Chlamydia trachomatis

  2021cites this paper
• Pelvic inflammatory disease in the adolescent and young adult: An update.

  2021cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2019cites this paper
• T Cell-Independent Gamma Interferon and B Cells Cooperate To Prevent Mortality Associated with Disseminated Chlamydia muridarum Genital Tract Infection

  2018cites this paper
• Pelvic inflammatory disease: management requires a patient, prudent, prejudice-free provider

  2018cites this paper
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  2018cites this paper
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  2018cites this paper
• Development of a Chlamydia trachomatis vaccine for urogenital infections: novel tools and new strategies point to bright future prospects

  2018cites this paper
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  2018cites this paper
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  2017cites this paper
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  2017cites this paper
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  2016cites this paper