Neuropathic Pain: Literature Review and Recommendations of Potential Phytotherapies

Introduction: One of the common syndromes that affect humanity is neuropathic pain (NP), yet poorly understood with no efficient treatment till now. Consequently, it is extremely crucial to seek further evidence for accurate diagnosis and optimum treatment. The aim of this work is to summarize the findings related to neuropathic pain in terms of etiology, types, diagnosis, current and future management prospective, and identify the gaps in neuropathic pain therapy. Methods: A literature investigation was carried out by analyzing classical peer reviewed papers and textbooks, taking into consideration worldwide well established scientific databases mainly PUBMED and SCOPUS to retrieve accessible published literature. The selection of phytotherapies was based upon their potentials in relieving NP in pre-clinical or clinical models. Results: One of the most critical points in this research is that recommendations of the future plans should be focused on the engagement of phytotherapy in the treatment regimen aiming at improving patients’ quality of life and reaching optimum efficacy and minimum toxicity. Phytotherapies offer relatively low-risk options to NP patients and have an increasing evidence to be the future of neuropathic pain management. Patients suffering from neuropathy are depending increasingly on phytotherapies; however, they need more clinical trials in order to fully understand their mechanism of actions. Conclusion: Health-care specialists should be regularly informed about neuropathic pain current therapies and promising future phytotherapies, bearing in mind the risk/benefit profile of the utilization of these therapies in the amelioration of NP.

• Publication year

  2017

• Venue

  Polymer Journal

• Publication date

  2017-06-05

• Fields of study

  Medicine

• Identifiers
  DOI 10.5530/PJ.2017.4.72
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Topical Citrullus colocynthis (bitter apple) extract oil in painful diabetic neuropathy: A double‐blind randomized placebo‐controlled clinical trial

  2016cited by this paper
• Phytotherapeutic activity of curcumol: Isolation, GC–MS identification, and assessing potentials against acute and subchronic hyperglycemia, tactile allodynia, and hyperalgesia

  2016cited by this paper
• Antihyperalgesic Activity of Rhodiola rosea in a Diabetic Rat Model

  2016cited by this paper
• Nerve injury and neuropathic pain — A question of age

  2016cited by this paper
• Inhaled Cannabis for Chronic Neuropathic Pain: A Meta-analysis of Individual Patient Data.

  2015cited by this paper
• Restoring the spinal pain gate: GABA(A) receptors as targets for novel analgesics.

  2015cited by this paper
• Neuroprotective effects of Gymnema sylvestre on streptozotocin-induced diabetic neuropathy in rats.

  2015cited by this paper
• An evaluation of the protective role of Ficus racemosa Linn. in streptozotocin-induced diabetic neuropathy with neurodegeneration

  2015cited by this paper
• Acute and subchronic in-vivo effects of Ferula hermonis L. and Sambucus nigra L. and their potential active isolates in a diabetic mouse model of neuropathic pain

  2015cited by this paper
• Diabetes in people with intellectual disabilities: A systematic review of the literature.

  2015cited by this paper
• Neuropathic pain in osteoarthritis: a review of pathophysiological mechanisms and implications for treatment.

  2014cited by this paper
• Treatment of Post‐Amputation Pain With Peripheral Nerve Stimulation

  2014cited by this paper
• Amelioration of Diabetes and Painful Diabetic Neuropathy by Punica granatum L. Extract and Its Spray Dried Biopolymeric Dispersions

  2014cited by this paper
• A double-blind, placebo-controlled, crossover pilot trial with extension using an oral mucosal cannabinoid extract for treatment of chemotherapy-induced neuropathic pain.

  2014cited by this paper
• Effects of Cleome viscosa on hyperalgesia, oxidative stress and lipid profile in STZ induced diabetic neuropathy in Wistar rats.

  2014cited by this paper
• Alloxan-induced diabetic thermal hyperalgesia, prophylaxis and phytotherapeutic effects of Rheum ribes L. in mouse model

  2014cited by this paper
• Diagnosis and management of neuropathic pain: review of literature and recommendations of the Polish Association for the Study of Pain and the Polish Neurological Society - Part Two.

  2014cited by this paper
• Dioscorea Extract (DA-9801) Modulates Markers of Peripheral Neuropathy in Type 2 Diabetic db/db Mice

  2014cited by this paper
• St. John's Wort seed and feverfew flower extracts relieve painful diabetic neuropathy in a rat model of diabetes.

  2014cited by this paper
• Functional Food Quality of Curcuma caesia, Curcuma zedoaria and Curcuma aeruginosa Endemic to Northeastern India

  2013cited by this paper
• REPRINT OF POLISH TRANSLATION OF ARTICLE BY ACCORD INTERNATIONAL ASSOCIATION FOR THE STUDY OF PAIN (IASP) - Pain 152 (2011) 507-513 A nationwide study of three invasive treatments for trigeminal neuralgia

  2013cited by this paper
• Minocycline selectively inhibits M1 polarization of microglia

  2013cited by this paper
• Refractory Trigeminal Neuralgia

  2013cited by this paper
• Mechanisms and pharmacology of diabetic neuropathy – experimental and clinical studies

  2013cited by this paper
• Endogenous Lebanese Plants Treating Diabetes and Related Complications

  2013cited by this paper
• Neuropathic pain in the community: More under-treated than refractory?

  2013cited by this paper
• The Burden of Hip Osteoarthritis in the United States: Epidemiologic and Economic Considerations

  2013cited by this paper
• Risk factors for and prevalence of knee osteoarthritis in the rural areas of Shanxi Province, North China: a COPCORD study

  2013cited by this paper
• Antitussive and bronchodilatory effects of Lythrum salicaria polysaccharide-polyphenolic conjugate.

  2012cited by this paper
• Effect of green tea extracts on oxaliplatin-induced peripheral neuropathy in rats

  2012cited by this paper
• Chinese herbal medicine in treatment of diabetic peripheral neuropathy: a systematic review and meta-analysis.

  2012cited by this paper
• Epidemiology of Neuropathic Pain and Its Impact on Quality of Life

  2012cited by this paper
• Painful diabetic peripheral neuropathy: consensus recommendations on diagnosis, assessment and management

  2011cited by this paper
• The prevalence, correlates and treatment of pain in the European Union

  2011cited by this paper
• Evidence-based guideline: Treatment of painful diabetic neuropathy: Report of the American Academy of Neurology, the American Association of Neuromuscular and Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation

  2011cited by this paper
• The roles of sodium channels in nociception: implications for mechanisms of neuropathic pain.

  2011cited by this paper
• The specific disease burden of neuropathic pain: Results of a French nationwide survey

  2011cited by this paper
• Isolation and Identification of Phase 1 Metabolites of Curcumol in Rats

  2010cited by this paper
• A crystal lapiferin derived from Ferula vesceritensis induces apoptosis pathway in MCF-7 breast cancer cells

  2010cited by this paper
• Nowe wytyczne dotyczące leczenia bólu neuropatycznego

  2010cited by this paper
• [Neuropathic pain in cancer.].

  2009cited by this paper
• NEUROPATHIC PAIN : REDEFINITION AND A GRADING SYSTEM FOR CLINICAL AND RESEARCH PURPOSES. Author's reply

  2009cited by this paper
• Incidence of facial pain in the general population

  2009cited by this paper
• NEUROPATHIC PAIN: REDEFINITION AND A GRADING SYSTEM FOR CLINICAL AND RESEARCH PURPOSES

  2009cited by this paper
• Cellular and molecular mechanisms of pain.

  2009cited by this paper
• Vertebral metastases with high risk of symptomatic malignant spinal cord compression.

  2009influential reference
• European elderberry (Sambucus nigra L.) rich in sugars, organic acids, anthocyanins and selected polyphenols

  2009cited by this paper
• Polymer-based non-viral gene delivery as a concept for the treatment of cancer

  2009cited by this paper
• Peripheral mechanisms of neuropathic pain – involvement of lysophosphatidic acid receptor-mediated demyelination

  2008cited by this paper
• Prevalence of chronic pain with neuropathic characteristics in the general population

  2008cited by this paper
• Modulation of pain transmission by G-protein-coupled receptors.

  2008cited by this paper
• Spinal cord mechanisms of pain.

  2008cited by this paper
• Reversal of pathological pain through specific spinal GABAA receptor subtypes

  2008cited by this paper
• Central sensitization

  2008cited by this paper
• Pain after mastectomy and breast reconstruction.

  2008cited by this paper
• In vivo assessment of antidiabetic and antioxidant activities of rosemary (Rosmarinus officinalis) in alloxan-diabetic rabbits.

  2008cited by this paper
• The antioxidant response as a drug target in diabetic neuropathy.

  2008cited by this paper
• Discovery of orally efficacious tetracyclic metabotropic glutamate receptor 1 (mGluR1) antagonists for the treatment of chronic pain.

  2007cited by this paper
• Natural history of pain following herpes zoster

  2007cited by this paper
• Can vitamin C prevent complex regional pain syndrome in patients with wrist fractures? A randomized, controlled, multicenter dose-response study.

  2007cited by this paper
• The roles of sodium channels in nociception: Implications for mechanisms of pain.

  2007cited by this paper
• Recommendations for the management of herpes zoster.

  2007cited by this paper
• Proposed new diagnostic criteria for complex regional pain syndrome.

  2007cited by this paper
• The neuropathic pain triad: neurons, immune cells and glia

  2007cited by this paper
• [Survey of current experimental studies of effects of traditional Chinese compound recipe on diabetic peripheral neuropathy].

  2007cited by this paper
• Epidemiology of osteoarthritis: an update

  2006cited by this paper
• Immune and inflammatory mechanisms in neuropathic pain.

  2006cited by this paper
• The epidemiology of chronic pain of predominantly neuropathic origin. Results from a general population survey.

  2006cited by this paper
• Clinical and experimental findings in humans and animals with chemotherapy-induced peripheral neuropathy.

  2006cited by this paper
• A review on the role of antioxidants in the management of diabetes and its complications.

  2005cited by this paper
• Is successful rehabilitation of complex regional pain syndrome due to sustained attention to the affected limb? A randomised clinical trial

  2005cited by this paper
• Postamputation Pain and Sensory Changes in Treatment-naive Patients: Characteristics and Responses to Treatment with Tramadol, Amitriptyline, and Placebo

  2005cited by this paper
• Local anesthetic sympathetic blockade for complex regional pain syndrome.

  2005cited by this paper
• Diabetic neuropathies: a statement by the American Diabetes Association.

  2005cited by this paper
• Hypoglycemic effects of turmeric (Curcuma longa L. rhizomes) on genetically diabetic KK-Ay mice.

  2005cited by this paper
• [Effect of FZHY recipe on elastase expression in liver fibrosis in rats].

  2005cited by this paper
• Pregabalin for the treatment of painful diabetic peripheral neuropathy: a double‐blind, placebo‐controlled trial

  2004cited by this paper
• Taxol‐induced sensory disturbance is characterized by preferential impairment of myelinated fiber function in cancer patients

  2004cited by this paper
• Risk factors for postherpetic neuralgia in patients with herpes zoster

  2004cited by this paper
• The coding of noxious mechanical and thermal stimuli of deep dorsal horn neurones is attenuated in NK1 knockout mice.

  2003cited by this paper
• PHENOTYPIC AND ALLOZYME VARIATION IN MEDITERRANEAN AND DESERT POPULATIONS OF WILD BARLEY, HORDEUM SPONTANEUM KOCH

  2002cited by this paper
• Spinal Neurons that Possess the Substance P Receptor Are Required for the Development of Central Sensitization

  2002cited by this paper
• Partial Peripheral Nerve Injury Promotes a Selective Loss of GABAergic Inhibition in the Superficial Dorsal Horn of the Spinal Cord

  2002cited by this paper
• Diagnosis and differential diagnosis of trigeminal neuralgia.

  2002cited by this paper
• Physical therapy and cognitive-behavioral treatment for complex regional pain syndromes.

  2002cited by this paper
• Advances in the management of neuropathic pain.

  2001cited by this paper
• Molecular mechanisms of nociception

  2001cited by this paper
• Mechanisms of neuropathic pain.

  2001cited by this paper
• Epidemiology and clinical features of HIV‐1 associated neuropathies

  2001cited by this paper
• Chemotherapy-evoked painful peripheral neuropathy.

  2001cited by this paper
• Traditional uses of Salvia libanotica (East Mediterranean sage) and the effects of its essential oils.

  2000cited by this paper
• A new flavonoid glycoside from Centaurea horrida.

  2000cited by this paper
• Evaluation of three methods to rate impairment in patients with complex regional pain syndrome I of one upper extremity

  2000cited by this paper
• Plasma viral load and CD4 lymphocytes predict HIV-associated dementia and sensory neuropathy

  1999cited by this paper
• Membrane Potential Oscillations in Dorsal Root Ganglion Neurons: Role in Normal Electrogenesis and Neuropathic Pain

  1999cited by this paper
• Myelinated afferent fiber types that become spontaneously active and mechanosensitive following nerve transection in the rat.

  1999cited by this paper
• Paradoxical heat sensation in healthy subjects: peripherally conducted by A delta or C fibres?

  1999cited by this paper
• Radical scavenging activity of tea catechins and their related compounds.

  1999cited by this paper
• In vivo antinociceptive activity of anti‐rat mGluR1 and mGluR5 antibodies in rats

  1998cited by this paper
• Painful neuropathies.

  1998cited by this paper

• Electroacupuncture effects on trigeminal neuralgia with comorbid anxiety and depression: The role of frequency and acupoint specificity

  2025cites this paper
• Harmaline attenuates chemotherapy-induced neuropathy: Modulation of the Nrf-2 pathway and NK-1 receptor signaling.

  2024cites this paper
• Nano-cubosomes of the phyto-active principle in Withania somnifera: LC-MS-NMR, anti-microbial, and insights of the anti-neuropathic and anti-inflammatory mechanism.

  2024cites this paper
• Rationalized Approach for The Treatment of Neuropathic Pain

  2021cites this paper
• Analgesia effect of lentivirus-siSCN9A infected neurons in vincristine induced neuropathic pain rats

  2021cites this paper
• Niosomes of active Fumaria officinalis phytochemicals: antidiabetic, antineuropathic, anti-inflammatory, and possible mechanisms of action

  2020cites this paper
• Phytochemical and anti-neuropathic investigations of Crocus sativus via alleviating inflammation, oxidative stress and pancreatic beta-cells regeneration

  2019cites this paper
• Anti-inflammatory and anti-neuropathic effects of a novel quinic acid derivative from Acanthus syriacus

  2019cites this paper
• PATIENT REPORTED OUTCOMES ON BIOGETICA FORMULATIONS IN TRIGEMINAL NEURALGIA

  2019cites this paper
• Gastroprotective and anti-inflammatory effects of Prunus cerasus phytochemicals and their possible mechanisms of action

  2019cites this paper
• Combating Diabetes and its Emerging Complications Utilizing Natural Phytochemicals

  2019cites this paper
• The Effect of Pregabalin on the Quality of Life in Patients with Central Post-Stroke Pain

  2018cites this paper
• Phytochemical analysis of Juglans regia oil and kernel exploring their antinociceptive and anti-inflammatory potentials utilizing combined bio-guided GC-FID, GC-MS and HPLC analyses

  2018cites this paper
• A Novel Potential Role of Vitamin K2-7 in Relieving Peripheral Neuropathy

  2018cites this paper