Endothelin-1 is a paracrine growth factor that modulates melanogenesis of human melanocytes and participates in their responses to ultraviolet radiation.

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research

• Publication date

  1998-07-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  PMID 9690625
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1998cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1996cited by this paper
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  1996cited by this paper
• Signalling mechanisms of endothelin-induced mitogenesis and melanogenesis in human melanocytes.

  1996cited by this paper
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  1996cited by this paper
• Mitogenic and melanogenic stimulation of normal human melanocytes by melanotropic peptides.

  1995cited by this paper
• Comparison of the responses of human melanocytes with different melanin contents to ultraviolet B irradiation.

  1995cited by this paper
• Endothelin-1 as a new melanogen: coordinated expression of its gene and the tyrosinase gene in UVB-exposed human epidermis.

  1995influential reference
• The retinoblastoma tumor suppressor protein.

  1995cited by this paper
• Ultraviolet B light induces G1 arrest in human melanocytes by prolonged inhibition of retinoblastoma protein phosphorylation associated with long-term expression of the p21Waf-1/SDI-1/Cip-1 protein.

  1995cited by this paper
• Long-term proliferation of human melanocytes is supported by the physiologic mitogens alpha-melanotropin, endothelin-1, and basic fibroblast growth factor.

  1995cited by this paper
• Proopiomelanocortin-derived peptides are synthesized and released by human keratinocytes.

  1994cited by this paper
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  1994cited by this paper
• Endothelins: molecular biology, biochemistry, pharmacology, physiology, and pathophysiology.

  1994cited by this paper
• Tyrosinase related protein 1 (TRP1) functions as a DHICA oxidase in melanin biosynthesis.

  1994cited by this paper
• Alpha melanocyte stimulating hormone (alpha MSH) stimulates normal human melanocyte growth by binding to high-affinity receptors.

  1993cited by this paper
• The human endothelin-B receptor gene. Structural organization and chromosomal assignment.

  1993cited by this paper
• Calcium plays a complex role in the regulation of melanogenesis in murine B16 melanoma cells.

  1993cited by this paper
• The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.

  1993cited by this paper
• Protein kinase C and protein tyrosine kinase activity contribute to mitogenic signaling by endothelin-1. Cross-talk between G protein-coupled receptors and pp60c-src.

  1993cited by this paper
• Cultured human keratinocytes synthesize and secrete endothelin-1.

  1993cited by this paper
• Distinct subdomains of human endothelin receptors determine their selectivity to endothelinA-selective antagonist and endothelinB-selective agonists.

  1993cited by this paper
• WAF1, a potential mediator of p53 tumor suppression.

  1993cited by this paper
• The p53 tumor suppressor protein, a modulator of cell proliferation.

  1992cited by this paper
• Endothelin induces transcription of fos/jun family genes: a prominent role for calcium ion.

  1992cited by this paper
• Mitogenic, melanogenic, and cAMP responses of cultured neonatal human melanocytes to commonly used mitogens

  1992cited by this paper
• Endothelins secreted from human keratinocytes are intrinsic mitogens for human melanocytes.

  1992cited by this paper
• Molecular cloning and expression of the human melanocyte stimulating hormone receptor cDNA

  1992cited by this paper
• Effects of staurosporine, PMA and A23187 on human melanocyte cultures with dibutyryl cyclic AMP

  1992cited by this paper
• The cloning of a family of genes that encode the melanocortin receptors.

  1992cited by this paper
• Effects of endothelins on signal transduction and proliferation in human melanocytes.

  1991cited by this paper
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  1991cited by this paper
• Enzymatic control of pigmentation in mammals

  1991cited by this paper
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  1990cited by this paper
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  1990cited by this paper
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  1990cited by this paper
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  1990cited by this paper
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  1989cited by this paper
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  1989cited by this paper
• Endothelin stimulates phospholipase C, Na+/H+ exchange, c-fos expression, and mitogenesis in rat mesangial cells.

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• The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.

  1989cited by this paper
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  1989cited by this paper
• A novel potent vasoconstrictor peptide produced by vascular endothelial cells

  1988cited by this paper
• Basic fibroblast growth factor from human keratinocytes is a natural mitogen for melanocytes

  1988cited by this paper
• Acidic and basic fibroblast growth factors stimulate tyrosine kinase activity in vivo.

  1988cited by this paper
• Inhibition of tyrosinase activity and protein synthesis in melanoma cells by calcium ionophore A23187.

  1987cited by this paper
• Human melanocytes cultured from nevi and melanomas.

  1986cited by this paper
• αMelanocyte Stimulating Hormone: Chemical Nature and Mechanism of Action

  1983cited by this paper
• L-Tyrosine-3, 5-3H Assay for Tyrosinase Development in Skin of Newborn Hamsters

  1969cited by this paper

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