Intercellular communication via intracellular calcium oscillations.

In this letter, we present the results of a simple model for intercellular communication via calcium oscillations, motivated in part by a recent experimental study. The model describes two cells (a "donor" and "sensor") whose intracellular dynamics involve a calcium-induced, calcium release process. The cells are coupled by assuming that the input of the sensor cell is proportional to the output of the donor cell. As one varies the frequency of calcium oscillations of the donor cell, the sensor cell passes through a sequence of N : M phase-locked regimes and exhibits a "Devil's staircase" behavior. Such a phase-locked response has been seen experimentally in pulsatile stimulation of single cells. We also study a stochastic version of the coupled two-cell model. We find that phase locking holds for realistic choices for the cell volume.

• Publication year

  2001

• Venue

  Journal of Theoretical Biology

• Publication date

  2001-11-15

• Fields of study

  Biology, Medicine, Physics, Chemistry

• Identifiers
  DOI 10.1006/JTBI.2003.3201arXiv physics/0111137PMID 12713937
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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