Abnormal mTOR Activation in Autism.

The mechanistic target of rapamycin (mTOR) is an important signaling hub that integrates environmental information regarding energy availability and stimulates anabolic molecular processes and cell growth. Abnormalities in this pathway have been identified in several syndromes in which autism spectrum disorder (ASD) is highly prevalent. Several studies have investigated mTOR signaling in developmental and neuronal processes that, when dysregulated, could contribute to the development of ASD. Although many potential mechanisms still remain to be fully understood, these associations are of great interest because of the clinical availability of mTOR inhibitors. Clinical trials evaluating the efficacy of mTOR inhibitors to improve neurodevelopmental outcomes have been initiated.

• Publication year

  2018

• Venue

  Annual Review of Neuroscience

• Publication date

  2018-07-08

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1146/annurev-neuro-080317-061747PMID 29490194
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• mTOR Signaling in Growth, Metabolism, and Disease.

  2017cited by this paper
• Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system

  2017cited by this paper
• Differential roles for Akt and mTORC1 in the hypertrophy of Pten mutant neurons, a cellular model of brain overgrowth disorders.

  2017cited by this paper
• Influence of seizures on early development in tuberous sclerosis complex.

  2017cited by this paper
• mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases

  2017cited by this paper
• Striatal Transcriptome and Interactome Analysis of Shank3-overexpressing Mice Reveals the Connectivity between Shank3 and mTORC1 Signaling

  2017cited by this paper
• Reverse Pathway Genetic Approach Identifies Epistasis in Autism Spectrum Disorders

  2017cited by this paper
• Blood transcriptomic comparison of individuals with and without autism spectrum disorder: A combined‐samples mega‐analysis

  2017cited by this paper
• The genomic landscape of tuberous sclerosis complex

  2017cited by this paper
• RNA sequencing of transformed lymphoblastoid cells from siblings discordant for autism spectrum disorders reveals transcriptomic and functional alterations: Evidence for sex‐specific effects

  2017cited by this paper
• Is functional brain connectivity atypical in autism? A systematic review of EEG and MEG studies

  2017cited by this paper
• Multistep regulation of TFEB by MTORC1

  2017cited by this paper
• Dynamic Akt/mTOR Signaling in Children with Autism Spectrum Disorder

  2017cited by this paper
• Autism spectrum disorder and other neurobehavioural comorbidities in rare disorders of the Ras/MAPK pathway

  2017cited by this paper
• Everolimus for treatment of tuberous sclerosis complex‐associated neuropsychiatric disorders

  2017cited by this paper
• Neuronal CTGF/CCN2 negatively regulates myelination in a mouse model of tuberous sclerosis complex

  2017cited by this paper
• Prevalence and Characteristics of Autism Spectrum Disorder Among Children Aged 8 Years — Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2012

  2016cited by this paper
• Association of MTOR Mutations With Developmental Brain Disorders, Including Megalencephaly, Focal Cortical Dysplasia, and Pigmentary Mosaicism.

  2016cited by this paper
• Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders

  2016cited by this paper
• Genome Sequencing of Autism-Affected Families Reveals Disruption of Putative Noncoding Regulatory DNA.

  2016cited by this paper
• Adjunctive everolimus therapy for treatment-resistant focal-onset seizures associated with tuberous sclerosis (EXIST-3): a phase 3, randomised, double-blind, placebo-controlled study.

  2016cited by this paper
• CLK2 inhibition ameliorates autistic features associated with SHANK3 deficiency

  2016cited by this paper
• Deficient autophagy in microglia impairs synaptic pruning and causes social behavioral defects

  2016cited by this paper
• mTORC1 Inhibition Corrects Neurodevelopmental and Synaptic Alterations in a Human Stem Cell Model of Tuberous Sclerosis.

  2016cited by this paper
• Targeting Translation Control with p70 S6 Kinase 1 Inhibitors to Reverse Phenotypes in Fragile X Syndrome Mice

  2016cited by this paper
• Impaired Mitochondrial Dynamics and Mitophagy in Neuronal Models of Tuberous Sclerosis Complex.

  2016cited by this paper
• Symptom profiles of autism spectrum disorder in tuberous sclerosis complex

  2016cited by this paper
• Rapamycin prevents, but does not reverse, aberrant migration in Pten knockout neurons.

  2016cited by this paper
• Congenital disorders of autophagy: an emerging novel class of inborn errors of neuro-metabolism.

  2016cited by this paper
• Maternal immune activation: Implications for neuropsychiatric disorders

  2016cited by this paper
• mTORC1–S6K1 inhibition or mTORC2 activation improves hippocampal synaptic plasticity and learning in Angelman syndrome mice

  2016cited by this paper
• Mammalian FMRP S499 Is Phosphorylated by CK2 and Promotes Secondary Phosphorylation of FMRP

  2016cited by this paper
• Germline and somatic mutations in the MTOR gene in focal cortical dysplasia and epilepsy

  2016cited by this paper
• mTOR kinase is needed for the development and stabilization of dendritic arbors in newly born olfactory bulb neurons

  2016cited by this paper
• Genomic analysis of the molecular neuropathology of tuberous sclerosis using a human stem cell model

  2016cited by this paper
• Decreased mTOR signaling pathway in human idiopathic autism and in rats exposed to valproic acid

  2015cited by this paper
• A germline MTOR mutation in Aboriginal Australian siblings with intellectual disability, dysmorphism, macrocephaly, and small thoraces

  2015cited by this paper
• Rett syndrome: disruption of epigenetic control of postnatal neurological functions.

  2015cited by this paper
• Hyperactivity of Newborn Pten Knock-out Neurons Results from Increased Excitatory Synaptic Drive

  2015cited by this paper
• Altered white matter connectivity as a neural substrate for social impairment in Autism Spectrum Disorder.

  2015cited by this paper
• The Stress-Induced Atf3-Gelsolin Cascade Underlies Dendritic Spine Deficits in Neuronal Models of Tuberous Sclerosis Complex

  2015cited by this paper
• Hypomyelination following deletion of Tsc2 in oligodendrocyte precursors

  2015cited by this paper
• Germline activating MTOR mutation arising through gonadal mosaicism in two brothers with megalencephaly and neurodevelopmental abnormalities

  2015cited by this paper
• Imbalanced Mechanistic Target of Rapamycin C1 and C2 Activity in the Cerebellum of Angelman Syndrome Mice Impairs Motor Function

  2015cited by this paper
• Mammalian Target of Rapamycin (mTOR) Tagging Promotes Dendritic Branch Variability through the Capture of Ca2+/Calmodulin-dependent Protein Kinase II α (CaMKIIα) mRNAs by the RNA-binding Protein HuD*

  2015cited by this paper
• Impaired Reelin-Dab1 Signaling Contributes to Neuronal Migration Deficits of Tuberous Sclerosis Complex.

  2015cited by this paper
• Prevalence of autism spectrum disorder phenomenology in genetic disorders: a systematic review and meta-analysis.

  2015cited by this paper
• Genes, circuits, and precision therapies for autism and related neurodevelopmental disorders

  2015cited by this paper
• Sirolimus for progressive neurofibromatosis type 1-associated plexiform neurofibromas: a neurofibromatosis Clinical Trials Consortium phase II study.

  2015cited by this paper
• Autism Spectrum Disorder Profile in Neurofibromatosis Type I

  2015cited by this paper
• Rheb inhibits protein synthesis by activating the PERK‐eIF2α signaling cascade

  2015cited by this paper
• Rheb activation disrupts spine synapse formation through accumulation of syntenin in tuberous sclerosis complex

  2015cited by this paper
• Conditional Ablation of Raptor or Rictor Has Differential Impact on Oligodendrocyte Differentiation and CNS Myelination

  2014cited by this paper
• Mammalian Target of Rapamycin Promotes Oligodendrocyte Differentiation, Initiation and Extent of CNS Myelination

  2014cited by this paper
• Neuronal Tsc1/2 complex controls autophagy through AMPK-dependent regulation of ULK1.

  2014cited by this paper
• mTOR regulates brain morphogenesis by mediating GSK3 signaling

  2014cited by this paper
• Balanced mTORC1 Activity in Oligodendrocytes Is Required for Accurate CNS Myelination

  2014cited by this paper
• Loss of mTOR-dependent macroautophagy causes autistic-like synaptic pruning deficits.

  2014cited by this paper
• Behavioral signatures related to genetic disorders in autism

  2014cited by this paper
• Patches of disorganization in the neocortex of children with autism.

  2014cited by this paper
• Selective suppression of excessive GluN2C expression rescues early epilepsy in a tuberous sclerosis murine model

  2014cited by this paper
• Selective activation of mTORC1 signaling recapitulates microcephaly, tuberous sclerosis, and neurodegenerative diseases.

  2014cited by this paper
• Autism traits in the RASopathies

  2013cited by this paper
• Excitatory/inhibitory synaptic imbalance leads to hippocampal hyperexcitability in mouse models of tuberous sclerosis.

  2013cited by this paper
• SHANK3 overexpression causes manic-like behavior with unique pharmacogenetic properties

  2013cited by this paper
• SHANK3 and IGF1 restore synaptic deficits in neurons from 22q13 deletion syndrome patients

  2013cited by this paper
• Symptomatology of autism spectrum disorder in a population with neurofibromatosis type 1

  2013cited by this paper
• The translation of translational control by FMRP: therapeutic targets for FXS

  2013cited by this paper
• Inactivation of mTORC1 in the Developing Brain Causes Microcephaly and Affects Gliogenesis

  2013cited by this paper
• Prospective investigation of autism and genotype-phenotype correlations in 22q13 deletion syndrome and SHANK3 deficiency

  2013cited by this paper
• PTEN knockdown alters dendritic spine/protrusion morphology, not density

  2013cited by this paper
• mTORC2 controls actin polymerization required for consolidation of long-term memory

  2013cited by this paper
• Ablation of the mTORC2 component rictor in brain or Purkinje cells affects size and neuron morphology

  2013cited by this paper
• mTORC1 targets the translational repressor 4E-BP2, but not S6 kinase 1/2, to regulate neural stem cell self-renewal in vivo.

  2013cited by this paper
• Cowden syndrome and the PTEN hamartoma tumor syndrome: systematic review and revised diagnostic criteria.

  2013cited by this paper
• mTOR-dependent abnormalities in autophagy characterize human malformations of cortical development: evidence from focal cortical dysplasia and tuberous sclerosis

  2013cited by this paper
• Identification of small exonic CNV from whole-exome sequence data and application to autism spectrum disorder.

  2013cited by this paper
• Dysregulation of synaptic plasticity precedes appearance of morphological defects in a Pten conditional knockout mouse model of autism

  2013cited by this paper
• The neurobehavioral and molecular phenotype of Angelman Syndrome

  2013cited by this paper
• Impaired induction of long‐term potentiation‐like plasticity in patients with high‐functioning autism and Asperger syndrome

  2013cited by this paper
• Global transcriptional and translational repression in human-embryonic-stem-cell-derived Rett syndrome neurons.

  2013cited by this paper
• Rheb regulates mitophagy induced by mitochondrial energetic status.

  2013cited by this paper
• Brain functional networks in syndromic and non-syndromic autism: a graph theoretical study of EEG connectivity

  2013cited by this paper
• Pentylenetetrazole‐induced seizures cause acute, but not chronic, mTOR pathway activation in rat

  2012cited by this paper
• The Interaction between Early Life Epilepsy and Autistic-Like Behavioral Consequences: A Role for the Mammalian Target of Rapamycin (mTOR) Pathway

  2012cited by this paper
• TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1.

  2012cited by this paper
• Erk1/2 MAPK and mTOR signaling sequentially regulates progression through distinct stages of oligodendrocyte differentiation

  2012cited by this paper
• The functions and regulation of the PTEN tumour suppressor

  2012cited by this paper
• Regulation of presynaptic neurotransmission by macroautophagy.

  2012cited by this paper
• Genetic removal of p70 S6 kinase 1 corrects molecular, synaptic, and behavioral phenotypes in fragile X syndrome mice.

  2012cited by this paper
• Loss of CDKL5 disrupts kinome profile and event-related potentials leading to autistic-like phenotypes in mice

  2012cited by this paper
• Autistic-like behavior and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice

  2012cited by this paper
• A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

  2012cited by this paper
• Somatic activation of AKT3 causes hemispheric developmental brain malformations.

  2012cited by this paper
• PTEN Regulation of Local and Long-Range Connections in Mouse Auditory Cortex

  2012cited by this paper
• Impaired Autophagy in Neurons after Disinhibition of Mammalian Target of Rapamycin and Its Contribution to Epileptogenesis

  2012cited by this paper
• Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks.

  2012cited by this paper
• Reduced AKT/mTOR signaling and protein synthesis dysregulation in a Rett syndrome animal model.

  2011cited by this paper
• Mutations causing syndromic autism define an axis of synaptic pathophysiology

  2011cited by this paper
• Loss of Tsc1 In Vivo Impairs Hippocampal mGluR-LTD and Increases Excitatory Synaptic Function

  2011cited by this paper

• First Report of a Child With a DeSanto-Shinawi Syndrome and a Polymorphous Low-Grade Neuroepithelial Tumor of the Young.

  2026cites this paper
• Nitric Oxide-Mediated S-Nitrosylation of TSC2 Drives mTOR dysregulation across Shank3 and Cntnap2 Models of Autism Spectrum Disorder.

  2026cites this paper
• Nitric oxide and peroxynitrite as new biomarkers for early diagnosis of autism.

  2025cites this paper
• Exploring the potential of the ketogenic diet in autism spectrum disorder: metabolic, genetic, and therapeutic insights

  2025cites this paper
• Using cortical organoids to understand the pathogenesis of malformations of cortical development

  2025cites this paper
• Exome sequencing identifies protein-coding variants associated with loneliness and social isolation.

  2025cites this paper
• Glycosylation Pathways Targeted by Deregulated miRNAs in Autism Spectrum Disorder

  2025cites this paper
• Altered Monocyte Populations and Activation Marker Expression in Children with Autism and Co-Occurring Gastrointestinal Symptoms

  2025cites this paper
• Morphological and functional differences between hippocampal and cortical microglia and its impact on neuronal over-excitation in a germline Pten mutant mouse model.

  2025cites this paper
• Unlocking the therapeutic potential of protein kinase inhibitors in neurodegenerative and psychiatric disorders

  2025cites this paper
• Chemogenetic induction of CA1 hyperexcitability triggers indistinguishable autistic traits in asymptomatic mice differing in Ambra1 expression and sex

  2025cites this paper
• Multi-omics study reveals differential expression and phosphorylation of autophagy-related proteins in autism spectrum disorder

  2025cites this paper
• Mdga2 deficiency leads to an aberrant activation of BDNF/TrkB signaling that underlies autism-relevant synaptic and behavioral changes in mice

  2025cites this paper
• Animal studies reveal downregulation of the Beclin-1 autophagy pathway as shared mechanism in Autism Spectrum Disorder: a systematic review and meta-analysis

  2025cites this paper
• The mTOR and total protein levels of stunted children

  2025cites this paper
• Molecular basis of autism spectrum disorders

  2025cites this paper
• Mechanisms of brain overgrowth in autism spectrum disorder with macrocephaly

  2025cites this paper
• Cytoplasmic and nuclear protein interaction networks of the synapto-nuclear messenger CRTC1 in neurons reveal cooperative chromatin binding between CREB1 and CRTC1, MEF2C and RFX3

  2025cites this paper
• mTORC1-selective inhibitors rescue cellular phenotypes in TSC iPSC-derived neurons

  2025cites this paper
• Neuroplasticity-Based Approaches to Sensory Processing Alterations in Autism Spectrum Disorder

  2025cites this paper
• Characterizing Developmental and Behavioral Profiles in Developmental Synaptopathies to Inform Clinical Trial Endpoints.

  2025cites this paper
• Valproic acid triggers a sex-independent autism-like deficits, gut-brain axis, and neurodegenerative changes in the autism model of Wistar rats.

  2025cites this paper
• Disentangling the role of tau pathology in autism spectrum disorders.

  2025cites this paper
• Valproate-Induced Autism and Sexual Hormone Disturbances: A Literature Review and Hypotheses

  2025cites this paper
• Everolimus ameliorates cognitive deficits and synaptic dysfunction in mice with prefrontal cortical ADNP knockdown.

  2025cites this paper
• TSC tunes progenitor balance and upper-layer neuron generation in neocortex

  2025cites this paper
• Neurodevelopmental and Psychiatric Studies in Children and Adolescents With Neurofibromatosis Type I: A Comprehensive Scoping Review.

  2025cites this paper
• Neuronal hyperactivity becomes mTORC1 independent due to transcriptional changes in tuberous sclerosis complex disease models

  2025cites this paper
• Dysregulated GluA2-Y876 phosphorylation contributes to loss of synaptic upscaling in GRIP1 mutant mice with reduced sociability and increased repetitive behavior.

  2025cites this paper
• Insights into the structure and function of the hippocampus: implications for the pathophysiology and treatment of autism spectrum disorder

  2024cites this paper
• Reducing Filamin A Restores Cortical Synaptic Connectivity and Early Social Communication Following Cellular Mosaicism in Autism Spectrum Disorder Pathways

  2024cites this paper
• Therapeutic potential of CBD in Autism Spectrum Disorder.

  2024cites this paper
• Biomimetic nanoparticles with enhanced rapamycin delivery for autism spectrum disorder treatment via autophagy activation and oxidative stress modulation

  2024cites this paper
• Enhanced hippocampal LTP but normal NMDA receptor and AMPA receptor function in a rat model of CDKL5 deficiency disorder

  2024cites this paper
• A spectrum of AKT3 activating mutations cause focal malformations of cortical development (FMCDs) in cortical organoids.

  2024cites this paper
• Synergistic hyperactivation of both mTORC1 and mTORC2 underlies the neural abnormalities of PTEN-deficient human neurons and cortical organoids.

  2024cites this paper
• Boolean Modeling of Biological Network Applied to Protein–Protein Interaction Network of Autism Patients

  2024cites this paper
• Establishment of animal models and behavioral studies for autism spectrum disorders

  2024cites this paper
• Preliminary findings on the effect of vitamin B6 on zebrafish social behavior

  2024cites this paper
• Inhibition of p70 Ribosomal S6 Kinase (S6K1) Reduces Cortical Blood Flow in a Rat Model of Autism-Tuberous Sclerosis

  2024cites this paper
• Cerebellar phenotypes in germline PTEN mutation carriers

  2024cites this paper
• Diet-induced hyperhomocysteinemia causes sex-dependent deficiencies in offspring musculature and brain function

  2024cites this paper
• Inhibition of purinergic P2 receptors prevents synaptic and behavioral alterations in a rodent model of autism spectrum disorders.

  2024cites this paper
• Metabolic dynamics in astrocytes and microglia during post-natal development and their implications for autism spectrum disorders

  2024cites this paper
• Dysregulated acetylcholine-mediated dopamine neurotransmission in the eIF4E Tg mouse model of autism spectrum disorders

  2024cites this paper
• Signaling in autism: Relevance to nutrients and sex.

  2024cites this paper
• Metformin efficacy and safety as an adjunctive treatment for irritability in children with autism spectrum disorder: A randomized, double-blind, placebo-controlled trial

  2024cites this paper
• Whole‐genome sequencing analysis of Japanese autism spectrum disorder trios

  2024cites this paper
• Construction destruction: Contribution of dyregulated proteostasis to neurodevelopmental disorders.

  2024cites this paper
• mTORC1, the maestro of cell metabolism and growth

  2024cites this paper
• Baicalein Ameliorates Insulin Resistance of HFD/STZ Mice Through Activating PI3K/AKT Signal Pathway of Liver and Skeletal Muscle in a GLP-1R-Dependent Manner

  2024cites this paper
• Autism Spectrum Disorder Symptom Profiles in Fragile X Syndrome, Angelman Syndrome, Tuberous Sclerosis Complex and Neurofibromatosis Type 1

  2024cites this paper
• Targeting the circadian modulation: novel therapeutic approaches in the management of ASD

  2024cites this paper
• The multifaceted role of mitochondria in autism spectrum disorder

  2024cites this paper
• Copper-deficiency is associated with impairments in social behavior and oligodendrocyte development via mTOR signaling pathway

  2023cites this paper
• mTOR Signaling Disruption and Its Association with the Development of Autism Spectrum Disorder

  2023cites this paper
• Transition from Animal-Based to Human Induced Pluripotent Stem Cells (iPSCs)-Based Models of Neurodevelopmental Disorders: Opportunities and Challenges

  2023cites this paper
• Tsc2 mutation rather than Tsc1 mutation dominantly causes a social deficit in a mouse model of tuberous sclerosis complex

  2023cites this paper
• Molecular mechanisms of exercise intervention in alleviating the symptoms of autism spectrum disorder: Targeting the structural alterations of synapse

  2023influential citation
• Treatment-Resistant Epilepsy and Tuberous Sclerosis Complex: Treatment, Maintenance, and Future Directions

  2023influential citation
• Translatome analysis of Tuberous Sclerosis Complex-1 patient-derived neural progenitor cells reveal rapamycin-dependent and independent alterations

  2023cites this paper
• Microtubule Cytoskeletal Network Alterations in a Transgenic Model of Tuberous Sclerosis Complex: Relevance to Autism Spectrum Disorders

  2023cites this paper
• Abnormal mTOR Signaling Pathway Activity in Autism Spectrum Disorders: Prospects of Mechanism-Based Therapy

  2023cites this paper
• Increased degradation of FMRP contributes to neuronal hyperexcitability in tuberous sclerosis complex

  2023cites this paper
• Seizure reduction in TSC2‐mutant mouse model by an mTOR catalytic inhibitor

  2023influential citation
• Targeting mitophagy for depression amelioration: a novel therapeutic strategy

  2023cites this paper
• Translatome analysis of tuberous sclerosis complex 1 patient-derived neural progenitor cells reveals rapamycin-dependent and independent alterations

  2023cites this paper
• Altered motor learning and coordination in mouse models of autism spectrum disorder

  2023cites this paper
• Prospects and hot spots for mammalian target of rapamycin in the field of neuroscience from 2002 to 2021

  2022cites this paper
• The trilateral interactions between mammalian target of rapamycin (mTOR) signaling, the circadian clock, and psychiatric disorders: an emerging model

  2022cites this paper
• Haploinsufficiency of a Circadian Clock Gene Bmal1 (Arntl or Mop3) Causes Brain-Wide mTOR Hyperactivation and Autism-like Behavioral Phenotypes in Mice

  2022influential citation
• Exposure to the Amino Acids Histidine, Lysine, and Threonine Reduces mTOR Activity and Affects Neurodevelopment in a Human Cerebral Organoid Model

  2022cites this paper
• The non-essential TSC complex component TBC1D7 restricts tissue mTORC1 signaling and brain and neuron growth

  2022cites this paper
• Food Allergy-Induced Autism-Like Behavior is Associated with Gut Microbiota and Brain mTOR Signaling

  2022cites this paper
• Postnatal Cytomegalovirus Infection May Increase the Susceptibility of Tuberous Sclerosis Complex to Autism Spectrum Disorders

  2022cites this paper
• Local translation in primary afferents and its contribution to pain.

  2022cites this paper
• Mammalian target of rapamycin (mTOR) signaling pathway and traumatic brain injury: A novel insight into targeted therapy

  2022cites this paper
• Autism spectrum disorder-like behavior induced in rat offspring by perinatal exposure to di-(2-ethylhexyl) phthalate

  2022cites this paper
• Abnormal mTOR Activity in Pediatric Autoimmune Neuropsychiatric and MIA-Associated Autism Spectrum Disorders

  2022influential citation
• Challenges of Organoid Research.

  2022cites this paper
• Cannabidiol for the treatment of autism spectrum disorder: hope or hype?

  2022cites this paper
• Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications

  2022cites this paper
• mTOR-Dependent Spine Dynamics in Autism

  2022cites this paper
• mTORC2 Inhibition Improves Morphological Effects of PTEN Loss, But Does Not Correct Synaptic Dysfunction or Prevent Seizures

  2022cites this paper
• Primary Cilia Dysfunction in Neurodevelopmental Disorders beyond Ciliopathies

  2022cites this paper
• Microglial Pten safeguards postnatal integrity of the cortex and sociability

  2022cites this paper
• Therapeutic modulation of JAK-STAT, mTOR, and PPAR-γ signaling in neurological dysfunctions

  2022cites this paper
• Cortical wiring by synapse type-specific control of local protein synthesis

  2022cites this paper
• From Mouse to Man: N-Methyl-d-Aspartic Acid Receptor Activation as a Promising Pharmacotherapeutic Strategy for Autism Spectrum Disorders.

  2022cites this paper
• Repurposing SGLT2 Inhibitors for Neurological Disorders: A Focus on the Autism Spectrum Disorder

  2022cites this paper
• Brain region and gene dosage-differential transcriptomic changes in Shank2-mutant mice

  2022cites this paper
• Multidimensional analysis of behavior predicts genotype with high accuracy in a mouse model of Angelman syndrome

  2022cites this paper
• Dysregulation of mTOR signaling mediates common neurite and migration defects in both idiopathic and 16p11.2 deletion autism neural precursor cells

  2022cites this paper
• High fat diet-induced obesity leads to depressive and anxiety-like behaviors in mice via AMPK/mTOR-mediated autophagy.

  2021cites this paper
• Mechanisms Underlying the Cognitive and Behavioural Effects of Maternal Obesity

  2021cites this paper
• SHANK2 mutations impair apoptosis, proliferation and neurite outgrowth during early neuronal differentiation in SH-SY5Y cells

  2021cites this paper
• Cross-level analysis of molecular and neurobehavioral function in a prospective series of patients with germline heterozygous PTEN mutations with and without autism

  2021cites this paper
• Protein synthesis as a modifiable target for autism‐related dendritic spine pathophysiologies

  2021cites this paper
• Kinase Signaling in Dendritic Development and Disease

  2021cites this paper
• Deciphering the roles of glycogen synthase kinase 3 (GSK3) in the treatment of autism spectrum disorder and related syndromes

  2021cites this paper