Transgenic models of Alzheimer’s disease: Learning from animals

No abstract is available for this paper.

• Publication year

  2005

• Venue

  NeuroRx

• Publication date

  2005-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1602/neurorx.2.3.423PMID 16389306PMCID PMC1144486
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2022cites this paper
• Current Trends in the Animal Models for Screening of Nootropic Agents.

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  2021cites this paper
• Early lysosome defects precede neurodegeneration with amyloid-β and tau aggregation in NHE6-null rat brain.

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• Characterization of an APP/tau rat model of Alzheimer’s disease by positron emission tomography and immunofluorescent labeling

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• Regulation of common neurological disorders by gut microbial metabolites

  2021cites this paper
• PICALM rescues glutamatergic neurotransmission, behavioural function and survival in a Drosophila model of Aβ42 toxicity

  2020cites this paper
• Synaptic plasticity in Alzheimer’s disease and healthy aging

  2020cites this paper
• Boon and Bane of Transgenic Animal: A Brief Review

  2020cites this paper
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  2019cites this paper
• Experimental Pharmacology in Transgenic Rodent Models of Alzheimer’s Disease

  2019cites this paper
• Improving Mouse Models for Dementia. Are All the Effects in Tau Mouse Models Due to Overexpression?

  2019cites this paper
• Rederivation of transgenic rodent models expressing disease modified tau protein-a report

  2019cites this paper
• Development and validation of Alzheimer’s Disease Animal Model for the Purpose of Regenerative Medicine

  2019cites this paper
• Pathogenic Tau Protein Species: Promising Therapeutic Targets for Ocular Neurodegenerative Diseases

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• Effects of the drug combination memantine and melatonin on impaired memory and brain neuronal deficits in an amyloid‐predominant mouse model of Alzheimer's disease

  2019cites this paper
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  2018cites this paper
• Modulation of gut microbiota by dietary supplementation with tuna oil and algae oil alleviates the effects of D-galactose-induced ageing

  2018cites this paper
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• In Vivo MRI of Amyloid Plaques in a Cholesterol-Fed Rabbit Model of Alzheimer’s Disease

  2018cites this paper
• Amyloid-β oligomers synaptotoxicity: The emerging role of EphA4/c-Abl signaling in Alzheimer's disease.

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• Analysis of protein SUMOylation and its role in Alzheimer's disease using mouse models

  2017cites this paper
• Streptozotocin alters glucose transport, connexin expression and endoplasmic reticulum functions in neurons and astrocytes.

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