Single-Particle Reconstruction of Biological Molecules-Story in a Sample (Nobel Lecture).

J. Frank

Published 2018 in Angewandte Chemie

ABSTRACT

Pictures tell a thousand words: The development of single-particle cryo-electron microscopy set the stage for high-resolution structure determination of biological molecules. In his Nobel lecture, J. Frank describes the ground-breaking discoveries that have enabled the development of cryo-EM. The method has taken biochemistry into a new era.

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