Chronic heart rate reduction remodels ion channel transcripts in the mouse sinoatrial node but not in the ventricle.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Physiological Genomics

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1152/PHYSIOLGENOMICS.00161.2005PMID 16219869
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Functional genomics of cardiac ion channel genes.

  2005cited by this paper
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  2005influential reference
• Transmural expression of transient outward potassium current subunits in normal and failing canine and human hearts

  2004cited by this paper
• Rhythmic Ryanodine Receptor Ca2+ Releases During Diastolic Depolarization of Sinoatrial Pacemaker Cells Do Not Require Membrane Depolarization

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• Long-Term Amiodarone Administration Remodels Expression of Ion Channel Transcripts in the Mouse Heart

  2004influential reference
• Regulation of Ion Channel Expression

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• A Multiprotein Trafficking Complex Composed of SAP97, CASK, Veli, and Mint1 Is Associated with Inward Rectifier Kir2 Potassium Channels*

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• Molecular determinants of cardiac memory and their regulation.

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  2003cited by this paper
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  2003cited by this paper
• Chronic beta-adrenoceptor blockade and human atrial cell electrophysiology: evidence of pharmacological remodelling.

  2003cited by this paper
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  2003cited by this paper
• Asynchronous development of electrical remodeling and cardiac hypertrophy in the complete AV block dog.

  2003cited by this paper
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  2003cited by this paper
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  2003cited by this paper
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  2003cited by this paper
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  2002cited by this paper
• Repolarization abnormalities and their arrhythmogenic consequences in porcine tachycardia-induced cardiomyopathy.

  2002cited by this paper
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  2002cited by this paper
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  2002cited by this paper
• Electrical, contractile and structural remodeling during atrial fibrillation.

  2002cited by this paper
• Myocardial remodelling: pharmacological targets

  2002cited by this paper
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  2001cited by this paper
• Effects of heart rate reduction with ivabradine on exercise-induced myocardial ischemia and stunning.

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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
• Cellular electropharmacology of amiodarone.

  1997cited by this paper
• Mode of action of bradycardic agent, S 16257, on ionic currents of rabbit sinoatrial node cells

  1996cited by this paper
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  1996cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1994cited by this paper
• Pacemaker mechanisms in cardiac tissue.

  1993cited by this paper
• Class I and IV antiarrhythmic drugs and cytosolic calcium regulate mRNA encoding the sodium channel alpha subunit in rat cardiac muscle.

  1992cited by this paper
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  1988cited by this paper

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