Accelerating axonal growth promotes motor recovery after peripheral nerve injury in mice.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Journal of Clinical Investigation

• Publication date

  2011-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1172/JCI58675PMID 21965333PMCID PMC3223863
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Current concepts of the treatment of adult brachial plexus injuries.

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• Locally Synthesized Calcitonin Gene-Related Peptide Has a Critical Role in Peripheral Nerve Regeneration

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• Selective Contralateral C7 Transfer in Posttraumatic Brachial Plexus Injuries: A Report of 56 Cases

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• Role of heat shock protein 27 phosphorylation in migration of vascular smooth muscle cells

  2009cited by this paper
• Neuropathic pain: a maladaptive response of the nervous system to damage.

  2009cited by this paper
• Expression of ATF3 and axonal outgrowth are impaired after delayed nerve repair

  2008cited by this paper
• Cyclic strain-induced HSP27 phosphorylation modulates actin filaments in airway smooth muscle cells.

  2008influential reference
• Functional organization of the transcriptome in human brain

  2008cited by this paper
• Axonal growth therapeutics: regeneration or sprouting or plasticity?

  2008cited by this paper
• Interleukin‐10 reduces scarring and enhances regeneration at a site of sciatic nerve repair

  2007cited by this paper
• Extracellular stimuli specifically regulate localized levels of individual neuronal mRNAs

  2007cited by this paper
• Filopodia: The Fingers That Do the Walking

  2007cited by this paper
• Peripheral regeneration.

  2007cited by this paper
• ATF3 Increases the Intrinsic Growth State of DRG Neurons to Enhance Peripheral Nerve Regeneration

  2007influential reference
• Reinnervation of the tibialis anterior following sciatic nerve crush injury: a confocal microscopic study in transgenic mice.

  2007cited by this paper
• Complement Induction in Spinal Cord Microglia Results in Anaphylatoxin C5a-Mediated Pain Hypersensitivity

  2007cited by this paper
• Anthrax lethal toxin paralyzes actin‐based motility by blocking Hsp27 phosphorylation

  2007influential reference
• Schwann Cells Express Motor and Sensory Phenotypes That Regulate Axon Regeneration

  2006cited by this paper
• RhoA-kinase coordinates F-actin organization and myosin II activity during semaphorin-3A-induced axon retraction

  2006cited by this paper
• Conservation and evolution of gene coexpression networks in human and chimpanzee brains

  2006cited by this paper
• SRY-box containing gene 11 (Sox11) transcription factor is required for neuron survival and neurite growth.

  2006cited by this paper
• The expression of the chemorepellent Semaphorin 3A is selectively induced in terminal Schwann cells of a subset of neuromuscular synapses that display limited anatomical plasticity and enhanced vulnerability in motor neuron disease.

  2006cited by this paper
• Role of the peripheral benzodiazepine receptor in sensory neuron regeneration.

  2005cited by this paper
• Differential Transport and Local Translation of Cytoskeletal, Injury-Response, and Neurodegeneration Protein mRNAs in Axons

  2005cited by this paper
• Axon retraction and degeneration in development and disease.

  2005cited by this paper
• Optimized large-scale production of high titer lentivirus vector pseudotypes.

  2004cited by this paper
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  2004cited by this paper
• Control of actin dynamics by p38 MAP kinase – Hsp27 distribution in the lamellipodium of smooth muscle cells

  2004influential reference
• Myosin II activity is required for severing-induced axon retraction in vitro.

  2004cited by this paper
• Mutant small heat-shock protein 27 causes axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy

  2004cited by this paper
• Expression of the Activating Transcription Factor 3 Prevents c-Jun N-Terminal Kinase-Induced Neuronal Death by Promoting Heat Shock Protein 27 Expression and Akt Activation

  2003cited by this paper
• Amacrine-Signaled Loss of Intrinsic Axon Growth Ability by Retinal Ganglion Cells

  2002cited by this paper
• Raf and akt mediate distinct aspects of sensory axon growth.

  2002cited by this paper
• Replicate high-density rat genome oligonucleotide microarrays reveal hundreds of regulated genes in the dorsal root ganglion after peripheral nerve injury.

  2002influential reference
• Hsp27 upregulation and phosphorylation is required for injured sensory and motor neuron survival.

  2002cited by this paper
• A decline in glial cell-line-derived neurotrophic factor expression is associated with impaired regeneration after long-term Schwann cell denervation.

  2002cited by this paper
• Schwann Cells Express Active Agrin and Enhance Aggregation of Acetylcholine Receptors on Muscle Fibers

  2001cited by this paper
• Hemi-contralateral C7 transfer to median nerve in the treatment of root avulsion brachial plexus injury.

  2001cited by this paper
• A 25-year perspective of peripheral nerve surgery: evolving neuroscientific concepts and clinical significance.

  2000cited by this paper
• Differential patterns of ERK and STAT3 phosphorylation after sciatic nerve transection in the rat.

  2000cited by this paper
• Essential Role of Neural Wiskott-Aldrich Syndrome Protein in Neurite Extension in PC12 Cells and Rat Hippocampal Primary Culture Cells*

  2000cited by this paper
• Effects of short‐ and long‐term Schwann cell denervation on peripheral nerve regeneration, myelination, and size

  2000cited by this paper
• Regulated Actin Cytoskeleton Assembly at Filopodium Tips Controls Their Extension and Retraction

  1999cited by this paper
• HSP27 inhibits cytochrome c‐dependent activation of procaspase‐9

  1999cited by this paper
• In vivo observations of terminal Schwann cells at normal, denervated, and reinnervated mouse neuromuscular junctions.

  1999cited by this paper
• Peripheral nerve regeneration and neurotrophic factors

  1999cited by this paper
• Regeneration of dorsal column fibers into and beyond the lesion site following adult spinal cord injury.

  1999cited by this paper
• Heat Shock Protein 27: Developmental Regulation and Expression after Peripheral Nerve Injury

  1998influential reference
• Axonal injury and peripheral nerve grafting in the thalamus and cerebellum of the adult rat: upregulation of c‐jun and correlation with regenerative potential

  1998cited by this paper
• Overexpression of growth-associated proteins in the neurons of adult transgenic mice.

  1997cited by this paper
• A Transcription-Dependent Switch Controls Competence of Adult Neurons for Distinct Modes of Axon Growth

  1997cited by this paper
• J. Virol. Methods

  1996cited by this paper
• Enhancement of mouse sciatic nerve regeneration by the long chain fatty alcohol, N-Hexacosanol.

  1996cited by this paper
• Nerve sprouting in muscle is induced and guided by processes extended by Schwann cells.

  1995cited by this paper
• Contributing factors to poor functional recovery after delayed nerve repair: prolonged denervation

  1995cited by this paper
• Bax-Deficient Mice with Lymphoid Hyperplasia and Male Germ Cell Death

  1995cited by this paper
• Contributing factors to poor functional recovery after delayed nerve repair: prolonged axotomy

  1995cited by this paper
• Expression of c‐Jun as a Response to Dorsal Root and Peripheral Nerve Section in Damaged and Adjacent Intact Primary Sensory Neurons in the Rat

  1993cited by this paper
• Induction of Chinese hamster HSP27 gene expression in mouse cells confers resistance to heat shock. HSP27 stabilization of the microfilament organization.

  1993cited by this paper
• Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins

  1992influential reference
• Terminal Schwann cells elaborate extensive processes following denervation of the motor endplate

  1992cited by this paper
• Direct nerve crossing with the intercostal nerve to treat avulsion injuries of the brachial plexus.

  1989cited by this paper
• The induction of a regenerative propensity in sensory neurons following peripheral axonal injury

  1986cited by this paper
• Expression of several adhesive macromolecules (N-CAM, L1, J1, NILE, uvomorulin, laminin, fibronectin, and a heparan sulfate proteoglycan) in embryonic, adult, and denervated adult skeletal muscle

  1986cited by this paper
• Peripheral injury enhances central regeneration of primary sensory neurones

  1984cited by this paper
• Picrosirius staining plus polarization microscopy, a specific method for collagen detection in tissue sections

  1979cited by this paper
• Nerve conduction, tactile sensibility, and the electromyogram after suture or compression of peripheral nerve: a longitudinal study in man.

  1979cited by this paper

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