Mining the thiol proteome for sulfenic acid modifications reveals new targets for oxidation in cells.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  ACS Chemical Biology

• Publication date

  2009-08-13

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1021/cb900105qPMID 19645509
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Quantifying the global cellular thiol–disulfide status

  2009cited by this paper
• Direct and specific inactivation of protein tyrosine kinases in the Src and FGFR families by reversible cysteine oxidation

  2009cited by this paper
• Phospholipase D-mediated Activation of IQGAP1 through Rac1 Regulates Hyperoxia-induced p47phox Translocation and Reactive Oxygen Species Generation in Lung Endothelial Cells*

  2009cited by this paper
• Facile synthesis and biological evaluation of a cell-permeable probe to detect redox-regulated proteins.

  2009cited by this paper
• Shotgun redox proteomics identifies specifically modified cysteines in key metabolic enzymes under oxidative stress in Saccharomyces cerevisiae.

  2009cited by this paper
• Chemical dissection of an essential redox switch in yeast.

  2009cited by this paper
• Calreticulin, a multi-process calcium-buffering chaperone of the endoplasmic reticulum.

  2009cited by this paper
• Discovering mechanisms of signaling-mediated cysteine oxidation.

  2008cited by this paper
• Quantifying changes in the thiol redox proteome upon oxidative stress in vivo

  2008cited by this paper
• Expanding the functional diversity of proteins through cysteine oxidation.

  2008cited by this paper
• Redox compartmentalization in eukaryotic cells.

  2008cited by this paper
• Redox characteristics of the eukaryotic cytosol.

  2008cited by this paper
• Depletion of the ATPase NSF from Golgi membranes with hypo-S-nitrosylation of vasorelevant proteins in endothelial cells exposed to monocrotaline pyrrole.

  2008cited by this paper
• High-throughput small angle X-ray scattering from proteins in solution using a microfluidic front-end.

  2008cited by this paper
• Overexpression of Mitochondrial Hsp70/Hsp75 Protects Astrocytes against Ischemic Injury in vitro

  2008cited by this paper
• Redox regulation of Ran GTPase.

  2008cited by this paper
• A structural analysis of the catalytic mechanism of methionine sulfoxide reductase A from Neisseria meningitidis.

  2008cited by this paper
• Regulation of the Catalytic Activity and Structure of Human Thioredoxin 1 via Oxidation and S-Nitrosylation of Cysteine Residues*

  2008cited by this paper
• A chemical approach for detecting sulfenic acid-modified proteins in living cells.

  2008cited by this paper
• A clickable inhibitor reveals context-dependent autoactivation of p90 RSK.

  2007cited by this paper
• Location, Location, Location: Altered Transcription Factor Trafficking in Neurodegeneration

  2007cited by this paper
• ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis

  2007cited by this paper
• Recent Advances and Perspectives in the Chemistry of Sulfenic Acids

  2007cited by this paper
• Protein Sulfenation as a Redox Sensor

  2007cited by this paper
• Fluorescent probes for nitric oxide and hydrogen peroxide in cell signaling.

  2007cited by this paper
• High-Throughput Identification of Catalytic Redox-Active Cysteine Residues

  2007cited by this paper
• Fluorescent and affinity-based tools to detect cysteine sulfenic acid formation in proteins.

  2007cited by this paper
• The catalytic mechanism of peroxiredoxins.

  2007cited by this paper
• Glutathionylation of beta-actin via a cysteinyl sulfenic acid intermediary

  2007cited by this paper
• Nitric oxide regulation of protein trafficking in the cardiovascular system.

  2007cited by this paper
• Human spermatozoa contain multiple targets for protein S‐nitrosylation: An alternative mechanism of the modulation of sperm function by nitric oxide?

  2007cited by this paper
• The Requirement of Reversible Cysteine Sulfenic Acid Formation for T Cell Activation and Function1

  2007cited by this paper
• Dynamic rerouting of the carbohydrate flux is key to counteracting oxidative stress

  2007cited by this paper
• Ferric iron increases ROS formation, modulates cell growth and enhances genotoxic damage by 4-hydroxynonenal in human colon tumor cells.

  2006cited by this paper
• Domain Architecture of Protein-disulfide Isomerase Facilitates Its Dual Role as an Oxidase and an Isomerase in Ero1p-mediated Disulfide Formation*♦

  2006cited by this paper
• Reaction mechanism and kinetics of the traceless Staudinger ligation.

  2006cited by this paper
• A comparative study of bioorthogonal reactions with azides.

  2006cited by this paper
• The Utility of N,N-Biotinyl Glutathione Disulfide in the Study of Protein S-Glutathiolation*S

  2006cited by this paper
• TIP47 is a key effector for Rab9 localization

  2006cited by this paper
• SNOSID, a proteomic method for identification of cysteine S-nitrosylation sites in complex protein mixtures.

  2006cited by this paper
• Cytosolic and nuclear protein targets of thiol-reactive electrophiles.

  2006cited by this paper
• Identification of S-nitrosylation motifs by site-specific mapping of the S-nitrosocysteine proteome in human vascular smooth muscle cells.

  2006cited by this paper
• The Saccharomyces cerevisiae Proteome of Oxidized Protein Thiols

  2006cited by this paper
• Dual Role of Peroxiredoxin I in Macrophage-derived Foam Cells*

  2006cited by this paper
• Cell signaling. H2O2, a necessary evil for cell signaling.

  2006cited by this paper
• Subcellular Targeting and Differential S-Nitrosylation of Endothelial Nitric-oxide Synthase*

  2006cited by this paper
• Mechanism-based probe for the analysis of cathepsin cysteine proteases in living cells.

  2006cited by this paper
• Kinetic Analysis of the Ku-DNA Binding Activity Reveals a Redox-dependent Alteration in Protein Structure That Stimulates Dissociation of the Ku-DNA Complex*

  2006cited by this paper
• Nitric oxide signaling: no longer simply on or off.

  2006cited by this paper
• Specificity in reactive oxidant signaling: think globally, act locally

  2006cited by this paper
• Glutaredoxin: Role in Reversible Protein S-Glutathionylation and Regulation of Redox Signal Transduction and Protein Translocation

  2005cited by this paper
• Interactions among Yeast Protein-Disulfide Isomerase Proteins and Endoplasmic Reticulum Chaperone Proteins Influence Their Activities*

  2005cited by this paper
• Rck2 is required for reprogramming of ribosomes during oxidative stress.

  2005cited by this paper
• Synthesis of chemical probes to map sulfenic acid modifications on proteins.

  2005cited by this paper
• IQGAP1 Regulates Reactive Oxygen Species–Dependent Endothelial Cell Migration Through Interacting With Nox2

  2005cited by this paper
• Proteomic detection of hydrogen peroxide-sensitive thiol proteins in Jurkat cells.

  2005cited by this paper
• Thiol–Disulfide Balance: From the Concept of Oxidative Stress to that of Redox Regulation

  2005cited by this paper
• Redox redux: revisiting PTPs and the control of cell signaling.

  2005cited by this paper
• ATPase Activity of p97/Valosin-containing Protein Is Regulated by Oxidative Modification of the Evolutionally Conserved Cysteine 522 Residue in Walker A Motif*

  2005cited by this paper
• S-nitroso proteome of Mycobacterium tuberculosis: Enzymes of intermediary metabolism and antioxidant defense.

  2005cited by this paper
• Intracellular Reactive Oxygen Species Activate Src Tyrosine Kinase during Cell Adhesion and Anchorage-Dependent Cell Growth

  2005cited by this paper
• Mechanism of Redox-mediated Guanine Nucleotide Exchange on Redox-active Rho GTPases*

  2005cited by this paper
• Identification of S-nitrosylated proteins in endotoxin-stimulated RAW264.7 murine macrophages.

  2005cited by this paper
• DNA damage responses to oxidative stress.

  2004cited by this paper
• Protein Disulfide Bond Formation in the Cytoplasm during Oxidative Stress*

  2004influential reference
• Detection and Mapping of Widespread Intermolecular Protein Disulfide Formation during Cardiac Oxidative Stress Using Proteomics with Diagonal Electrophoresis*

  2004cited by this paper
• In situ detection and visualization of S-nitrosylated proteins following chemical derivatization: identification of Ran GTPase as a target for S-nitrosylation.

  2004cited by this paper
• Protein Thiol Modifications Visualized In Vivo

  2004cited by this paper
• Mechanism of p21Ras S-nitrosylation and kinetics of nitric oxide-mediated guanine nucleotide exchange.

  2004cited by this paper
• Redox signaling: thiol chemistry defines which reactive oxygen and nitrogen species can act as second messengers.

  2004cited by this paper
• Roles for cysteine residues in the regulatory CXXC motif of human mitochondrial branched chain aminotransferase enzyme.

  2004cited by this paper
• Widespread sulfenic acid formation in tissues in response to hydrogen peroxide

  2004cited by this paper
• ERp57 Is a Multifunctional Thiol-Disulfide Oxidoreductase*

  2004cited by this paper
• Identification of carbonylated proteins by MALDI-TOF mass spectroscopy reveals susceptibility of ER.

  2004cited by this paper
• S-Glutathiolation of Ras Mediates Redox-sensitive Signaling by Angiotensin II in Vascular Smooth Muscle Cells*[boxs]

  2004cited by this paper
• Oxidation state of the active-site cysteine in protein tyrosine phosphatase 1B

  2003cited by this paper
• Not Every Disulfide Lasts Forever: Disulfide Bond Formation as a Redox Switch

  2003cited by this paper
• Structure of rabbit-muscle glyceraldehyde-3-phosphate dehydrogenase.

  2003cited by this paper
• Metal and redox modulation of cysteine protein function.

  2003cited by this paper
• Sulfenic acid formation in human serum albumin by hydrogen peroxide and peroxynitrite.

  2003cited by this paper
• Reversible Oxidation of the Active Site Cysteine of Peroxiredoxins to Cysteine Sulfinic Acid

  2003cited by this paper
• Characterization of the yeast peroxiredoxin Ahp1 in its reduced active and overoxidized inactive forms using NMR.

  2003cited by this paper
• Oxidative Stress Induces Nuclear Loss of DNA Repair Proteins Ku70 and Ku80 and Apoptosis in Pancreatic Acinar AR42J Cells*

  2003cited by this paper
• Molecular chaperones, stress proteins and redox homeostasis

  2003cited by this paper
• Calnexin, Calreticulin, and ERp57 Cooperate in Disulfide Bond Formation in Human CD1d Heavy Chain*

  2002cited by this paper
• Ezrin turnover and cell shape changes catalyzed by proteasome in oxidatively stressed cells

  2002cited by this paper
• Identification by redox proteomics of glutathionylated proteins in oxidatively stressed human T lymphocytes

  2002influential reference
• Differential Acquisition of Antigenic Peptides by Hsp70 and Hsc70 under Oxidative Conditions*

  2002cited by this paper
• Detection, Quantitation, Purification, and Identification of Cardiac Proteins S-Thiolated during Ischemia and Reperfusion*

  2002cited by this paper
• Proteomics Analysis of Cellular Response to Oxidative Stress

  2002cited by this paper
• Human placental calreticulin characterization of domain structure and post-translational modifications.

  2001cited by this paper
• Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair

  2001cited by this paper
• Changes in thiol content and expression of glutathione redox system genes in the hippocampus and cerebellum in Alzheimer's disease.

  2001cited by this paper
• Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily.

  2001cited by this paper
• The Structure of calnexin, an ER chaperone involved in quality control of protein folding.

  2001cited by this paper
• Rab GTPases: specifying and deciphering organelle identity and function.

  2001cited by this paper
• Structural, redox, and mechanistic parameters for cysteine-sulfenic acid function in catalysis and regulation.

  2001cited by this paper
• The Rab GTPase family

  2001cited by this paper
• Redox‐dependent signal transduction

  2000cited by this paper
• Oxidative stress promotes specific protein damage in Saccharomyces cerevisiae.

  2000cited by this paper

• Defining and refining the cysteine redoxome through sulfur chemical biology.

  2026cites this paper
• “IEDDA”-activated fluorescent sensing for protein cysteine redox modifications profiling

  2026cites this paper
• Pervanadate: So much more than a protein tyrosine phosphatase inhibitor.

  2026cites this paper
• Chemoselective Tagging of Protein Methacrylation.

  2025cites this paper
• BioSemAF-BiLSTM: a protein sequence feature extraction framework based on semantic and evolutionary information

  2025cites this paper
• A cascade-regulated nanoadjuvant for antigen oxidation and capture to potentiate in-situ cancer vaccination.

  2025cites this paper
• Cysteine-based redox sensors in the cardiovascular system - from identification to physiology and drug discovery.

  2025cites this paper
• Determination of total reactive sulfide species in biological matrix after administration of hydrogen sulfide donors or cellular oxidative stress

  2025cites this paper
• A metal ion mediated functional dichotomy encodes plasticity during translation quality control

  2025cites this paper
• Diastereoselective synthesis of cyclopropyl sulfoxides via hydrosulfenation

  2025cites this paper
• A redox-dependent switch governing sensory axon degeneration and regeneration

  2025cites this paper
• Redox regulation of proteostasis

  2024cites this paper
• ROS-mediated regulation of β2AR function: Does oxidation play a meaningful role towards β2-agonist tachyphylaxis in airway obstructive diseases?

  2024cites this paper
• S-Sulfenylation Driven Antigen Capture Boosted by Radiation for Enhanced Cancer Immunotherapy.

  2024cites this paper
• Oxidative stress-mediated protein sulfenylation in human diseases: Past, present, and future

  2024cites this paper
• A global view of the human post-translational modification landscape

  2023cites this paper
• Highly Electrophilic Intermediates in the Bypass Mechanism of Glutathione Peroxidase: Synthesis, Reactivity, and Structures of Selenocysteine-Derived Cyclic Selenenyl Amides.

  2023cites this paper
• Detection of Cysteine Sulfenic Acid on E. coli Proteins with a Biotin-Benzoboroxole Probe.

  2023cites this paper
• Using DCP-Rho1 as a fluorescent probe to visualize sulfenic acid-containing proteins in living plant cells.

  2023cites this paper
• Agonists and hydrogen peroxide mediate hyperoxidation of β2-adrenergic receptor in airway epithelial cells: Implications for tachyphylaxis to β2-agonists in constrictive airway disorders

  2023cites this paper
• Gasotransmitter-Mediated Cysteinome Oxidative Posttranslational Modifications: Formation, Biological Effects, and Detection

  2023cites this paper
• Quantitative Chemoproteomic Methods for Reactive Cysteinome Profiling

  2023cites this paper
• Galectin-3 S-glutathionylation regulates its effect on adipocyte insulin signaling.

  2022cites this paper
• Experimental Approaches for Investigating Disulfide-Based Redox Relays in Cells.

  2022cites this paper
• Coordinated NADPH oxidase/hydrogen peroxide functions regulate cutaneous sensory axon de- and regeneration

  2022cites this paper
• Prominent role of cysteine residues C49 and C343 in regulating Plasmodiumfalciparum pyruvate kinase activity.

  2022cites this paper
• Redox regulation of RAD51 Cys319 and homologous recombination by peroxiredoxin 1

  2022cites this paper
• Redox regulation of DUBs and its therapeutic implications in cancer

  2021cites this paper
• Endogenous SO2-dependent Smad3 redox modification controls vascular remodeling

  2021cites this paper
• Cysteine post-translational modifications: ten years from chemical proteomics to bioinformatics

  2021cites this paper
• Sod1 integrates oxygen availability to redox regulate NADPH production and the thiol redoxome

  2021cites this paper
• Synthetic approaches for cyclohexane-1,3-diones: A versatile precursor for bioactive molecules

  2021cites this paper
• Nitrosative stress inhibits aminoacylation and editing activities of mitochondrial threonyl-tRNA synthetase by S-nitrosation

  2020cites this paper
• Cysteine redox state regulates human β2-adrenergic receptor binding and function

  2020cites this paper
• Regulation of the Proteolytic Activity of Cysteine Cathepsins by Oxidants

  2020cites this paper
• SulSite-GTB: identification of protein S-sulfenylation sites by fusing multiple feature information and gradient tree boosting

  2020cites this paper
• Genomic innovation of ATD alleviates mistranslation associated with multicellularity in Animalia

  2020cites this paper
• Wittig reagents for chemoselective sulfenic acid ligation enables global site stoichiometry analysis and redox-controlled mitochondrial targeting

  2020cites this paper
• Introduction to approaches and tools for the evaluation of protein cysteine oxidation.

  2020cites this paper
• Chemical Tagging of Protein Lipoylation.

  2020cites this paper
• Redox Proteomes in human physiology and disease mechanisms.

  2020cites this paper
• Cysteine modifications (oxPTM) and protein sulphenylation-mediated sulfenome expression in plants: evolutionary conserved signaling networks?

  2020cites this paper
• Synthesis of Peptide Cysteine Dimedone Using Fmoc‐Cys(Dmd)‐OH: Glutathione Cysteine Dimedone as a Probe in Investigating the Sulfenic Acid Mediated Oxidation of Glutathione

  2020cites this paper
• A critical evaluation of probes for cysteine sulfenic acid.

  2020cites this paper
• Reduction of sulfenic acids by ascorbate in proteins, connecting thiol-dependent to alternative redox pathways.

  2020cites this paper
• Click Chemistry in Proteomic Investigations.

  2020cites this paper
• The Staudinger Ligation.

  2020cites this paper
• Profiling of post-translational modifications by chemical and computational proteomics.

  2020cites this paper
• Identification of Sulfenylated Cysteines in Arabidopsis thaliana Proteins Using a Disulfide-Linked Peptide Reporter

  2020cites this paper
• Site-Specific Proteomic Mapping of Modified Cysteine Residues.

  2019cites this paper
• Dual-Reactivity trans-Cyclooctenol Probes for Sulfenylation in Live Cells Enable Temporal Control via Bioorthogonal Quenching.

  2019cites this paper
• Rapid and Multigram Synthesis of Vinylogous Esters under Continuous Flow: An Access to Transetherification and Reverse Reaction of Vinylogous Esters

  2019cites this paper
• Characterization of Polysulfides, Polysulfanes, and Other Unique Species in the Reaction between GSNO and H2S

  2019cites this paper
• Potencia y Energía

  2019cites this paper
• Proteome-Wide Survey Reveals Norbornene Is Complementary to Dimedone and Related Nucleophilic Probes for Cysteine Sulfenic Acid

  2019cites this paper
• Activity-Based Sensing for Site-Specific Proteomic Analysis of Cysteine Oxidation.

  2019cites this paper
• Proteome‐Wide Survey of Cysteine Oxidation by Using a Norbornene Probe

  2019cites this paper
• SIMLIN: a bioinformatics tool for prediction of S-sulphenylation in the human proteome based on multi-stage ensemble-learning models

  2019cites this paper
• Mining for protein S-sulfenylation in Arabidopsis uncovers redox-sensitive sites

  2019cites this paper
• Redox Homeostasis in Photosynthetic Organisms: Novel and Established Thiol-Based Molecular Mechanisms

  2019cites this paper
• Hydrogen Sulfide Signaling and Enzymology

  2019cites this paper
• Challenges and Opportunities for Small-Molecule Fluorescent Probes in Redox Biology Applications

  2018cites this paper
• Protein Promiscuity in H2O2 Signaling

  2018cites this paper
• Tailoring protein nanomechanics through chemical reactivity with single bond resolution

  2018cites this paper
• Redox Signaling by Reactive Electrophiles and Oxidants.

  2018cites this paper
• Norbornene Probes for the Detection of Cysteine Sulfenic Acid in Cells.

  2018cites this paper
• Pathways crossing mammalian and plant sulfenomic landscapes.

  2018cites this paper
• Chemical methods for mapping cysteine oxidation.

  2018cites this paper
• Regulation of oxidoreductase enzymes during inflammation

  2018cites this paper
• Mitochondrial protein sulfenation during aging in the rat brain

  2018cites this paper
• Measurement of the total angiotensinogen and its reduced and oxidised forms in human plasma using targeted LC-MS/MS

  2018cites this paper
• MinOmics, an Integrative and Immersive Tool for Multi-Omics Analysis

  2018cites this paper
• Ethanol Induced Disordering of Pancreatic Acinar Cell Endoplasmic Reticulum: An ER Stress/Defective Unfolded Protein Response Model

  2018cites this paper
• How Are Proteins Reduced in the Endoplasmic Reticulum?

  2018cites this paper
• The Small Matter of a Red Ox, a Particularly Sensitive Pink Cat, and the Quest for the Yellow Stone of Wisdom

  2018cites this paper
• The Deep Thioredoxome in Chlamydomonas reinhardtii: New Insights into Redox Regulation.

  2017cites this paper
• The Role of Peroxiredoxins in the Transduction of H2O2 Signals

  2017cites this paper
• Therapeutic potential of NADPH oxidase 1/4 inhibitors

  2017cites this paper
• Highly selective detection of disulfenylated proteins through a dimedone-based fluorescent probe and application in cells

  2017cites this paper
• Diverse Redoxome Reactivity Profiles of Carbon Nucleophiles.

  2017cites this paper
• Cysteine perthiosulfenic acid (Cys-SSOH): A novel intermediate in thiol-based redox signaling?☆

  2017cites this paper
• Chemical proteomics reveals ADP-ribosylation of small GTPases during oxidative stress.

  2017cites this paper
• Influence of mono-lithium based initiators with different steric volumes on 1,4 unit content of hydroxyl terminated polybutadiene using anionic polymerization

  2017cites this paper
• Redox modulation of thimet oligopeptidase activity by hydrogen peroxide

  2017cites this paper
• The Reactive Sulfur Species Concept: 15 Years On

  2017cites this paper
• Biological and Chemical Adaptation to Endogenous Hydrogen Peroxide Production in Streptococcus pneumoniae D39

  2017cites this paper
• IKKα regulates human keratinocyte migration through surveillance of the redox environment

  2017cites this paper
• Mitochondria in Skeletal Muscle Health, Aging and Diseases

  2017cites this paper
• Chemical Probes for Redox Signaling and Oxidative Stress

  2017cites this paper
• Proteomic Characterization of Reversible Thiol Oxidations in Proteomes and Proteins

  2017cites this paper
• Metal-Assisted Oxo Atom Addition to an Fe(III) Thiolate.

  2017cites this paper
• Development Of Chemical Tools To Investigate Protein S-Glutathionylation In Response To Metabolic Alteration

  2017cites this paper
• Assessment of Cysteine Reactivity of Human Hemoglobin at Its Residue Level: A Mass Spectrometry-Based Approach

  2017cites this paper
• Copper-zinc superoxide dismutase is activated through a sulfenic acid intermediate at a copper ion entry site

  2017influential citation
• Norbornene probes for the study of cysteine oxidation

  2017cites this paper
• Inorganic Reactive Sulfur-Nitrogen Species: Intricate Release Mechanisms or Cacophony in Yellow, Blue and Red?

  2017cites this paper
• Protein cysteine oxidation in redox signaling: Caveats on sulfenic acid detection and quantification.

  2017cites this paper
• Principles for integrating reactive species into in vivo biological processes: Examples from exercise physiology.

  2016cites this paper
• An Investigation of Polymer Encapsualted Gold Nanoparticles for Use in Analytical Methods for Proteomic Based Research

  2016cites this paper
• Quantitative Protein Sulfenic Acid Analysis Identifies Platelet Releasate-Induced Activation of Integrin β2 on Monocytes via NADPH Oxidase.

  2016cites this paper