Paraneoplastic cerebellar degeneration: Yo antibody alters mitochondrial calcium buffering capacity

Neurodegeneration is associated with dysfunction of calcium buffering capacity and thereby sustained cellular and mitochondrial calcium overload. Paraneoplastic cerebellar degeneration (PCD), characterized by progressive Purkinje neurone degeneration following paraneoplastic Yo antibody internalization and binding to cerebellar degeneration‐related protein CDR2 and CDR2L, has been linked to intracellular calcium homeostasis imbalance due to calbindin D28k malfunction. Therefore, we hypothesized that Yo antibody internalization affects not only calbindin calcium binding capacity, but also calcium‐sensitive mitochondrial‐associated signalling, causing mitochondrial calcium overload and thereby Purkinje neurone death.

• Publication year

  2018

• Venue

  Neuropathology and Applied Neurobiology

• Publication date

  2018-05-24

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1111/nan.12492PMID 29679372PMCID 7379599
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Cannabinoid Receptor

  2019cited by this paper
• Paraneoplastic cerebellar degeneration: Yo antibody alters mitochondrial calcium buffering capacity

  2018cited by this paper
• Role of mitochondrial ROS in the brain: from physiology to neurodegeneration

  2018cited by this paper
• Delta-9-Tetrahydrocannabinol/Cannabidiol Oromucosal Spray (Sativex®): A Review in Multiple Sclerosis-Related Spasticity

  2017cited by this paper
• Cerebellar degeneration-related proteins 2 and 2-like are present in ovarian cancer in patients with and without Yo antibodies

  2017cited by this paper
• Mitochondrial drug targets in neurodegenerative diseases.

  2016cited by this paper
• Proteolytic degradation and potential role of onconeural protein cdr2 in neurodegeneration

  2016cited by this paper
• Molecular Targets of Cannabidiol in Neurological Disorders

  2015cited by this paper
• Evidence to support mitochondrial neuroprotection, in severe traumatic brain injury

  2015cited by this paper
• ‘Medusa head ataxia’: the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 1: Anti-mGluR1, anti-Homer-3, anti-Sj/ITPR1 and anti-CARP VIII

  2015cited by this paper
• ‘Medusa head ataxia’: the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 3: Anti-Yo/CDR2, anti-Nb/AP3B2, PCA-2, anti-Tr/DNER, other antibodies, diagnostic pitfalls, summary and outlook

  2015cited by this paper
• Calcium and ROS: A mutual interplay

  2015cited by this paper
• Neuronal calcium signaling: function and dysfunction

  2014cited by this paper
• Paraneoplastic CDR2 and CDR2L antibodies affect Purkinje cell calcium homeostasis

  2014cited by this paper
• Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane.

  2014cited by this paper
• KB-R7943, a plasma membrane Na(+)/Ca(2+) exchanger inhibitor, blocks opening of the mitochondrial permeability transition pore.

  2014cited by this paper
• CGP37157, an inhibitor of the mitochondrial Na+/Ca2+ exchanger, protects neurons from excitotoxicity by blocking voltage-gated Ca2+ channels

  2014cited by this paper
• KB-R 7943 , a plasma membrane Na + / Ca 2 + exchanger inhibitor , blocks opening of the mitochondrial permeability transition pore

  2014cited by this paper
• Seroprevalence of autoantibodies against brain antigens in health and disease

  2014cited by this paper
• Treatment of Paraneoplastic Cerebellar Degeneration

  2013cited by this paper
• Direct modulation of the outer mitochondrial membrane channel, voltage-dependent anion channel 1 (VDAC1) by cannabidiol: a novel mechanism for cannabinoid-induced cell death

  2013cited by this paper
• CDR2L Antibodies: A New Player in Paraneoplastic Cerebellar Degeneration

  2013cited by this paper
• Cannabidiol as potential anticancer drug

  2013cited by this paper
• Cyclosporine A inhibits breast cancer cell growth by downregulating the expression of pyruvate kinase subtype M2.

  2012cited by this paper
• Cellular immune suppression in paraneoplastic neurologic syndromes targeting intracellular antigens.

  2012cited by this paper
• KB‐R7943, an inhibitor of the reverse Na+/Ca2+ exchanger, blocks N‐methyl‐D‐aspartate receptor and inhibits mitochondrial complex I

  2011cited by this paper
• CDR2 antigen and Yo antibodies

  2010cited by this paper
• Cell death and proliferation in acute slices and organotypic cultures of mammalian CNS.

  2009cited by this paper
• Morphological and immunohistochemical characterization of paraneoplastic cerebellar degeneration associated with Yo antibodies

  2009cited by this paper
• Losing your nerves? Maybe it's the antibodies

  2009cited by this paper
• Cannabidiol Targets Mitochondria to Regulate Intracellular Ca2+ Levels

  2009cited by this paper
• Calbindin positive Purkinje cells in the pathology of human cerebellum occurring at the time of its development.

  2009cited by this paper
• Functional analysis of CD8+ T cell responses to the onconeural self protein cdr2 in patients with paraneoplastic cerebellar degeneration.

  2008cited by this paper
• Distribution of calcium-binding proteins in the cerebellum

  2008cited by this paper
• In Situ Activation of Antigen-Specific CD8+ T Cells in the Presence of Antigen in Organotypic Brain Slices1

  2008cited by this paper
• Immunohistochemical localization of cannabinoid CB1 receptor in inhibitory interneurons in the cerebellum

  2008cited by this paper
• Mitochondria and Ca2+ signaling: old guests, new functions

  2007cited by this paper
• Paraneoplastic neurological syndromes and onconeural antibodies: clinical and immunological aspects.

  2007cited by this paper
• Changes in calcium dynamics following the reversal of the sodium-calcium exchanger have a key role in AMPA receptor-mediated neurodegeneration via calpain activation in hippocampal neurons

  2007cited by this paper
• Mitochondrial and Plasma Membrane Potential of Cultured Cerebellar Neurons during Glutamate-Induced Necrosis, Apoptosis, and Tolerance

  2007cited by this paper
• Brain slices as models for neurodegenerative disease and screening platforms to identify novel therapeutics.

  2007cited by this paper
• A T cell receptor associated with naturally occurring human tumor immunity

  2007cited by this paper
• Overexpression of calbindin‐D28K in hippocampal progenitor cells increases neuronal differentiation and neurite outgrowth

  2006cited by this paper
• Endocannabinoids: A Critical Regulator of Activity in the Developing Brain

  2006cited by this paper
• TNFα potentiates glutamate neurotoxicity by inhibiting glutamate uptake in organotypic brain slice cultures: neuroprotection by NFκB inhibition

  2005cited by this paper
• TNF alpha potentiates glutamate neurotoxicity by inhibiting glutamate uptake in organotypic brain slice cultures: neuroprotection by NF kappa B inhibition.

  2005cited by this paper
• Paraneoplastic antibodies detected by isoelectric focusing of cerebrospinal fluid and serum.

  2004cited by this paper
• An interferon-γ ELISPOT and immunohistochemical investigation of cytotoxic T lymphocyte-mediated tumour immunity in patients with paraneoplastic cerebellar degeneration and anti-Yo antibodies

  2004cited by this paper
• Neuroimmunology of the paraneoplastic neurological degenerations.

  2004cited by this paper
• Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits

  2003cited by this paper
• Mifepristone (RU486) protects Purkinje cells from cell death in organotypic slice cultures of postnatal rat and mouse cerebellum

  2003cited by this paper
• Calbindin in Cerebellar Purkinje Cells Is a Critical Determinant of the Precision of Motor Coordination

  2003cited by this paper
• ‘New’ functions for ‘old’ proteins: The role of the calcium-binding proteins calbindin D-28k, calretinin and parvalbumin, in cerebellar physiology. Studies with knockout mice

  2002cited by this paper
• A method for characterising cell death in vitro by combining propidium iodide staining with immunohistochemistry.

  2002cited by this paper
• Cannabinoid receptor modulation of synapses received by cerebellar Purkinje cells.

  2000cited by this paper
• Cdr2, a target antigen of naturally occuring human tumor immunity, is widely expressed in gynecological tumors.

  2000cited by this paper
• Markers for neuronal degeneration in organotypic slice cultures.

  1999cited by this paper
• The cytoplasmic Purkinje onconeural antigen cdr2 down-regulates c-Myc function: implications for neuronal and tumor cell survival.

  1999cited by this paper
• A Protein Kinase, PKN, Accumulates in Alzheimer Neurofibrillary Tangles and Associated Endoplasmic Reticulum-Derived Vesicles and Phosphorylates Tau Protein

  1998cited by this paper
• PKN interacts with a paraneoplastic cerebellar degeneration-associated antigen, which is a potential transcription factor.

  1998cited by this paper
• Tumor-specific killer cells in paraneoplastic cerebellar degeneration

  1998cited by this paper
• Complex pharmacology of natural cannabinoids: evidence for partial agonist activity of delta9-tetrahydrocannabinol and antagonist activity of cannabidiol on rat brain cannabinoid receptors.

  1998cited by this paper
• A Post-Transcriptional Regulatory Mechanism Restricts Expression of the Paraneoplastic Cerebellar Degeneration Antigen cdr2 to Immune Privileged Tissues

  1997cited by this paper
• Isolation of a complementary DNA clone encoding an autoantigen recognized by an anti-neuronal cell antibody from a patient with paraneoplastic cerebellar degeneration.

  1991cited by this paper
• Isolation of a complementary DNA clone encoding an autoantigen recognized by an anti‐neuronal cell antibody from a patient with paraneoplastic cerebellar degeneration

  1990cited by this paper
• Autoimmune paraneoplastic cerebellar degeneration

  1988cited by this paper
• Annals of the New York Academy of Sciences Calcium Signaling as a Mediator of Cell Energy Demand and a Trigger to Cell Death

  year unknowncited by this paper

• Biomimetic Nanoplatform‐Mediated Protective Autophagy Blockage Enhancing Sonodynamic and Ca2+‐Overload Combined Therapy for Colon Cancer

  2025cites this paper
• CDR2 is a dynein adaptor recruited by kinectin to regulate ER sheet organization.

  2025cites this paper
• Altered exosomal miRNA profiles in patients with paraneoplastic cerebellar degeneration

  2024cites this paper
• Potential Protective Effects of Pungent Flavor Components in Neurodegenerative Diseases

  2024cites this paper
• Paraneoplastic neurologic syndrome associated with gynecologic and breast malignancies.

  2024cites this paper
• Paraneoplastic cerebellar and brainstem disorders.

  2024cites this paper
• [Blood-brain barrier breakdown and autoimmune cerebellar ataxia].

  2024cites this paper
• CDR2 is a dynein adaptor recruited by kinectin to regulate ER sheet organization

  2024cites this paper
• Roles of CDR2 and CDR2L in Anti-Yo Paraneoplastic Cerebellar Degeneration: A Literature Review

  2024cites this paper
• A Pilot Study to Develop Paraneoplastic Cerebellar Degeneration Mouse Model

  2023cites this paper
• Potential of dietary hemp and cannabinoids to modulate immune response to enhance health and performance in animals: opportunities and challenges

  2023cites this paper
• Development and Optimization of a Multilayer Rat Purkinje Neuron Culture

  2023cites this paper
• The Discovery of Anti-Yo (Anti-PCA1) Antibody in Patients with Paraneoplastic Cerebellar Degeneration: Opening a Window into Autoimmune Neurological Disease

  2022cites this paper
• Novelties in Autoimmune and Paraneoplastic Cerebellar Ataxias: Twenty Years of Progresses

  2022cites this paper
• Paraneoplastic and Other Autoimmune Encephalitides: Antineuronal Antibodies, T Lymphocytes, and Questions of Pathogenesis

  2022cites this paper
• A Breakdown of Immune Tolerance in the Cerebellum

  2022cites this paper
• Neuropatía sensorial como síndrome paraneoplásico del cáncer de vejiga: caso raro con revisión de literatura

  2022cites this paper
• Cannabidiol modulation of oxidative stress and signalling

  2021cites this paper
• Anti-Yo antibody-positive paraneoplastic cerebellar degeneration in a patient with possible cholangiocarcinoma: A case report and review of the literature

  2021cites this paper
• A Rare Coexistence of Paraneoplastic Cerebellar Degeneration: Papillary Thyroid Carcinoma

  2021cites this paper
• Reply to “CDR2 and CDR2L Yo Antigens in Paraneoplastic Cerebellar Degeneration”

  2020cites this paper
• Paraneoplastic Diseases of the Central Nervous System

  2020cites this paper
• CDR2 and CDR2L Yo Antigens in Paraneoplastic Cerebellar Degeneration

  2020cites this paper
• Subcellular Localization of Cerebellar Degeneration-Related Protein 1

  2020cites this paper
• Immunological Bases of Paraneoplastic Cerebellar Degeneration and Therapeutic Implications

  2020cites this paper
• Stroke-Like Presentation of Paraneoplastic Cerebellar Degeneration: a Single-Center Experience and Review of the Literature

  2019cites this paper
• Paraneoplastic cerebellar degeneration: Yo antibody alters mitochondrial calcium buffering capacity

  2018cites this paper