Loss of FOXA1/2 is essential for the epithelial-to-mesenchymal transition in pancreatic cancer.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Cancer Research

• Publication date

  2010-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1158/0008-5472.CAN-09-2979PMID 20160041PMCID PMC2831111
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Role of Ras Signaling in the Induction of Snail by Transforming Growth Factor-β*

  2009cited by this paper
• Absence of E-Cadherin Expression Distinguishes Noncohesive from Cohesive Pancreatic Cancer

  2008cited by this paper
• Cancer metastasis facilitated by developmental pathways: Sonic hedgehog, Notch, and bone morphogenic proteins

  2007cited by this paper
• Forkhead box A1 expression in breast cancer is associated with luminal subtype and good prognosis

  2007cited by this paper
• Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers

  2007cited by this paper
• Molecular genetics of Rett syndrome: when DNA methylation goes unrecognized

  2006cited by this paper
• E-cadherin transcriptional downregulation by promoter methylation but not mutation is related to epithelial-to-mesenchymal transition in breast cancer cell lines

  2006cited by this paper
• The Foxa family of transcription factors in development and metabolism

  2006influential reference
• DNA methylation of multiple tumor-related genes in association with overexpression of DNA methyltransferase 1 (DNMT1) during multistage carcinogenesis of the pancreas.

  2006cited by this paper
• FOXA1: Growth inhibitor and a favorable prognostic factor in human breast cancer

  2006cited by this paper
• Expression and role of Foxa proteins in prostate cancer

  2006cited by this paper
• The initiation of liver development is dependent on Foxa transcription factors

  2005cited by this paper
• Activation of a Methylated Promoter Mediated by a Sequence-specific DNA-binding Protein, RFX*

  2005cited by this paper
• Forkhead box A1 regulates prostate ductal morphogenesis and promotes epithelial cell maturation

  2005cited by this paper
• Regulatory mechanisms controlling human E-cadherin gene expression

  2005cited by this paper
• Foxa2 is required for the differentiation of pancreatic alpha-cells.

  2005cited by this paper
• Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1.

  2005cited by this paper
• Foxa2 is required for the differentiation of pancreatic α-cells

  2005cited by this paper
• Foxa2 regulates alveolarization and goblet cell hyperplasia

  2004cited by this paper
• Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis.

  2004cited by this paper
• Immunohistochemical localization of Foxa1 and Foxa2 in mouse embryos and adult tissues.

  2004cited by this paper
• Insulin regulates the activity of forkhead transcription factor Hnf-3β/Foxa-2 by Akt-mediated phosphorylation and nuclear/cytosolic localization

  2003cited by this paper
• A comprehensive characterization of pancreatic ductal carcinoma cell lines: towards the establishment of an in vitro research platform

  2003cited by this paper
• Opening of compacted chromatin by early developmental transcription factors HNF3 (FoxA) and GATA-4.

  2002cited by this paper
• The Hepatocyte Nuclear Factor 3 α Gene, HNF3α (FOXA1), on Chromosome Band 14q13 Is Amplified and Overexpressed in Esophageal and Lung Adenocarcinomas

  2002cited by this paper
• The hepatocyte nuclear factor 3 alpha gene, HNF3alpha (FOXA1), on chromosome band 14q13 is amplified and overexpressed in esophageal and lung adenocarcinomas.

  2002cited by this paper
• Molecular Mechanisms of Gene Silencing Mediated by DNA Methylation

  2002cited by this paper
• Epithelial–mesenchymal transitions in tumour progression

  2002cited by this paper
• Transforming growth factor beta1 treatment leads to an epithelial-mesenchymal transdifferentiation of pancreatic cancer cells requiring extracellular signal-regulated kinase 2 activation.

  2001influential reference
• The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion.

  2001cited by this paper
• The transcription factor Snail controls epithelial–mesenchymal transitions by repressing E-cadherin expression

  2000cited by this paper
• Hypermethylation of multiple genes in pancreatic adenocarcinoma.

  2000cited by this paper
• The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells

  2000cited by this paper
• Impaired glucose homeostasis and neonatal mortality in hepatocyte nuclear factor 3alpha-deficient mice.

  1999cited by this paper
• Inactivation of the winged helix transcription factor HNF3alpha affects glucose homeostasis and islet glucagon gene expression in vivo.

  1999cited by this paper
• Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor.

  1999cited by this paper
• Regulation of a transcription factor network required for differentiation and metabolism.

  1998cited by this paper
• Hepatocyte Nuclear Factor 3 b Is Involved in Pancreatic b -Cell-Specific Transcription of the pdx-1 Gene

  1997cited by this paper
• Hepatocyte nuclear factor 3beta is involved in pancreatic beta-cell-specific transcription of the pdx-1 gene

  1997cited by this paper
• Control of cell behavior during vertebrate development by Slug, a zinc finger gene.

  1994cited by this paper
• HNF-3 beta is essential for node and notochord formation in mouse development.

  1994cited by this paper
• HNF-3β is essential for node and notochord formation in mouse development

  1994cited by this paper
• The winged-helix transcription factor HNF-3 beta is required for notochord development in the mouse embryo.

  1994cited by this paper
• Production of scatter factor-like activity by a nitrosamine-induced pancreatic cancer cell line.

  1993cited by this paper
• Cáncer

  1939cited by this paper

• Non-invasive epidermis sampling for DNA methylation-based prediction of skin cancer phenotypes

  2026cites this paper
• Dissecting Context-Specific Effects of ERK5 Signaling in Triple-Negative Breast Cancer

  2026cites this paper
• Spatial transcriptomic analysis of mouse parathyroid gland cells expressing an activating variant of Gcm2.

  2025cites this paper
• Machine Learning-Based Identification of Survival-Associated CpG Biomarkers in Pancreatic Ductal Adenocarcinoma

  2025cites this paper
• Myriad mechanisms: factors regulating the synthesis of aberrant mucin-type O-glycosylation found on cancer cells.

  2025cites this paper
• STAT3 sustains tumorigenicity following mutant KRAS ablation

  2025cites this paper
• The transcription factor FOXQ1 in cancer

  2025cites this paper
• Integrative genomic and transcriptomic profiling reveals dysregulation of FOXA1-AGR2 axis in penoscrotal extramammary Paget's disease.

  2025cites this paper
• Dynamic behavior of cell-cell adhesion factors in collective cell migration.

  2025cites this paper
• Down-regulation of RBM47 due to diminished activation by forkhead box A1 (FOXA1) and silencing by CpG methylation is associated with epithelial-mesenchymal transition and metastasis of colorectal cancer

  2025cites this paper
• Overcoming therapy resistance in pancreatic cancer: challenges and emerging strategies.

  2025cites this paper
• A FOXA1/SPDEF Co-regulatory Axis Drives ERBB2 and Suppresses TEAD/YAP-Driven EMT to Maintain Luminal Identity in HER2+ Breast Cancer

  2025cites this paper
• Regulation of gene expression by FOXA1

  2025cites this paper
• Distinctive Expression of Metastamirs in Breast Cancer Mesenchymal Stem Cells Isolated from Solid Tumor.

  2024cites this paper
• Long non-coding RNAs as the pivotal regulators of epithelial mesenchymal transition through WNT/β-catenin signaling pathway in tumor cells.

  2024cites this paper
• miR-6855-5p Enhances Radioresistance and Promotes Migration of Pancreatic Cancer by Inducing Epithelial-Mesenchymal Transition via Suppressing FOXA1: Potential of Plasma Exosomal miR-6855-5p as an Indicator of Radiosensitivity in Patients with Pancreatic Cancer

  2024cites this paper
• Development of gemcitabine-modified miRNA mimics as cancer therapeutics for pancreatic ductal adenocarcinoma

  2024cites this paper
• TGF-β1 facilitates gallbladder carcinoma metastasis by regulating FOXA1 translation efficiency through m6A modification

  2024cites this paper
• FOXA2-initiated transcriptional activation of INHBA induced by methylmalonic acid promotes pancreatic neuroendocrine neoplasm progression

  2024cites this paper
• Development of 3D-iNET ORION: a novel, pre-clinical, three-dimensional in vitro cell model for modeling human metastatic neuroendocrine tumor of the pancreas

  2024cites this paper
• FOXA1 and FOXA2: the regulatory mechanisms and therapeutic implications in cancer

  2024cites this paper
• Loss of Claudin-1 incurred by DNMT aberration promotes pancreatic cancer progression.

  2024cites this paper
• Forkhead box A2 Promotes Colorectal Cancer Progression and Targets BCL2-Associated X (BAX) Protein

  2023cites this paper
• Development of Gemcitabine-Modified miRNA Mimics as Cancer Therapeutics for Pancreatic Ductal Adenocarcinoma

  2023cites this paper
• Unraveling the Molecular Puzzle: Exploring Gene Networks across Diverse EMT Status of Cell Lines

  2023cites this paper
• Bioinformatic miRNA-mRNAs Analysis Revels to miR-934 as a Potential Regulator of the Epithelial–Mesenchymal Transition in Triple-Negative Breast Cancer

  2023cites this paper
• FOXA2 and STAT5A regulate oncogenic activity of KIF5B-RET fusion.

  2023cites this paper
• Key transcriptional effectors of the pancreatic acinar phenotype and oncogenic transformation

  2023cites this paper
• The Mechanism of Ubiquitination or Deubiquitination Modifications in Regulating Solid Tumor Radiosensitivity

  2023cites this paper
• Pathophysiological role of BACH transcription factors in digestive system diseases

  2023cites this paper
• FoxA2 is a reliable marker for the diagnosis of yolk sac tumour postpubertal‐type

  2023cites this paper
• The epithelial–mesenchymal plasticity landscape: principles of design and mechanisms of regulation

  2023cites this paper
• FOXQ1 recruits the MLL complex to activate transcription of EMT and promote breast cancer metastasis

  2022influential citation
• SNHG1/miR-194-5p/MTFR1 Axis Promotes TGFβ1-Induced EMT, Migration and Invasion of Tongue Squamous Cell Carcinoma Cells

  2022cites this paper
• FOXA1 in Breast Cancer: A Luminal Marker with Promising Prognostic and Predictive Impact

  2022cites this paper
• BACH1 promotes clear cell renal cell carcinoma progression by upregulating oxidative stress‐related tumorigenicity

  2022cites this paper
• Forkhead Box Transcription Factors: Double-Edged Swords in Cancer

  2022cites this paper
• Roles of lncRNAs Mediating Wnt/β-Catenin Signaling in HCC

  2022cites this paper
• Establishment of a reference single-cell RNA sequencing dataset for human pancreatic adenocarcinoma

  2022cites this paper
• Epigenetics in Pancreatic Ductal Adenocarcinoma: Impact on Biology and Utilization in Diagnostics and Treatment

  2022influential citation
• Increased FOXA1 levels induce apoptosis and inhibit proliferation in FOXA1-low expressing basal breast cancer cells.

  2022cites this paper
• FOXA1, FOXA2, SOX10 and GAS2 Gene Expression in Oral Squamous Cell Carcinoma and Their Relationship with Clinicopathological Indices

  2022cites this paper
• Epithelial–mesenchymal transition: The history, regulatory mechanism, and cancer therapeutic opportunities

  2022cites this paper
• Cellular specificity of androgen receptor, coregulators, and pioneer factors in prostate cancer

  2022cites this paper
• PGC1α Cooperates with FOXA1 to Regulate Epithelial Mesenchymal Transition through the TCF4-TWIST1

  2022influential citation
• Histone deacetylase 3 promotes alveolar epithelial–mesenchymal transition and fibroblast migration under hypoxic conditions

  2022cites this paper
• FOXA2 suppresses endometrial carcinogenesis and epithelial-mesenchymal transition by regulating enhancer activity

  2022cites this paper
• Transcriptional and post-transcriptional control of epithelial-mesenchymal plasticity: why so many regulators?

  2022cites this paper
• Circulating miR-1246 and miR-485-3p as Promising Biomarkers of Clinical Response and Outcome in Melanoma Patients Treated with Targeted Therapy

  2022cites this paper
• Contribution of common plastic-related endocrine disruptors to epithelial-mesenchymal transition (EMT) and tumor progression.

  2022cites this paper
• Deregulation of Transcription Factor Networks Driving Cell Plasticity and Metastasis in Pancreatic Cancer

  2021cites this paper
• Identification of Prognostic Gene Biomarkers in Non-Small Cell Lung Cancer Progression by Integrated Bioinformatics Analysis

  2021cites this paper
• GATA3 functions downstream of BRCA1 to suppress EMT in breast cancer

  2021cites this paper
• PBX1: a key character of the hallmarks of cancer

  2021cites this paper
• Updates on Molecular and Biochemical Development and Progression of Prostate Cancer

  2021cites this paper
• FoXA2 promotes esophageal squamous cell carcinoma progression by ZEB2 activation

  2021influential citation
• FOXA1 can be modulated by HDAC3 in the progression of epithelial ovarian carcinoma

  2021cites this paper
• Inhibition of β-Catenin/CREB Binding Protein Signaling Attenuates House Dust Mite-Induced Goblet Cell Metaplasia in Mice

  2021influential citation
• Systematic Pan-Cancer Analysis and Experimental Verification Identify FOXA1 as an Immunological and Prognostic Biomarker in Epithelial Ovarian Cancer

  2021cites this paper
• Epithelial to Mesenchymal Transition

  2021cites this paper
• Inhibiting roles of FOXA2 in liver cancer cell migration and invasion by transcriptionally suppressing microRNA-103a-3p and activating the GREM2/LATS2/YAP axis

  2021cites this paper
• MRE11 promotes oral cancer progression through RUNX2/CXCR4/AKT/FOXA2 signaling in a nuclease-independent manner

  2021cites this paper
• The transcription factor BACH1 at the crossroads of cancer biology: From epithelial–mesenchymal transition to ferroptosis

  2021cites this paper
• Epithelial cell plasticity drives endoderm formation during gastrulation

  2021cites this paper
• Gene commander in the trash heap: Transcriptional regulation and ubiquitination modification mediated by RNF6 in carcinogenesis.

  2021cites this paper
• A systems-based framework to computationally describe putative transcription factors and signaling pathways regulating glycan biosynthesis

  2021cites this paper
• FoxA1 and FoxA2 regulate growth and cellular identity in NKX2-1-positive lung adenocarcinoma

  2021cites this paper
• Identification of phenotype-specific networks from paired gene expression–cell shape imaging data

  2021cites this paper
• An in vivo functional genomics screen of nuclear receptors and their co-regulators identifies FOXA1 as an essential gene in lung tumorigenesis

  2020cites this paper
• Epigenetic Landscape in Pancreatic Ductal Adenocarcinoma: On the Way to Overcoming Drug Resistance?

  2020cites this paper
• Inhibiting roles of FOXA2 in hepatocellular carcinoma cell migration and invasion by transcriptionally suppressing microRNA-103a-3p and activating the GREM2/LATS2 axis

  2020cites this paper
• IGF-1 and hyperglycaemia-induced FOXA1 and IGFBP-2 affect epithelial to mesenchymal transition in prostate epithelial cells

  2020cites this paper
• Functionally analyzing the important roles of hepatocyte nuclear factor 3 (FoxA) in tumorigenesis.

  2020cites this paper
• LINC00261 Is Differentially Expressed in Pancreatic Cancer Subtypes and Regulates a Pro-Epithelial Cell Identity

  2020cites this paper
• FOXA1/2 depletion drives global reprogramming of differentiation state and metabolism in a human liver cell line and inhibits differentiation of human stem cell-derived hepatic progenitor cells

  2020cites this paper
• Shaping Chromatin States in Prostate Cancer by Pioneer Transcription Factors

  2020cites this paper
• MicroRNA-1246 Promotes Melanoma Progression Through Targeting FOXA2

  2020cites this paper
• MicroRNA-1246 Promotes Melanoma Progression Through Targeting FOXA2

  2020cites this paper
• Serum miR-1290 and miR-1246 as Potential Diagnostic Biomarkers of Human Pancreatic Cancer

  2020cites this paper
• Opposing Roles of FoxA1 and FoxA3 in Intrahepatic Cholangiocarcinoma Progression

  2020cites this paper
• Silencing of FOXA2 decreases E-cadherin expression and is associated with lymph node metastasis in oral cancer.

  2020cites this paper
• Targeting Epigenetic Dependencies in Solid Tumors: Evolutionary Landscape Beyond Germ Layers Origin

  2020cites this paper
• Epigenetic regulation of Epithelial–Mesenchymal Transition in Pancreatic Ductal Adenocarcinoma

  2020cites this paper
• Computational identification of biomarker genes for lung cancer considering treatment and non-treatment studies

  2020cites this paper
• Knockdown of Forkhead box A1 suppresses the tumorigenesis and progression of human colon cancer cells through regulating the phosphatase and tensin homolog/Akt pathway

  2020cites this paper
• LncRNA SNHG17 promotes proliferation and invasion of ovarian cancer cells through up-regulating FOXA1.

  2020cites this paper
• FOXA1 Expression in Nasopharyngeal Carcinoma: Association with Clinicopathological Characteristics and EMT Markers

  2020cites this paper
• Molecular characterization of organoids derived from pancreatic intraductal papillary mucinous neoplasms

  2020cites this paper
• EMT Factors and Metabolic Pathways in Cancer

  2020cites this paper
• A compendium of mutational cancer driver genes

  2020cites this paper
• BACH1 promotes pancreatic cancer metastasis by repressing epithelial genes and enhancing epithelial-mesenchymal transition.

  2020influential citation
• Loss of FoxA2 accelerates neoplastic changes in the intrahepatic bile duct partly via the MAPK signaling pathway

  2019cites this paper
• Reciprocal regulation of pancreatic ductal adenocarcinoma growth and molecular subtype by HNF4α and SIX1/4

  2019cites this paper
• SOX9 как одно из центральных звеньев оси регуляции эмбрионального развития и прогрессии рака поджелудочной железы

  2019cites this paper
• RNF6 facilitates metastasis and radioresistance in hepatocellular carcinoma through ubiquitination of FoxA1

  2019cites this paper
• Association of FOXA1 and EMT markers (Twist1 and E-cadherin) in breast cancer

  2019cites this paper
• FOXA1 reprograms the TGF-β-stimulated transcriptional program from a metastasis promoter to a tumor suppressor in nasopharyngeal carcinoma.

  2019cites this paper
• Small molecule JQ1 promotes prostate cancer invasion via BET-independent inactivation of FOXA1.

  2019cites this paper
• FOXA2 controls the cis‐regulatory networks of pancreatic cancer cells in a differentiation grade‐specific manner

  2019cites this paper
• Hepatocyte Nuclear Factor 3β Plays a Suppressive Role in Colorectal Cancer Progression

  2019cites this paper