Clinical significance of translocation t(1;19) in childhood acute lymphoblastic leukemia in the context of contemporary therapies: a report from the Children's Cancer Group.

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Journal of Clinical Oncology

• Publication date

  1998-02-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1200/JCO.1998.16.2.527PMID 9469337
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Clinical features and treatment outcome of children with myeloid antigen positive acute lymphoblastic leukemia: a report from the Children's Cancer Group.

  1997cited by this paper
• Uniform approach to risk classification and treatment assignment for children with acute lymphoblastic leukemia.

  1996cited by this paper
• Structural determinants within Pbx1 that mediate cooperative DNA binding with pentapeptide-containing Hox proteins: proposal for a model of a Pbx1-Hox-DNA complex

  1996cited by this paper
• Improved clinical outcome for children with T-lineage acute lymphoblastic leukemia after contemporary chemotherapy: a Children's Cancer Group Study.

  1996cited by this paper
• Oncoprotein E2A-Pbx1 immortalizes a myeloid progenitor in primary marrow cultures without abrogating its factor-dependence.

  1994cited by this paper
• Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation

  1994cited by this paper
• Immunologic, cytogenetic, and clinical characterization of childhood acute lymphoblastic leukemia with the t(1;19) (q23; p13) or its derivative.

  1994cited by this paper
• Human t(1;19)(q23;p13) pre-B acute lymphoblastic leukemia in mice with severe combined immunodeficiency.

  1993cited by this paper
• Predictability of the t(1;19)(q23;p13) from surface antigen phenotype: implications for screening cases of childhood acute lymphoblastic leukemia for molecular analysis: a Pediatric Oncology Group study.

  1993cited by this paper
• Different molecular consequences of the 1;19 chromosomal translocation in childhood B-cell precursor acute lymphoblastic leukemia.

  1992cited by this paper
• Different Molecular Consequences of the 1;19 Chromosomal Translocation in Childhood B - Cell Precursor Acute Lymphoblastic Leukemia

  1992cited by this paper
• Isochromosomes in childhood acute lymphoblastic leukemia: a collaborative study of 83 cases.

  1992cited by this paper
• Prognostic significance of the balanced t(1;19) and unbalanced der(19)t(1;19) translocations in acute lymphoblastic leukemia.

  1992cited by this paper
• The human t(1;19) translocation in pre-B ALL produces multiple nuclear E2A-Pbx1 fusion proteins with differing transforming potentials.

  1991cited by this paper
• Lymphomatous presentation of childhood acute lymphoblastic leukemia. A subgroup at high risk of early treatment failure

  1991cited by this paper
• The t(1;19)(q23;p13) results in consistent fusion of E2A and PBX1 coding sequences in acute lymphoblastic leukemias.

  1991cited by this paper
• Heterogeneity of presenting features and their relation to treatment outcome in 120 children with T-cell acute lymphoblastic leukemia.

  1990cited by this paper
• Poor prognosis of children with pre-B acute lymphoblastic leukemia is associated with the t(1;19)(q23;p13): a Pediatric Oncology Group study.

  1990cited by this paper
• Biology and clinical significance of cytogenetic abnormalities in childhood acute lymphoblastic leukemia.

  1990cited by this paper
• Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor.

  1990cited by this paper
• Poor prognosis of children with pre-B acute lymphoblastic leukemia is associated with the t(1;19)(q23;p13): a Pediatric Oncology Group study

  1990cited by this paper
• Cytogenetics of pre-B-cell acute lymphoblastic leukemia with emphasis on prognostic implications of the t(1;19).

  1990cited by this paper
• Molecular analysis of the t(1;19) breakpoint cluster region in pre‐b cell acute lymphoblastic leukemias

  1990cited by this paper
• A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL.

  1990cited by this paper
• Immunophenotype-karyotype associations in human acute lymphoblastic leukemia.

  1989cited by this paper
• The gene for enhancer binding proteins E12/E47 lies at the t(1;19) breakpoint in acute leukemias.

  1989cited by this paper
• Biphenotypic leukemic lymphocyte precursors in CD2+CD19+ acute lymphoblastic leukemia and their putative normal counterparts in human fetal hematopoietic tissues.

  1989cited by this paper
• Chromosomal translocations play a unique role in influencing prognosis in childhood acute lymphoblastic leukemia.

  1986cited by this paper
• Balanced and unbalanced 1;19 translocation‐associated acute lymphoblastic leukemias

  1986cited by this paper
• Cytogenetic features and serum lactic dehydrogenase level predict a poor treatment outcome for children with pre-B-cell leukemia.

  1986cited by this paper
• Karyotypic and clinical findings in a consecutive series of children with acute lymphocytic leukemia.

  1985cited by this paper
• Pre-B cell leukemia associated with chromosome translocation 1;19.

  1984cited by this paper
• An international system for human cytogenetic nomenclature

  1978cited by this paper
• Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples.

  1977cited by this paper
• Regression Models and Life-Tables

  1972cited by this paper
• Evaluation of survival data and two new rank order statistics arising in its consideration.

  1966cited by this paper
• Nonparametric Estimation from Incomplete Observations

  1958cited by this paper

• Spectrum of Cytogenetic Abnormalities in Adolescent and Young Adult Patients of B-Cell Acute Lymphoblastic Leukemia in a Tertiary Care Hospital in Pakistan

  2025cites this paper
• Unraveling the Prognostic Role of t(1:19) in Pediatric Pre-B Acute Lymphoblastic Leukemia: Insights from a Saudi Nationwide Cohort.

  2024cites this paper
• Case of B-acute lymphoblastic leukaemia with t(1;19)(q23;p13.3) TCF3::PBX1 and co-occurring CBL mutation in an elderly patient

  2024cites this paper
• Real world outcome of B ALL with t (1; 19) (q23; p13)/TCF3::PBX1 in adolescents and adults treated with intensive regimes.

  2024cites this paper
• Current Pharmaceutical Biotechnology

  2022cites this paper
• Incidence and Prognostic Impact of TCF3-PBX1 Fusion in Childhood Acute Lymphoblastic Leukemia: A Single Centre Experience

  2021cites this paper
• Clinical features and prognostic impact of TCF3-PBX1 in childhood acute lymphoblastic leukemia: A single-center retrospective study of 837 patients from China.

  2021cites this paper
• Fusion genes as biomarkers in pediatric cancers: A review of the current state and applicability in diagnostics and personalized therapy.

  2020cites this paper
• Translocation t(1;19)(q23;p13) in adult acute lymphoblastic leukemia – a distinct subtype with favorable prognosis

  2020cites this paper
• Long-Term Results of the Risk-Stratified Treatment of TCF3-PBX1-Positive Pediatric Acute Lymphoblastic Leukemia in China.

  2020cites this paper
• Evaluation of Cytogenetic Abnormalities in Patients with Acute Lymphoblastic Leukemia

  2019cites this paper
• Treatment and biology of pediatric acute lymphoblastic leukemia

  2018cites this paper
• der(21)t(1;21)(q11-12;p11-13) and der(21)t(1;21)(q21-32;p11-13)

  2018cites this paper
• Application of Saccharomyces cerevisiae to improve pediatric acute lymphoblastic leukemia outcomes

  2018cites this paper
• E2A/PBX1, MLL/AF4, BCR/ABL (M-BCR), BCR/ABL(m-BCR) Gene Rearrangements in Acute Lymphoblastic Leukemia in Iranian Children

  2018cites this paper
• Diagnosis and Treatment of Childhood Acute Lymphoblastic Leukemia

  2018cites this paper
• Excellent outcome of acute lymphoblastic leukaemia with TCF3‐PBX1 rearrangement in Hong Kong

  2018cites this paper
• Chapter 2 Acute Lymphoblastic Leukemia

  2017cites this paper
• Molecular processes involved in B cell acute lymphoblastic leukaemia

  2017cites this paper
• Cytogenetic analysis of hematologic malignant diseases

  2017cites this paper
• Childhood pre-B cell acute lymphoblastic leukemia with translocation t(1;19)(q21.1;p13.3) and two additional chromosomal aberrations involving chromosomes 1, 6, and 13: a case report

  2017cites this paper
• Pediatric acute lymphoblastic leukemia with t(1;19)/TCF3‐PBX1 in Taiwan

  2017cites this paper
• B lymphoblastic leukemia/lymphoma: new insights into genetics, molecular aberrations, subclassification and targeted therapy

  2017cites this paper
• [Cytopathologic features of childhood acute leukemia at the Hospital de Especialidades Pediátricas, Chiapas, Mexico].

  2017cites this paper
• The mechanism of B cell acute lymphoblastic leukemia development

  2017cites this paper
• Long-term outcome of 6-month maintenance chemotherapy for acute lymphoblastic leukemia in children

  2017cites this paper
• Cytological features of childhood acute leukemia at the Hospital de Especialidades Pediátricas, Chiapas, Mexico

  2017cites this paper
• Venetoclax responses of pediatric ALL xenografts reveal sensitivity of MLL-rearranged leukemia.

  2016cites this paper
• Chromosomal aberrations in childhood acute lymphoblastic leukemia: 15-year single center experience.

  2016cites this paper
• Chromosomal Translocations and Gene Rearrangements in Acute Lymphoblastic Leukaemia

  2015cites this paper
• Geographic/ethnic variability of chromosomal and molecular abnormalities in leukemia

  2015cites this paper
• Molecular basis and clinical significance of genetic aberrations in B-cell precursor acute lymphoblastic leukemia.

  2015cites this paper
• Clinical Features and Prognostic Significance of TCF3-PBX1 Fusion Gene in Chinese Children with Acute Lymphoblastic Leukemia by Using a Modified ALL-BFM-95 Protocol

  2015cites this paper
• Impact of TCF3 Rearrangement on CNS Relapse in Egyptian Pediatric Acute Lymphoblastic Leukemia

  2014cites this paper
• Atlas of Genetics and Cytogenetics in Oncology and Haematology

  2014cites this paper
• Clinically defining and managing high-risk pediatric patients with acute lymphoblastic leukemia.

  2014cites this paper
• Immunophenotypic Diagnosis of Acute Lymphoblastic Leukemia using Flow Cytometry; Experience at King Hussein Medical Center

  2014influential citation
• Acute Lymphoblastic Leukemia: Genetic Events and Molecular Signatures

  2014cites this paper
• The Importance of Clinical Nutrition in Patients with Genetic Disorders Diagnosed with 5000 Genetic Studies

  2014cites this paper
• Estudios citogenéticos en niños con Leucemia Linfocitica Aguda-B en Costa Rica

  2014cites this paper
• B-ce LL precursor aBnormaL ities in chiL dhood acute LymphoBL astic Leukemia

  2014cites this paper
• La importancia de la nutrición clínica en pacientes con alteraciones genéticas diagnosticadas en 4617 estudios genéticos

  2014cites this paper
• Chapter 9 Role of Cytogenetic Analysis in the Diagnosis and Classification of Hematopoietic Neoplasms

  2013cites this paper
• High modal number and triple trisomies are highly correlated favorable factors in childhood B-cell precursor high hyperdiploid acute lymphoblastic leukemia treated according to the NOPHO ALL 1992/2000 protocols

  2013influential citation
• Concurrent t(4;11) and t(1:19) in a Pediatric Patient with B-Lymphoblastic Leukemia/Lymphoma (B-ALL): A Case Report and Review of the Literature.

  2013cites this paper
• Rational design of an immunoconjugate for selective knock-down of leukemia-specific E2A-PBX1 fusion gene expression in human Pre-B leukemia.

  2013cites this paper
• Survival of Patients with Acute Lymphoblastic Leukemia

  2013cites this paper
• Classification et facteurs pronostiques des leucémies aiguës

  2012cites this paper
• Unbalanced 1q Whole-Arm Translocation Resulting in der(14)t(1;14)(q11–12;p11) in Myelodysplastic Syndrome

  2012cites this paper
• Molecular Diagnosis in Hematopathology

  2011cites this paper
• Stellenwert der Fremdstoff-metabolisierenden Enzyme GSTM1 und GSTT1 bei ALL-Rezidiven im Kindesalter

  2011cites this paper
• Paediatric B‐cell precursor acute lymphoblastic leukaemia with t(1;19)(q23;p13): clinical and cytogenetic characteristics of 47 cases from the Nordic countries treated according to NOPHO protocols

  2011cites this paper
• Prognostic impact of t(1;19)/ TCF3–PBX1 in childhood acute lymphoblastic leukemia in the context of Berlin–Frankfurt–Münster-based protocols

  2011cites this paper
• Coexistence of Translocation(1,19) and the Philadelphia Chromosome in a Child's First Presentation of Chronic Myeloid Leukemia in Blast Crisis Treated with Dasatinib

  2011cites this paper
• Precursor B-Cell Acute Lymphoblastic Leukemia

  2010cites this paper
• 24B-Cell Acute Lymphoblastic Leukemia

  2010cites this paper
• Pediatric Clinics of North America: Hematopoietic Stem Cell Transplantation Stem Cell Transplantation for Leukemia

  2010cites this paper
• Hematopoietic stem cell transplantation for leukemia.

  2010cites this paper
• [Acute lymphoblastic leukemias with translocations (1;19)(q23;p13): a description of 3 new cases and a review of the literature].

  2010cites this paper
• Prognostic Factors in Children with Acute Leukemia : Recent Advances

  2010cites this paper
• Acute Leukaemia: Integration of Morphological, Immunophenotypic and Genetic Information and the WHO Classification

  2010cites this paper
• Cytogenetics and molecular genetics of acute lymphoblastic leukemia.

  2009cites this paper
• Childhood acute lymphoblastic leukemia: update on prognostic factors

  2009cites this paper
• Increased risk for CNS relapse in pre-B cell leukemia with the t(1;19)/TCF3-PBX1

  2009cites this paper
• High-risk childhood acute lymphoblastic leukemia.

  2009cites this paper
• A Look at Acute Lymphoblastic Leukemia in Children

  2009cites this paper
• Adults with acute lymphoblastic leukemia and translocation (1;19) abnormality have a favorable outcome with hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone alternating with methotrexate and high‐dose cytarabine chemotherapy

  2009cites this paper
• Vascular density and bone marrow fibrosis in childhood acute lymphoblastic leukemia

  2008cites this paper
• Chapter 27 – Molecular Genetics of ALL

  2008cites this paper
• Copy number alterations in childhood acute lymphoblastic leukemia and their association with minimal residual disease

  2008cites this paper
• The Neoplasms of Precursor Lymphoblasts

  2008cites this paper
• The application of conventional cytogenetics, FISH, and RT-PCR to detect genetic changes in 70 children with ALL

  2008cites this paper
• Acute lymphoblastic leukemia in adolescents and young adults in Finland

  2008cites this paper
• Ring chromosomes in human neoplasias

  2008cites this paper
• Diagnosis of Acute Lymphoblastic Leukemia

  2008cites this paper
• Expression of CD44, but not CD44v6, predicts relapse in children with B cell progenitor acute lymphoblastic leukemia lacking adverse or favorable genetics

  2008cites this paper
• Toward a therapeutically relevant, molecularly based classification of lymphoma: are we there yet?

  2007cites this paper
• Molecular cytogenetic characterization of TCF3 (E2A)/19p13.3 rearrangements in B‐cell precursor acute lymphoblastic leukemia

  2007cites this paper
• Incidence and outcome of TCF3-PBX1-positive acute lymphoblastic leukemia in Austrian children

  2007cites this paper
• Characterisation of genomic translocation breakpoints and identification of an alternative TCF3/PBX1 fusion transcript in t(1;19)(q23;p13)‐positive acute lymphoblastic leukaemias

  2007cites this paper
• Risk- and response-based classification of childhood B-precursor acute lymphoblastic leukemia: a combined analysis of prognostic markers from the Pediatric Oncology Group (POG) and Children's Cancer Group (CCG).

  2007cites this paper
• Children ' s Cancer Group lymphoblastic leukemia : a combined analysis of prognostic markers Risk-and response-based classification of childhood B-precursor acute

  2007cites this paper
• The eighth international childhood acute lymphoblastic leukemia workshop (‘Ponte di Legno meeting’) report: Vienna, Austria, April 27–28, 2005

  2006cites this paper
• Poor outcome of adult acute lymphoblastic leukemia patients carrying the (1;19)(q23;p13) translocation

  2006cites this paper
• Expressió de ZAP-70 en linfòcits B normals i síndromes limfoproliferatives B

  2006cites this paper
• Novel genomic determinants of apoptotic defects in acute lymphoblastic leukemia

  2006cites this paper
• Multidrug resistance and minimal residual disease in childhood malignancies

  2005cites this paper
• Molecular signatures in childhood acute leukemia and their correlations to expression patterns in normal hematopoietic subpopulations.

  2005cites this paper
• Formation of der(19)t(1;19)(q23;p13) in acute lymphoblastic leukemia

  2005cites this paper
• A new model of pre-B acute lymphoblastic leukemia chemically induced in rats.

  2005cites this paper
• Interphase FISH to detect PBX1/E2A fusion resulting from the der(19)t(1;19)(q23;p13.3) or t(1;19)(q23;p13.3) in paediatric patients with acute lymphoblastic leukaemia

  2005cites this paper
• Caiphostin C Triggers Calcium-dependent Apoptosis in Human Acute Lymphoblastic Leukemia Cells1

  2005cites this paper
• Gene Expression Studies of Hematologic

  2005cites this paper
• 染色体分析でt(1 ; 19)がみられたがE2A-PBX1キメラmRNAがみられなかった小児急性リンパ性白血病

  2005cites this paper
• Translocation t(1;19) is related to low cellular drug resistance in childhood acute lymphoblastic leukaemia

  2005cites this paper
• Gene Expression Studies of Hematologic Malignacies

  2005cites this paper
• Gene Expression Studies of Hematologic

  2005cites this paper
• Genomic Assessment of Pediatric Acute Leukemia

  2005cites this paper
• Gene Expression Studies of Hematologic

  2005cites this paper
• Split-signal FISH for detection of chromosome aberrations in acute lymphoblastic leukemia

  2004cites this paper