Blocking lactate export by inhibiting the Myc target MCT1 Disables glycolysis and glutathione synthesis.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Cancer Research

• Publication date

  2014-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1158/0008-5472.CAN-13-2034PMID 24285728PMCID PMC3946415
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• p. n. 6

  2016cited by this paper
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  2008influential reference
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  2008influential reference
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  2000influential reference
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  2000influential reference
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  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1997cited by this paper
• Analysis of mitochondrial morphology and function with novel fixable fluorescent stains.

  1996cited by this paper
• Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis.

  1991cited by this paper
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  1988cited by this paper
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  1985cited by this paper
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  1964cited by this paper
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  1964cited by this paper
• [Origin of cancer cells].

  1956cited by this paper
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  1956cited by this paper

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