Non-animal methods to predict skin sensitization (II): an assessment of defined approaches**

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Critical Reviews in Toxicology

• Publication date

  2018-02-23

• Fields of study

  Medicine, Chemistry, Environmental Science, Computer Science

• Identifiers
  DOI 10.1080/10408444.2018.1429386PMID 29474122PMCID PMC7393691
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Chemical applicability domain of the local lymph node assay (LLNA) for skin sensitisation potency. Part 4. Quantitative correlation of LLNA potency with human potency

  2018cited by this paper
• International regulatory requirements for skin sensitization testing.

  2018cited by this paper
• Non-animal methods to predict skin sensitization (I): the Cosmetics Europe database*

  2018influential reference
• Alternative Integrated Testing for Skin Sensitization: Assuring Consumer Safety

  2018cited by this paper
• An improvement of LLNA:DA to assess the skin sensitization potential of chemicals.

  2017cited by this paper
• Standardisation of defined approaches for skin sensitisation testing to support regulatory use and international adoption: position of the International Cooperation on Alternative Test Methods

  2017cited by this paper
• Multivariate models for prediction of human skin sensitization hazard

  2017influential reference
• In Silico Prediction of Physicochemical Properties of Environmental Chemicals Using Molecular Fingerprints and Machine Learning

  2017cited by this paper
• Prediction of skin sensitization potency using machine learning approaches

  2017cited by this paper
• An Integrated Chemical Environment to Support 21st-Century Toxicology

  2017cited by this paper
• Fragrances Categorized According to Relative Human Skin Sensitization Potency

  2017cited by this paper
• Local Tolerance Testing under REACH: Accepted Non-animal Methods are Not on Equal Footing with Animal Tests

  2016cited by this paper
• Analysis of the Local Lymph Node Assay (LLNA) variability for assessing the prediction of skin sensitisation potential and potency of chemicals with non-animal approaches.

  2016cited by this paper
• Safety Evaluation of Cosmetic Ingredients Regarding Their Skin Sensitization Potential

  2016cited by this paper
• Can currently available non-animal methods detect pre and pro-haptens relevant for skin sensitization?

  2016cited by this paper
• Chemical applicability domain of the Local Lymph Node Assay (LLNA) for skin sensitisation potency. Part 2. The biological variability of the murine Local Lymph Node Assay (LLNA) for skin sensitisation.

  2016cited by this paper
• Predicting skin sensitisation using a decision tree integrated testing strategy with an in silico model and in chemico/in vitro assays.

  2016influential reference
• Consensus of classification trees for skin sensitisation hazard prediction.

  2016cited by this paper
• Integrated decision strategies for skin sensitization hazard

  2016influential reference
• LLNA variability: An essential ingredient for a comprehensive assessment of non-animal skin sensitization test methods and strategies.

  2015cited by this paper
• Bayesian integrated testing strategy (ITS) for skin sensitization potency assessment: a decision support system for quantitative weight of evidence and adaptive testing strategy

  2015cited by this paper
• Predicting skin sensitizer potency based on in vitro data from KeratinoSens and kinetic peptide binding: global versus domain-based assessment.

  2015cited by this paper
• Development and utilization of an ex vivo bromodeoxyuridine local lymph node assay protocol for assessing potential chemical sensitizers

  2015cited by this paper
• Prospective multicentre study of the U-SENS test method for skin sensitization testing.

  2015cited by this paper
• Assessing skin sensitization hazard in mice and men using non-animal test methods.

  2015influential reference
• Test battery with the human cell line activation test, direct peptide reactivity assay and DEREK based on a 139 chemical data set for predicting skin sensitizing potential and potency of chemicals

  2015influential reference
• Systematic evaluation of non-animal test methods for skin sensitisation safety assessment.

  2015cited by this paper
• Integrated Testing Strategies (ITS) for safety assessment.

  2015cited by this paper
• Evaluation of combinations of in vitro sensitization test descriptors for the artificial neural network‐based risk assessment model of skin sensitization

  2015influential reference
• The Myeloid U937 Skin Sensitization Test (U-SENS) addresses the activation of dendritic cell event in the adverse outcome pathway for skin sensitization.

  2015cited by this paper
• OECD Series on Testing and Assessment No. 203: New Guidance Document on an Integrated Approach on Testing and Assessment (IATA) for Skin Corrosion and Irritation

  2014cited by this paper
• Evaluating the performance of integrated approaches for hazard identification of skin sensitizing chemicals.

  2014cited by this paper
• A simple and robust scoring technique for binary classification

  2014influential reference
• Towards AOP application--implementation of an integrated approach to testing and assessment (IATA) into a pipeline tool for skin sensitization.

  2014cited by this paper
• LuSens: a keratinocyte based ARE reporter gene assay for use in integrated testing strategies for skin sensitization hazard identification.

  2014cited by this paper
• Applying the skin sensitisation adverse outcome pathway (AOP) to quantitative risk assessment.

  2014cited by this paper
• Categorization of Chemicals According to Their Relative Human Skin Sensitizing Potency

  2014influential reference
• From pathways to people: applying the adverse outcome pathway (AOP) for skin sensitization to risk assessment.

  2013cited by this paper
• 15 Years Out: Reinventing ICCVAM

  2013cited by this paper
• Data integration of non-animal tests for the development of a test battery to predict the skin sensitizing potential and potency of chemicals.

  2013influential reference
• Bayesian integrated testing strategy to assess skin sensitization potency: from theory to practice

  2013cited by this paper
• Putting the parts together: combining in vitro methods to test for skin sensitizing potentials.

  2012cited by this paper
• Prediction of skin sensitization potency of chemicals by human Cell Line Activation Test (h-CLAT) and an attempt at classifying skin sensitization potency.

  2012cited by this paper
• Immunotoxicant Screening and Prioritization in the Twenty-first Century

  2012cited by this paper
• Non-animal test methods for predicting skin sensitization potentials

  2012cited by this paper
• Integrating non-animal test information into an adaptive testing strategy - skin sensitization proof of concept case.

  2011cited by this paper
• The LLNA: A Brief Review of Recent Advances and Limitations

  2011influential reference
• DEVELOPMENT OF A

  2011cited by this paper
• Chemical allergy: translating biology into hazard characterization.

  2011cited by this paper
• Allergic contact dermatitis caused by isopropyl alcohol: a missed allergen?

  2011cited by this paper
• Determining epidermal disposition kinetics for use in an integrated nonanimal approach to skin sensitization risk assessment.

  2011cited by this paper
• Performance of a novel keratinocyte-based reporter cell line to screen skin sensitizers in vitro.

  2010cited by this paper
• Potency values from the local lymph node assay: application to classification, labelling and risk assessment.

  2010cited by this paper
• Skin sensitizers induce antioxidant response element dependent genes: application to the in vitro testing of the sensitization potential of chemicals.

  2008cited by this paper
• TIMES-SS--a promising tool for the assessment of skin sensitization hazard. A characterization with respect to the OECD validation principles for (Q)SARs and an external evaluation for predictivity.

  2007influential reference
• Quantification of chemical peptide reactivity for screening contact allergens: a classification tree model approach.

  2007cited by this paper
• The epidemiology of contact allergy in the general population – prevalence and main findings

  2007cited by this paper
• Janeway's immunobiology

  2007cited by this paper
• Development of an in vitro skin sensitization test using human cell lines: the human Cell Line Activation Test (h-CLAT). I. Optimization of the h-CLAT protocol.

  2006cited by this paper
• Development of a peptide reactivity assay for screening contact allergens.

  2004cited by this paper
• Local Lymph Node Assay: Validation Assessment for Regulatory Purposes

  2000cited by this paper
• Does Sensitization to Contact Allergens Begin in Infancy?

  2000cited by this paper

• Federation of toxicological data resources for in silico new approach methodologies (NAMs)

  2026cites this paper
• Advances in the application of computational toxicology in cosmetic safety assessment.

  2026cites this paper
• Using a reconstructed human vaginal epithelium to assess irritation: A proof-of-concept study supporting regulatory qualification of the method for use with personal lubricants.

  2026cites this paper
• A simple fluorometric test method for assessing skin sensitization potential of chemicals by using N-acetyl-L-cysteine methyl ester in chemico

  2025cites this paper
• Assessment of immunotoxicity in the 21st century: where we are and what we need to replace animals

  2025cites this paper
• Determination of U-SENS™ borderline range thresholds to address uncertainty for skin sensitization assessment in a regulatory context.

  2025cites this paper
• Prognostic systems in preventive toxicology (literature review)

  2025cites this paper
• Reapplication of the Type IV Hypersensitivity Quantitative Risk Assessment to Assess Ingredients Used on Canines

  2025cites this paper
• From animal testing to in Silico models: a systematic review and practical guide to cosmetic assessment

  2025cites this paper
• Ways to broaden the awareness, consideration and adoption of new approach methodologies (NAMs).

  2025cites this paper
• SbD4Skin by EosCloud: Integrating multi-view molecular representation for predicting skin sensitization, irritation, and acute dermal toxicity

  2025cites this paper
• In Vitro Skin Models for Skin Sensitisation: Challenges and Future Directions

  2025cites this paper
• New Horizons in Skin Sensitization Assessment of Complex Mixtures: The Use of New Approach Methodologies Beyond Regulatory Approaches

  2025cites this paper
• Refining of Spectrophotometric Direct Peptide Reactivity Assay (Spectro-DPRA) for In Vitro Skin Sensitization: A Novel Predictive Model Based on Decision Tree.

  2025cites this paper
• An extended Reference Chemical Potency List (RCPL) for characterising the performance of New Approach Methodologies (NAMs) in measuring the skin sensitisation potency of fragrance chemicals.

  2025cites this paper
• Regulatory frameworks for fragrance safety in cosmetics: a global overview

  2025cites this paper
• Immunomodulatory and skin-compatible effects of Amaranthus retroflexus volatile compounds: An in-silico network and pathway-based approach

  2025cites this paper
• In Silico Prediction of Skin Sensitization for Compounds via Flexible Evidence Combination Based on Machine Learning and Dempster-Shafer Theory.

  2024cites this paper
• Use of in vitro methods combined with in silico analysis to identify potential skin sensitizers in the Tox21 10K compound library

  2024cites this paper
• Beyond Encapsulation: Exploring Macrophage-Fibroblast Cross Talk in Implant-Induced Fibrosis

  2024cites this paper
• Computational application of internationally harmonized defined approaches to skin sensitization: DASS App

  2024cites this paper
• The skin sensitization adverse outcome pathway: exploring the role of mechanistic understanding for higher tier risk assessment

  2024cites this paper
• Modulation of Photosensitizing Responses in Cell Culture Environments by Different Medium Components

  2024cites this paper
• Increasing Accessibility of Bayesian Network-Based Defined Approaches for Skin Sensitisation Potency Assessment

  2024influential citation
• P19-82 Assessment of plant protection products and biocides: recent developments and future perspectives on using non-animal methods

  2024cites this paper
• In Vitro Prediction of Skin-Sensitizing Potency Using the GARDskin Dose–Response Assay: A Simple Regression Approach

  2024cites this paper
• New approach methodologies (NAMs) for the in vitro assessment of cleaning products for respiratory irritation: workshop report

  2024cites this paper
• Skin Sensitization Potency Prediction Based on Read‐Across (RAx) Incorporating RhE‐Based Testing Strategy (RTSv1)–Defined Approach: RTSv1‐Based RAx

  2024cites this paper
• The skin allergy risk assessment-integrated chemical environment (SARA-ICE) defined approach to derive points of departure for skin sensitization

  2024cites this paper
• An Integrated Testing Strategy and Online Tool for Assessing Skin Sensitization of Agrochemical Formulations

  2024cites this paper
• Effects of novel flame retardants tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) and triphenyl phosphate (TPhP) on function and homeostasis in human and rat pancreatic beta-cell lines

  2024cites this paper
• Integration of MUTZ-Langerhans cells into a 3D full-thickness skin equivalent and influences of serum reduction and undefined medium supplements on differentiation.

  2024cites this paper
• Human relevance of in vivo and in vitro skin irritation tests for hazard classification of pesticides

  2024cites this paper
• The dimer effect: A refinement approach towards skin sensitization assessment in‐chemico using Amino acid Derivative Reactivity Assay

  2024cites this paper
• Quantum-Mechanics Calculations Elucidate Skin-Sensitizing Pharmaceutical Compounds.

  2024cites this paper
• Deriving a Continuous Point of Departure for Skin Sensitization Risk Assessment Using a Bayesian Network Model

  2024influential citation
• Low-cost quantum mechanical descriptors for data efficient skin sensitization QSAR models

  2024cites this paper
• The evaluation of skin sensitization potential of the UVCB substance diisopentyl phthalate by in silico and in vitro methods

  2024cites this paper
• Development of a mammalian neurosensory full‐thickness skin equivalent and its application to screen sensitizing stimuli

  2023cites this paper
• Utilizing integrated testing strategy (ITSv1) defined approach and read across to predict skin sensitization of Cannabidiol

  2023cites this paper
• Mapping of Data Requirements and Assessment Methodologies Linked to the Regulatory Frameworks and Remits of the Relevant EU Agencies (ECHA, EFSA and EMA) and EC Scientific Committees (SCCS and SCHEER)

  2023cites this paper
• Usage of model combination in computational toxicology.

  2023cites this paper
• Challenges integrating skin sensitization data for assessment of difficult to test substances.

  2023cites this paper
• Enhancing developmental and reproductive toxicity knowledge: A new AOP stemming from glutathione depletion

  2023cites this paper
• PhotoSENSIL-18 assay development: enhancing the safety testing of cosmetic raw materials and finished products to support the in vitro photosensitization assessment ?

  2023cites this paper
• Development of an in chemico high-throughput screening method for the identification of skin sensitization potential

  2023cites this paper
• Skin sensitisation prediction using read-across, an illustrative next generation risk assessment (NGRA) case study for vanillin.

  2023cites this paper
• New approach methodologies in human regulatory toxicology – Not if, but how and when!

  2023cites this paper
• The Skin Sensitisation of Cosmetic Ingredients: Review of Actual Regulatory Status

  2023cites this paper
• Applying a next generation risk assessment framework for skin sensitisation to inconsistent new approach methodology information.

  2023cites this paper
• Incorporating integrated testing strategy (ITSv1) defined approach into read-across (RAx) in predicting skin sensitization potency: ITSv1-based RAx.

  2023cites this paper
• Propylene glycol, skin sensitisation and allergic contact dermatitis: A scientific and regulatory conundrum.

  2023cites this paper
• Reduced specificity for the local lymph node assay for lipophilic chemicals: Implications for the validation of new approach methods for skin sensitization

  2023cites this paper
• Plant extracts, polymers and new approach methods: Practical experience with skin sensitization assessment.

  2023cites this paper
• Synthesis and Assessment of Non-allergenic Aromatic Amine Hair Dyes as Efficient Alternatives to Paraphenylenediamine

  2022cites this paper
• Reference Chemical Potency List (RCPL): A new tool for evaluating the accuracy of skin sensitisation potency measurements by New Approach Methodologies (NAMs).

  2022cites this paper
• Application of Defined Approaches to Assess Skin Sensitization Potency of Isothiazolinone Compounds

  2022cites this paper
• Advancing New Approach Methodologies (NAMs) for Tobacco Harm Reduction: Synopsis from the 2021 CORESTA SSPT—NAMs Symposium

  2022cites this paper
• Alternative Methods for Skin-Sensitization Assessment

  2022cites this paper
• Decision making in next generation risk assessment for skin allergy: Using historical clinical experience to benchmark risk.

  2022cites this paper
• Improvements to in silico skin sensitisation predictions through privacy-preserving data sharing.

  2022cites this paper
• Application of AOPs to assist regulatory assessment of chemical risks – Case studies, needs and recommendations

  2022cites this paper
• SkinSensPred as a Promising in Silico Tool for Integrated Testing Strategy on Skin Sensitization

  2022cites this paper
• How to resolve inconclusive predictions from defined approaches for skin sensitisation in OECD Guideline No. 497.

  2022cites this paper
• A framework for establishing scientific confidence in new approach methodologies

  2022cites this paper
• A History of Regulatory Animal Testing: What Can We Learn?

  2022cites this paper
• Standardisation and international adoption of defined approaches for skin sensitisation

  2022cites this paper
• A development of a graph‐based ensemble machine learning model for skin sensitization hazard and potency assessment

  2022influential citation
• Characterization and Evaluation of Commercial Carboxymethyl Cellulose Potential as an Active Ingredient for Cosmetics

  2022cites this paper
• Co-Culture of THP-1 Cells and Normal Human Epidermal Keratinocytes (NHEK) for Modified Human Cell Line Activation Test (h-CLAT)

  2022cites this paper
• Development of a 96-Well Electrophilic Allergen Screening Assay for Skin Sensitization Using a Measurement Science Approach

  2022cites this paper
• Replacement of animal testing by integrated approaches to testing and assessment (IATA): a call for in vivitrosi

  2022cites this paper
• Application of Defined Approaches for Skin Sensitization to Agrochemical Products

  2022cites this paper
• Expansion of the Cosmetics Europe skin sensitisation database with new substances and PPRA data.

  2022cites this paper
• Implementation of a dermal sensitization threshold (DST) concept for risk assessment: structure-based DST and in vitro data-based DST

  2022influential citation
• Integrated skin sensitization assessment based on OECD methods (I): Deriving a point of departure for risk assessment.

  2022cites this paper
• Integrated skin sensitization assessment based on OECD methods (II): Hazard and potency by combining kinetic peptide reactivity and the "2 out of 3" Defined Approach.

  2022cites this paper
• Replacement

  2022cites this paper
• Skin Sensitization Testing: The Ascendancy of Non-Animal Methods

  2022cites this paper
• Amending the U-SENS™ skin sensitization test method for interfering auto-fluorescent chemicals.

  2022cites this paper
• Next generation risk assessment for skin allergy: Decision making using new approach methodologies.

  2022cites this paper
• Use of Lhasa Limited Products for the In Silico Prediction of Drug Toxicity.

  2022cites this paper
• Weight of Evidence Approach for Skin Sensitization Potency Categorization of Fragrance Ingredients

  2022cites this paper
• True Grit: A Story of Perseverance Making Two out of Three the First Non-Animal Testing Strategy (Adopted as OECD Guideline No. 497)

  2022cites this paper
• Benchmarking performance of SENS-IS assay against weight of evidence skin sensitization potency categories.

  2022cites this paper
• Probabilistic Risk Assessment – The Keystone for the Future of Toxicology

  2022cites this paper
• PreS/MD: Predictor of Sensitization hazard for chemical substances released from Medical Devices.

  2022cites this paper
• Assessment of the skin sensitization potential of fragrance ingredients using the U-SENS™ assay.

  2021cites this paper
• Development of novel alternative hair dyes to hazardous para-phenylenediamine.

  2021cites this paper
• TOXPANEL: A Gene-Set Analysis Tool to Assess Liver and Kidney Injuries

  2021cites this paper
• Beyond adverse outcome pathways: making toxicity predictions from event networks, SAR models, data and knowledge

  2021cites this paper
• Integration of data across toxicity endpoints for improved safety assessment of chemicals: the example of carcinogenicity assessment

  2021cites this paper
• Applying evidence-based methods to the development and use of adverse outcome pathways.

  2021cites this paper
• Next Generation Risk Assessment for Skin Sensitisation: A Case Study with Propyl Paraben.

  2021cites this paper
• Toxicity prediction based on artificial intelligence: A multidisciplinary overview

  2021cites this paper
• Implementation of the Principles of the 3Rs of Animal Testing at CDER: Past, Present and Future.

  2021cites this paper
• Beyond dermal exposure: The respiratory tract as a target organ in hazard assessments of cosmetic ingredients.

  2021cites this paper
• A convenient fluorometric test method for skin sensitization using glutathione in chemico

  2021cites this paper
• Laboratory Techniques for Identifying Causes of Allergic Dermatitis.

  2021cites this paper
• A triangular approach for the validation of new approach methods for skin sensitization.

  2021cites this paper