Emergence of Noise-Induced Oscillations in the Central Circadian Pacemaker

Computational modeling and experimentation explain how intercellular coupling and intracellular noise can generate oscillations in a mammalian neuronal network even in the absence of cell-autonomous oscillators.

• Publication year

  2010

• Venue

  PLoS Biology

• Publication date

  2010-10-01

• Fields of study

  Biology, Medicine, Physics, Computer Science

• Identifiers
  DOI 10.1371/journal.pbio.1000513PMID 20967239PMCID 2953532
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Circadian clock gene Bmal1 is not essential; functional replacement with its paralog, Bmal2.

  2010cited by this paper
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  2009cited by this paper
• Robust Food Anticipatory Activity in BMAL1-Deficient Mice

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• The methamphetamine-sensitive circadian oscillator does not employ canonical clock genes

  2009cited by this paper
• Daily rhythms of food-anticipatory behavioral activity do not require the known circadian clock

  2009cited by this paper
• Quantification of Circadian Rhythms in Single Cells

  2009cited by this paper
• The SCN‐independent clocks, methamphetamine and food restriction

  2009cited by this paper
• cAMP-Dependent Signaling as a Core Component of the Mammalian Circadian Pacemaker

  2008cited by this paper
• Synchrony and entrainment properties of robust circadian oscillators

  2008cited by this paper
• The genetics of mammalian circadian order and disorder: implications for physiology and disease

  2008cited by this paper
• Circadian Behavioral Rhythms in Cry1/Cry2 Double-Deficient Mice Induced by Methamphetamine

  2008cited by this paper
• Circadian mutant Overtime reveals F-box protein FBXL3 regulation of cryptochrome and period gene expression.

  2007influential reference
• Neurons and networks in daily rhythms

  2007cited by this paper
• Intercellular coupling confers robustness against mutations in the SCN circadian clock network.

  2007cited by this paper
• Synchrony Dynamics During Initiation, Failure, and Rescue of the Segmentation Clock

  2007cited by this paper
• The Per2 Negative Feedback Loop Sets the Period in the Mammalian Circadian Clock Mechanism

  2007cited by this paper
• Understanding circuit dynamics using the stomatogastric nervous system of lobsters and crabs.

  2007cited by this paper
• Reciprocity between phase shifts and amplitude changes in the mammalian circadian clock

  2007cited by this paper
• Synchronization-Induced Rhythmicity of Circadian Oscillators in the Suprachiasmatic Nucleus

  2007cited by this paper
• Modeling the Behavior of Coupled Cellular Circadian Oscillators in the Suprachiasmatic Nucleus

  2007cited by this paper
• Living with noisy genes: how cells function reliably with inherent variability in gene expression.

  2007cited by this paper
• Tunability and Noise Dependence in Differentiation Dynamics

  2007cited by this paper
• A molecular model for intercellular synchronization in the mammalian circadian clock.

  2007cited by this paper
• Gates and Oscillators II: Zeitgebers and the Network Model of the Brain Clock

  2007cited by this paper
• Cycling of CRYPTOCHROME proteins is not necessary for circadian-clock function in mammalian fibroblasts.

  2007cited by this paper
• Modeling the Electrophysiology of Suprachiasmatic Nucleus Neurons

  2007cited by this paper
• Coupling and internal noise sustain synchronized oscillation in calcium system.

  2007cited by this paper
• Circadian synchrony in networks of protein rhythm driven neurons

  2006cited by this paper
• Circadian rhythms and molecular noise.

  2006cited by this paper
• Feedback repression is required for mammalian circadian clock function

  2006cited by this paper
• Noise-resistant and synchronized oscillation of the segmentation clock

  2006cited by this paper
• GABA and Gi/o differentially control circadian rhythms and synchrony in clock neurons

  2006cited by this paper
• Rat pups and random robots generate similar self-organized and intentional behavior: Research Articles

  2006cited by this paper
• Modeling the VPAC2-activated cAMP/PKA signaling pathway: from receptor to circadian clock gene induction.

  2006cited by this paper
• An opposite role for tau in circadian rhythms revealed by mathematical modeling.

  2006cited by this paper
• Collective synchronization in populations of globally coupled phase oscillators with drifting frequencies.

  2005cited by this paper
• A functional analysis of circadian pacemakers in nocturnal rodents

  2005cited by this paper
• A GABAergic mechanism is necessary for coupling dissociable ventral and dorsal regional oscillators within the circadian clock.

  2005cited by this paper
• Stochasticity in gene expression: from theories to phenotypes

  2005cited by this paper
• Vasoactive intestinal polypeptide mediates circadian rhythmicity and synchrony in mammalian clock neurons

  2005cited by this paper
• Methods to record circadian rhythm wheel running activity in mice.

  2005influential reference
• Stochastic simulation of the mammalian circadian clock.

  2005influential reference
• Spontaneous synchronization of coupled circadian oscillators.

  2005cited by this paper
• Real-time reporting of circadian-regulated gene expression by luciferase imaging in plants and mammalian cells.

  2005cited by this paper
• Real-time luminescence reporting of circadian gene expression in mammals.

  2005cited by this paper
• Noise in Gene Expression: Origins, Consequences, and Control

  2005cited by this paper
• Mammalian circadian biology: elucidating genome-wide levels of temporal organization.

  2004cited by this paper
• Circadian gene expression in individual fibroblasts: cell-autonomous and self-sustained oscillators pass time to daughter cells.

  2004cited by this paper
• Modeling feedback loops of the Mammalian circadian oscillator.

  2004cited by this paper
• Bioluminescence imaging of individual fibroblasts reveals persistent, independently phased circadian rhythms of clock gene expression.

  2004cited by this paper
• Temporal Precision in the Mammalian Circadian System: A Reliable Clock from Less Reliable Neurons

  2004cited by this paper
• Modeling a synthetic multicellular clock: repressilators coupled by quorum sensing.

  2004cited by this paper
• INAUGURAL ARTICLE: PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues

  2004cited by this paper
• Simulation of circadian rhythm generation in the suprachiasmatic nucleus with locally coupled self-sustained oscillators.

  2003cited by this paper
• Synchronization of Cellular Clocks in the Suprachiasmatic Nucleus

  2003influential reference
• Stochastic models for circadian rhythms: effect of molecular noise on periodic and chaotic behaviour.

  2003cited by this paper
• A clockwork web: circadian timing in brain and periphery, in health and disease

  2003cited by this paper
• Toward a detailed computational model for the mammalian circadian clock

  2003cited by this paper
• A detailed predictive model of the mammalian circadian clock

  2003influential reference
• Regulation of inhibitory synaptic transmission by vasoactive intestinal peptide (VIP) in the mouse suprachiasmatic nucleus.

  2003cited by this paper
• Intercellular coupling mechanism for synchronized and noise-resistant circadian oscillators.

  2002cited by this paper
• Mechanisms of noise-resistance in genetic oscillators

  2002cited by this paper
• Modeling rhythmic interlimb coordination: beyond the Haken-Kelso-Bunz model.

  2002cited by this paper
• Response Element-binding Protein ( CREB )-dependent Activation of Per 1 Is Required for Light-induced Signaling in the Suprachiasmatic Nucleus Circadian Clock

  2002cited by this paper
• Robustness of circadian rhythms with respect to molecular noise

  2002cited by this paper
• Exploring complex networks

  2001cited by this paper
• Posttranslational mechanisms regulate the mammalian circadian clock.

  2001influential reference
• Biological rhythms: Circadian clocks limited by noise

  2000cited by this paper
• A synthetic oscillatory network of transcriptional regulators

  2000cited by this paper
• Mop3 is an essential component of the master circadian pacemaker in mammals.

  2000influential reference
• mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop.

  1999cited by this paper
• Role of the CLOCK protein in the mammalian circadian mechanism.

  1998cited by this paper
• Positional cloning of the mouse circadian clock gene.

  1997cited by this paper
• Cellular construction of a circadian clock: period determination in the suprachiasmatic nuclei.

  1997cited by this paper
• Individual neurons dissociated from rat suprachiasmatic nucleus express independently phased circadian firing rhythms.

  1995cited by this paper
• Mathematical Models of the Circadian Sleep-Wake Cycle.

  1984cited by this paper
• Role of the suprachiasmatic nuclei in the circadian system of the house sparrow, Passer domesticus

  1982cited by this paper
• Topics in the Theory of Random Noise

  1969cited by this paper
• Topics in the theory of random noise

  1967cited by this paper
• Biological rhythms and the behavior of populations of coupled oscillators.

  1967cited by this paper

• Sinusoidal regulation reduces circadian period variability

  2025cites this paper
• A novel circadian behavior rhythm in arrhythmic Period triple knockout mice revealed by constant light exposure

  2025cites this paper
• Bmal1 Modulates Striatal cAMP Signaling and Motor Learning

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• The suprachiasmatic nucleus at 50: looking back, then looking forward

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• Rhythms in lipid droplet content driven by a metabolic oscillator are conserved throughout evolution

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• Maternal dietary fat during lactation shapes single nucleus transcriptomic profile of postnatal offspring hypothalamus in a sexually dimorphic manner in mice

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• The clock in growing hyphae and their synchronization in Neurospora crassa

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• Functional interactions between neurotransmitters and neuropeptides in regulating suprachiasmatic nucleus function and circadian rhythms

  2024cites this paper
• Coupling allows robust mammalian redox circadian rhythms despite heterogeneity and noise

  2024cites this paper
• Effects of external stimuli on the dynamics of deterministic and stochastic Hindmarsh–Rose neuron models

  2024cites this paper
• Circadian rhythms in the blood–brain barrier: impact on neurological disorders and stress responses

  2023cites this paper
• Cascade-enhanced transport efficiency of biochemical systems.

  2023cites this paper
• Coupling allows robust redox circadian rhythms despite heterogeneity and noise

  2023cites this paper
• Network-driven intracellular cAMP coordinates circadian rhythm in the suprachiasmatic nucleus

  2023cites this paper
• Improved estimation for energy dissipation in biochemical oscillations.

  2022cites this paper
• Cryptochrome 1 as a state variable of the circadian clockwork of the suprachiasmatic nucleus: Evidence from translational switching

  2022cites this paper
• The macroscopic limit to synchronization of cellular clocks in single cells of Neurospora crassa

  2022cites this paper
• Noise-induced stabilization of the FitzHugh-Nagumo neuron dynamics: Multistability and transient chaos.

  2022cites this paper
• Extensive Soma-Soma Plate-Like Contact Sites (Ephapses) Connect Suprachiasmatic Nucleus Neurons

  2022cites this paper
• Seasonal changes in day length induce multisynaptic neurotransmitter switching to regulate hypothalamic network activity and behavior

  2022cites this paper
• Deterministic coherence resonance analysis of coupled chaotic oscillators: fractional approach

  2022cites this paper
• Time-keeping and decision-making in living cells: Part I

  2022cites this paper
• Can the clocks tick together despite the noise? Stochastic simulations and analysis

  2022cites this paper
• Intercellular coupling between peripheral circadian oscillators by TGF-β signaling

  2021cites this paper
• The Circadian Clock Gene, Bmal1, Regulates Intestinal Stem Cell Signaling and Represses Tumor Initiation

  2021cites this paper
• CHRONO and DEC1/DEC2 compensate for lack of CRY1/CRY2 in expression of coherent circadian rhythm but not in generation of circadian oscillation in the neonatal mouse SCN

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• Cut the noise or couple up: Coordinating circadian and synthetic clocks

  2021cites this paper
• Nested calcium dynamics support daily cell unity and diversity in the suprachiasmatic nuclei of free-behaving mice

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• Cell–cell coupling and DNA methylation abnormal phenotypes in the after-hours mice

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• A spatio-temporal model to reveal oscillator phenotypes in molecular clocks: Parameter estimation elucidates circadian gene transcription dynamics in single-cells

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• Modelling the functional roles of synaptic and extra-synaptic γ-aminobutyric acid receptor dynamics in circadian timekeeping

  2021cites this paper
• The asymmetric particle population density method for simulation of coupled noisy oscillators

  2021cites this paper
• Introduction to the Clock System.

  2021cites this paper
• Comment on “Circadian rhythms in the absence of the clock gene Bmal1”

  2021cites this paper
• Likelihood-free nested sampling for parameter inference of biochemical reaction networks

  2020cites this paper
• Noise induces oscillation in the two weakly coupled subgroups of the suprachiasmatic nucleus

  2020cites this paper
• The Cell-Autonomous Clock of VIP Receptor VPAC2 Cells Regulates Period and Coherence of Circadian Behavior

  2020cites this paper
• Small protein number effects in stochastic models of autoregulated bursty gene expression.

  2020cites this paper
• Identifying a stochastic clock network with light entrainment for single cells of Neurosporacrassa

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• Dual-Color Single-Cell Imaging of the Suprachiasmatic Nucleus Reveals a Circadian Role in Network Synchrony.

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• Photoperiod-Induced Neurotransmitter Switching in the Circadian Pacemaker Regulates Hypothalamic Dopamine Expression

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• Systems Level Understanding of Circadian Integration with Cell Physiology.

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• The cell-autonomous clock of VIP receptor VPAC2 cells drives circadian behaviour

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• Mechanisms of circadian clock interactions with aryl hydrocarbon receptor signalling

  2020cites this paper
• Noise-driven cellular heterogeneity in circadian periodicity

  2020cites this paper
• Epigenetic inheritance of circadian period in clonal cells

  2020cites this paper
• Role of biological rhythms in the interpretation of clinical laboratory results. Basic concepts.

  2020cites this paper
• Entrainment range affected by the difference in sensitivity to light-information between two groups of SCN neurons

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  2020cites this paper
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• Chemical modulation of circadian rhythms and assessment of cellular behavior via indirubin and derivatives.

  2020cites this paper
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  2020cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
• Sleep and Orofacial Pain: Physiological Interactions and Clinical Management

  2019cites this paper
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  2018cites this paper
• Periodicity induced by noise and interaction in the kinetic mean-field FitzHugh–Nagumo model

  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
• Emergence of collective oscillations in adaptive cells

  2018cites this paper
• Network Dynamics Mediate Circadian Clock Plasticity.

  2017cites this paper
• Clock-Enhancing Small Molecules and Potential Applications in Chronic Diseases and Aging

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  2017cites this paper
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• Evaluating the Autonomy of the Drosophila Circadian Clock in Dissociated Neuronal Culture

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  2016cites this paper
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  2016cites this paper
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  2016cites this paper