We demonstrate an attractive nanomachine "capture and transport" target isolation strategy based on molecularly imprinted polymers (MIPs). MIP-based catalytic microtubular engines are prepared by electropolymerization of the outer polymeric layer in the presence of the target analyte (template). Tailor-made selective artificial recognition sites are thus introduced into the tubular microtransporters through complementary nanocavities in the outer polymeric layer. The new microtransporter concept is illustrated using bilayer poly(3,4-ethylenedioxythiophene) (PEDOT)/Pt-Ni microengines and fluorescein isothiocyanate (FITC)-labeled avidin (Av-FITC) as the template. The avidin-imprinted polymeric layer selectively concentrates the fluorescent-tagged protein target onto the moving microengine without the need for additional external functionalization, allowing "on-the-fly" extraction and isolation of Av-FITC from raw serum and saliva samples along with real-time visualization of the protein loading and transport. The new micromachine-MIP-based target isolation strategy can be extended to the capture and transport of other important target molecules, leading toward diverse biomedical and environmental applications.
Molecularly imprinted polymer-based catalytic micromotors for selective protein transport.
Jahir Orozco,A. Cortés,Guanzhi Cheng,Sirilak Sattayasamitsathit,W. Gao,Xiaomiao Feng,Yufeng Shen,Joseph Wang
Published 2013 in Journal of the American Chemical Society
ABSTRACT
PUBLICATION RECORD
- Publication year
2013
- Venue
Journal of the American Chemical Society
- Publication date
2013-03-28
- Fields of study
Medicine, Materials Science, Chemistry, Engineering
- Identifiers
- External record
- Source metadata
Semantic Scholar, PubMed
CITATION MAP
EXTRACTION MAP
CLAIMS
- No claims are published for this paper.
CONCEPTS
- No concepts are published for this paper.
REFERENCES
Showing 1-33 of 33 references · Page 1 of 1