Use-Dependent Hemispheric Balance

In the human brain, homologous regions of the primary motor cortices (M1s) are connected through transcallosal fibers. Interhemispheric communication between the two M1s plays a major role in the control of unimanual hand movements, and the strength of this connection seems to be dependent on arm activity. For instance, a lesion in the M1 can induce an increase in the excitability of the intact M1 and an abnormal high inhibitory influence onto the damaged M1. This can be attributable to either the disuse of the affected limb or the overuse of the unaffected one. Here, to directly investigate cortical modifications induced by an abnormal asymmetric use of the two limbs, we studied both the excitability of the two M1s and transcallosal interaction between them in healthy subjects whose right hand was immobilized for 10 h. The left “not-immobilized” arm was completely free to move in one group of participants (G1) and limited in the other one (G2). We found that the non-use reduced the excitability of the left M1 and decreased the inhibitory influence onto the right hemisphere in the two groups. However, an increase in the excitability of right M1 and a deeper inhibitory interaction onto the left hemisphere were evident only in G1. Thus, modifications in the right M1 were not directly produced by the non-use but would depend on the overuse of the “not-immobilized” arm. Our findings suggest that the balance between the two M1s is strongly use dependent.

• Publication year

  2011

• Venue

  Journal of Neuroscience

• Publication date

  2011-03-02

• Fields of study

  Biology, Medicine, Psychology

• Identifiers
  DOI 10.1523/JNEUROSCI.4893-10.2011PMID 21368053PMCID PMC6623942
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2009cited by this paper
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  2008influential reference
• 1‐Hz repetitive TMS over ipsilateral motor cortex influences the performance of sequential finger movements of different complexity

  2008cited by this paper
• Human Motor Corpus Callosum: Topography, Somatotopy, and Link between Microstructure and Function

  2007cited by this paper
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  2007cited by this paper
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  2006influential reference
• Transcallosal sensorimotor integration: effects of sensory input on cortical projections to the contralateral hand.

  2006cited by this paper
• Non-invasive brain stimulation: a new strategy to improve neurorehabilitation after stroke?

  2006cited by this paper
• Effect of low-frequency repetitive transcranial magnetic stimulation on interhemispheric inhibition.

  2005influential reference
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  2004cited by this paper
• Modulation of motor cortex excitability after upper limb immobilization.

  2004cited by this paper
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  2004cited by this paper
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  2002cited by this paper
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  2002cited by this paper
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  2002influential reference
• Enhanced tactile spatial acuity and cortical processing during acute hand deafferentation

  2002cited by this paper
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  2001influential reference
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  2001cited by this paper
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  2000cited by this paper
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  2000cited by this paper
• Compendium of physical activities: an update of activity codes and MET intensities.

  2000influential reference
• Mechanisms of Deafferentation-Induced Plasticity in Human Motor Cortex

  1998cited by this paper
• Motor cortex plasticity during constraint-induced movement therapy in stroke patients.

  1998cited by this paper
• Reversible changes of motor cortical outputs following immobilization of the upper limb.

  1997cited by this paper
• Changes of cortical motor area size during immobilization.

  1995cited by this paper
• The effect of magnetic coil orientation on the latency of surface EMG and single motor unit responses in the first dorsal interosseous muscle.

  1994cited by this paper
• The relationship between human long-latency somatosensory evoked potentials recorded from the cortical surface and from the scalp.

  1992cited by this paper
• Interhemispheric inhibition of the human motor cortex.

  1992cited by this paper
• The organization of behavior.

  1992cited by this paper
• Commissural projections of the cortical hand motor area in monkeys

  1979cited by this paper
• Inputs from low threshold muscle and cutaneous afferents of hand and forearm to areas 3a and 3b of baboon's cerebral cortex.

  1976cited by this paper
• The responses of human muscle spindle endings to vibration of non‐contracting muscles.

  1976cited by this paper
• Responses of cortical neurons (areas 3a and 4) to ramp stretch of hindlimb muscles in the baboon.

  1976cited by this paper
• The assessment and analysis of handedness: the Edinburgh inventory.

  1971cited by this paper
• Effects of transcallosal volleys on pyramidal tract cell activity of cat.

  1962cited by this paper

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