Cloning and Functional Expression of Rat CLC-5, a Chloride Channel Related to Kidney Disease (*)

No abstract is available for this paper.

• Publication year

  1995

• Venue

  Journal of Biological Chemistry

• Publication date

  1995-12-29

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1074/JBC.270.52.31172PMID 8537381
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Characterization of carrier females and affected males with X-linked recessive nephrolithiasis

  1996cited by this paper
• Induction of endogenous channels by high levels of heterologous membrane proteins in Xenopus oocytes.

  1995cited by this paper
• Gating of the voltage-dependent chloride channel CIC-0 by the permeant anion

  1995cited by this paper
• Transcription factors and aldolase B gene expression in microdissected renal proximal tubules and derived cell lines.

  1995cited by this paper
• Properties of voltage‐gated chloride channels of the ClC gene family.

  1995cited by this paper
• Characterization of a human and murine gene (CLCN3) sharing similarities to voltage-gated chloride channels and to a yeast integral membrane protein.

  1995cited by this paper
• Heteromeric olfactory cyclic nucleotide-gated channels: a subunit that confers increased sensitivity to cAMP.

  1994cited by this paper
• Molecular physiology of anion channels.

  1994cited by this paper
• Two highly homologous members of the ClC chloride channel family in both rat and human kidney.

  1994cited by this paper
• Systematic sequencing of the Escherichia coli genome: analysis of the 2.4-4.1 min (110,917-193,643 bp) region.

  1994cited by this paper
• A second subunit of the olfactory cyclic nucleotide-gated channel confers high sensitivity to cAMP.

  1994cited by this paper
• A gene from the Xp22.3 region shares homology with voltage-gated chloride channels.

  1994cited by this paper
• Purification, reconstitution, and subunit composition of a voltage-gated chloride channel from Torpedo electroplax.

  1994cited by this paper
• Isolation and partial characterization of a chloride channel gene which is expressed in kidney and is a candidate for Dent's disease (an X-linked hereditary nephrolithiasis).

  1994cited by this paper
• Cloning and expression of a protein kinase C-regulated chloride channel abundantly expressed in rat brain neuronal cells.

  1994cited by this paper
• Multimeric structure of ClC‐1 chloride channel revealed by mutations in dominant myotonia congenita (Thomsen).

  1994cited by this paper
• Role of F-actin in the activation of Na+-K+-Cl− cotransport by forskolin and vasopressin in mouse kidney cultured thick ascending limb cells

  1994cited by this paper
• A new subunit of the cyclic nucleotide-gated cation channel in retinal rods

  1993cited by this paper
• Whole-cell currents in single and confluent M-1 mouse cortical collecting duct cells

  1993cited by this paper
• The GEF1 gene of Saccharomyces cerevisiae encodes an integral membrane protein; mutations in which have effects on respiration and iron-limited growth

  1993cited by this paper
• Molecular cloning of a chloride channel that is regulated by dehydration and expressed predominantly in kidney medulla.

  1993cited by this paper
• Regions involved in the opening of CIC-2 chloride channel by voltage and cell volume

  1992cited by this paper
• A chloride channel widely expressed in epithelial and non-epithelial cells

  1992cited by this paper
• Cl− channels in basolateral renal medullary membrane vesicles: IV. Analogous channel activation by Cl− or cAMP-dependent protein kinase

  1991cited by this paper
• Primary structure and functional expression of a developmentally regulated skeletal muscle chloride channel

  1991cited by this paper
• cAMP-activated chloride channel in the basolateral membrane of the thick ascending limb of the mouse kidney

  1990cited by this paper
• Endocytosis and lysosomal hydrolysis of proteins in proximal tubules.

  1990cited by this paper
• Ion channels in the thick ascending limb of Henle's loop.

  1990cited by this paper
• Primary structure of Torpedo marmorata chloride channel isolated by expression cloning in Xenopus oocytes

  1990cited by this paper
• Acidification of the endocytic and exocytic pathways.

  1986cited by this paper
• Functional messenger RNAs are produced by SP6 in vitro transcription of cloned cDNAs.

  1984cited by this paper
• Distribution of hexokinase and phosphoenolpyruvate carboxykinase along the rabbit nephron.

  1981cited by this paper
• Electrical properties of amphibian urinary bladder epithelia

  1977cited by this paper

• Feasibility of multimodal magnetic resonance imaging to assess maternal hyperoxygenation in sheep pregnancy

  2025cites this paper
• Endosomal chloride/proton exchangers need inhibitory TMEM9 β-subunits for regulation and prevention of disease-causing overactivity

  2025cites this paper
• TMEM9 and SEC22B interact with ClC-5 to shape renal proximal tubule function and Dent’s Disease type I pathogenesis

  2025cites this paper
• Drosophila ClC-c Is a Homolog of Human CLC-5 and a New Model for Dent Disease Type 1

  2024cites this paper
• ClC-5 knockout mitigates angiotensin II-induced hypertension and endothelial dysfunction.

  2024cites this paper
• Molecular Dynamics Investigation of the Influenza Hemagglutinin Conformational Changes in Acidic pH

  2024cites this paper
• TMEM9B Regulates Endosomal ClC-3 and ClC-4 Transporters

  2024cites this paper
• Characterization of pre-mRNA Splicing Defects Caused by CLCN5 and OCRL Mutations and Identification of Novel Variants Associated with Dent Disease

  2023cites this paper
• Biophysical Aspects of Neurodegenerative and Neurodevelopmental Disorders Involving Endo-/Lysosomal CLC Cl−/H+ Antiporters

  2023cites this paper
• 11C-Labeled Radiotracer for Noninvasive and Quantitative Assessment of the Thiocyanate Efflux System in the Brain.

  2022cites this paper
• Lentiviral vector mediated gene therapy for type I Dent disease ameliorates Dent disease-like phenotypes for three months in ClC-5 null mice

  2022cites this paper
• Altered voltage‐dependence of slowly activating chloride‐proton antiport by late endosomal ClC‐6 explains distinct neurological disorders

  2022cites this paper
• Low Chloride–Regulated ClC-5 Contributes to Arterial Smooth Muscle Cell Proliferation and Cerebrovascular Remodeling

  2022cites this paper
• Determinants, Maintenance and Function of Organellar pH.

  2022cites this paper
• Ion channels as a therapeutic target for renal fibrosis

  2022influential citation
• Backbone amides are determinants of Cl− selectivity in CLC ion channels

  2022cites this paper
• Placental MRI Predicts Fetal Oxygenation and Growth Rates in Sheep and Human Pregnancy

  2022cites this paper
• Abundant Monovalent Ions as Environmental Signposts for Pathogens during Host Colonization

  2021cites this paper
• Novel Dent disease 1 cellular models reveal biological processes underlying ClC-5 loss-of-function

  2021cites this paper
• Neurodegeneration Upon Dysfunction of Endosomal/Lysosomal CLC Chloride Transporters

  2021cites this paper
• Remote ischemic postconditioning for neuroprotection after newborn hypoxia–ischemia: systematic review of preclinical studies

  2021cites this paper
• Global gene-expression analysis reveals the molecular processes underlying ClC-5 loss-of-function in novel Dent Disease 1 cellular models

  2020cites this paper
• Uncoupling endosomal CLC chloride/proton exchange causes severe neurodegeneration

  2020cites this paper
• Diversity of functional alterations of the ClC‐5 exchanger in the region of the proton glutamate in patients with Dent disease 1

  2020cites this paper
• The Role of the Endosomal Chloride/Proton Antiporter ClC-5 in Proximal Tubule Endocytosis and Kidney Physiology

  2020cites this paper
• A Recurrent Gain-of-Function Mutation in CLCN6, Encoding the ClC-6 Cl-/H+-Exchanger, Causes Early-Onset Neurodegeneration.

  2020cites this paper
• 6-[124I]Iodo-9-pentylpurine for imaging the activity of the sodium iodide symporter in the brain.

  2020cites this paper
• Divergent Cl- and H+ pathways underlie transport coupling and gating in CLC exchangers and channels

  2020cites this paper
• From protein uptake to Dent disease: an overview of the CLCN5 gene.

  2020cites this paper
• Mutations in an intracellular vestibule that bifurcates from the pore of ClC-1 chloride ion channels affect anion permeation

  2020cites this paper
• Cystic fibrosis from genotype to phenotype: review article

  2020cites this paper
• Characterizing chloride-dependent acidification in brain clathrin-coated vesicles 1.

  2019cites this paper
• Properties of single-channel and whole cell Cl- currents in guinea pig detrusor smooth muscle cells.

  2019cites this paper
• Extracellular pH and Intracellular Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) Control Cl- Currents in Guinea Pig Detrusor Smooth Muscle Cells.

  2019cites this paper
• Divergent Cl− and H+ pathways underlie transport coupling and gating in CLC exchangers and channels

  2019cites this paper
• Cl− and H+ coupling properties and subcellular localizations of wildtype and disease-associated variants of the voltage-gated Cl−/H+ exchanger ClC-5

  2019cites this paper
• Channels and Transporters in Cell Signaling Properties of single-channel and whole cell Cl (cid:2) currents in guinea pig detrusor smooth muscle cells

  2019influential citation
• A novel CLCN5 pathogenic mutation supports Dent disease with normal endosomal acidification

  2018cites this paper
• Identification of Chloride Channels CLCN3 and CLCN5 Mediating the Excitatory Cl− Currents Activated by Sphingosine-1-Phosphate in Sensory Neurons

  2018cites this paper
• CLC Chloride Channels and Transporters: Structure, Function, Physiology, and Disease.

  2018cites this paper
• The signaling role for chloride in the bidirectional communication between neurons and astrocytes.

  2018cites this paper
• Modulation of ClC‐3 gating and proton/anion exchange by internal and external protons and the anion selectivity filter

  2018cites this paper
• Genetic Analysis of Dent's Disease and Functional Research of CLCN5 Mutations

  2017cites this paper
• Functional coupling of V-ATPase and CLC-5

  2017cites this paper
• ClC Channels and Transporters: Structure, Physiological Functions, and Implications in Human Chloride Channelopathies

  2017influential citation
• Trans reentrant loop structures in secondary transporters

  2017cites this paper
• respiratory epithelia ClC-5: ontogeny of an alternative chloride channel in

  2016cites this paper
• Fluorescent Visualization of Cellular Proton Fluxes.

  2016cites this paper
• kidneyregulates expression of ClC-5 chloride channel in the

  2016cites this paper
• A pure chloride channel mutant of CLC-5 causes Dent’s disease via insufficient V-ATPase activation

  2016cites this paper
• HPAFhuman pancreatic duct adenocarcinoma cell line Characterization of vectorial chloride transport pathways

  2016cites this paper
• Chapter Five - Ubiquitination of Ion Channels and Transporters.

  2016cites this paper
• Common gating of both CLC subunits underlies voltage-dependent activation of the 2 Cl-/ 1 H +-exchanger ClC-7 / Ostm

  2016cites this paper
• Regulatory–auxiliary subunits of CLC chloride channel–transport proteins

  2015cites this paper
• ClC-5: Physiological role and biophysical mechanisms.

  2015influential citation
• Discovery of CLC transport proteins: cloning, structure, function and pathophysiology

  2015influential citation
• A tale of two CLCs: biophysical insights toward understanding ClC‐5 and ClC‐7 function in endosomes and lysosomes

  2015cites this paper
• Caractérisation des canaux potassiques du tubule contourné proximal et des propriétés régulatrices des canaux chlorure de la membrane basolatérale des cellules intercalaires du tubule connecteur

  2015cites this paper
• Rab27a GTPase modulates L-type Ca2+ channel function via interaction with the II-III linker of CaV1.3 subunit.

  2015cites this paper
• The Na+/I- symporter (NIS): mechanism and medical impact.

  2014cites this paper
• Complexity of the 5′UTR region of the CLCN5 gene: eleven 5′UTR ends are differentially expressed in the human kidney

  2014cites this paper
• Ostm 1 Exchanger + / 1 H − Activation of the 2 Cl Subunits Underlies Voltage-dependent Common Gating of Both CLC Transporter Membrane Biology :

  2013cites this paper
• Common Gating of Both CLC Transporter Subunits Underlies Voltage-dependent Activation of the 2Cl−/1H+ Exchanger ClC-7/Ostm1*

  2013cites this paper
• Cl− channels in smooth muscle cells

  2013cites this paper
• A single point mutation reveals gating of the human ClC-5 Cl−/H+ antiporter

  2013cites this paper
• Functional coupling of chloride–proton exchanger ClC-5 to gastric H+,K+-ATPase

  2013cites this paper
• Characterization of an outward rectifying chloride current of Xenopus tropicalis oocytes.

  2013cites this paper
• Changing expression of chloride channels during preimplantation mouse development.

  2013cites this paper
• Characterization of Disease-causing Mutations in the Chloride-Proton Antiporter ClC-5

  2013cites this paper
• Chloride in vesicular trafficking and function.

  2013cites this paper
• Genetics and Pathophysiology of Cystic Fibrosis

  2012cites this paper
• Analyse fonctionnelle de nouvelles mutations pathogènes du canal chlorure CLC-KB impliquées dans le syndrome de Bartter

  2012cites this paper
• Trans reentrant loop structures in secondary transporters

  2012cites this paper
• On the mechanism of gating charge movement of ClC-5, a human Cl(-)/H(+) antiporter.

  2012cites this paper
• Cell biology and physiology of CLC chloride channels and transporters.

  2012influential citation
• Dent’s disease: clinical features and molecular basis

  2011cites this paper
• Thyroid iodide efflux: a team effort?

  2011cites this paper
• ClC-5 mutations associated with Dent’s disease: a major role of the dimer interface

  2011cites this paper
• Expression and Localization of CLC Chloride Transport Proteins in the Avian Retina

  2011cites this paper
• Heterogeneity in the processing of CLCN5 mutants related to Dent disease

  2011cites this paper
• Anion- and proton-dependent gating of ClC-4 anion/proton transporter under uncoupling conditions.

  2011cites this paper
• Extracellular Determinants of Anion Discrimination of the Cl−/H+ Antiporter Protein CLC-5*

  2011cites this paper
• Secretory Carrier Membrane Protein 2 Regulates Exocytic Insertion of NKCC2 into the Cell Membrane*

  2011cites this paper
• ClC‐7 is a slowly voltage‐gated 2Cl−/1H+‐exchanger and requires Ostm1 for transport activity

  2011cites this paper
• Voltage-dependent charge movement associated with activation of the CLC-5 2Cl−/1H+ exchanger

  2010cites this paper
• Role of ClC-5 in Renal Endocytosis Is Unique among ClC Exchangers and Does Not Require PY-motif-dependent Ubiquitylation*

  2010cites this paper
• Lysosomal Pathology and Osteopetrosis upon Loss of H+-Driven Lysosomal Cl– Accumulation

  2010cites this paper
• Sorting Motifs of the Endosomal/Lysosomal CLC Chloride Transporters*

  2010cites this paper
• functional expression ClC-type chloride channels: novel variants and Transporter Function. Caenorhabditis elegans Model Organisms: New Insights: Into Ion Channel and

  2010cites this paper
• Die hyperosmolaritätsvermittelte Induktion des nierenspezifischen Chloridkanals CLC-K1 und seiner Untereinheit Barttin wird durch die Serum und Glukokortikoid induzierbare Kinase 1 und das Tonicity-responsive Enhancer Binding Protein reguliert

  2010cites this paper
• Structure of a Eukaryotic CLC Transporter Defines an Intermediate State in the Transport Cycle

  2010cites this paper
• Proton block of the CLC-5 Cl−/H+ exchanger

  2010cites this paper
• CLC-b-mediated NO-3/H+ exchange across the tonoplast of Arabidopsis vacuoles.

  2010cites this paper
• The Late Endosomal ClC-6 Mediates Proton/Chloride Countertransport in Heterologous Plasma Membrane Expression*

  2010cites this paper
• The G215R Mutation in the Cl−/H+-Antiporter ClC-7 Found in ADO II Osteopetrosis Does Not Abolish Function but Causes a Severe Trafficking Defect

  2010cites this paper
• Osteogenic role of endosomal chloride channels in MC3T3-E1 cells

  2010cites this paper
• Chloride channelopathies.

  2009cites this paper
• The CLC Family of Chloride Channels and Transporters

  2009cites this paper
• Physiological roles of CLC Cl−/H+ exchangers in renal proximal tubules

  2009cites this paper
• Residues Important for Nitrate/Proton Coupling in Plant and Mammalian CLC Transporters*

  2009cites this paper