Nociceptive neurons regulate innate and adaptive immunity and neuropathic pain through MyD88 adapter

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Cell Research

• Publication date

  2014-08-12

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/cr.2014.106PMID 25112711PMCID PMC4220153
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Emerging targets in neuroinflammation-driven chronic pain

  2014cited by this paper
• Extracellular microRNAs activate nociceptor neurons to elicit pain via TLR7 and TRPA1.

  2014cited by this paper
• Nociceptive Sensory Neurons Drive Interleukin-23 Mediated Psoriasiform Skin Inflammation

  2014cited by this paper
• Toll-like receptor 4 signaling contributes to Paclitaxel-induced peripheral neuropathy.

  2014cited by this paper
• Bacteria activate sensory neurons that modulate pain and inflammation

  2013cited by this paper
• Paclitaxel‐induced neuropathic pain is age dependent and devolves on glial response

  2013cited by this paper
• Neurogenic inflammation and the peripheral nervous system in host defense and immunopathology

  2012cited by this paper
• Nav1.8 expression is not restricted to nociceptors in mouse peripheral nervous system

  2012cited by this paper
• TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice.

  2012cited by this paper
• Emerging role of Toll-like receptors in the control of pain and itch

  2012cited by this paper
• Toll-like receptor 2/MyD88 signaling mediates zymosan-induced joint hypernociception in mice: participation of TNF-α, IL-1β and CXCL1/KC.

  2012cited by this paper
• The role of TLR2 in nerve injury‐induced neuropathic pain is essentially mediated through macrophages in peripheral inflammatory response

  2011cited by this paper
• Toll-like receptor 7 mediates pruritus

  2010cited by this paper
• T-Cell Infiltration and Signaling in the Adult Dorsal Spinal Cord Is a Major Contributor to Neuropathic Pain-Like Hypersensitivity

  2009cited by this paper
• Neural regulation of innate immunity: a coordinated nonspecific host response to pathogens

  2006cited by this paper

• T cells modulate the development and maintenance of painful paclitaxel-induced peripheral neuropathy in RNU rats

  2026cites this paper
• Spinal overexpression of CAPN1 in CaMKII neurons mediates paclitaxel-induced neuropathic pain via NCS-1-TRPV4 signaling

  2026cites this paper
• CtBP1–LSD1 complex drives ErbB2 activation via H3K9me2 demethylation in DRGs during paclitaxel-induced neuropathic pain

  2025cites this paper
• Leukocyte-intrinsic ER stress responses contribute to chemotherapy-induced peripheral neuropathy.

  2025cites this paper
• 外周神经在创面修复中的作用研究进展

  2025cites this paper
• Baicalein Alleviates Neuropathic Pain by Inhibiting Microglial Activation and Inflammation Via the TLR4/NF- κ B p65 Pathway

  2025cites this paper
• Endothelin A receptor in nociceptors is essential for persistent mechanical pain in a chronic pancreatitis of mouse model

  2025cites this paper
• Mechanism-based nonopioid analgesic targets

  2025cites this paper
• Neuroimmune Pain and Its Manipulation by Pathogens

  2025cites this paper
• CRMP2 phosphorylation regulates polarization and spinal infiltration of CD4+ T lymphocytes, inhibits spinal glial activation, and arthritic pain

  2025cites this paper
• Causal Impact of Immune Phenotypes on Herpes Zoster and Postherpetic Neuralgia: Insights from Mendelian Randomization Analysis

  2025cites this paper
• Autistic-like behaviors and impaired chronic inflammatory pain in primary nociceptive neuron-specific deletion of Mecp2 or Fmr1 knockout male mice.

  2025cites this paper
• Geranyl hydroquinone alleviates rheumatoid arthritis-associated pain by suppressing neutrophil accumulation, N1 polarization and ROS production in mice

  2025cites this paper
• Myeloid Differentiation Primary Response Protein 88: An Important Therapeutic Target for Chronic Pain

  2025cites this paper
• The Role of Central Sensitization in Autoimmune Connective Tissue Diseases: A Comparative Cross‐Sectional Study

  2025cites this paper
• Role of microbiota in pain: From bench to bedside

  2025cites this paper
• Schwann cell Lrp1 deletion drives trigeminal neuron sensitization and orofacial pain by modulating mitochondrial function and TRPV1/TRPA1 activity

  2025cites this paper
• Immune drivers of pain resolution and protection

  2024cites this paper
• Trends and hotspots in burns-related pain research: A bibliometric analysis.

  2024cites this paper
• Increased keratinocyte activity and PIEZO1 signaling contribute to paclitaxel-induced mechanical hypersensitivity.

  2024cites this paper
• Exploring neuroinflammation: A key driver in neuropathic pain disorders.

  2024cites this paper
• The role of immunity in comorbid pain and depression

  2024cites this paper
• Interplay between cannabinoids and the neuroimmune system in migraine

  2024cites this paper
• Targeting dorsal root ganglia for chemotherapy-induced peripheral neuropathy: from bench to bedside

  2024cites this paper
• A chemogenetic screen reveals that Trpv1-expressing neurons control regulatory T cells in the gut

  2024cites this paper
• Targeting Microglial Immunoproteasome: A Novel Approach in Neuroinflammatory-Related Disorders

  2024cites this paper
• Genetically predicted immune cells mediate the association between gut microbiota and neuropathy pain

  2024cites this paper
• PD-L1/PD-1 pathway: a potential neuroimmune target for pain relief

  2024cites this paper
• Expression of MHC II in DRG neurons attenuates paclitaxel-induced cold hypersensitivity in male and female mice

  2024cites this paper
• Impact of inflammation and Treg cell regulation on neuropathic pain in spinal cord injury: mechanisms and therapeutic prospects

  2024cites this paper
• Inducible co-stimulatory molecule (ICOS) alleviates paclitaxel-induced neuropathic pain via an IL-10-mediated mechanism in female mice

  2023cites this paper
• Optogenetic Activation of Peripheral Somatosensory Neurons in Transgenic Mice as a Neuropathic Pain Model for Assessing the Therapeutic Efficacy of Analgesics.

  2023cites this paper
• Macrophages and microglia in inflammation and neuroinflammation underlying different pain states

  2023cites this paper
• Complement Receptor C3aR1 Contributes to Paclitaxel-Induced Peripheral Neuropathic Pain in Mice and Rats.

  2023cites this paper
• Differential Effects of Regulatory T Cells in the Meninges and Spinal Cord of Male and Female Mice with Neuropathic Pain

  2023cites this paper
• The Role of Neuroinflammation in Complex Regional Pain Syndrome: A Comprehensive Review

  2023cites this paper
• Ropivacaine Promotes Axon Regeneration by Regulating Nav1.8-mediated Macrophage Signaling after Sciatic Nerve Injury in Rats

  2023cites this paper
• Immunotherapies in chronic pain through modulation of neuroimmune interactions.

  2023cites this paper
• Neuroimmune Mechanisms Underlying Post-acute Sequelae of SARS-CoV-2 (PASC) Pain, Predictions from a Ligand-Receptor Interactome

  2023cites this paper
• A Review of the Role of Lymphocytes in Chronic Neuropathic Pain: A Clinical Perspective

  2023cites this paper
• Novel expression of MHC II in DRG neurons attenuates paclitaxel-induced cold hypersensitivity in male and female mice

  2023cites this paper
• The mechanistic basis for the effects of electroacupuncture on neuropathic pain within the central nervous system.

  2023cites this paper
• Pain-resolving immune mechanisms in neuropathic pain

  2023cites this paper
• Protease-Activated Receptor 2 (PAR2) expressed in sensory neurons contributes to signs of pain and neuropathy in paclitaxel treated mice

  2023cites this paper
• Ovariectomy increases paclitaxel-induced mechanical hypersensitivity and reduces anti-inflammatory CD4+ T cells in the dorsal root ganglion of female mice

  2022cites this paper
• Toll-like receptors in chronic pain

  2022cites this paper
• Inducible co-stimulatory molecule (ICOS) alleviates Paclitaxel induced peripheral neuropathy via an IL-10-mediated mechanism in female mice

  2022cites this paper
• Frankincense-Myrrh treatment alleviates neuropathic pain via the inhibition of neuroglia activation mediated by the TLR4/MyD88 pathway and TRPV1 signaling.

  2022cites this paper
• Exploring the Correlation Between the Regulation of Macrophages by Regulatory T Cells and Peripheral Neuropathic Pain

  2022cites this paper
• Intrathecal administration of bone marrow stromal cells and TGF-β1 alleviate chemotherapy-induced neuropathic pain in male mice

  2022influential citation
• Neurophysiopathological Aspects of Paclitaxel-induced Peripheral Neuropathy

  2022cites this paper
• Infiltration Profile of Regulatory T Cells in Osteoarthritis-Related Pain and Disability

  2022cites this paper
• Pulsed radiofrequency treatment of the dorsal root ganglion in patients with chronic neuropathic pain: A narrative review

  2022cites this paper
• The Role of Neuro-Immune Interactions in Chronic Pain: Implications for Clinical Practice

  2022cites this paper
• Shaoyao Gancao Decoction Ameliorates Paclitaxel-Induced Peripheral Neuropathy via Suppressing TRPV1 and TLR4 Signaling Expression in Rats

  2022cites this paper
• New Progress in Basic Research of Macrophages in the Pathogenesis and Treatment of Low Back Pain

  2022cites this paper
• Proteome and Network Analysis Provides Novel Insights Into Developing and Established Chemotherapy-Induced Peripheral Neuropathy

  2022cites this paper
• Pain in Axial Spondyloarthritis: Insights from Immunology and Brain Imaging.

  2021cites this paper
• Schmerz bei rheumatischen Erkrankungen

  2021cites this paper
• Immune Actions on the Peripheral Nervous System in Pain

  2021cites this paper
• Attenuation of nociceptive and paclitaxel-induced neuropathic pain by targeting inflammatory, CGRP and Substance P signaling using 3-Hydroxyflavone.

  2021cites this paper
• Role of Peripheral Immune Cells for Development and Recovery of Chronic Pain

  2021influential citation
• Deletion of MyD88 adaptor in nociceptor alleviates low-dose formalin-induced acute pain and persistent pain in mice

  2021cites this paper
• Suppression of TLR4-MyD88 signaling pathway attenuated chronic mechanical pain in a rat model of endometriosis

  2021cites this paper
• Neuroimmune Consequences of eIF4E Phosphorylation on Chemotherapy-Induced Peripheral Neuropathy

  2021cites this paper
• Low-Dose Interleukin-2 and Regulatory T Cell Treatments Attenuate Punctate and Dynamic Mechanical Allodynia in a Mouse Model of Sciatic Nerve Injury

  2021cites this paper
• Role of innate immunity in chemotherapy-induced peripheral neuropathy.

  2021cites this paper
• Sensory neuron–associated macrophages as novel modulators of neuropathic pain

  2021cites this paper
• Sensory Neuron TLR4 mediates the development of nerve-injury induced mechanical hypersensitivity in female mice.

  2021cites this paper
• The effects of combined chemotherapy and anti-PD-1 treatment on peripheral neuropathy and neuroinflammation in mice.

  2021cites this paper
• Probing the peripheral immune response in mouse models of oxaliplatin-induced peripheral neuropathy highlights their limited translatability

  2021cites this paper
• The Interplay between Chronic Pain, Opioids, and the Immune System

  2021cites this paper
• IL-23/IL-17A/TRPV1 axis produces mechanical pain via macrophage-sensory neuron crosstalk in female mice.

  2021cites this paper
• Regulatory T-cells inhibit microglia-induced pain hypersensitivity in female mice

  2021cites this paper
• Corneal dendritic cells and the subbasal nerve plexus following neurotoxic treatment with oxaliplatin or paclitaxel

  2021cites this paper
• Vincristine-Induced Peripheral Neuropathy in Childhood Acute Lymphoblastic Leukemia: Genetic Variation as a Potential Risk Factor

  2021influential citation
• The Cannabidiol Analog PECS-101 Prevents Chemotherapy-Induced Neuropathic Pain via PPARγ Receptors

  2021cites this paper
• Innate Receptors Expression by Lung Nociceptors: Impact on COVID-19 and Aging

  2021cites this paper
• T regulatory cells and TGF-β1: predictors of the host response in mesh complications.

  2020cites this paper
• Luteoloside Exerts Analgesic Effect in a Complete Freund’s Adjuvant-Induced Inflammatory Model via Inhibiting Interleukin-1β Expression and Macrophage/Microglia Activation

  2020cites this paper
• Systematic Immunophenotyping Reveals Sex-Specific Responses After Painful Injury in Mice

  2020cites this paper
• Immunotherapy for the management of cancer pain

  2020cites this paper
• How Do Sensory Neurons Sense Danger Signals?

  2020influential citation
• Qualitative sex differences in pain processing: emerging evidence of a biased literature

  2020cites this paper
• Local Sympathectomy Promotes Antiinflammatory Responses and Relief of Paclitaxel-induced Mechanical and Cold Allodynia in Mice.

  2020cites this paper
• Toll-like receptor 7 contributes to neuropathic pain by activating NF-κB in primary sensory neurons.

  2020cites this paper
• Behavioral, Electrophysiological, and Histological Characterization of a New Rat Model for Neoadjuvant Chemotherapy–Induced Neuropathic Pain: Therapeutic Potential of Duloxetine and Allopregnanolone Concomitant Treatment

  2020cites this paper
• Low-dose interleukin-2 reverses behavioral sensitization in multiple mouse models of headache disorders.

  2020cites this paper
• Vincristine-induced peripheral neuropathy: a mini-review.

  2020cites this paper
• MHCII-restricted T helper cells: an emerging trigger for chronic tactile allodynia after nerve injuries

  2020cites this paper
• Fish nasal immunity: From mucosal vaccines to neuroimmunology.

  2020cites this paper
• Mechanisms of microbial–neuronal interactions in pain and nociception

  2020cites this paper
• Bortezomib-induced aerobic glycolysis contributes to chemotherapy-induced painful peripheral neuropathy

  2019cites this paper
• Cisplatin educates CD8+ T cells to prevent and resolve chemotherapy-induced peripheral neuropathy in mice.

  2019cites this paper
• Essential roles of C-type lectin Mincle in induction of neuropathic pain in mice

  2019cites this paper
• Evodiamine ameliorates paclitaxel-induced neuropathic pain by inhibiting inflammation and maintaining mitochondrial anti-oxidant functions

  2019cites this paper
• Regulatory T Cells and Their Derived Cytokine, Interleukin-35, Reduce Pain in Experimental Autoimmune Encephalomyelitis

  2019cites this paper
• 1-Palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (PLAG) attenuates gemcitabine-induced neutrophil extravasation

  2019cites this paper
• Monoclonal Antibody Targeting the Matrix Metalloproteinase 9 Prevents and Reverses Paclitaxel-Induced Peripheral Neuropathy in Mice.

  2019cites this paper
• Regulation of pain by neuro-immune interactions between macrophages and nociceptor sensory neurons.

  2019cites this paper