Variants in the CD36 gene associate with the metabolic syndrome and high-density lipoprotein cholesterol.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Human Molecular Genetics

• Publication date

  2008-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/hmg/ddn060PMID 18305138PMCID PMC2655228
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2005influential reference
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