Mitochondria as an important target in heavy metal toxicity in rat hepatoma AS-30D cells.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Toxicology and Applied Pharmacology

• Publication date

  2008-08-15

• Fields of study

  Biology, Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1016/j.taap.2008.03.017PMID 18501399
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Reactive oxygen species produced by the mitochondrial respiratory chain are involved in Cd 2 +-induced injury of rat ascites hepatoma AS30 D cells

  2006cited by this paper
• Reactive oxygen species produced by the mitochondrial respiratory chain are involved in Cd2+-induced injury of rat ascites hepatoma AS-30D cells.

  2006cited by this paper
• Short-term and long-term effects of fatty acids in rat hepatoma AS-30D cells: the way to apoptosis.

  2006cited by this paper
• Free radicals, metals and antioxidants in oxidative stress-induced cancer.

  2006cited by this paper
• Metals, toxicity and oxidative stress.

  2005influential reference
• Cadmium chloride-induced oxidative stress in skeletal muscle cells in vitro.

  2005cited by this paper
• Oxidative stress, mitochondrial permeability transition, and cell death in Cu-exposed trout hepatocytes.

  2005cited by this paper
• Cadmium-induced apoptosis in C6 glioma cells: Influence of oxidative stress

  2004cited by this paper
• In vitro assessment of copper-induced toxicity in the human hepatoma line, Hep G2.

  2004cited by this paper
• Cadmium inhibits the electron transfer chain and induces reactive oxygen species.

  2004cited by this paper
• Cd2+ versus Ca2+-produced mitochondrial membrane permeabilization: a proposed direct participation of respiratory complexes I and III.

  2004cited by this paper
• Acute toxicity of cadmium and copper in hepatopancreas cells from the Roman snail (Helix pomatia).

  2004cited by this paper
• Cd2+ -promoted mitochondrial permeability transition: a comparison with other heavy metals.

  2004cited by this paper
• Mediating of caspase‐independent apoptosis by cadmium through the mitochondria‐ROS pathway in MRC‐5 fibroblasts

  2004cited by this paper
• Mechanism of primary Cd2+-induced rat liver mitochondria dysfunction: discrete modes of Cd2+ action on calcium and thiol-dependent domains.

  2003cited by this paper
• Carcinogenic metal induced sites of reactive oxygen species formation in hepatocytes.

  2003cited by this paper
• Mercuric chloride induces apoptosis via a mitochondrial-dependent pathway in human leukemia cells.

  2003cited by this paper
• Cadmium directly induced the opening of membrane permeability pore of mitochondria which possibly involved in cadmium-triggered apoptosis.

  2003cited by this paper
• Copper, but not cadmium, is acutely toxic for trout hepatocytes: short-term effects on energetics and ion homeostasis.

  2003cited by this paper
• Cyclosporin A-sensitive permeability transition pore is involved in Cd(2+)-induced dysfunction of isolated rat liver mitochondria: doubts no more.

  2002cited by this paper
• Induction of apoptosis in mammalian cells by cadmium and zinc.

  2002cited by this paper
• Uncoupling effect of mercuric chloride on mitochondria isolated from an hepatic cell line

  2001cited by this paper
• Bivalent Metal Ions Modulate Cd2+ Effects on Isolated Rat Liver Mitochondria

  2001cited by this paper
• Mechanisms of cadmium‐mediated acute hepatotoxicity

  2000cited by this paper
• Copper toxicity affects proliferation and viability of human hepatoma cells (HepG2 line)

  2000cited by this paper
• A comparison of hepatocyte cytotoxic mechanisms for Cu2+ and Cd2+.

  2000cited by this paper
• Mercury-induced apoptosis in human lymphoid cells: evidence that the apoptotic pathway is mercurial species dependent.

  2000cited by this paper
• Glutathione depletion and oxidative damage in mitochondria following exposure to cadmium in rat liver and kidney.

  1999cited by this paper
• Mercuric chloride induces apoptosis in human T lymphocytes: evidence of mitochondrial dysfunction.

  1998cited by this paper
• The mitochondrial death/life regulator in apoptosis and necrosis.

  1998cited by this paper
• Mercuric chloride toxicity in rat liver mitochondria and isolated hepatocytes.

  1997cited by this paper
• Mercuric compounds inhibit human monocyte function by inducing apoptosis: evidence for formation of reactive oxygen species, development of mitochondrial membrane permeability transition and loss of reductive reserve.

  1997cited by this paper
• Cadmium-induced production of superoxide anion and nitric oxide, DNA single strand breaks and lactate dehydrogenase leakage in J774A.1 cell cultures.

  1996cited by this paper
• Oxidative mechanisms in the toxicity of metal ions.

  1995influential reference
• Assays of cell viability: discrimination of cells dying by apoptosis.

  1994cited by this paper
• Studies on Hg(II)-induced H2O2 formation and oxidative stress in vivo and in vitro in rat kidney mitochondria.

  1993cited by this paper
• Sites of inhibition of mitochondrial electron transport by cadmium.

  1993cited by this paper
• A new method for the cytofluorimetric analysis of mitochondrial membrane potential using the J-aggregate forming lipophilic cation 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazolcarbocyanine iodide (JC-1).

  1993influential reference
• Comparative action of methylmercury and divalent inorganic mercury on nerve terminal and intraterminal mitochondrial membrane potentials.

  1992cited by this paper
• A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry.

  1991cited by this paper
• Effect of cadmium on membrane potential in isolated rat hepatocytes.

  1990cited by this paper
• Toxic injury from mercuric chloride in rat hepatocytes.

  1990cited by this paper
• Effects of Helminthosporium maydis Race T Toxin on Electron Transport in Susceptible Corn Mitochondria and Prevention of Toxin Actions by Dicyclohexylcarbodiimide.

  1989cited by this paper
• The effects of cadmium on succinate and NADH‐linked substrate oxidations in rat hepatic mitochondria

  1986cited by this paper
• Consequences of cadmium toxicity in rat hepatocytes: mitochondrial dysfunction and lipid peroxidation.

  1986cited by this paper
• On the mechanism of mercurial‐induced permeability of the mitochondrial membrane to K+

  1979cited by this paper
• Effect of methyl mercury on phosphorylation, transport, and oxidation in mammalian mitochondria.

  1977cited by this paper
• Control of the energy coupling modes in mitochondria by mercurials.

  1974cited by this paper
• Ion transport by heart mitochondria. The effects of Cu 2+ on membrane permeability.

  1972cited by this paper
• Biometry: The Principles and Practice of Statistics in Biological Research

  1969cited by this paper

• 2,4-Epibrassinolide Mitigates Cd Stress by Enhancing Chloroplast Structural Remodeling and Chlorophyll Metabolism in Vigna angularis Leaves

  2025cites this paper
• Mechanistic insights into the toxicological effects of heavy metal cocktails from a polluted river using fish cell line toxicity assays

  2025cites this paper
• Quantification of heavy metal exposure in a British population cohort links total mercury levels in plasma with skin tissue-specific changes in mitochondrial-related gene expression.

  2025cites this paper
• Association of cadmium and lead exposure with mortality in cancer survivors: A prospective cohort study.

  2025cites this paper
• Secondary target organs exhibit differential ability to clear cadmium after cadmium oxide nanoparticle inhalation.

  2025cites this paper
• Application of Modulators of Ca2+-Activated Big-Conductance Potassium Channels Against Cd2+-Induced Cytotoxicity: A Study on Two Rat Cell Lines, PC12 and AS-30D

  2025influential citation
• A comprehensive review on nature-inspired redox systems based on humic acids: Bridging microbial electron transfer and high-performance supercapacitors

  2025cites this paper
• Effect of ambient lead on progesterone and pregnancy-associated glycoprotein 1 and their relationship with abortion in Zaraibi goats: a field study

  2024influential citation
• Chelating agent-assisted extraction of toxic elements towards ensuring food and beverage safety: Advances and challenges

  2024cites this paper
• Spirulina platensis shields the submandibular gland from cadmium toxicity by bolstering antioxidant defenses and maintaining its structural integrity.

  2024cites this paper
• Curcumin protects against cadmium-induced germ cell death in the testis of rats.

  2024cites this paper
• Multistress Interplay: Time and Duration of Ocean Acidification Modulate the Toxicity of Mercury and Other Metals.

  2024cites this paper
• Chronic cadmium exposure impairs flight behavior by dampening flight muscle carbon metabolism in bumblebees.

  2024cites this paper
• Heavy Metal Exposure: Molecular Pathways, Clinical Implications, and Protective Strategies

  2024cites this paper
• Mechanism of Cadmium-induced nephrotoxicity.

  2024cites this paper
• Phospholipid scramblase 3: a latent mediator connecting mitochondria and heavy metal apoptosis

  2023cites this paper
• Study of thorium-induced micro-structural changes in mice femoral bone using SR-µCT

  2023cites this paper
• Mitochondrial Oxidative Stress Is the General Reason for Apoptosis Induced by Different-Valence Heavy Metals in Cells and Mitochondria

  2023cites this paper
• In Vitro Cytotoxic Effect of Aqueous Extracts from Leaves and Rhizomes of the Seagrass Posidonia oceanica (L.) Delile on HepG2 Liver Cancer Cells: Focus on Autophagy and Apoptosis

  2023cites this paper
• Modulators of mitochondrial ATP-sensitive potassium channel affect cytotoxicity of heavy metals: Action on isolated rat liver mitochondria and AS-30D ascites hepatoma cells.

  2023cites this paper
• Cadmium and Chlorpyrifos Induced Lipid Peroxidation in Brain, Liver and Kidney of Wistar Rats

  2023cites this paper
• Complementary imaging of nanoclusters interacting with mitochondria via stimulated emission depletion and scanning transmission electron microscopy.

  2023cites this paper
• Phylogeny and adaptative evolution to chemosynthetic habitat in barnacle (Cirripedia: Thoracica) revealed by mitogenomes

  2022cites this paper
• Toxic and carcinogenic effects of hexavalent chromium in mammalian cells in vivo and in vitro: a recent update

  2022cites this paper
• Quercetin protects mouse oocytes against chromium-induced damage in vitro and in vivo.

  2022cites this paper
• Evaluation of the effect of nitrate and chloride on Cd(II)-induced cell oxidative stress by scanning electrochemical microscopy.

  2022cites this paper
• Heavy metals induced mitochondrial dysfunction in animals: Molecular mechanism of toxicity.

  2022cites this paper
• Role of Endolysosome Function in Iron Metabolism and Brain Carcinogenesis.

  2021cites this paper
• Biochemical and histological alterations induced by nickel oxide nanoparticles in the ground beetle Blaps polychresta (Forskl, 1775) (Coleoptera: Tenebrionidae)

  2021cites this paper
• The protective role of selenium against dental amalgam-induced intracellular oxidative toxicity through the TRPV1 channel in DBTRG glioblastoma cells

  2021cites this paper
• Bioactive phytochemicals from Salvia officinalis attenuate cadmium-induced oxidative damage and genotoxicity in rats

  2021cites this paper
• Cadmium-induced oxidative stress in Meretrix meretrix gills leads to mitochondria-mediated apoptosis

  2021cites this paper
• Protective effect of eugenol on hepatic inflammation and oxidative stress induced by cadmium in male rats.

  2021cites this paper
• Zeta-carbonic anhydrases show CS2 hydrolase activity: A new metabolic carbon acquisition pathway in diatoms?

  2021cites this paper
• BIOLUMINOMETRIC ASSAY OF CELL ATP DETECTION UNDER STRESS CONDITIONS AND IN THE ASSESSMENT OF CLEANNESS OF THE FOOD PRODUCING COMPANY

  2021cites this paper
• Underlying mechanisms of cytotoxicity in HepG2 hepatocarcinoma cells exposed to arsenic, cadmium and mercury individually and in combination.

  2021cites this paper
• Effects of environmental metals on mitochondrial bioenergetics of the CD-1 mice pancreatic beta-cells.

  2020cites this paper
• A novel near-infrared fluorescent probe with an improved Stokes shift for specific detection of Hg2+ in mitochondria.

  2020cites this paper
• The Effects of Cadmium Toxicity

  2020cites this paper
• Toxic-Metal-Induced Alteration in miRNA Expression Profile as a Proposed Mechanism for Disease Development

  2020cites this paper
• Metals, autoimmunity, and neuroendocrinology: Is there a connection?

  2020cites this paper
• Mitigating effect of paxilline against injury produced by Cd2+ in rat pheochromocytoma PC12 and ascites hepatoma AS-30D cells.

  2020cites this paper
• Probing the Role of the Chloroplasts in Heavy Metal Tolerance and Accumulation in Euglena gracilis

  2020cites this paper
• Mercury-Induced Inhibition of Tyrosine Phosphorylation of Sperm Proteins and Altered Functional Dynamics of Buck Spermatozoa: an In Vitro Study

  2020cites this paper
• Hepato-protective effect of Pleurotus ostreatus extracts in cadmium- intoxicated rats

  2020cites this paper
• Novel rhodamine dye with large Stokes shifts by fusing the 1,4-diethylpiperazine moiety and its applications in fast detection of Cu2+

  2020cites this paper
• A near-infrared fluorescent probe with an improved Stokes shift achieved by tuning the donor–acceptor–donor character of the rhodamine skeleton and its applications

  2020cites this paper
• Ameliorative effects of resveratrol against cadmium-induced nephrotoxicity via modulating nuclear xenobiotic receptor response and PINK1/Parkin-mediated Mitophagy.

  2020cites this paper
• Roles of oxidative stress, apoptosis, and inflammation in metal-induced dysfunction of beta pancreatic cells isolated from CD1 mice

  2020cites this paper
• Evaluation of mitochondrial toxicity of cadmium in clam Ruditapes philippinarum using iTRAQ-based proteomics.

  2019cites this paper
• ζ-Carbonic anhydrases

  2019cites this paper
• Heavy metals mediated phospholipids scrambling by human phospholipid scramblase 3: a probable role in mitochondrial apoptosis.

  2019cites this paper
• Dietary Polyphenols and Mitochondrial Function: Role in Health and Disease.

  2019cites this paper
• Cellular alterations in midgut cells of honey bee workers (Apis millefera L.) exposed to sublethal concentrations of CdO or PbO nanoparticles or their binary mixture.

  2019cites this paper
• Environmental cadmium exposure and pancreatic cancer: Evidence from case control, animal and in vitro studies.

  2019cites this paper
• Mitochondrial Stress Response in Neural Stem Cells Exposed to Electronic Cigarettes

  2019cites this paper
• Adaptation to the deep-sea hydrothermal vents and cold seeps: Insights from the transcriptomes of Alvinocaris longirostris in both environments

  2018cites this paper
• Microcystin-LR increases genotoxicity induced by aflatoxin B1 through oxidative stress and DNA base excision repair genes in human hepatic cell lines.

  2018cites this paper
• Pace of life syndrome under warming and pollution: integrating life history, behavior, and physiology across latitudes

  2018cites this paper
• A NIR-BODIPY derivative for sensing copper(II) in blood and mitochondrial imaging.

  2018cites this paper
• Evolutionary and physiological processes involved in carotenoid coloration in animals

  2018cites this paper
• Respiratory complex II in mitochondrial dysfunction-mediated cytotoxicity: Insight from cadmium.

  2018cites this paper
• Exposure of Macrophages to Low-Dose Gadolinium-Based Contrast Medium: Impact on Oxidative Stress and Cytokines Production

  2018cites this paper
• Deep Analysis of Mitochondria and Cell Health Using Machine Learning

  2018cites this paper
• Mitochondria in Liver Diseases

  2018cites this paper
• Luteolin-mediated PI3K/AKT/Nrf2 signaling pathway ameliorates inorganic mercury-induced cardiac injury.

  2018cites this paper
• Biochemical and transcriptional analyses of cadmium-induced mitochondrial dysfunction and oxidative stress in human osteoblasts

  2018cites this paper
• The combined effects or arsenic cadmium and mercury on hepatocarcinoma and neuroblastoma cells in vitro

  2018cites this paper
• Cadmium Alters Mitochondrial Membrane Potential, Inhibits Electron Transport Chain Activity and Induces Callose Deposition in Rice Seedlings

  2018cites this paper
• Towards the identification of environmental exposures and epigenetic marks related to the etiology of Autism

  2017cites this paper
• The toxicology of mercury: Current research and emerging trends.

  2017cites this paper
• Zinc and calcium alter the relationship between mitochondrial respiration, ROS and membrane potential in rainbow trout (Oncorhynchus mykiss) liver mitochondria.

  2017cites this paper
• Protective effect of methanolic Peel extract of Punica granatum on cadmium- induced hepatotoxicity in mice: Histological and ultrastructural investigation

  2017cites this paper
• Cobalt inhibits motility of axonal mitochondria and induces axonal degeneration in cultured dorsal root ganglion cells of rat

  2017cites this paper
• Copper exposure reduces production of red carotenoids in a marine copepod

  2016cites this paper
• Genetic and biochemical intricacy shapes mitochondrial cytopathies.

  2016cites this paper
• Biology of Mitochondrial ABCs and Their Contribution to Pathology

  2016cites this paper
• Inhaled Cadmium Oxide Nanoparticles: Their in Vivo Fate and Effect on Target Organs

  2016cites this paper
• Green self-assembly of zein-conjugated ZnO/Cd(OH)Cl hierarchical nanocomposites with high cytotoxicity and immune organs targeting

  2016cites this paper
• A Switch-On NIR Probe for Specific Detection of Hg2+ Ion in Aqueous Medium and in Mitochondria.

  2016cites this paper
• Impairment of mitochondrial energy metabolism of two marine fish by in vitro mercuric chloride exposure.

  2015cites this paper
• Heme oxygenase-1 attenuates cadmium-induced mitochondrial-caspase 3- dependent apoptosis in human hepatoma cell line

  2015cites this paper
• The effect of modulators of large-conductance Ca2+-modulated K+ channels on rat AS-30D ascites hepatoma cells and isolated liver mitochondria treated with Cd2+

  2015cites this paper
• Cadmium-Containing Carbonic Anhydrase CDCA1 in Marine Diatom Thalassiosira weissflogii

  2015cites this paper
• Dopaminergic dysfunction is associated with IL-1β-dependent mood alterations in experimental autoimmune encephalomyelitis.

  2015cites this paper
• New Perspectives on Dietary-derived Treatments and Food Safety—Antinomy in a New Era

  2015cites this paper
• Toxicity of Copper on Isolated Liver Mitochondria: Impairment at Complexes I, II, and IV Leads to Increased ROS Production

  2014cites this paper
• Functional Characterization of Corynebacterium glutamicum Mycothiol S-Conjugate Amidase

  2014cites this paper
• On the Mechanism(s) of Membrane Permeability Transition in Liver Mitochondria of Lamprey, Lampetra fluviatilis L.: Insights from Cadmium

  2014cites this paper
• Zinc Supplementation Protects against Cadmium Accumulation and Cytotoxicity in Madin-Darby Bovine Kidney Cells

  2014cites this paper
• Thorium induced cytoproliferative effect in human liver cell HepG2: role of insulin-like growth factor 1 receptor and downstream signaling.

  2014cites this paper
• [Copper intoxication decreases lifespan and induces neurologic alterations in Drosophila melanogaster].

  2013cites this paper
• The toxic Doppelganger: on the ionic and molecular mimicry of cadmium.

  2013cites this paper
• Research progress in molecular mechanism of cadmium metabolism

  2013cites this paper
• Effect of diazoxide on AS-30D rat ascites hepatoma cells treated by Cd2+

  2013cites this paper
• Zebrafish: a model animal for analyzing the impact of environmental pollutants on muscle and brain mitochondrial bioenergetics.

  2013cites this paper
• La intoxicación con cobre disminuye la sobrevida e induce alteraciones neurológicas en Drosophila melanogaster.

  2013cites this paper
• Evaluation of Trace Elements in Pancreatic Cancer Patients in Iran

  2013cites this paper
• Cadmium induced Drp1-dependent mitochondrial fragmentation by disturbing calcium homeostasis in its hepatotoxicity

  2013cites this paper
• Combined exposure to 3-chloro-4-dichloromethyl-5-hydroxy-2(5H)-furanone and microsytin-LR increases genotoxicity in Chinese hamster ovary cells through oxidative stress.

  2013cites this paper