Modulation of CD8(+) T-cell activation events by monocytic and granulocytic myeloid-derived suppressor cells.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Immunobiology

• Publication date

  2013-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.imbio.2013.07.003PMID 23932436
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Tumor necrosis factor-α blocks differentiation and enhances suppressive activity of immature myeloid cells during chronic inflammation.

  2013cited by this paper
• STAT3 regulates arginase-I in myeloid-derived suppressor cells from cancer patients.

  2013cited by this paper
• Angiotensin II drives the production of tumor-promoting macrophages.

  2013cited by this paper
• Abstract 1515: Epigenetic silencing of retinoblastoma gene regulates pathologic differentiation of myeloid cells in cancer.

  2013cited by this paper
• Molecular Pathways: Tumor-Infiltrating Myeloid Cells and Reactive Oxygen Species in Regulation of Tumor Microenvironment

  2012cited by this paper
• Multiple myeloma induces the immunosuppressive capacity of distinct myeloid-derived suppressor cell subpopulations in the bone marrow

  2012cited by this paper
• Targeting PI3 kinase/AKT/mTOR signaling in cancer.

  2012cited by this paper
• Immune tolerance to tumor antigens occurs in a specialized environment of the spleen.

  2012cited by this paper
• The CD4+ T-cell help signal is transmitted from APC to CD8+ T-cells via CD27–CD70 interactions

  2012cited by this paper
• Quantification of lymph node transit times reveals differences in antigen surveillance strategies of naïve CD4+ and CD8+ T cells

  2012cited by this paper
• The role of interleukin-2 during homeostasis and activation of the immune system

  2012cited by this paper
• Nanobody-based targeting of the macrophage mannose receptor for effective in vivo imaging of tumor-associated macrophages.

  2012cited by this paper
• Characterization of the nature of granulocytic myeloid‐derived suppressor cells in tumor‐bearing mice

  2012cited by this paper
• Coordinated regulation of myeloid cells by tumours

  2012cited by this paper
• Myeloid-derived suppressor cells: mechanisms of action and recent advances in their role in transplant tolerance

  2012cited by this paper
• On the armament and appearances of human myeloid-derived suppressor cells.

  2012cited by this paper
• G-CSF stem cell mobilization in human donors induces polymorphonuclear and mononuclear myeloid-derived suppressor cells.

  2012cited by this paper
• Subset characterization of myeloid-derived suppressor cells arising during induction of BM chimerism in mice

  2012cited by this paper
• Metabolism of L-Arginine by Myeloid-Derived Suppressor Cells in Cancer: Mechanisms of T cell suppression and Therapeutic Perspectives

  2012cited by this paper
• Signal transduction via the T cell antigen receptor in naïve and effector/memory T cells.

  2012cited by this paper
• Mechanisms for T cell receptor triggering

  2011cited by this paper
• Mononuclear phagocyte heterogeneity in cancer: different subsets and activation states reaching out at the tumor site.

  2011cited by this paper
• Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells

  2011cited by this paper
• Autocrine IL-2 is required for secondary population expansion of CD8+ memory T cells

  2011cited by this paper
• A Paradoxical Role for Myeloid-Derived Suppressor Cells in Sepsis and Trauma

  2011cited by this paper
• Tumor-infiltrating myeloid cells induce tumor cell resistance to cytotoxic T cells in mice.

  2011cited by this paper
• Positive feedback between PGE2 and COX2 redirects the differentiation of human dendritic cells toward stable myeloid-derived suppressor cells.

  2011cited by this paper
• Effect of oral L-arginine supplementation on blood pressure: a meta-analysis of randomized, double-blind, placebo-controlled trials.

  2011cited by this paper
• Modulation of human T‐cell functions by reactive nitrogen species

  2011cited by this paper
• MDSC in autoimmunity.

  2011cited by this paper
• Myeloid-derived suppressor cells inhibit T-cell activation by depleting cystine and cysteine.

  2010cited by this paper
• Once a killer, always a killer: from cytotoxic T cell to memory cell

  2010cited by this paper
• Mechanism of T Cell Tolerance Induced by Myeloid-Derived Suppressor Cells

  2010cited by this paper
• Different tumor microenvironments contain functionally distinct subsets of macrophages derived from Ly6C(high) monocytes.

  2010cited by this paper
• Tumor-induced tolerance and immune suppression depend on the C/EBPbeta transcription factor.

  2010cited by this paper
• Plasticity in programming of effector and memory CD8+ T‐cell formation

  2010cited by this paper
• HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment

  2010cited by this paper
• STAT3 controls myeloid progenitor growth during emergency granulopoiesis.

  2010cited by this paper
• Myeloid‐derived suppressor cells in parasitic infections

  2010cited by this paper
• Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells.

  2010cited by this paper
• l-Arginine Deprivation Regulates Cyclin D3 mRNA Stability in Human T Cells by Controlling HuR Expression

  2010cited by this paper
• Myeloid-Derived Suppressor Cells Down-Regulate L-Selectin Expression on CD4+ and CD8+ T Cells1

  2009cited by this paper
• Hierarchy of immunosuppressive strength among myeloid‐derived suppressor cell subsets is determined by GM‐CSF

  2009cited by this paper
• Mechanism Regulating Reactive Oxygen Species in Tumor-Induced Myeloid-Derived Suppressor Cells1

  2009cited by this paper
• Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein

  2008cited by this paper
• Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity.

  2008cited by this paper
• Proinflammatory S100 Proteins Regulate the Accumulation of Myeloid-Derived Suppressor Cells1

  2008cited by this paper
• Subsets of Myeloid-Derived Suppressor Cells in Tumor-Bearing Mice1

  2008cited by this paper
• Myeloid-Derived Suppressor Cells Accumulate in Kidney Allograft Tolerance and Specifically Suppress Effector T Cell Expansion1

  2008cited by this paper
• Tumor-Induced CD11b+Gr-1+ Myeloid Cells Suppress T Cell Sensitization in Tumor-Draining Lymph Nodes1

  2008cited by this paper
• Tumor-Draining Lymph Nodes Suppress T Cell Sensitization in Myeloid Cells + Gr-1 + Tumor-Induced CD 11 b

  2008cited by this paper
• L-arginine availability regulates T-lymphocyte cell-cycle progression.

  2007cited by this paper
• Reduced inflammation in the tumor microenvironment delays the accumulation of myeloid-derived suppressor cells and limits tumor progression.

  2007cited by this paper
• Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer

  2007cited by this paper
• Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function

  2006cited by this paper
• Duration of the initial TCR stimulus controls the magnitude but not functionality of the CD8+ T cell response

  2006cited by this paper
• Peroxisome proliferator-activated receptor γ (PPARγ) ligands reverse CTL suppression by alternatively activated (M2) macrophages in cancer

  2006cited by this paper
• Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells.

  2006cited by this paper
• Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell–dendritic cell interaction

  2006cited by this paper
• Peroxisome proliferator-activated receptor gamma (PPARgamma) ligands reverse CTL suppression by alternatively activated (M2) macrophages in cancer.

  2006cited by this paper
• Arginase I in myeloid suppressor cells is induced by COX-2 in lung carcinoma

  2005cited by this paper
• Regulation of immune responses by L-arginine metabolism

  2005cited by this paper
• Nitroaspirin corrects immune dysfunction in tumor-bearing hosts and promotes tumor eradication by cancer vaccination.

  2005cited by this paper
• Regulation of dendritic cell differentiation and antitumor immune response in cancer by pharmacologic-selective inhibition of the janus-activated kinase 2/signal transducers and activators of transcription 3 pathway.

  2005cited by this paper
• Arginase-producing myeloid suppressor cells in renal cell carcinoma patients: a mechanism of tumor evasion.

  2005cited by this paper
• T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases

  2004cited by this paper
• Arginase I Production in the Tumor Microenvironment by Mature Myeloid Cells Inhibits T-Cell Receptor Expression and Antigen-Specific T-Cell Responses

  2004cited by this paper
• Antigen-Specific Inhibition of CD8+ T Cell Response by Immature Myeloid Cells in Cancer Is Mediated by Reactive Oxygen Species1

  2004cited by this paper
• L-Arginine modulates CD3zeta expression and T cell function in activated human T lymphocytes.

  2004cited by this paper
• IL-4-Induced Arginase 1 Suppresses Alloreactive T Cells in Tumor-Bearing Mice1

  2003cited by this paper
• l-Arginine Consumption by Macrophages Modulates the Expression of CD3ζ Chain in T Lymphocytes1

  2003cited by this paper
• Oxidative‐stress‐induced T lymphocyte hyporesponsiveness is caused by structural modification rather than proteasomal degradation of crucial TCR signaling molecules

  2003cited by this paper
• Inhibition of myeloid cell differentiation in cancer: the role of reactive oxygen species

  2003cited by this paper
• Myeloid Suppressor Lines Inhibit T Cell Responses by an NO-Dependent Mechanism1

  2002cited by this paper
• Reactive Oxygen Species Differentially Affect T Cell Receptor-signaling Pathways*

  2002cited by this paper
• Regulation of T cell receptor CD3zeta chain expression by L-arginine.

  2002cited by this paper
• Regulation of T Cell Receptor CD3ζ Chain Expression byl-Arginine*

  2002cited by this paper
• Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation

  2001cited by this paper
• Activated granulocytes and granulocyte-derived hydrogen peroxide are the underlying mechanism of suppression of t-cell function in advanced cancer patients.

  2001cited by this paper
• Nitric Oxide Inhibits the Transcription Repressor Yin-Yang 1 Binding Activity at the Silencer Region of the Fas Promoter: A Pivotal Role for Nitric Oxide in the Up-Regulation of Fas Gene Expression in Human Tumor Cells1

  2001cited by this paper
• T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions

  1998cited by this paper

• Tumor cell-derived microparticles containing MTX (MTX-TMPs) in the treatment of cholangiocarcinoma by modulating MDSCs.

  2025cites this paper
• Baseline Expanded Disability Status Scale Score and CD8+ T Cell Levels as Risk Factors for Disability Progression in Multiple Sclerosis

  2025cites this paper
• Myelodysplastic Neoplasms (MDS): Pathogenesis and Therapeutic Prospects

  2025cites this paper
• Metformin improves CD8+ T cell responses and parasitemia control via macrophage modulation during Trypanosoma cruzi infection.

  2025cites this paper
• Spatial Biology and Organoid Technologies Reveal a Potential Therapy-Resistant Cancer Stem Cell Population in Pancreatic Ductal Adenocarcinoma

  2025cites this paper
• Extracellular vesicle-mediated communication between CD8+ cytotoxic T cells and tumor cells

  2024cites this paper
• Myeloid-derived suppressor cells-induced exhaustion of CD8 + T-cell participates in rejection after liver transplantation

  2024cites this paper
• Thrombopoietin receptor agonists regulate myeloid-derived suppressor cell-mediated immunomodulatory effects in ITP

  2024cites this paper
• A gene network database for the identification of key genes for diagnosis, prognosis, and treatment in sepsis

  2023cites this paper
• Epitope-based minigene vaccine targeting fibroblast activation protein α induces specific immune responses and anti-tumor effects in 4 T1 murine breast cancer model.

  2022cites this paper
• Systemic delivery of gemcitabine analogue and STAT3 siRNA promotes antitumor immunity against melanoma

  2022cites this paper
• Myeloid-Derived Suppressor Cells in Solid Tumors

  2022cites this paper
• In silico data mining of human body fluids to unravel the immunomes in breast cancer

  2021cites this paper
• Pancreatic Cancer Patient-Derived Organoid Platforms: A Clinical Tool to Study Cell- and Non-Cell-Autonomous Mechanisms of Treatment Response

  2021cites this paper
• Disruption of Her2-Induced PD-L1 Inhibits Tumor Cell Immune Evasion in Patient-Derived Gastric Cancer Organoids

  2021cites this paper
• Landscape of Myeloid-derived Suppressor Cell in Tumor Immunotherapy

  2021cites this paper
• Hedgehog transcriptional effector GLI mediates mTOR-Induced PD-L1 expression in gastric cancer organoids.

  2021cites this paper
• Identification and characterization of B220+/B220− subpopulations in murine Gr1+CD11b+ cells during tumorigenesis

  2021cites this paper
• In silico data mining of human body fluids to unravel the immunomes in breast cancer

  2021cites this paper
• Polyanhydride Nanoparticles Induce Low Inflammatory Dendritic Cell Activation Resulting in CD8+ T Cell Memory and Delayed Tumor Progression

  2020cites this paper
• Human Gastrointestinal Organoid Models for Studying Microbial Disease and Cancer.

  2020cites this paper
• Development of Systemic Immune Dysregulation in a Rat Trauma Model with Biomaterial-Associated Infection

  2020influential citation
• Role of microenvironmental acidity and tumor exosomes in cancer immunomodulation

  2020cites this paper
• Hydrogen sulfide: an endogenous regulator of the immune system.

  2020cites this paper
• Murine- and Human-Derived Autologous Organoid/Immune Cell Co-Cultures as Pre-Clinical Models of Pancreatic Ductal Adenocarcinoma

  2020cites this paper
• C-Reactive Protein Promotes the Expansion of Myeloid Derived Cells With Suppressor Functions

  2019cites this paper
• Dendritic cells are what they eat: how their metabolism shapes T helper cell polarization.

  2019cites this paper
• Eosinophils downregulate lung alloimmunity by decreasing TCR signal transduction.

  2019cites this paper
• The STING of inflammatory adjuvants: Is the Toll too high?

  2019cites this paper
• LncRNA MALAT1 negatively regulates MDSCs in patients with lung cancer

  2018cites this paper
• TLR8 ligation induces apoptosis of monocytic myeloid‐derived suppressor cells

  2018cites this paper
• Fabrication and Use of Poly(d,l-lactide-co-glycolide)-Based Formulations Designed for Modified Release of 5-Fluorouracil.

  2018cites this paper
• Targeting the glucose metabolism of myeloid-derived suppressor cells (MDSCs) to stimulate cancer immunity.

  2017influential citation
• Tumor-associated neutrophils induce apoptosis of non-activated CD8 T-cells in a TNFα and NO-dependent mechanism, promoting a tumor-supportive environment

  2017cites this paper
• Myeloid‐derived suppressor cell‐like fibrocytes are increased and associated with preserved lung function in chronic obstructive pulmonary disease

  2017cites this paper
• The Ontogeny and Microenvironmental Regulation of Tumor-Associated Macrophages

  2016cites this paper
• In Vivo Mobilization and Functional Characterization of Nonhuman Primate Monocytic Myeloid‐Derived Suppressor Cells

  2016cites this paper
• Invariant NKT cells are resistant to circulating CD15+ myeloid‐derived suppressor cells in patients with head and neck cancer

  2016cites this paper
• Characterization of Surgery-Induced Vaccine Dysfunction in a Therapeutic Murine Melanoma Model

  2016cites this paper
• IL-17A weakens the antitumor immuity by inhibiting apoptosis of MDSCs in Lewis lung carcinoma bearing mice

  2016cites this paper
• CCL2, but not its receptor, is essential to restrict immune privileged central nervous system‐invasion of Japanese encephalitis virus via regulating accumulation of CD11b+ Ly‐6Chi monocytes

  2016cites this paper
• Clinical significance of plasmacytoid dendritic cells and myeloid-derived suppressor cells in melanoma

  2015cites this paper
• Cytotoxic T Lymphocytes and Their Granzymes: An Overview

  2015cites this paper
• A translational exploration of melanoma immunology focused on indoleamine 2,3-dioxygenase : lessons for immunoprofiling and immunotherapy

  2015cites this paper
• Increased monocytic CD14⁺HLADRlow/- myeloid-derived suppressor cells in obesity.

  2015cites this paper
• Myeloid-derived suppressor cells in B cell malignancies

  2015cites this paper
• Rapamycin Impairs Antitumor CD8+ T-cell Responses and Vaccine-Induced Tumor Eradication.

  2015cites this paper
• Presence of circulating Her2-reactive CD8 + T-cells is associated with lower frequencies of myeloid-derived suppressor cells and regulatory T cells, and better survival in older breast cancer patients

  2015cites this paper
• Cooperative therapeutic anti-tumor effect of IL-15 agonist ALT-803 and co-targeting soluble NKG2D ligand sMIC

  2015cites this paper
• Transcriptional regulation of myeloid‐derived suppressor cells

  2015cites this paper
• Transformation of human mast cells by interferon-gamma and the potential role of myeloid derived suppressor cells in mastocytosis.

  2014cites this paper
• Myeloid-Derived Suppressor Cells as Therapeutic Target in Hematological Malignancies

  2014cites this paper
• Social networking of human neutrophils within the immune system.

  2014cites this paper