Role of folate in nonalcoholic fatty liver disease.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Canadian Journal of Physiology and Pharmacology

• Publication date

  2017-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1139/cjpp-2016-0681PMID 28460180
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Application of the Key Events Dose-response Framework to Folate Metabolism

  2016influential reference
• Lack of phosphatidylethanolamine N-methyltransferase in mice does not promote fatty acid oxidation in skeletal muscle.

  2016cited by this paper
• The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD).

  2016cited by this paper
• Non-alcoholic fatty liver disease in 2015.

  2015cited by this paper
• Obesity is associated with increased red blood cell folate despite lower dietary intakes and serum concentrations.

  2015cited by this paper
• Folic acid supplementation during high-fat diet feeding restores AMPK activation via an AMP-LKB1-dependent mechanism.

  2015cited by this paper
• Nonalcoholic fatty liver disease: Update on pathogenesis, diagnosis, treatment and the role of S-adenosylmethionine

  2015cited by this paper
• Insights into Severe 5,10‐Methylenetetrahydrofolate Reductase Deficiency: Molecular Genetic and Enzymatic Characterization of 76 Patients

  2015cited by this paper
• Epigenetic Alterations in Human Liver From Subjects With Type 2 Diabetes in Parallel With Reduced Folate Levels.

  2015cited by this paper
• Nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 Diabetes

  2014cited by this paper
• The intestinal absorption of folates.

  2014influential reference
• Adaptive immune responses triggered by oxidative stress contribute to hepatic inflammation in NASH

  2014cited by this paper
• Reactive oxygen species and redox compartmentalization

  2014cited by this paper
• Quantitative flux analysis reveals folate-dependent NADPH production

  2014cited by this paper
• Folate, alcohol, and liver disease.

  2013cited by this paper
• Novel insights on interactions between folate and lipid metabolism

  2013influential reference
• Non‐alcoholic steatohepatitis: Pathogenesis and novel therapeutic approaches

  2013cited by this paper
• Folate deficiency enhances the inflammatory response of macrophages.

  2013cited by this paper
• Naringin ameliorates metabolic syndrome by activating AMP-activated protein kinase in mice fed a high-fat diet.

  2012cited by this paper
• Corrigendum:The Diagnosis and Management of Non-alcoholic Fatty Liver Disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association

  2012cited by this paper
• AMPK: a nutrient and energy sensor that maintains energy homeostasis

  2012cited by this paper
• Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis.

  2012cited by this paper
• Animal models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis.

  2012cited by this paper
• Folate depletion changes gene expression of fatty acid metabolism, DNA synthesis, and circadian cycle in male mice.

  2012cited by this paper
• The Diagnosis and Management of Non-alcoholic Fatty Liver Disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association

  2012cited by this paper
• Folic acid supplementation attenuates high fat diet induced hepatic oxidative stress via regulation of NADPH oxidase.

  2012cited by this paper
• Mechanisms of membrane transport of folates into cells and across epithelia.

  2011cited by this paper
• Folic acid supplementation inhibits NADPH oxidase‐mediated superoxide anion production in the kidney

  2011cited by this paper
• Trafficking of intracellular folates.

  2011influential reference
• Cytokines, macrophage lipid metabolism and foam cells: implications for cardiovascular disease therapy.

  2011cited by this paper
• Human Fatty Liver Disease: Old Questions and New Insights

  2011influential reference
• Dihydrofolate reductase deficiency due to a homozygous DHFR mutation causes megaloblastic anemia and cerebral folate deficiency leading to severe neurologic disease.

  2011cited by this paper
• Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis

  2010cited by this paper
• Folic Acid and L-5-Methyltetrahydrofolate

  2010influential reference
• Diversity in Antioxidant Response Enzymes in Progressive Stages of Human Nonalcoholic Fatty Liver Disease

  2010cited by this paper
• Obesity and nonalcoholic fatty liver disease: Biochemical, metabolic, and clinical implications

  2010cited by this paper
• CDC Grand Rounds: additional opportunities to prevent neural tube defects with folic acid fortification.

  2010cited by this paper
• Total folate and folic acid intake from foods and dietary supplements in the United States: 2003-2006.

  2010cited by this paper
• Histopathology of nonalcoholic fatty liver disease.

  2010cited by this paper
• Steatosis in mice is associated with gender, folate intake, and expression of genes of one-carbon metabolism.

  2010influential reference
• Compartmentalization of Mammalian folate-mediated one-carbon metabolism.

  2010influential reference
• The extremely slow and variable activity of dihydrofolate reductase in human liver and its implications for high folic acid intake

  2009cited by this paper
• Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD).

  2009cited by this paper
• Lack of Phosphatidylethanolamine N-Methyltransferase Alters Plasma VLDL Phospholipids and Attenuates Atherosclerosis in Mice

  2009influential reference
• Long-term follow-up of patients with nonalcoholic fatty liver.

  2009cited by this paper
• Dietary intake and status of folate and vitamin B12 and their association with homocysteine and cardiovascular disease in European populations

  2009cited by this paper
• Folate: a functional food constituent.

  2009cited by this paper
• Folic Acid Supplementation Modifies β-Adrenoceptor–Mediated In Vitro Lipolysis of Obese/Diabetic (+db/+db) Mice

  2009cited by this paper
• Membrane transporters and folate homeostasis: intestinal absorption and transport into systemic compartments and tissues

  2009cited by this paper
• Systematic review of risk factors for fibrosis progression in non-alcoholic steatohepatitis.

  2009cited by this paper
• Mitochondrial C1-Tetrahydrofolate Synthase (MTHFD1L) Supports the Flow of Mitochondrial One-carbon Units into the Methyl Cycle in Embryos*

  2009cited by this paper
• Reduction in Neural-Tube Defects after Folic Acid Fortification in Canada

  2009cited by this paper
• Measures of adiposity and body fat distribution in relation to serum folate levels in postmenopausal women in a feeding study

  2008influential reference
• Animal models of NASH: Getting both pathology and metabolic context right

  2008cited by this paper
• Thematic Review Series: Glycerolipids. Phosphatidylcholine and choline homeostasis Published, JLR Papers in Press, January 19, 2008.

  2008cited by this paper
• Disruption of lipid metabolism in the liver of the pregnant rat fed folate-deficient and methyl donor-deficient diets

  2008cited by this paper
• Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease.

  2008cited by this paper
• Folic acid metabolism in human subjects revisited: potential implications for proposed mandatory folic acid fortification in the UK.

  2007influential reference
• Nuclear factor‐κB and the hepatic inflammation‐fibrosis‐cancer axis

  2007cited by this paper
• DNA methylation: The nuts and bolts of repression

  2007cited by this paper
• pH-Dependent radical scavenging activity of folates.

  2007cited by this paper
• gamma-Glutamyl hydrolase, not glutamate carboxypeptidase II, hydrolyzes dietary folate in rat small intestine.

  2007cited by this paper
• Reduction in neural-tube defects after folic acid fortification in Canada.

  2007cited by this paper
• Changes in mitochondrial DNA deletion, content, and biogenesis in folate-deficient tissues of young rats depend on mitochondrial folate and oxidative DNA injuries.

  2007cited by this paper
• Nuclear factor-kappaB and the hepatic inflammation-fibrosis-cancer axis.

  2007cited by this paper
• γ-Glutamyl Hydrolase, Not Glutamate Carboxypeptidase II, Hydrolyzes Dietary Folate in Rat Small Intestine

  2007cited by this paper
• Re-evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease.

  2007cited by this paper
• Folic acid inhibits homocysteine-induced superoxide anion production and nuclear factor kappa B activation in macrophages.

  2006cited by this paper
• Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption.

  2006cited by this paper
• Overproduction of large VLDL particles is driven by increased liver fat content in man

  2006cited by this paper
• [Homocysteine lowering with folic acid and B vitamins in vascular disease].

  2006cited by this paper
• Homocysteine lowering with folic acid and B vitamins in vascular disease.

  2006cited by this paper
• Effect of short-term folic acid supplementation on insulin sensitivity and inflammatory markers in overweight subjects

  2006cited by this paper
• LIVER FAILURE AND LIVER DISEASE Nonalcoholic Fatty Liver Disease: From Steatosis to Cirrhosis

  2006cited by this paper
• Neural tube defects and folate: case far from closed

  2006cited by this paper
• From fat to inflammation.

  2006cited by this paper
• Hyperhomocysteinemia induces liver injury in rat: Protective effect of folic acid supplementation.

  2006cited by this paper
• Review: The role of insulin resistance in nonalcoholic fatty liver disease.

  2006cited by this paper
• Design and validation of a histological scoring system for nonalcoholic fatty liver disease

  2005cited by this paper
• Folic acid reverses hyper-responsiveness of LPS-induced chemokine secretion from monocytes in patients with hyperhomocysteinemia.

  2005cited by this paper
• Endothelial dysfunction and cardiovascular risk profile in nonalcoholic fatty liver disease

  2005cited by this paper
• High prevalence of folic acid and vitamin B12 deficiencies in infants, children, adolescents and pregnant women in Venezuela

  2005cited by this paper
• Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease.

  2005cited by this paper
• Serum folate and homocysteine levels in obese females with non-alcoholic fatty liver.

  2005influential reference
• Physiology of folate and vitamin B12 in health and disease.

  2004influential reference
• Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean?

  2004cited by this paper
• Oxidative stress-related parameters in the liver of non-alcoholic fatty liver disease patients.

  2004cited by this paper
• Body mass index and serum folate in childbearing age women

  2004cited by this paper
• Non-alcoholic fatty liver disease: a multicentre clinical study by the Italian Association for the Study of the Liver.

  2004cited by this paper
• Inflammatory cytokines and cardiovascular disease.

  2003cited by this paper
• A Gender-specific Role For Phosphatidylethanolamine N-Methyltransferase-derived Phosphatidylcholine in the Regulation of Plasma High Density and Very Low Density Lipoproteins in Mice*

  2003cited by this paper
• Localization of the PE methylation pathway and SR-BI to the canalicular membrane Published, JLR Papers in Press, June 16, 2003. DOI 10.1194/jlr.M200488-JLR200

  2003cited by this paper
• Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis

  2002cited by this paper
• Cytoplasmic Serine Hydroxymethyltransferase Mediates Competition between Folate-dependent Deoxyribonucleotide andS-Adenosylmethionine Biosyntheses*

  2002cited by this paper
• In situ detection of lipid peroxidation and oxidative DNA damage in non-alcoholic fatty liver diseases.

  2002cited by this paper
• Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis.

  2002cited by this paper
• Free radical scavenging behavior of folic acid: evidence for possible antioxidant activity.

  2001influential reference
• Nonalcoholic fatty liver disease: a feature of the metabolic syndrome.

  2001cited by this paper
• Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities.

  2001cited by this paper
• Folate depletion and elevated plasma homocysteine promote oxidative stress in rat livers.

  2001cited by this paper

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  2020cites this paper
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