Cardiac copper deficiency activates a systemic signaling mechanism that communicates with the copper acquisition and storage organs.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Cell Metabolism

• Publication date

  2010-05-05

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1016/j.cmet.2010.04.003PMID 20444417PMCID PMC2901851
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A Role for the ATP7A Copper-transporting ATPase in Macrophage Bactericidal Activity*

  2009cited by this paper
• Human copper transporter Ctr1 is functional in Drosophila, revealing a high degree of conservation between mammals and insects

  2009cited by this paper
• Regulation of iron acquisition and storage: consequences for iron-linked disorders

  2008cited by this paper
• Fine tuning of hepcidin expression by positive and negative regulators.

  2008cited by this paper
• Mechanisms for copper acquisition, distribution and regulation.

  2008cited by this paper
• ATP7B Expression in Human Breast Epithelial Cells Is Mediated by Lactational Hormones

  2008cited by this paper
• Cellular multitasking: the dual role of human Cu-ATPases in cofactor delivery and intracellular copper balance.

  2008cited by this paper
• Role of Menkes ATPase in Angiotensin II–Induced Hypertension: A Key Modulator for Extracellular Superoxide Dismutase Function

  2008cited by this paper
• Copper deficient rats and mice both develop anemia but only rats have lower plasma and brain iron levels.

  2008cited by this paper
• Hormonal regulation of the Menkes and Wilson copper-transporting ATPases in human placental Jeg-3 cells.

  2007cited by this paper
• Copper deficiency

  2007cited by this paper
• Drosophila Ctr1A Functions as a Copper Transporter Essential for Development*

  2007cited by this paper
• Rodent brain and heart catecholamine levels are altered by different models of copper deficiency.

  2007cited by this paper
• Dietary copper supplementation reverses hypertrophic cardiomyopathy induced by chronic pressure overload in mice

  2007cited by this paper
• Copper and iron disorders of the brain.

  2007cited by this paper
• Biochemical basis of regulation of human copper-transporting ATPases.

  2007cited by this paper
• Copper-transporting ATPases ATP7A and ATP7B: cousins, not twins

  2007cited by this paper
• Hepcidin antimicrobial peptide transgenic mice exhibit features of the anemia of inflammation.

  2007cited by this paper
• Chronological changes in tissue copper, zinc and iron in the toxic milk mouse and effects of copper loading

  2006cited by this paper
• Inducible Cardiac-Restricted Expression of Enteroviral Protease 2A Is Sufficient to Induce Dilated Cardiomyopathy

  2006cited by this paper
• Copper transport protein (Ctr1) levels in mice are tissue specific and dependent on copper status.

  2006cited by this paper
• Ctr1 drives intestinal copper absorption and is essential for growth, iron metabolism, and neonatal cardiac function.

  2006cited by this paper
• Activation of superoxide dismutases: putting the metal to the pedal.

  2006cited by this paper
• Drosophila as a model for the identification of genes causing adult human heart disease

  2006cited by this paper
• Mechanisms of the Copper-dependent Turnover of the Copper Chaperone for Superoxide Dismutase*

  2006cited by this paper
• Variable response of selected cuproproteins in rat choroid plexus and cerebellum following perinatal copper deficiency

  2006cited by this paper
• Copper trafficking to the mitochondrion and assembly of copper metalloenzymes.

  2006cited by this paper
• Structure of the Ctr1 copper trans'PORE'ter reveals novel architecture.

  2006cited by this paper
• CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life

  2005cited by this paper
• Cu, Zn-Superoxide Dismutase is Lower and Copper Chaperone CCS is Higher in Erythrocytes of Copper-Deficient Rats and Mice

  2004cited by this paper
• Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization

  2004cited by this paper
• Making a better RNAi vector for Drosophila: use of intron spacers.

  2003cited by this paper
• Copper Modulates the Degradation of Copper Chaperone for Cu,Zn Superoxide Dismutase by the 26 S Proteosome*

  2003cited by this paper
• Phenotyping hypertrophy: eschew obfuscation.

  2003cited by this paper
• Cardiac hypertrophy: the good, the bad, and the ugly.

  2003cited by this paper
• Essential role for Atox1 in the copper-mediated intracellular trafficking of the Menkes ATPase

  2003cited by this paper
• Copper chelation represses the vascular response to injury

  2003cited by this paper
• Supplying copper to the cuproenzyme peptidylglycine alpha-amidating monooxygenase.

  2003cited by this paper
• Calcium: Phospholamban: a crucial regulator of cardiac contractility

  2003cited by this paper
• Supplying Copper to the Cuproenzyme Peptidylglycine α-Amidating Monooxygenase*

  2003cited by this paper
• Left ventricular diastolic function in physiologic and pathologic hypertrophy.

  2002cited by this paper
• The Molecular Basis of Copper Homeostasis Copper-Related Disorders

  2002cited by this paper
• Left Ventricular Hypertrophy and Diastolic Dysfunction in Healthy Pregnant Women

  2002cited by this paper
• Concentric versus eccentric remodeling.

  2002cited by this paper
• Mechanisms of Copper Incorporation into Human Ceruloplasmin*

  2002cited by this paper
• Iron overload can induce mild copper deficiency.

  2001cited by this paper
• Temporally Regulated and Tissue-Specific Gene Manipulations in the Adult and Embryonic Heart Using a Tamoxifen-Inducible Cre Protein

  2001cited by this paper
• A role for the COUP-TF-related gene seven-up in the diversification of cardioblast identities in the dorsal vessel of Drosophila.

  2001cited by this paper
• Long-term functional consequences of malnutrition during brain development: copper.

  2000cited by this paper
• Targeted disruption of the mouse Sod I gene makes the hearts vulnerable to ischemic reperfusion injury.

  2000cited by this paper
• The Menkes copper transporter is required for the activation of tyrosinase.

  2000cited by this paper
• Cellular and functional defects in a mouse model of heart failure.

  2000cited by this paper
• Mutations in SCO2 are associated with a distinct form of hypertrophic cardiomyopathy and cytochrome c oxidase deficiency.

  2000cited by this paper
• Expression of Menkes Copper-transporting ATPase, MNK, in the Lactating Human Breast: Possible Role in Copper Transport into Milk

  1999cited by this paper
• Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: comparison of the recombinase activity of the tamoxifen-inducible Cre-ER(T) and Cre-ER(T2) recombinases.

  1999cited by this paper
• Human whole-body copper metabolism.

  1998cited by this paper
• Gene recombination in postmitotic cells. Targeted expression of Cre recombinase provokes cardiac-restricted, site-specific rearrangement in adult ventricular muscle in vivo.

  1997cited by this paper
• Superoxide dismutase protects calcineurin from inactivation

  1996cited by this paper
• Expression of the Menkes gene homologue in mouse tissues lack of effect of copper on the mRNA levels

  1994cited by this paper
• A Unified Perspective on Copper Deficiency and Cardiomyopathy

  1993cited by this paper
• Tissue-specific regulation of the alpha-myosin heavy chain gene promoter in transgenic mice.

  1991cited by this paper
• Constructing deletions with defined endpoints in Drosophila.

  1990cited by this paper
• Changes in tissue growth, concentrations of copper, iron, cytochrome oxidase and superoxide dismutase subsequent to dietary or genetic copper deficiency in mice.

  1983cited by this paper
• Mechanical properties of the copper-deficient rat heart.

  1982cited by this paper
• Myocardial lesions in the offspring of female rats fed a copper deficient diet.

  1974cited by this paper

• Trace Element Intake from Dairy-Free Infant Porridges and Its Nutritional and Safety Implications for Infants Aged Six Months and Older

  2026cites this paper
• Identification of Cuproptosis-Related Genes and Their Potential Role in COPD Pathogenesis: A Bioinformatics Analysis

  2025cites this paper
• The role of metal ion metabolism in the pathogenesis of diabetes and associated complications

  2025cites this paper
• Signal Transduction Strategies for DNAzyme-Based Sensing and Imaging of Metal Ions in Cells and in Vivo

  2025cites this paper
• Copper in Human Health and Disease: Insights from Inherited Disorders.

  2025cites this paper
• Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration

  2025cites this paper
• Comparative review of copper-associated chronic hepatitis in dogs and Wilson disease in humans

  2025cites this paper
• The Yin and Yang of copper in cardiovascular health and disease

  2025cites this paper
• The multifaceted roles of copper in biology.

  2025cites this paper
• Copper-associated Chronic Hepatitis in Dogs.

  2025cites this paper
• A metabolic perspective on cuproptosis.

  2025cites this paper
• From cell death to neurological disease: Unraveling the role of copper.

  2025cites this paper
• Integrative analysis of copper dysregulation and cuproptosis in postnatal hematopoiesis.

  2025cites this paper
• Copper deficiency disrupts OXPHOS and mitochondrial dynamics through MTCH2-dependent copper trafficking in skeletal muscle

  2025cites this paper
• Copper metabolism in hepatocellular carcinoma: from molecular mechanisms to therapeutic opportunities

  2025cites this paper
• Mammalian copper homeostasis: physiological roles and molecular mechanisms

  2024cites this paper
• Maternal dietary copper deficiency induces cardiomyopathy and liver injury in mice by activating autophagy.

  2024cites this paper
• Redox homeostasis in cardiac fibrosis: Focus on metal ion metabolism

  2024cites this paper
• An integrated view of cisplatin-induced nephrotoxicity, hepatotoxicity, and cardiotoxicity: characteristics, common molecular mechanisms, and current clinical management

  2024cites this paper
• Deadly excess copper

  2024cites this paper
• Copper-dependent cell death (cuproptosis): perspectives for pharmacological correction in human diseases

  2024cites this paper
• Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration

  2024cites this paper
• Cuproptosis and Cu: a new paradigm in cellular death and their role in non-cancerous diseases

  2024cites this paper
• Cardiac copper content and its relationship with heart physiology: Insights based on quantitative genetic and functional analyses using BXD family mice

  2023cites this paper
• Association between serum copper levels and muscle mass: results from NHANES 2011–2016

  2023cites this paper
• Phenanthroline and Schiff Base associated Cu(II)-coordinated compounds containing N, O as donor atoms for potent anticancer activity.

  2023cites this paper
• Construction and validation of a cuproptosis-related diagnostic gene signature for atrial fibrillation based on ensemble learning

  2023cites this paper
• Exploring cuproptosis as a mechanism and potential intervention target in cardiovascular diseases

  2023cites this paper
• Leishmania major-induced alteration of host cellular and systemic copper homeostasis drives the fate of infection

  2023cites this paper
• Association between dietary copper and cardiovascular disease: A narrative review.

  2023cites this paper
• Identification of cuproptosis-related biomarkers in dilated cardiomyopathy and potential therapeutic prediction of herbal medicines

  2023cites this paper
• Properties of recombinant extracellular N-terminal domain of human high-affinity copper transporter 1 (hNdCTR1) and its interactions with Cu(II) and Ag(I) ions.

  2023cites this paper
• The Role of Copper Homeostasis in Brain Disease

  2022cites this paper
• Oral Elesclomol Treatment Alleviates Copper Deficiency in Animal Models

  2022cites this paper
• An Emerging Role of Defective Copper Metabolism in Heart Disease

  2022cites this paper
• Mitochondrial dysfunction reactivates α-fetoprotein expression that drives copper-dependent immunosuppression in mitochondrial disease models

  2022influential citation
• The Molecular Mechanisms of Defective Copper Metabolism in Diabetic Cardiomyopathy

  2022cites this paper
• Wilson Disease: Update on Pathophysiology and Treatment

  2022cites this paper
• Copper

  2022cites this paper
• Copper homeostasis and cuproptosis in health and disease

  2022cites this paper
• Copper Toxicity Is Not Just Oxidative Damage: Zinc Systems and Insight from Wilson Disease

  2021cites this paper
• High‐Affinity Copper Transporter Ctr1

  2021cites this paper
• Chronic tribasic copper chloride exposure induces rat liver damage by disrupting the mitophagy and apoptosis pathways.

  2021cites this paper
• Fluorescent Biosensors Based on Silicon Nanowires

  2021cites this paper
• Dynamic and cell-specific transport networks for intracellular copper ions.

  2021cites this paper
• Biodegradable copper-metformin nanoscale coordination polymers for enhanced chemo/chemodynamic synergistic therapy by reducing oxygen consumption to promote H2O2 accumulation.

  2021cites this paper
• Role of Copper on Mitochondrial Function and Metabolism

  2021cites this paper
• The molecular and cellular basis of copper dysregulation and its relationship with human pathologies

  2021cites this paper
• Mitochondrial dysfunction triggers secretion of the immunosuppressive factor α-fetoprotein

  2021influential citation
• Expression of cardiac copper chaperone encoding genes and their correlation with cardiac function parameters in goats

  2021cites this paper
• Physicochemical properties, antioxidant activities and sensory characteristics of commercial gape vinegars during long-term storage

  2020cites this paper
• The molecular mechanisms of copper metabolism and its roles in human diseases

  2020influential citation
• Electron paramagnetic resonance spectroscopy reveals alterations in the redox state of endogenous copper and iron complexes in photodynamic stress-induced ischemic mouse liver

  2020cites this paper
• One ring to bring them all and in the darkness bind them: The Trafficking of Heme without Deliverers.

  2020cites this paper
• Effects of Hot-Melt Extruded Nano-Copper as an Alternative for the Pharmacological Dose of Copper Sulfate in Weanling Pigs

  2020cites this paper
• Changes in mammalian copper homeostasis during microbial infection.

  2020cites this paper
• Copper mediates mitochondrial biogenesis in retinal pigment epithelial cells.

  2020cites this paper
• Copper Metabolism and the Liver

  2020cites this paper
• Elesclomol alleviates Menkes pathology and mortality by escorting Cu to cuproenzymes in mice

  2020cites this paper
• Biological applications of copper-containing materials

  2020cites this paper
• Molecular Insights Into Lysyl Oxidases in Cartilage Regeneration and Rejuvenation

  2020cites this paper
• Active uptake of hydrophilic copper complex Cu(ii)-TETA in primary cultures of neonatal rat cardiomyocytes.

  2019cites this paper
• X-ray structures of the high-affinity copper transporter Ctr1

  2019cites this paper
• Restoration of myocellular copper-trafficking proteins and mitochondrial copper enzymes repairs cardiac function in rats with diabetes-evoked heart failure.

  2019cites this paper
• Liver Cirrhosis with Inherited Liver Diseases: Wilson Disease

  2019cites this paper
• Advances in Toxicological Research of the Anticancer Drug Cisplatin.

  2019cites this paper
• Effects of corn supplementation on the antioxidant activity, selected minerals, and gene expression of selenoprotein and metallothionein in serum, liver, and kidney of sheep-fed palm kernel cake: urea-treated rice straw diets

  2019cites this paper
• Human Nervous System Disorders

  2019cites this paper
• Handling heme: The mechanisms underlying the movement of heme within and between cells

  2019cites this paper
• The Role of Copper Homeostasis at the Host-Pathogen Axis: From Bacteria to Fungi

  2019cites this paper
• Reconstitution of a thermophilic Cu+ importer in vitro reveals intrinsic high-affinity slow transport driving accumulation of an essential metal ion

  2018cites this paper
• Intestinal DMT1 Is Essential for Optimal Assimilation of Dietary Copper in Male and Female Mice with Iron-Deficiency Anemia.

  2018cites this paper
• Intersection of Iron and Copper Metabolism in the Mammalian Intestine and Liver.

  2018cites this paper
• The perfusion of cisplatin and cisplatin structural analogues through the isolated rat heart: The effects on coronary flow and cardiodynamic parameters.

  2018cites this paper
• CHCA-1 is a copper-regulated CTR1 homolog required for normal development, copper accumulation, and copper-sensing behavior in Caenorhabditis elegans

  2018cites this paper
• Copper-Fructose Interactions: A Novel Mechanism in the Pathogenesis of NAFLD

  2018cites this paper
• Feature Article: Trientine selectively delivers copper to the heart and suppresses pressure overload-induced cardiac hypertrophy in rats

  2018cites this paper
• Title In vivo bioluminescence imaging reveals copper deficiency in a murine model of nonalcoholic fatty liver disease

  2018cites this paper
• Copper transporters and copper chaperones: roles in cardiovascular physiology and disease.

  2018cites this paper
• Sco1 mouse models of human disease: a tool to investigate the role of mitochondria in the regulation of copper homeostasis

  2018cites this paper
• Copper: Basic Physiological and Nutritional Aspects

  2017cites this paper
• The role of subcutaneous adipose tissue in supporting the copper balance in rats with a chronic deficiency in holo-ceruloplasmin

  2017cites this paper
• The mammalian phosphate carrier SLC25A3 is a mitochondrial copper transporter required for cytochrome c oxidase biogenesis

  2017cites this paper
• The mitochondrial metallochaperone SCO1 maintains CTR1 at the plasma membrane to preserve copper homeostasis in the murine heart

  2017cites this paper
• Copper and Zinc Homeostasis: Lessons from Drosophila melanogaster

  2017cites this paper
• Organ-specific regulation of ATP7A abundance is coordinated with systemic copper homeostasis

  2017cites this paper
• A role for the Drosophila zinc transporter Zip88E in protecting against dietary zinc toxicity

  2017cites this paper
• Gene expression patterns in the progression of canine copper-associated chronic hepatitis

  2017cites this paper
• Inter-organ signaling by HRG-7 promotes systemic heme homeostasis

  2017cites this paper
• Canine Copper-Associated Hepatitis.

  2017cites this paper
• Inter-organ signalling by HRG-7 promotes systemic haem homeostasis

  2017cites this paper
• Cyanine and Squaric Acid Metal Sensors

  2017cites this paper
• Orchestration of dynamic copper navigation - new and missing pieces.

  2017cites this paper
• Analytical Methods for Imaging Metals in Biology: From Transition Metal Metabolism to Transition Metal Signaling.

  2017cites this paper
• Abundance and Significance of Iron, Zinc, Copper, and Calcium in the Hearts of Patients With Friedreich Ataxia.

  2016cites this paper
• The Inorganic Perspective of VEGF: Interactions of Cu(2+) with Peptides Encompassing a Recognition Domain of the VEGF Receptor.

  2016cites this paper
• Chelation Treatment During Acute and Chronic Metal Overexposures: Experimental and Clinical Studies

  2016cites this paper
• Biology of frailty: Modulation of ageing genes and its importance to prevent age-associated loss of function.

  2016cites this paper
• Copper Regulates Cyclic AMP-Dependent Lipolysis

  2016cites this paper
• Canine Models for Copper Homeostasis Disorders

  2016cites this paper