High-density lipoproteins: a new potential therapeutic target for the prevention of cardiovascular disease.

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Arteriosclerosis, Thrombosis and Vascular Biology

• Publication date

  2004-03-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1161/01.ATV.0000121505.88326.D2PMID 15003970
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Raising High-Density Lipoprotein in Humans Through Inhibition of Cholesteryl Ester Transfer Protein: An Initial Multidose Study of Torcetrapib

  2004cited by this paper
• New insights into the role of the adenosine triphosphate-binding cassette transporters in high-density lipoprotein metabolism and reverse cholesterol transport.

  2003cited by this paper
• Effect of recombinant ApoA-I Milano on coronary atherosclerosis in patients with acute coronary syndromes: a randomized controlled trial.

  2003cited by this paper
• Platelet-activating Factor Acetylhydrolase, and Not Paraoxonase-1, Is the Oxidized Phospholipid Hydrolase of High Density Lipoprotein Particles*

  2003cited by this paper
• Cholesteryl Ester Transfer Protein: A Novel Target for Raising HDL and Inhibiting Atherosclerosis

  2003cited by this paper
• Effects of nonstatin lipid drug therapy on high-density lipoprotein metabolism.

  2003cited by this paper
• Benefit-risk assessment of Rosuvastatin 10 to 40 milligrams.

  2003cited by this paper
• Rupture of the Atherosclerotic Plaque: Does a Good Animal Model Exist?

  2003cited by this paper
• Role of the hepatic ABCA1 transporter in modulating intrahepatic cholesterol and plasma HDL cholesterol concentrations Published, JLR Papers in Press, November 4, 2002. DOI 10.1194/jlr.M200414-JLR200

  2003cited by this paper
• Importance of different pathways of cellular cholesterol efflux.

  2003cited by this paper
• Vascular biology of atherosclerosis: overview and state of the art.

  2003cited by this paper
• Pharmacologic therapy for patients with chronic heart failure and reduced systolic function: review of trials and practical considerations.

  2003cited by this paper
• Effects of Apolipoprotein A-I on ATP-binding Cassette Transporter A1-mediated Efflux of Macrophage Phospholipid and Cholesterol

  2003cited by this paper
• Effect of high-density lipoproteins on the expression of adhesion molecules in endothelial cells

  2002cited by this paper
• MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial.

  2002cited by this paper
• Cholesteryl ester transfer protein inhibitor (JTT-705) and the development of atherosclerosis in rabbits with severe hypercholesterolaemia.

  2002cited by this paper
• Efficacy and Safety of a Novel Cholesteryl Ester Transfer Protein Inhibitor, JTT-705, in Humans: A Randomized Phase II Dose-Response Study

  2002cited by this paper
• Oxysterol-activated LXRalpha/RXR induces hSR-BI-promoter activity in hepatoma cells and preadipocytes.

  2002cited by this paper
• MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20536 high-risk individuals: a randomised placebo-controlled trial. Commentary

  2002cited by this paper
• The impact of phospholipid transfer protein (PLTP) on HDL metabolism.

  2001cited by this paper
• ABCA1. The gatekeeper for eliminating excess tissue cholesterol.

  2001cited by this paper
• Cellular Localization and Trafficking of the Human ABCA1 Transporter* 210

  2001cited by this paper
• Apolipoprotein specificity for lipid efflux by the human ABCAI transporter.

  2001cited by this paper
• 27-Hydroxycholesterol Is an Endogenous Ligand for Liver X Receptor in Cholesterol-loaded Cells*

  2001cited by this paper
• PREVENTION OF CORONARY HEART DISEASE WITH PRAVASTATIN IN MEN WITH HYPERCHOLESTEROLEMIA

  2000cited by this paper
• A cholesteryl ester transfer protein inhibitor attenuates atherosclerosis in rabbits

  2000cited by this paper
• Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor.

  2000cited by this paper
• ABC1 gene expression and ApoA-I-mediated cholesterol efflux are regulated by LXR.

  2000cited by this paper
• The Effect of Pravastatin on Coronary Events after Myocardial Infarction in Patients with Average Cholesterol Levels

  2000cited by this paper
• Pros and cons of inhibiting cholesteryl ester transfer protein

  2000cited by this paper
• Vaccine-Induced Antibodies Inhibit CETP Activity In Vivo and Reduce Aortic Lesions in a Rabbit Model of Atherosclerosis

  2000cited by this paper
• Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha.

  2000cited by this paper
• Scavenger receptor BI and cholesterol trafficking.

  1999cited by this paper
• Cholesterol efflux to apolipoprotein AI involves endocytosis and resecretion in a calcium-dependent pathway.

  1999cited by this paper
• Increased atherosclerosis in ApoE and LDL receptor gene knock-out mice as a result of human cholesteryl ester transfer protein transgene expression.

  1999cited by this paper
• Cholesteryl Ester Transfer Protein Corrects Dysfunctional High Density Lipoproteins and Reduces Aortic Atherosclerosis in Lecithin Cholesterol Acyltransferase Transgenic Mice*

  1999cited by this paper
• Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of AFCAPS/TexCAPS. Air Force/Texas Coronary Atherosclerosis Prevention Study.

  1998cited by this paper
• Effect of Antisense Oligonucleotides against Cholesteryl Ester Transfer Protein on the Development of Atherosclerosis in Cholesterol-fed Rabbits*

  1998cited by this paper
• A low prevalence of coronary heart disease among subjects with increased high-density lipoprotein cholesterol levels, including those with plasma cholesteryl ester transfer protein deficiency.

  1998cited by this paper
• High plasma HDL concentrations associated with enhanced atherosclerosis in transgenic mice overexpressing lecithinchoesteryl acyltransferase

  1997cited by this paper
• Increased coronary heart disease in Japanese-American men with mutation in the cholesteryl ester transfer protein gene despite increased HDL levels.

  1996cited by this paper
• The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events Trial investigators.

  1996cited by this paper
• Structural and functional differences of subspecies of apoA-I-containing lipoprotein in patients with plasma cholesteryl ester transfer protein deficiency.

  1995cited by this paper
• Decreased affinity of low density lipoprotein (LDL) particles for LDL receptors in patients with cholesteryl ester transfer protein deficiency

  1995cited by this paper
• Decreased early atherosclerotic lesions in hypertriglyceridemic mice expressing cholesteryl ester transfer protein transgene.

  1995cited by this paper
• Characterization of high-density apolipoprotein particles A-I and A-I:A-II isolated from humans with cholesteryl ester transfer protein deficiency.

  1995cited by this paper
• Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group.

  1995cited by this paper
• Increased catabolic rate of low density lipoproteins in humans with cholesteryl ester transfer protein deficiency.

  1995cited by this paper
• Lowering cholesterol with drugs and diet.

  1995cited by this paper
• Genetic cholesteryl ester transfer protein deficiency caused by two prevalent mutations as a major determinant of increased levels of high density lipoprotein cholesterol.

  1994cited by this paper
• Antibodies to glutamic acid decarboxylase as predictors of insulin-dependent diabetes mellitus before clinical onset of disease.

  1994cited by this paper
• Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)

  1994cited by this paper
• Large and cholesteryl ester-rich high-density lipoproteins in cholesteryl ester transfer protein (CETP) deficiency can not protect macrophages from cholesterol accumulation induced by acetylated low-density lipoproteins.

  1994cited by this paper
• Human apolipoprotein A-I gene expression increases high density lipoprotein and suppresses atherosclerosis in the apolipoprotein E-deficient mouse.

  1994cited by this paper
• Severe atherosclerosis in transgenic mice expressing simian cholesteryl ester transfer protein

  1993cited by this paper
• Protection of low-density lipoprotein against oxidative modification by high-density lipoprotein associated paraoxonase.

  1993cited by this paper
• Delayed catabolism of high density lipoprotein apolipoproteins A-I and A-II in human cholesteryl ester transfer protein deficiency.

  1993cited by this paper
• Familial hypoalphalipoproteinemia in premature coronary artery disease.

  1993cited by this paper
• Lipids and risk of coronary heart disease. The Framingham Study.

  1992cited by this paper
• Inhibition of early atherogenesis in transgenic mice by human apolipoprotein AI

  1991cited by this paper
• Detection of two species of low density lipoprotein particles in cholesteryl ester transfer protein deficiency.

  1991cited by this paper
• Regression of atherosclerotic lesions by high density lipoprotein plasma fraction in the cholesterol-fed rabbit.

  1990cited by this paper
• Accumulation of apolipoprotein E-rich high density lipoproteins in hyperalphalipoproteinemic human subjects with plasma cholesteryl ester transfer protein deficiency.

  1990cited by this paper
• Increased high-density lipoprotein levels caused by a common cholesteryl-ester transfer protein gene mutation.

  1990cited by this paper
• High-density lipoprotein--the clinical implications of recent studies.

  1989cited by this paper
• Early incorporation of cell-derived cholesterol into pre-beta-migrating high-density lipoprotein.

  1988cited by this paper
• Small polydisperse low density lipoproteins in familial hyperalphalipoproteinemia with complete deficiency of cholesteryl ester transfer activity.

  1988cited by this paper
• Regulation of low-density lipoprotein receptors: implications for pathogenesis and therapy of hypercholesterolemia and atherosclerosis.

  1987cited by this paper
• Central role of high density lipoprotein in plasma free cholesterol metabolism.

  1982cited by this paper
• An in vivo evaluation in man of the transfer of esterified cholesterol between lipoproteins and into the liver and bile.

  1981cited by this paper
• Multicompartmental analysis of cholesterol metabolism in man. Characterization of the hepatic bile acid and biliary cholesterol precursor sites.

  1978cited by this paper
• The plasma lecithins:cholesterol acyltransferase reaction.

  1968cited by this paper

• Identification of protein targets for dyslipidaemia and cardiovascular diseases among people with South Asian ancestry: a mendelian randomisation study

  2025cites this paper
• Prioritizing protein targets for dyslipidaemia and cardiovascular diseases using Mendelian randomization in South Asians

  2024cites this paper
• A Study on Multiple Facets of Apolipoprotein A1 Milano

  2023cites this paper
• HDL and Cholesterol Ester Transfer Protein (CETP).

  2022cites this paper
• Insulin Downregulates the Expression of ATP-binding Cassette Transporter A-I in Human Hepatoma Cell Line HepG2 in a FOXO1 and LXR Dependent Manner

  2022cites this paper
• The Role of High-Density Lipoprotein in Cardiovascular Disease: Benefits, Functions, and Treatments

  2022influential citation
• Genes in human obesity loci are causal obesity genes in C. elegans

  2021cites this paper
• A. M IFNγ+LPS : lower cholesterol uptake, storage & efflux B. M IL-4/IL-10 : high cholesterol uptake, storage & efflux C. M oxPAPC : moderate cholesterol uptake/processing, high efflux

  2021cites this paper
• OX-HDL: A Starring Role in Cardiorenal Syndrome and the Effects of Heme Oxygenase-1 Intervention

  2020cites this paper
• Macrophage polarisation associated with atherosclerosis differentially affects their capacity to handle lipids.

  2020cites this paper
• Forty‐eight weeks of statin therapy for type 2 diabetes mellitus patients with lower extremity atherosclerotic disease: Comparison of the effects of pitavastatin and atorvastatin on lower femoral total plaque areas

  2020cites this paper
• Understanding HDL: Overview

  2019cites this paper
• Targeting Foam Cell Formation in Atherosclerosis: Therapeutic Potential of Natural Products

  2019cites this paper
• Effect of Fermented Pentaclethra Macrophylla Benth (African Oil Bean) Seed Extract on Plasma Lipid Profile in Healthy Rat Model-A Preliminary Study

  2019cites this paper
• Change of HDL by Life Style

  2019cites this paper
• Effet anti-inflammatoire et anti obésité des extraits polyphénoliques de feuilles de caroube "Ceratonia siliqua" et cladode de figuier de barbarie "Opuntia ficus-indica"

  2018cites this paper
• Anti-obesity effects of pectinase and cellulase enzyme-treated Ecklonia cava extract in high-fat diet-fed C57BL/6N mice

  2017cites this paper
• Glucotoxicity Induced Oxidative Stress and Inflammation In Vivo and In Vitro in Psammomys obesus: Involvement of Aqueous Extract of Brassica rapa rapifera

  2016cites this paper
• volving Concepts of Dyslipidemia , therosclerosis , and Cardiovascular Disease

  2016cites this paper
• Discovery of High-Density Lipoprotein Gene Targets from Classical Genetics to Genome-Wide Association Studies

  2016cites this paper
• Anti-hyperlipidemic activities of Ilex latifolia and other selected herbs

  2016cites this paper
• Effect of purified gambir leaves extract to prevent atherosclerosis in rats

  2016cites this paper
• High-Density Lipoprotein Function

  2016cites this paper
• Cheonggukjang, a soybean paste fermented with B. licheniformis-67 prevents weight gain and improves glycemic control in high fat diet induced obese mice

  2016cites this paper
• The short-term influence of a Mediterranean-type diet and mild exercise with and without red wine on patients with the metabolic syndrome.

  2016cites this paper
• Erratum to: Remodeling pattern is related to the degree of coronary plaque regression induced by pitavastatin: a sub-analysis of the TOGETHAR trial with intravascular ultrasound and coronary angioscopy

  2015cites this paper
• Rosiglitazone attenuates atherosclerosis and increases high-density lipoprotein function in atherosclerotic rabbits

  2015cites this paper
• Investigation of total HDL and HDL subclass kinetics using stable isotope techniques in healthy subjects

  2015cites this paper
• Some molecular targets for antihyperlipidemic drug research.

  2014cites this paper
• Celastrol suppresses obesity process via increasing antioxidant capacity and improving lipid metabolism.

  2014cites this paper
• Oxidized high-density lipoprotein induces the proliferation and migration of vascular smooth muscle cells by promoting the production of ROS.

  2014cites this paper
• Remodeling pattern is related to the degree of coronary plaque regression induced by pitavastatin: a sub-analysis of the TOGETHAR trial with intravascular ultrasound and coronary angioscopy

  2014cites this paper
• Exercise Improves Immune Function, Antidepressive Response, and Sleep Quality in Patients with Chronic Primary Insomnia

  2014cites this paper
• Response of serum lipids to a fat meal in Black South African subjects with different apoe genotypes

  2013cites this paper
• Recalculation of 23 mouse HDL QTL datasets improves accuracy and allows for better candidate gene analysis

  2013cites this paper
• The relationship between serum amyloid A and apolipoprotein A‐I in high‐density lipoprotein isolated from patients with coronary heart disease

  2013cites this paper
• ATIVIDADE DA PARAOXONASE / ARIL-ESTERASE (PON) E INCORPORAÇÃO DE FOSFOLIPÍDEOS EM PARTÍCULAS DE HDL NA HIPERTRIGLICERIDEMIA HUMANA

  2013cites this paper
• Evidence that periodontal treatment improves biomarkers and CVD outcomes.

  2013cites this paper
• Evidence that periodontal treatment improves biomarkers and CVD outcomes.

  2013cites this paper
• Substituted Benzamides Containing Azaspiro Rings as Upregulators of Apolipoprotein A-I Transcription

  2012cites this paper
• Vulnerable Plaque: From Bench to Bedside; Local Pacification Versus Systemic Therapy

  2012cites this paper
• Grape seed proanthocyanidins extracts promote apolipoprotein A-I mRNA expression in HepG2 cells under experimental sugar and high-sugar conditions.

  2012cites this paper
• PPAR Medicines and Human Disease: The ABCs of It All

  2012cites this paper
• Impaired functionality of HDL in diabetes

  2012cites this paper
• Impact of glucotoxicity induced in vivo and in vitro in Psammomys obesus

  2012cites this paper
• Progress and challenges in translating the biology of atherosclerosis

  2011cites this paper
• CETP Inhibition: Does the Future Look Promising?

  2011cites this paper
• High-density lipoprotein metabolism in human apolipoprotein B(100) transgenic/brown adipose tissue deficient mice: a model of obesity-induced hyperinsulinemia.

  2011cites this paper
• Structural and biophysical insight into cholesteryl ester-transfer protein.

  2011cites this paper
• Novel Biomarkers and Subclinical Atherosclerosis

  2011cites this paper
• High-Density Lipoprotein Metabolism

  2011cites this paper
• Pitavastatin increases ABCA1 expression by dual mechanisms: SREBP2-driven transcriptional activation and PPARα-dependent protein stabilization but without activating LXR in rat hepatoma McARH7777 cells.

  2011cites this paper
• Role for inducible cAMP early repressor in promoting pancreatic beta cell dysfunction evoked by oxidative stress in human and rat islets

  2011cites this paper
• Pitavastatin Increases ABCA 1 Expression by Dual Mechanisms : SREBP 2-Driven Transcriptional Activation and PPAR α-Dependent Protein Stabilization but Without Activating LXR in Rat Hepatoma McARH 7777 Cells

  2011cites this paper
• Variants d'apolipoprotéine a1 résistants à l'oxydation dimères

  2011cites this paper
• RVX-208: a small molecule that increases apolipoprotein A-I and high-density lipoprotein cholesterol in vitro and in vivo.

  2010cites this paper
• Simvastatin treatment prevents oxidative damage to DNA in whole blood leukocytes of dyslipidemic type 2 diabetic patients

  2010cites this paper
• Altérations métaboliques et nature des acides gras : implication dans la différenciation des cellules régénératives du tissu adipeux

  2010cites this paper
• High‐density lipoprotein affects antigen presentation by interfering with lipid raft: a promising anti‐atherogenic strategy

  2010cites this paper
• Cholesteryl ester transfer protein and its inhibition

  2010cites this paper
• Current drug targets for antihyperlipidemic therapy.

  2010cites this paper
• Senescence-related truncation and multimerization of apolipoprotein A-I in high-density lipoprotein with an elevated level of advanced glycated end products and cholesteryl ester transfer activity.

  2010cites this paper
• PPARγ activates ABCA1 gene transcription but reduces the level of ABCA1 protein in HepG2 cells.

  2010cites this paper
• Targeting dyslipidemia in the metabolic syndrome: an update.

  2010cites this paper
• Contemporary Reviews in Cardiovascular Medicine

  2010cites this paper
• Effect of Light and Heavy Smoking on High Density Lipoprotein Cholesterol Level

  2010cites this paper
• Molecular mechanisms of HDL-cholesterol elevation by statins and its effects on HDL functions.

  2010cites this paper
• Promoting mechanisms of vascular health: circulating progenitor cells, angiogenesis, and reverse cholesterol transport.

  2009cites this paper
• Effect of Rimonabant on the High-Triglyceride/Low–HDL-Cholesterol Dyslipidemia, Intraabdominal Adiposity, and Liver Fat: The ADAGIO-Lipids Trial

  2009cites this paper
• [Visualizing arterial macrophage warfare with nuclear magnetic resonance, positron-emission tomography and computerized tomography].

  2009cites this paper
• Cholesteryl ester transfer protein: at the heart of the action of lipid-modulating therapy with statins, fibrates, niacin, and cholesteryl ester transfer protein inhibitors

  2009cites this paper
• [New challenges in the treatment of dyslipidemia and cardiovascular risk].

  2009cites this paper
• Visualización de la guerra macrofágica arterial con resonancia magnética nuclear, tomografía de emisión de positrones y tomografía computarizada

  2009cites this paper
• Biomedicinal implications of high-density lipoprotein: its composition, structure, functions, and clinical applications.

  2009cites this paper
• Mechanistic studies of blood pressure in rats treated with a series of cholesteryl ester transfer protein inhibitors

  2009cites this paper
• Targeting Apolipoproteins in Magnetic Resonance Imaging

  2009cites this paper
• Safety and tolerability of dalcetrapib.

  2009cites this paper
• Latest Insights Into High-Density Lipoprotein Functions

  2009cites this paper
• A Novel ELISA to Detect Methionine Sulfoxide−Containing Apolipoprotein A−I

  2009cites this paper
• Nuevos retos en el tratamiento de las dislipidemias y del riesgo cardiovascular

  2009cites this paper
• The expression of the human apolipoprotein genes and their regulation by PPARs

  2008cites this paper
• High glucose induces transactivation of the human paraoxonase 1 gene in hepatocytes.

  2008cites this paper
• Origins of intestinal ABCA1-mediated HDL-cholesterol** This work was supported by National Institutes of Health Grant DK-067132. Published, JLR Papers in Press, August 18, 2008.

  2008cites this paper
• Infusion of Reconstituted High-Density Lipoprotein Leads to Acute Changes in Human Atherosclerotic Plaque

  2008cites this paper
• Cholesterol ester transfer protein: a therapeutic target in atherosclerosis?

  2008cites this paper
• Etude des effets de la protéine C-réactive sur certains aspects de la biologie des cellules mononucléées circulantes et des monocytes humains : Implications pour la physiopathologie des maladies cardiovasculaires

  2008cites this paper
• Oxidative mechanisms and atherothrombotic cardiovascular disease.

  2008cites this paper
• A point mutant of apolipoprotein A-I, V156K, exhibited potent anti-oxidant and anti-atherosclerotic activity in hypercholesterolemic C57BL/6 mice

  2007cites this paper
• CHAPTER 8 – Inhibition of Cholesterol Biosynthesis, the Discovery of the Statins, and a Revolution in Preventive Cardiology

  2007cites this paper
• Sterol Regulatory Element-binding Protein-2- and Liver X Receptor-driven Dual Promoter Regulation of Hepatic ABC Transporter A1 Gene Expression

  2007cites this paper
• Astaxanthin ameliorates features of metabolic syndrome in SHR/NDmcr-cp.

  2007cites this paper
• Effects of peroxisome proliferator-activated receptors on lipoprotein metabolism and glucose control in type 2 diabetes mellitus.

  2007cites this paper
• Coronary heart disease aetiology: associations and causality.

  2007cites this paper
• High Density Lipoprotein Cholesterol Comes of Age

  2007cites this paper
• The biology and chemistry of hyperlipidemia.

  2007cites this paper
• The paradox of dysfunctional high-density lipoprotein

  2007cites this paper
• CHAPTER 5 – In Search of a Pathogenesis

  2007cites this paper
• Will torcetrapib be the next big thing in coronary heart disease risk reduction?

  2007cites this paper
• Modified lipoproteins as contrast agents for imaging of atherosclerosis.

  2007cites this paper
• HDL function as a target of lipid-modifying therapy.

  2007cites this paper