Activation of the epithelial Na+ channel triggers prostaglandin E2 release and production required for embryo implantation

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Nature Medicine

• Publication date

  2012-06-24

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/nm.2771PMID 22729284
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Regulation of smooth muscle contraction by the epithelium: role of prostaglandins.

  2011cited by this paper
• Deregulation of the serum- and glucocorticoid-inducible kinase SGK1 in the endometrium causes reproductive failure

  2011cited by this paper
• Disorders of implantation--are there diagnostic and therapeutic options?

  2011cited by this paper
• Promoting implantation by local injury to the endometrium.

  2010cited by this paper
• ENaC at the Cutting Edge: Regulation of Epithelial Sodium Channels by Proteases*

  2009cited by this paper
• Regulation of epithelial sodium channels by cGMP/PKGII

  2009cited by this paper
• Proteolytic Processing of the Epithelial Sodium Channel γ Subunit Has a Dominant Role in Channel Activation*

  2008cited by this paper
• Regulation of smooth muscle contractility by the epithelium in rat vas deferens: role of ATP‐induced release of PGE2

  2008cited by this paper
• Tryptase activates calcium-independent phospholipase A2 and releases PGE2 in airway epithelial cells.

  2008cited by this paper
• Trypsin can activate the epithelial sodium channel (ENaC) in microdissected mouse distal nephron.

  2008cited by this paper
• Cyclooxygenase-2 derived PGE2 and PGI2 play an important role via EP2 and PPARdelta receptors in early steps of oil induced decidualization in mice.

  2008cited by this paper
• Mechano-sensitivity of ENaC: may the (shear) force be with you

  2008cited by this paper
• Prostaglandins and the initiation of blastocyst implantation and decidualization.

  2007cited by this paper
• Prostaglandin E Receptors*

  2007cited by this paper
• Cytokines and chemokines during human embryo implantation: roles in implantation and early placentation.

  2007cited by this paper
• A short history of voltage‐gated calcium channels

  2006influential reference
• Signalling networks regulating cyclooxygenase-2.

  2006cited by this paper
• Production of prostaglandinE2 via bile acid is enhanced by trypsin and acid in normal human esophageal epithelial cells.

  2004cited by this paper
• Differential expression and localization of CFTR and ENaC in mouse endometrium during pre‐implantation

  2004cited by this paper
• Role of leukemia inhibitor factor (LIF) in decidualisation of murine uterine stromal cells in vitro.

  2004cited by this paper
• Membrane Potential-Dependent Inhibition of Platelet Adhesion to Endothelial Cells by Epoxyeicosatrienoic Acids

  2004cited by this paper
• Proteases at the Endometrial–Trophoblast Interface: Their Role in Implantation

  2004cited by this paper
• Distribution and Regulation of ENaC Subunit and CFTR mRNA Expression in Murine Female Reproductive Tract

  2002cited by this paper
• Regulation of the Epithelial Sodium Channel by Serine Proteases in Human Airways*

  2002cited by this paper
• Epithelial sodium channel/degenerin family of ion channels: a variety of functions for a shared structure.

  2002cited by this paper
• Pyrimidinoceptors-mediated activation of Ca(2+)-dependent Cl(-) conductance in mouse endometrial epithelial cells.

  2000cited by this paper
• An epithelial serine protease activates the amiloride-sensitive sodium channel

  1997cited by this paper
• Multiple female reproductive failures in cyclooxygenase 2-deficient mice.

  1997influential reference
• Reduced fertility and postischaemic brain injury in mice deficient in cytosolic phospholipase A2

  1997influential reference
• The role of calcium in the artificially induced decidual cell reaction in pseudopregnant mice.

  1996cited by this paper
• Ca(2+)-conductances in cultured rat retinal pigment epithelial cells.

  1994cited by this paper
• Ca2+‐conductances in cultured rat retinal pigment epithelial cells

  1994cited by this paper
• Prostaglandin E2, cAMP and cAMP-dependent protein kinase isozymes during decidualization of rat endometrial stromal cells in vitro.

  1993cited by this paper
• Trypsin-like hatching protease from mouse embryos: evidence for the presence in culture medium and its enzymatic properties.

  1990cited by this paper
• Comparative measurements of membrane potentials with microelectrodes and voltage-sensitive dyes.

  1984cited by this paper
• Changes in the pattern of endometrial protein synthesis during decidualization in the rat.

  1982cited by this paper
• Transmitter role of the luminal uterine epithelium in the induction of decidualization in rats.

  1981cited by this paper
• Apposition of uterine luminal epithelium during implantation in senescent golden hamsters.

  1979cited by this paper
• Comparative aspects of blastocyst-endometrial interactions at implantation.

  1978influential reference
• [The role of prostaglandins].

  1975influential reference
• Contractile responses of the guinea-pig trachea in vitro: modification by prostaglandin synthesis-inhibiting drugs.

  1975cited by this paper
• Binucleate and polyploid cells in the decidua of the mouse.

  1974cited by this paper
• Attachment reaction of the uterine luminal epithelium at implantation: light and electron microscopy of the hamster, guinea-pig, rabbit and mink.

  1972cited by this paper
• Effects of progesterone and oestradiol-17 beta on the luminal epithelium of the mouse uterus.

  1970cited by this paper
• Endocrine control of endometrial sensitivity during the induction of the decidual cell reaction in the mouse.

  1966influential reference

• Organoids as powerful models of endometrium epithelium in transcriptomic, cellular and functional mimicry

  2025cites this paper
• Molecular subtype of recurrent implantation failure reveals distinct endometrial etiology of female infertility

  2025cites this paper
• Non-coding RNAs in congenital heart disease and placental development: Bridging molecular mechanisms to clinical biomarkers and therapies

  2025cites this paper
• TRPV6 channel function is involved in endometrial epithelial cell Ca2+ signaling and female mouse fecundity

  2025cites this paper
• Participation of COX2/mPGES1/PGE2 in mouse and human endometrial stromal decidualization

  2025cites this paper
• Embryo-derived trypsin-induced calcium entry is inhibited by endometrial infertility factor, LEFTY2

  2025cites this paper
• Epithelial sodium channels: Tissue distribution, function, and regulation by mineralocorticoid aldosterone

  2025cites this paper
• Spatiotemporally distinct roles of cyclooxygenase-1 and cyclooxygenase-2 at fetomaternal interface in mice

  2024cites this paper
• Effects of CFTR-ENaC on spinal cord edema after spinal cord injury

  2024cites this paper
• The co-expression of the depolarizing and hyperpolarizing mechanosensitive ion channels in mammalian retinal neurons

  2024cites this paper
• Taurine is Essential for Mouse Uterine Luminal Fluid Resorption During Implantation Window Via the SCNN1A and AQP8 Signaling †

  2024cites this paper
• The L‐type calcium channel CaV1.3: A potential target for cancer therapy

  2024cites this paper
• Preeclampsia and transport of ions and small molecules: A literature review.

  2024cites this paper
• Uterine prostaglandin DP receptor-induced upon implantation contributes to decidualization together with EP4 receptor

  2024cites this paper
• Differential expression of ion channel coding genes in the endometrium of women experiencing recurrent implantation failures

  2024cites this paper
• The epithelial Na+ channel (ENaC) in ovarian granulosa cells modulates Ca2+ mobilization and gonadotrophin signaling for estrogen homeostasis and female fertility

  2024cites this paper
• The histone methyltransferase KMT2D is essential for embryo implantation via regulating precise differentiation of endometrial cells

  2024cites this paper
• Immunological testing for female infertility: a modern view on the problem

  2024cites this paper
• Histamine promotes mouse decidualization through stimulating epithelial amphiregulin release

  2024cites this paper
• RNA sequencing and gene co-expression network of in vitro matured oocytes and blastocysts of buffalo

  2024cites this paper
• Fludrocortisone improves endometrial receptivity by regulating expression of ENaC, SGK1, HAND2, miR-200a, miR-145, miR-451, mTOR, and 4E-BP1 during the implantation window in mice

  2024cites this paper
• Therapeutic Potential of Hydrogen Sulfide in Reproductive System Disorders

  2024cites this paper
• Role of Immunological Testing in Infertility

  2024cites this paper
• Revealing the mechanism of fiber promoting sow embryo implantation by altering the abundance of uterine fluid proteins: A proteomic perspective.

  2024cites this paper
• Regulatory effects of hydrogen sulfide on the female reproductive system.

  2023cites this paper
• Protease secretions by the invading blastocyst induce calcium oscillations in endometrial epithelial cells via the protease-activated receptor 2

  2023influential citation
• Adverse effect of assisted reproductive technology-related hyperoestrogensim on the secretion and absorption of uterine fluid in superovulating mice during the peri-implantation period

  2023cites this paper
• The Influence of Metabolic Factors and Diet on Fertility

  2023cites this paper
• The human periconceptional maternal-embryonic space in health and disease.

  2023cites this paper
• The regulation and function of acetylated high-mobility group box 1 during implantation and decidualization

  2023cites this paper
• Decreased fertility in female mice lacking urokinase plasminogen activator.

  2023cites this paper
• The presence of blastocyst within the uteri facilitates lumenal epithelium transformation for implantation via upregulating lysosome proteostasis activity

  2023cites this paper
• Local and systemic inflammatory response to the intrauterine infusion of enzymes during estrus in water buffaloes with subclinical endometritis.

  2023cites this paper
• Activation of SGK1/ENaC Signaling Pathway Improves the Level of Decidualization in Unexplained Recurrent Spontaneous Abortion

  2023cites this paper
• Human embryo implantation

  2023cites this paper
• Biphasic regulation of CFTR expression by ENaC in epithelial cells: The involvement of Ca2+-modulated cAMP production

  2022influential citation
• Use of biological and chemical molecules in regulating embryo implantation and endometrial receptivity

  2022cites this paper
• Progress in modern reproductive biology research in China

  2022cites this paper
• Investigation of Sperm and Seminal Plasma Candidate MicroRNAs of Bulls with Differing Fertility and In Silico Prediction of miRNA-mRNA Interaction Network of Reproductive Function

  2022cites this paper
• The role of immunologic tests for subfertility in the clinical environment.

  2022cites this paper
• High-Throughput In Vitro Screening Identified Nemadipine as a Novel Suppressor of Embryo Implantation

  2022cites this paper
• Estrogen Regulates the Expression and Localization of YAP in the Uterus of Mice

  2022cites this paper
• How Mechanical Forces Change the Human Endometrium during the Menstrual Cycle in Preparation for Embryo Implantation

  2021cites this paper
• Proteinase Activated Receptors Mediate the Trypsin-Induced Ca2 + Signaling in Human Uterine Epithelial Cells

  2021influential citation
• Intralipid therapy and adverse reproductive outcome: is there any evidence?

  2021cites this paper
• Regulation of smooth muscle contractility by the epithelium in rat tracheas: role of prostaglandin E2 induced by the neurotransmitter acetylcholine

  2021cites this paper
• Rictor/mTORC2 is involved in endometrial receptivity by regulating epithelial remodeling

  2021cites this paper
• Endometrial extracellular matrix rigidity and IFNτ ensure the establishment of early pregnancy through activation of YAP

  2021cites this paper
• Modelling the impact of decidual senescence on embryo implantation in human endometrial assembloids

  2021cites this paper
• Regulation and Function of Laminin A5 during Mouse and Human Decidualization

  2021cites this paper
• Activation of SGLT3a in endometrial epithelial cells induces paracrine stromal cell decidualization

  2021cites this paper
• O-GlcNAc modification mediates aquaporin 3 to coordinate endometrial cell glycolysis and affects embryo implantation

  2021cites this paper
• Involvement of Kisspeptin in androgen-induced hypothalamic endoplasmic reticulum stress and its rescuing effect in PCOS rats.

  2021cites this paper
• Distribution and Function of Prostaglandin E2 Receptors in Mouse Uterus: Translational Value for Human Reproduction

  2020cites this paper
• Decidualization score identifies an endometrial dysregulation in samples from women with recurrent pregnancy losses and unexplained infertility

  2020cites this paper
• Secretory phospholipase A2-X (Pla2g10) is a novel progesterone receptor target gene exclusively induced in uterine luminal epithelium for uterine receptivity in mice

  2020cites this paper
• The Enigmatic Role of Serum & Glucocorticoid Inducible Kinase 1 in the Endometrium

  2020cites this paper
• Endothelial epithelial sodium channel involves in high-fat diet-induced atherosclerosis in low-density lipoprotein receptor-deficient mice.

  2020cites this paper
• Progesterone Regulates Glucose Metabolism Through Glucose Transporter 1 to Promote Endometrial Receptivity

  2020cites this paper
• Genome-wide expression analysis of endometrium before and after endometrioma surgery.

  2020cites this paper
• Annexin A7 Regulates Endometrial Receptivity

  2020cites this paper
• Bisphenol A‐induced mechanistic impairment of decidualization

  2020cites this paper
• "Shedding light into the black box: Advances in in vitro systems for studying implantation".

  2020cites this paper
• Contributions of RNA-seq to improve in vitro embryo production (IVP)

  2019cites this paper
• MRP4 sustains Wnt/β-catenin signaling for pregnancy, endometriosis and endometrial cancer

  2019cites this paper
• In vitro exposure to pyrethroid-based products disrupts development of mouse preimplantation embryos.

  2019cites this paper
• Cyclooxygenase-2 and decidual immune cells

  2019cites this paper
• Spatial organization of endometrial gene expression at the onset of embryo attachment in pigs

  2019cites this paper
• CAPS Mutations Are Potentially Associated with Unexplained Recurrent Pregnancy Loss.

  2019cites this paper
• Uterine Luminal Epithelium as the Transient Gateway for Embryo Implantation.

  2019cites this paper
• Cooperative inflammation: The recruitment of inflammatory signaling in marsupial and eutherian pregnancy.

  2019cites this paper
• Administration of dexamethasone disrupts endometrial receptivity by alteration of expression of miRNA 223, 200a, LIF, Muc1, SGK1, and ENaC via the ERK1/2‐mTOR pathway

  2019cites this paper
• Beyond a chemopreventive reagent, aspirin is a master regulator of the hallmarks of cancer

  2019cites this paper
• The gasotransmitter hydrogen sulfide inhibits transepithelial anion secretion of pregnant mouse endometrial epithelium.

  2019cites this paper
• The TNF-derived TIP peptide activates the epithelial sodium channel and ameliorates experimental nephrotoxic serum nephritis.

  2019cites this paper
• Profile of Dr. Hefeng Huang

  2019cites this paper
• Functional expression of the mechanosensitive PIEZO1 channel in primary endometrial epithelial cells and endometrial organoids

  2019cites this paper
• Decreased decidual epithelial sodium channel (ENaC) alpha and gamma subunits in recurrent pregnancy loss (RPL)

  2019cites this paper
• ATP mediates the interaction between human blastocyst and endometrium

  2019cites this paper
• Annexin A8 (ANXA8) regulates proliferation of porcine endometrial cells via Akt signalling pathway

  2018cites this paper
• Prostaglandin E2 Is Required for BMP4-Induced Mesoderm Differentiation of Human Embryonic Stem Cells

  2018cites this paper
• Environmentally relevant levels of bisphenol A affect uterine decidualization and embryo implantation through the estrogen receptor/serum and glucocorticoid-regulated kinase 1/epithelial sodium ion channel α-subunit pathway in a mouse model.

  2018cites this paper
• A single preovulatory administration of ulipristal acetate affects the decidualization process of the human endometrium during the receptive period of the menstrual cycle.

  2018cites this paper
• Uterine TPPP3 plays important role in embryo implantation via modulation of β-Catenin†

  2018cites this paper
• The N terminus of α-ENaC mediates ENaC cleavage and activation by furin

  2018cites this paper
• Isoform-Specific Compensation of Cyclooxygenase (Ptgs) Genes during Implantation and Late-Stage Pregnancy

  2018cites this paper
• Activation of the epithelial sodium channel (ENaC) leads to cytokine profile shift to pro‐inflammatory in labor

  2018influential citation
• Inhibition of TMEM16A impedes embryo implantation and decidualization in mice

  2018cites this paper
• Intake of protein-rich foods in relation to outcomes of infertility treatment with assisted reproductive technologies.

  2018cites this paper
• Establishing life is a calcium-dependent TRiP: Transient receptor potential channels in reproduction.

  2018cites this paper
• Development and analysis of a FOXA2 conditional overexpression mouse model

  2018cites this paper
• Involvement of serum glucocorticoid‐regulated kinase 1 in reproductive success

  2017influential citation
• Decreased epithelial progesterone receptor A at the window of receptivity is required for preparation of the endometrium for embryo attachment†

  2017cites this paper
• Uterine Fluid in Pregnancy: A Biological and Clinical Outlook.

  2017cites this paper
• The functional expression of transient receptor potential channels in the mouse endometrium

  2017cites this paper
• HB-EGF regulates Prss 56 expression during mouse decidualization via EGFR / ERK / EGR 2 signaling pathway

  2017cites this paper
• Estradiol Suppresses TLR4-triggered Apoptosis of Decidual Stromal Cells and Drives an Anti-inflammatory TH2 Shift by Activating SGK1

  2017cites this paper
• Characterization of human endometrial glandular epithelium in vitro and in vivo.

  2017influential citation
• HB-EGF regulates Prss 56 expression during mouse decidualization via EGFR / ERK / EGR 2 signaling pathway

  2017cites this paper
• MRP4 regulates ENaC-dependent CREB/COX-2/PGE2 signaling during embryo implantation

  2017influential citation