Development, characterization and nasal delivery of rosmarinic acid-loaded solid lipid nanoparticles for the effective management of Huntington’s disease

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Drug Delivery

• Publication date

  2015-10-03

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.3109/10717544.2014.880860PMID 24512295
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2011influential reference
• Huntington's disease: a clinical review

  2010cited by this paper
• Subchronic administration of rosmarinic acid, a natural prolyl oligopeptidase inhibitor, enhances cognitive performances.

  2010cited by this paper
• Nutraceutical Antioxidants as Novel Neuroprotective Agents

  2010influential reference
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  2009influential reference
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  2009cited by this paper
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  2009influential reference
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  2009cited by this paper
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  2008influential reference
• Cyclooxygenase inhibition attenuates 3‐nitropropionic acid‐induced neurotoxicity in rats: possible antioxidant mechanisms

  2007influential reference
• Importance of solid lipid nanoparticles (SLN) in various administration routes and future perspectives

  2007cited by this paper
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  2006cited by this paper
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  2005cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2000cited by this paper
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  1999cited by this paper
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  1999cited by this paper
• 3-Nitropropionic acid animal model and Huntington's disease.

  1997cited by this paper
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  1997influential reference
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  1993cited by this paper
• Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids.

  1982cited by this paper
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  1959influential reference
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  1951cited by this paper
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  1949cited by this paper
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