PPARγ and Apoptosis in Cancer

Peroxisome proliferator-activated receptors (PPARs) are ligand binding transcription factors which function in many physiological roles including lipid metabolism, cell growth, differentiation, and apoptosis. PPARs and their ligands have been shown to play a role in cancer. In particular, PPARγ ligands including endogenous prostaglandins and the synthetic thiazolidinediones (TZDs) can induce apoptosis of cancer cells with antitumor activity. Thus, PPARγ ligands have a potential in both chemoprevention and therapy of several types of cancer either as single agents or in combination with other antitumor agents. Accordingly, the involvement of PPARγ and its ligands in regulation of apoptosis of cancer cells have been extensively studied. Depending on cell types or ligands, induction of apoptosis in cancer cells by PPARγ ligands can be either PPARγ-dependent or -independent. Through increasing our understanding of the mechanisms of PPARγ ligand-induced apoptosis, we can develop better strategies which may include combining other antitumor agents for PPARγ-targeted cancer chemoprevention and therapy. This review will highlight recent research advances on PPARγ and apoptosis in cancer.

• Publication year

  2008

• Venue

  PPAR Research

• Publication date

  2008-07-02

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1155/2008/704165PMID 18615184PMCID 2442903
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2008cited by this paper
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  2008cited by this paper
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  2007cited by this paper
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  2007cited by this paper
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  2007cited by this paper
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  2007cited by this paper
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  2007cited by this paper
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  2007cited by this paper
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  2007cited by this paper
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  2007influential reference
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  2007influential reference
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  2007cited by this paper
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  2006influential reference
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  2006influential reference
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  2006influential reference
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• PPARgamma is a key target of butyrate-induced caspase-3 activation in the colorectal cancer cell line Caco-2.

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  2006influential reference
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  2006influential reference
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  2006cited by this paper
• Peroxisome Proliferator-Activated Receptor-γ Activates p53 Gene Promoter Binding to the Nuclear Factor-κB Sequence in Human MCF7 Breast Cancer Cells

  2006cited by this paper
• A Peroxisome Proliferator-activated Receptor-γ Agonist, Troglitazone, Facilitates Caspase-8 and -9 Activities by Increasing the Enzymatic Activity of Protein-tyrosine Phosphatase-1B on Human Glioma Cells*

  2006influential reference
• 15-Deoxy-Δ12,14-prostaglandin J2 induces death receptor 5 expression through mRNA stabilization independently of PPARγ and potentiates TRAIL-induced apoptosis

  2006cited by this paper
• 15-Deoxy- 12,14-prostaglandin J2 induces apoptosis in human malignant B cells: an effect associated with inhibition of NF- B activity and down-regulation of antiapoptotic proteins

  2005cited by this paper
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  2005influential reference
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  2005cited by this paper
• Thiazolidenediones mediate apoptosis in prostate cancer cells in part through inhibition of Bcl-xL/Bcl-2 functions independently of PPARgamma.

  2005cited by this paper
• ET‐18‐O‐CH3‐induced apoptosis is causally linked to COX‐2 upregulation in H‐ras transformed human breast epithelial cells

  2005cited by this paper
• Peroxisome proliferator-activated receptor gamma agonists promote TRAIL-induced apoptosis by reducing survivin levels via cyclin D3 repression and cell cycle arrest.

  2005cited by this paper
• Peroxisome Proliferator-activated Receptor γ Agonists Promote TRAIL-induced Apoptosis by Reducing Survivin Levels via Cyclin D3 Repression and Cell Cycle Arrest*

  2005cited by this paper
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  2005cited by this paper
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  2005cited by this paper
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  2005cited by this paper
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  2004influential reference
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  2004cited by this paper
• GW9662, a potent antagonist of PPARγ, inhibits growth of breast tumour cells and promotes the anticancer effects of the PPARγ agonist rosiglitazone, independently of PPARγ activation

  2004cited by this paper
• Up-Regulation of Cyclooxygenase-2 Expression Is Involved in R(+)-Methanandamide-Induced Apoptotic Death of Human Neuroglioma Cells

  2004cited by this paper
• Roles of CHOP/GADD153 in endoplasmic reticulum stress

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  2004cited by this paper
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  2004cited by this paper
• [Effects of peroxisome proliferator-activated receptor-gamma agonist on Fas-mediated apoptosis in HT-29 cells].

  2003cited by this paper
• 15-Deoxy-delta12,14-prostaglandin J2, a ligand for peroxisome proliferators-activated receptor-gamma, induces apoptosis in human hepatoma cells.

  2003cited by this paper
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  2003influential reference
• 15‐deoxy‐Δ12,14‐prostaglandin J2, a ligand for peroxisome proliferators‐activated receptor‐γ, induces apoptosis in human hepatoma cells

  2003cited by this paper
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  2002influential reference
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  2002cited by this paper
• 15-Deoxy-delta12,14-prostaglandin J2-induced apoptosis does not require PPARgamma in breast cancer cells.

  2002cited by this paper
• PPARgamma-mediated antineoplastic effect of NSAID sulindac on human oral squamous carcinoma cells.

  2002cited by this paper
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  2001cited by this paper
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  2001cited by this paper
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  2001cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper

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