Mitochondrial Regulation of Cell Survival and Death During Low-Oxygen Conditions

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Antioxidants and Redox Signaling

• Publication date

  2009-10-15

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1089/ars.2009.2730PMID 19580395PMCID PMC2821141
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Prevention of hypoxia by myoglobin expression in human tumor cells promotes differentiation and inhibits metastasis.

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• Effect of hypoxia-inducible factor-1α on transcription of survivin in non-small cell lung cancer

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• p53 Initiates Apoptosis by Transcriptionally Targeting the Antiapoptotic Protein ARC

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• Enhanced sensitivity of DJ-1-deficient dopaminergic neurons to energy metabolism impairment: role of Na+/K+ ATPase.

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• Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1.

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• Loss of Mcl-1 Protein and Inhibition of Electron Transport Chain Together Induce Anoxic Cell Death

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• CoCl2-induced HIF-1alpha expression correlates with proliferation and apoptosis in MKN-1 cells: a possible role for the PI3K/Akt pathway.

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• Inhibition of mitochondrial respiration elevates oxygen concentration but leaves regulation of hypoxia-inducible factor (HIF) intact.

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• DJ-1, a novel regulator of the tumor suppressor PTEN.

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• Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress.

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• Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing.

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• Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation.

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• BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly.

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• Structural biology of the Bcl-2 family of proteins.

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• Redistribution of Intracellular Oxygen in Hypoxia by Nitric Oxide: Effect on HIF1α

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• Asparagine Hydroxylation of the HIF Transactivation Domain: A Hypoxic Switch

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• Anoxia-induced apoptosis occurs through a mitochondria-dependent pathway in lung epithelial cells.

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• Role of Nitric Oxide in Inflammation‐Mediated Neurodegeneration

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• Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O 2 tension

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• Hypoxic but not anoxic stabilization of HIF-1alpha requires mitochondrial reactive oxygen species.

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• Inhibitory PAS Domain Protein (IPAS) Is a Hypoxia-inducible Splicing Variant of the Hypoxia-inducible Factor-3α Locus*

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• Bcl-2 Family Members and Functional Electron Transport Chain Regulate Oxygen Deprivation-Induced Cell Death

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• The Bcl2 family: regulators of the cellular life-or-death switch

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• Regulation of p53 by Hypoxia: Dissociation of Transcriptional Repression and Apoptosis from p53-Dependent Transactivation

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• PUMA induces the rapid apoptosis of colorectal cancer cells.

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