A Novel Sperm-Delivered Toxin Causes Late-Stage Embryo Lethality and Transmission Ratio Distortion in C. elegans

A sperm-delivered toxin and an embryo-expressed antidote form a co-adapted gene complex in C. elegans that promotes its own transmission to the detriment of organisms carrying it.

• Publication year

  2011

• Venue

  PLoS Biology

• Publication date

  2011-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1371/journal.pbio.1001115PMID 21814493PMCID 3144186
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Methods in Cell Biology

  2012cited by this paper
• Transgenic solutions for the germline

  2010cited by this paper
• Recombinational Landscape and Population Genomics of Caenorhabditis elegans

  2009cited by this paper
• Evolution of the Caenorhabditis elegans genome.

  2009cited by this paper
• trimAl: a tool for automated alignment trimming in large-scale phylogenetic analyses

  2009cited by this paper
• Increased IP3/Ca2+ signaling compensates depletion of LET-413/DLG-1 in C. elegans epithelial junction assembly.

  2009cited by this paper
• Variability in gene expression underlies incomplete penetrance

  2009cited by this paper
• The maternal-effect, selfish genetic element Medea is associated with a composite Tc1 transposon

  2008cited by this paper
• Single-copy insertion of transgenes in Caenorhabditis elegans

  2008cited by this paper
• Widespread Genetic Incompatibility in C. Elegans Maintained by Balancing Selection

  2008influential reference
• Imaging individual mRNA molecules using multiple singly labeled probes

  2008influential reference
• The genetics and cell biology of Wolbachia-host interactions.

  2008cited by this paper
• Wolbachia: master manipulators of invertebrate biology

  2008cited by this paper
• An improved general amino acid replacement matrix.

  2008cited by this paper
• The t-complex-encoded guanine nucleotide exchange factor Fgd2 reveals that two opposing signaling pathways promote transmission ratio distortion in the mouse.

  2007cited by this paper
• The Caenorhabditis elegans cell‐cycle regulator ZYG‐11 defines a conserved family of CUL‐2 complex components

  2007cited by this paper
• Sarcomere assembly in C. elegans muscle.

  2006cited by this paper
• Spermatogenesis.

  2006cited by this paper
• Epithelial junctions and attachments.

  2006cited by this paper
• FER-1 regulates Ca2+-mediated membrane fusion during C. elegans spermatogenesis

  2006cited by this paper
• Transformation and microinjection

  2006cited by this paper
• High local genetic diversity and low outcrossing rate in Caenorhabditis elegans natural populations.

  2005cited by this paper
• Epidermal morphogenesis.

  2005cited by this paper
• A Novel Meiotic Drive Locus Almost Completely Distorts Segregation in Mimulus (Monkeyflower) Hybrids

  2005cited by this paper
• Sheltered load associated with S-alleles in Solanum carolinense

  2004cited by this paper
• MUSCLE: multiple sequence alignment with high accuracy and high throughput.

  2004influential reference
• Plant neocentromeres: fast, focused, and driven

  2004cited by this paper
• Evolutionary history of Caenorhabditis elegans inferred from microsatellites: evidence for spatial and temporal genetic differentiation and the occurrence of outbreeding.

  2004cited by this paper
• Multiple regulatory elements with spatially and temporally distinct activities control the expression of the epithelial differentiation gene lin-26 in C. elegans.

  2004cited by this paper
• A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood.

  2003influential reference
• A bacterial symbiont in the Bacteroidetes induces cytoplasmic incompatibility in the parasitoid wasp Encarsia pergandiella

  2003cited by this paper
• The Caenorhabditis elegans vab-10 spectraplakin isoforms protect the epidermis against internal and external forces

  2003cited by this paper
• Closing the (Ran)GAP on segregation distortion in Drosophila

  2003cited by this paper
• Caenorhabditis elegans inositol 5-phosphatase homolog negatively regulates inositol 1,4,5-triphosphate signaling in ovulation.

  2002cited by this paper
• The role of selfish genetic elements in eukaryotic evolution

  2001cited by this paper
• Creation of low-copy integrated transgenic lines in Caenorhabditis elegans.

  2001cited by this paper
• Sex Chromosome Meiotic Drive

  2001cited by this paper
• Nonrandom segregation during meiosis: the unfairness of females

  2001cited by this paper
• The HMMTOP transmembrane topology prediction server

  2001cited by this paper
• Molecular Cloning: A Laboratory Manual

  2001cited by this paper
• A genetic test of the mechanism of Wolbachia-induced cytoplasmic incompatibility in Drosophila.

  2000cited by this paper
• Sperm competition in the absence of fertilization in Caenorhabditis elegans.

  1999cited by this paper
• General method for plasmid construction using homologous recombination.

  1999influential reference
• Patterning the C. elegans embryo: moving beyond the cell lineage.

  1999cited by this paper
• Paternal effects in Drosophila: implications for mechanisms of early development.

  1998cited by this paper
• A Hidden Markov Model for Predicting Transmembrane Helices in Protein Sequences

  1998cited by this paper
• Larger sperm outcompete smaller sperm in the nematode Caenorhabditis elegans

  1998cited by this paper
• SOSUI: classification and secondary structure prediction system for membrane proteins

  1998cited by this paper
• The C. elegans spe-9 gene encodes a sperm transmembrane protein that contains EGF-like repeats and is required for fertilization.

  1998cited by this paper
• Approximate is Better than “Exact” for Interval Estimation of Binomial Proportions

  1998cited by this paper
• Distinct requirements for somatic and germline expression of a generally expressed Caernorhabditis elegans gene.

  1997cited by this paper
• Genealogical structure among alleles regulating self-incompatibility in natural populations of flowering plants.

  1997cited by this paper
• Identification and characterization of the vesicular GABA transporter

  1997cited by this paper
• Reconstitution in vitro of the motile apparatus from the amoeboid sperm of Ascaris shows that filament assembly and bundling move membranes.

  1996cited by this paper
• Refining Neural Network Predictions for Helical Transmembrane Proteins by Dynamic Programming

  1996cited by this paper
• A sperm-supplied factor required for embryogenesis in C. elegans.

  1996cited by this paper
• Identification and cloning of unc-119, a gene expressed in the Caenorhabditis elegans nervous system.

  1995cited by this paper
• Soma-germline asymmetry in the distributions of embryonic RNAs in Caenorhabditis elegans.

  1994cited by this paper
• Genes critical for muscle development and function in Caenorhabditis elegans identified through lethal mutations

  1994cited by this paper
• A codon-based model of nucleotide substitution for protein-coding DNA sequences.

  1994cited by this paper
• Elements regulating cell- and stage-specific expression of the C. elegans MyoD family homolog hlh-1.

  1994cited by this paper
• Tmbase-A database of membrane spanning protein segments

  1993cited by this paper
• The GABAergic nervous system of Caenorhabditis elegans

  1993cited by this paper
• Maternal-effect selfish genes in flour beetles.

  1992cited by this paper
• Membrane protein structure prediction. Hydrophobicity analysis and the positive-inside rule.

  1992cited by this paper
• Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences.

  1991cited by this paper
• Segregation distorters.

  1991cited by this paper
• Microorganisms associated with chromosome destruction and reproductive isolation between two insect species

  1990cited by this paper
• Pattern of nucleotide substitution at major histocompatibility complex class I loci reveals overdominant selection

  1988cited by this paper
• Structure, expression, and evolution of a heat shock gene locus in Caenorhabditis elegans that is flanked by repetitive elements.

  1986cited by this paper
• Monoclonal antibodies which distinguish certain classes of neuronal and supporting cells in the nervous tissue of the nematode Caenorhabditis elegans

  1985influential reference
• Caenorhabditis elegans spermatozoan locomotion: amoeboid movement with almost no actin

  1982cited by this paper
• Sperm morphogenesis in wild-type and fertilization-defective mutants of Caenorhabditis elegans

  1981cited by this paper
• Spore killer, a chromosomal factor in neurospora that kills meiotic products not containing it.

  1979cited by this paper
• Intersex, a temperature-sensitive mutant of the nematode Caenorhabditis elegans.

  1978cited by this paper
• Spermatogenesis in males of the free-living nematode, Caenorhabditis elegans.

  1978cited by this paper

• A systematic review and critical analysis of the evidence for transmission ratio distortion in humans.

  2026cites this paper
• Recurrent evolution of selfishness from an essential tRNA synthetase in Caenorhabditis tropicalis

  2025cites this paper
• The molecular evolutionary basis of species formation revisited.

  2025cites this paper
• sept-1/zina-1 is an Ancient Toxin-Antidote System in Caenorhabditis elegans

  2025cites this paper
• The ever-diversifying landscape of intra-genomic conflict.

  2025cites this paper
• The novel HRD motif kinase SPE-60 is required for sperm development and motility in Caenorhabditis elegans

  2025cites this paper
• An animal toxin-antidote system kills cells by creating a novel cation channel

  2025cites this paper
• Abundant Recurrent Mitochondrial Mutations and Widespread Mitonuclear Epistasis in Caenorhabditis elegans

  2025cites this paper
• Tools and methods for cell ablation and cell inhibition in Caenorhabditis elegans

  2024cites this paper
• A meiotic driver hijacks an epigenetic reader to disrupt mitosis in noncarrier offspring

  2024cites this paper
• Hybrid incompatibility emerges at the one-cell stage in interspecies Caenorhabditis embryos

  2024cites this paper
• Structural duality enables a single protein to act as a toxin–antidote pair for meiotic drive

  2024cites this paper
• Parental-effect gene-drive elements under partial selfing, or why do Caenorhabditis genomes have hyperdivergent regions?

  2024influential citation
• Parental-effect gene-drive elements under partial selfing, or why do Caenorhabditis genomes have hyperdivergent regions?

  2024cites this paper
• Mechanism of an animal toxin-antidote system

  2024influential citation
• Analysis of developmental gene expression using smFISH and in silico staging of C. elegans embryos

  2024cites this paper
• The kinase ZYG-1 phosphorylates the cartwheel protein SAS-5 to drive centriole assembly in C. elegans

  2024cites this paper
• Divergent C. elegans toxin alleles are suppressed by distinct mechanisms

  2024cites this paper
• Mutations in the NXF-1:NXT-1 mRNA export complex affect gene-expression driven by the hsp-16.41 promoter

  2023cites this paper
• Speciation and development

  2023cites this paper
• Synthetic gene drives as an anthropogenic evolutionary force.

  2023cites this paper
• A toxin-antidote system contributes to interspecific reproductive isolation in rice

  2023cites this paper
• A toxin-antidote selfish element increases fitness of its host

  2023influential citation
• Two sides to every coin: reciprocal introgression line populations in Caenorhabditis elegans

  2023cites this paper
• High-throughput phenotyping of infection by diverse microsporidia species reveals a wild C. elegans strain with opposing resistance and susceptibility traits

  2023cites this paper
• Genomic Approaches Are Improving Taxonomic Representation in Genetic Studies of Speciation.

  2023cites this paper
• Transmission ratio distortion detection by neutral genetic markers in the Pura Raza Española horse breed.

  2023cites this paper
• Synthetic biology in multicellular organisms: Opportunities in nematodes

  2023cites this paper
• Manipulating the Destiny of Wild Populations Using CRISPR.

  2023cites this paper
• Moderate heat stress-induced sterility is due to motility defects and reduced mating drive in C. elegans Males.

  2023cites this paper
• Genetic architecture and temporal analysis of Caenorhabditis briggsae hybrid developmental delay

  2022cites this paper
• Temperature Stressed Caenorhabditis elegans Males Prioritize Feeding over Mating Resulting in Sterility

  2022cites this paper
• Natural genetic variation as a tool for discovery in Caenorhabditis nematodes

  2022cites this paper
• Myrmecological News

  2022cites this paper
• An efficient negative selection marker for Mos1 -mediated single-copy integration in Caenorhabditis elegans

  2022cites this paper
• Sexual dimorphic regulation of recombination by the synaptonemal complex in C. elegans

  2022cites this paper
• Linkage mapping reveals loci that underlie differences in Caenorhabditis elegans growth

  2022cites this paper
• Cryptic genetic variation in a heat shock protein modifies the outcome of a mutation affecting epidermal stem cell development in C. elegans

  2021cites this paper
• Evolution: Drivers in a Traffic Jam

  2021cites this paper
• Bodo saltans (Kinetoplastida) is dependent on a novel Paracaedibacter-like endosymbiont that possesses multiple putative toxin-antitoxin systems

  2021cites this paper
• A histamine-gated channel is an efficient negative selection marker for C. elegans transgenesis

  2021cites this paper
• The genetics of gene expression in a Caenorhabditis elegans multiparental recombinant inbred line population

  2021cites this paper
• APOK3, a pollen killer antidote in Arabidopsis thaliana

  2021cites this paper
• Diversification of small RNA pathways underlies germline RNA interference incompetence in wild Caenorhabditis elegans strains

  2021cites this paper
• From QTL to gene: C. elegans facilitates discoveries of the genetic mechanisms underlying natural variation.

  2021cites this paper
• A role for worm cutl-24 in background- and parent-of-origin-dependent ER stress resistance

  2021cites this paper
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  2021cites this paper
• The genetics of gene expression in a C. elegans multi parental recombinant inbred line population

  2021cites this paper
• Rapid Self-Selecting and Clone-Free Integration of Transgenes into Engineered CRISPR Safe Harbor Locations in Caenorhabditis elegans

  2020cites this paper
• The Gene scb-1 Underlies Variation in Caenorhabditis elegans Chemotherapeutic Responses

  2020cites this paper
• A single locus underlies variation in Caenorhabditis elegans chemotherapeutic responses

  2020cites this paper
• Baby makes three: Maternal, paternal, and zygotic genetic effects shape larval phenotypic evolution

  2020cites this paper
• Ubiquitous selfish toxin-antidote elements in Caenorhabditis species

  2020cites this paper
• The conserved molting/circadian rhythm regulator NHR-23/NR1F1 serves as an essential co-regulator of C. elegans spermatogenesis

  2020cites this paper
• Discovering lethal alleles across the turkey genome using a transmission ratio distortion approach

  2020cites this paper
• Cryptic genetic variation in a heat shock protein shapes the expressivity of a mutation affecting stem cell behaviour in C. elegans

  2020cites this paper
• Characterizing a strong pan-muscular promoter (Pmlc-1) as a fluorescent co-injection marker to select for single-copy insertions

  2020cites this paper
• Toxin-Antidote Elements Across the Tree of Life.

  2020cites this paper
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  2020cites this paper
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  2020cites this paper
• Functional Dissection of C. elegans bZip-Protein CEBP-1 Reveals Novel Structural Motifs Required for Axon Regeneration and Nuclear Import

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• Males, Outcrossing, and Sexual Selection in Caenorhabditis Nematodes

  2019cites this paper
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  2019influential citation
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
• Measuring Sperm Guidance and Motility within the Caenorhabditis elegans Hermaphrodite Reproductive Tract.

  2019cites this paper
• Cleave and Rescue, a novel selfish genetic element and general strategy for gene drive

  2019cites this paper
• Making a Murderer: The Evolutionary Framing of Hybrid Gamete-Killers.

  2019cites this paper
• A Novel Gene Underlies Bleomycin-Response Variation in Caenorhabditis elegans

  2019cites this paper
• Long-read sequencing reveals intra-species tolerance of substantial structural variations and new subtelomere formation in C. elegans

  2019cites this paper
• The glucocorticoid receptor ligand-binding domain confers drug-gated protein regulation in C. elegans

  2018cites this paper
• Gene Drive: Evolved and Synthetic

  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
• Shared Genomic Regions Underlie Natural Variation in Diverse Toxin Responses

  2018cites this paper
• Unexpected patterns of segregation distortion at a selfish supergene in the fire ant Solenopsis invicta

  2018cites this paper
• The Genetic Architecture of Intra-Species Hybrid Mito-Nuclear Epistasis

  2018cites this paper
• Common genomic regions underlie natural variation in diverse toxin responses

  2018cites this paper
• A New Tool for Inducible Gene Expression in Caenorhabditis elegans

  2018cites this paper
• Fast genetic mapping of complex traits in C. elegans using millions of individuals in bulk

  2018cites this paper
• CBD-1 scaffolds two independent complexes required for eggshell vitelline layer formation and egg activation in C. elegans

  2018cites this paper
• A maternal-effect selfish genetic element in Caenorhabditis elegans

  2017cites this paper
• Genetics: Master Regulator or Master of Disguise?

  2017cites this paper
• Poisons, antidotes, and selfish genes

  2017cites this paper
• The Local Coexistence Pattern of Selfing Genotypes in Caenorhabditis elegans Natural Metapopulations

  2017cites this paper
• Systematic characterisation of temporal and fate asymmetries and its regulation during Caenorhabditis elegans Embryogensis /Ho Vincy Wing Sze.

  2017cites this paper
• The Natural Biotic Environment of Caenorhabditis elegans

  2017cites this paper
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  2017cites this paper
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