Protein kinase CK2 links extracellular growth factor signaling with the control of p27Kip1 stability in the heart

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Nature Medicine

• Publication date

  2008-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/nm1729PMID 18311148
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1994cited by this paper
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  1994cited by this paper
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  1993cited by this paper
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  1993cited by this paper

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