Oxidative and Electrophilic Stresses Activate Nrf2 through Inhibition of Ubiquitination Activity of Keap1

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Molecular and Cellular Biology

• Publication date

  2006-01-01

• Fields of study

  Biology, Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1128/MCB.26.1.221-229.2006PMID 16354693PMCID PMC1317630
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• BTB Protein Keap1 Targets Antioxidant Transcription Factor Nrf2 for Ubiquitination by the Cullin 3-Roc1 Ligase

  2005influential reference
• Keap1, the sensor for electrophiles and oxidants that regulates the phase 2 response, is a zinc metalloprotein.

  2005cited by this paper
• Inducible dissociation of SCFMet30 ubiquitin ligase mediates a rapid transcriptional response to cadmium

  2005cited by this paper
• Function and regulation of cullin–RING ubiquitin ligases

  2005cited by this paper
• Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome.

  2005cited by this paper
• Molecular Mechanisms Activating the Nrf2-Keap1 Pathway of Antioxidant Gene Regulation

  2005cited by this paper
• Keap1 Is a Redox-Regulated Substrate Adaptor Protein for a Cul3-Dependent Ubiquitin Ligase Complex

  2004influential reference
• A hitchhiker's guide to the cullin ubiquitin ligases: SCF and its kin.

  2004cited by this paper
• Transcription Factor Nrf2 Regulates Inflammation by Mediating the Effect of 15-Deoxy-Δ12,14-Prostaglandin J2

  2004cited by this paper
• Unique function of the Nrf2-Keap1 pathway in the inducible expression of antioxidant and detoxifying enzymes.

  2004cited by this paper
• Transcription factor Nrf2 regulates inflammation by mediating the effect of 15-deoxy-Delta(12,14)-prostaglandin j(2).

  2004cited by this paper
• Chemoprevention through the Keap1-Nrf2 signaling pathway by phase 2 enzyme inducers.

  2004cited by this paper
• Cellular mechanisms of redox cell signalling: role of cysteine modification in controlling antioxidant defences in response to electrophilic lipid oxidation products.

  2004cited by this paper
• The Keap1-BTB Protein Is an Adaptor That Bridges Nrf2 to a Cul3-Based E3 Ligase: Oxidative Stress Sensing by a Cul3-Keap1 Ligase

  2004influential reference
• The SCF ubiquitin ligase: insights into a molecular machine

  2004cited by this paper
• Protection against electrophile and oxidative stress by induction of phase 2 genes: the quest for the elusive sensor that responds to inducers.

  2004cited by this paper
• Nrf2-Keap1 defines a physiologically important stress response mechanism.

  2004cited by this paper
• Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes

  2004cited by this paper
• Redox-regulated Turnover of Nrf2 Is Determined by at Least Two Separate Protein Domains, the Redox-sensitive Neh2 Degron and the Redox-insensitive Neh6 Degron*

  2004cited by this paper
• Oxidative Stress Sensor Keap1 Functions as an Adaptor for Cul3-Based E3 Ligase To Regulate Proteasomal Degradation of Nrf2

  2004influential reference
• Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers

  2004influential reference
• Cullin 3 Promotes Proteasomal Degradation of the Topoisomerase I-DNA Covalent Complex

  2004cited by this paper
• Role of VHL gene mutation in human cancer.

  2004cited by this paper
• PERK-dependent Activation of Nrf2 Contributes to Redox Homeostasis and Cell Survival following Endoplasmic Reticulum Stress*

  2004cited by this paper
• RhoBTB2 is a substrate of the mammalian Cul3 ubiquitin ligase complex.

  2004cited by this paper
• Increased Protein Stability as a Mechanism That Enhances Nrf2-mediated Transcriptional Activation of the Antioxidant Response Element

  2003cited by this paper
• Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress

  2003influential reference
• Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival

  2003cited by this paper
• Neddylation and deneddylation of CUL-3 is required to target MEI-1/Katanin for degradation at the meiosis-to-mitosis transition in C. elegans.

  2003cited by this paper
• Keap1 regulates both cytoplasmic‐nuclear shuttling and degradation of Nrf2 in response to electrophiles

  2003cited by this paper
• NF-kappaB activation in cancer: a challenge for ubiquitination- and proteasome-based therapeutic approach.

  2003cited by this paper
• Degradation of Transcription Factor Nrf2 via the Ubiquitin-Proteasome Pathway and Stabilization by Cadmium*

  2003cited by this paper
• Thioredoxin as a Molecular Target of Cyclopentenone Prostaglandins*

  2003cited by this paper
• Regulatory mechanisms controlling gene expression mediated by the antioxidant response element.

  2003cited by this paper
• Keap1-dependent Proteasomal Degradation of Transcription Factor Nrf2 Contributes to the Negative Regulation of Antioxidant Response Element-driven Gene Expression*

  2003cited by this paper
• The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases?

  2003cited by this paper
• Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

  2002cited by this paper
• CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex.

  2002cited by this paper
• The Keap1 BTB/POZ Dimerization Function Is Required to Sequester Nrf2 in Cytoplasm*

  2002cited by this paper
• Structure of the Cul1–Rbx1–Skp1–F boxSkp2 SCF ubiquitin ligase complex

  2002cited by this paper
• HIF-1 and mechanisms of hypoxia sensing.

  2001cited by this paper
• Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups

  2001cited by this paper
• Ubiquitin enters the new millennium.

  2001cited by this paper
• Inhibition of the 26S proteasome induces expression of GLCLC, the catalytic subunit for gamma-glutamylcysteine synthetase.

  2000cited by this paper
• Mdm2 Is a RING Finger-dependent Ubiquitin Protein Ligase for Itself and p53*

  2000cited by this paper
• Covalent modification of all members of human cullin family proteins by NEDD8

  1999cited by this paper
• Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain.

  1999cited by this paper
• Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells.

  1999cited by this paper
• The ubiquitin system.

  1998cited by this paper

• Hexaraphane as a potential therapeutic strategy for tauopathies.

  2026cites this paper
• Pigment epithelium-derived factor and osteopontin protect retinal pigment epithelial cells from oxidative stress in human primary retinal pigment epithelial cells in 2D and 3D models.

  2026cites this paper
• Nuclear factor erythroid 2-related factor: potential use as a therapeutic strategy for viral infections

  2026cites this paper
• Relationship Between Obesity and Depression Considering the Inflammatory Theory

  2025cites this paper
• Redox‐Induced Stabilization of AMBRA1 by USP7 Promotes Intestinal Oxidative Stress and Colitis Through Antagonizing DUB3‐Mediated NRF2 Deubiquitination

  2025cites this paper
• The mechanism of Se in regulating the proliferation and apoptosis of sheep Leydig cells through the miR-200a/NRF2 pathway.

  2025cites this paper
• Comprehensive in-silico molecular analysis of early-onset gastric cancer identifies novel genes implicated in disease characterization and progression (Review)

  2025cites this paper
• KMN003 activates Nrf2 via disruption of the Keap1-Nrf2 interaction and p38-dependent transcriptional regulation.

  2025cites this paper
• Hepatoprotective effects of a Cassia fistula fruit extract and molecular insights into its phytoconstituents’ interactions with Keap1

  2025cites this paper
• Biliverdin Reductase A is a major determinant of neuroprotective Nrf2 signaling

  2025cites this paper
• Discovery of β-amino acid substituted naphthalene sulfonamide derivatives as potent Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2 (Keap1-Nrf2) protein-protein interaction inhibitors for ulcerative colitis management.

  2025cites this paper
• Crosstalk between ferroptosis and autophagy: broaden horizons of cancer therapy

  2025cites this paper
• Lycopene mitigates paclitaxel-induced cognitive impairment in mice; Insights into Nrf2/HO-1, NF-κB/NLRP3, and GRP-78/ATF-6 axes.

  2025cites this paper
• Investigation of the cytotoxic and genotoxic effects of removable retention appliances.

  2025cites this paper
• The CNC-family transcription factor NRF3: A crucial therapeutic target for cancer treatment.

  2025cites this paper
• Key Compounds and Mechanisms of Lactiplantibacillus plantarum SCS2 in Mitigating Oxidative Damage in INS-1 Cells

  2025cites this paper
• Lead induces cell-autonomous proliferation and metabolic reprogramming of hepatocytes

  2025cites this paper
• Vimentin Cytoskeleton Collapses in Response to the Small Molecule Inhibitor of FH2 domains (SMIFH2)-induced Electrophilic Stress.

  2025cites this paper
• Short-Term Effects of Dietary Selenomethionine Supplementation on Hepatic and Renal Transcriptomic Alterations Induced by Ochratoxin a in Broiler Chickens

  2025cites this paper
• HDAC Inhibition Protects RPE Cells from Oxidative Stress via Enhanced Mitochondrial Fusion, Cytoskeletal Repair, and Nrf-2 Activation.

  2025cites this paper
• Nitric oxide-mediated S-Nitrosylation contributes to signaling transduction in human physiological and pathological status (Review)

  2025cites this paper
• Protein sequence editing defines distinct and overlapping functions of SKN-1A/Nrf1 and SKN-1C/Nrf2

  2025cites this paper
• Activation, interaction and intimation of Nrf2 pathway and their mutational studies causing Nrf2 associated cancer.

  2025cites this paper
• Major Oxidative and Antioxidant Mechanisms During Heat Stress-Induced Oxidative Stress in Chickens

  2025cites this paper
• Considerations for antibody-based detection of NRF2 in human cells

  2025cites this paper
• KEAP1-NRF2 Interaction in Cancer: Competitive Interactors and Their Role in Carcinogenesis

  2025cites this paper
• The interplay involving oxidative stress and autophagy: Mechanisms, implications, and therapeutic opportunities.

  2025cites this paper
• Heme as activator and target for artemisinin: Towards multiple pharmacological bioactivity

  2025cites this paper
• Sulforaphane regulates hepatic autophagy and apoptosis by modulating Kupffer cells’ polarization via Nrf2/HO-1 pathway in the murine hemorrhagic shock/resuscitation model

  2025cites this paper
• Regulating Nrf2 activity: ubiquitin ligases and signaling molecules in redox homeostasis.

  2025cites this paper
• Molecular Insights into Oxidative-Stress-Mediated Cardiomyopathy and Potential Therapeutic Strategies

  2025cites this paper
• Downregulation of Parahippocampal Copper Chaperone for Superoxide Dismutase in Alzheimer’s Disease

  2025cites this paper
• Nitroxidative Stress, Cell—Signaling Pathways, and Manganese Porphyrins: Therapeutic Potential in Neuropathic Pain

  2025cites this paper
• Takotsubo Syndrome and Oxidative Stress: Physiopathological Linkage and Future Perspectives

  2025cites this paper
• Discovery of a novel chalcone-derived covalent Keap1 binder for mitigating cisplatin-induced mitochondrial dysfunction and nephrotoxicity

  2025cites this paper
• Isothiocyanates from cruciferous plants as geroprotectors.

  2025cites this paper
• Research progress on ferroptosis in drug resistance and therapy of gastric cancer

  2025cites this paper
• Takotsubo Syndrome and Cancer: Pathophysiological Links and Clinical Perspectives

  2025cites this paper
• Pharmacological targeting of nuclear factor (erythroid-derived 2)-like 2 (NRF2): a potential strategy to improve the efficacy of oncological photodynamic therapy.

  2025cites this paper
• Ionizing Radiation in Clinical Diagnostics and Radiotherapy: The Dual Role of NRF2 in Cell Protection and Carcinogenesis.

  2025cites this paper
• Sofalcone inhibits osteoclastogenesis through Keap1/Nrf2 signaling activation and mitigates ovariectomy-induced bone loss.

  2025cites this paper
• Deciphering the quantitative relationship between NRF2 and SRXN1 through semi-mechanistic computational modeling.

  2025cites this paper
• Biliverdin reductase A is a major determinant of protective NRF2 signaling

  2025cites this paper
• Novel Bioactive Peptides Targeting Keap1-Nrf2 Interaction for Combating UVA-Induced Skin Aging: Computational Discovery and Experimental Validation

  2025cites this paper
• Manganese Superoxide Dismutase: Structure, Function, and Implications in Human Disease

  2025cites this paper
• Advances in KEAP1-based PROTACs as emerging therapeutic modalities: Structural basis and progress

  2025cites this paper
• Protein sequence editing defines distinct and overlapping functions of SKN-1A/Nrf1 and SKN-1C/Nrf2

  2025cites this paper
• A novel crosstalk between Nrf2 and Smad2/3 bridged by two nuanced Keap1 isoforms with their divergent effects on these distinct family transcription factors.

  2024cites this paper
• Emerging insights into STK11, KEAP1 and KRAS mutations: implications for immunotherapy in patients with advanced non-small cell lung cancer

  2024cites this paper
• Model organisms for investigating the functional involvement of NRF2 in non-communicable diseases

  2024cites this paper
• Cobalt protoporphyrin promotes heme oxygenase 1 expression and ameliorates cardiac dysfunction in long-term fasting mice.

  2024cites this paper
• Sulforaphane treatment mimics contractile activity-induced mitochondrial adaptations in muscle myotubes.

  2024cites this paper
• Mitigating oxidative stress in oyster larvae: Curcumin promotes enhanced redox balance, antioxidant capacity, development, and resistance to antifouling compounds.

  2024cites this paper
• Crocin from saffron ameliorates allergic airway inflammation through NF-κB, IL-17, and Nrf2/HO-1 signaling pathways in mice

  2024cites this paper
• Oxidative stress levels and antioxidant defense mechanisms (Nrf2-Keap1 signaling pathway) in the Harderian glands of hibernating Daurian ground squirrels.

  2024cites this paper
• Role of kidney function on Nrf2 mRNA levels in type 2 diabetes

  2024cites this paper
• Evaluation of Antioxidant Effects of Pumpkin (Cucurbita pepo L.) Seed Extract on Aging- and Menopause-Related Diseases Using Saos-2 Cells and Ovariectomized Rats

  2024influential citation
• Theoretical studies on the antioxidant activity of potential marine xanthones

  2024cites this paper
• Dynamic regulation of the oxidative stress response by the E3 ligase TRIP12

  2024cites this paper
• Moderate Hypothermia Alleviates Sepsis-Associated Acute Lung Injury by Suppressing Ferroptosis Induced by Excessive Inflammation and Oxidative Stress via the Keap1/GSK3β/Nrf2/GPX4 Signaling Pathway

  2024cites this paper
• Structure-Based Identification of Kelch-like ECH-Associated Protein 1 as a Pharmacological Target of Electrophile-Containing Catechol-O-Methyltransferase Inhibitors.

  2024cites this paper
• Recognition of BACH1 quaternary structure degrons by two F-box proteins under oxidative stress.

  2024cites this paper
• NRF2 activation by 6-MSITC increases the generation of neuroprotective, soluble α amyloid precursor protein by inducing the metalloprotease gene ADAM17.

  2024cites this paper
• Recent Progress in Anti-Tumor Nanodrugs Based on Tumor Microenvironment Redox Regulation.

  2024cites this paper
• The SIRT-1/Nrf2/HO-1 Axis: Guardians of Neuronal Health in Neurological Disorders.

  2024cites this paper
• Single-cell transcriptomic analysis and luteolin treatment reveal three adipogenic genes, including Aspn, Htra1 and Efemp1.

  2024cites this paper
• Comparative evaluation of cigarette smoke and a heated tobacco product on microglial toxicity, oxidative stress and inflammatory response

  2024cites this paper
• The dynamic equilibrium between the protective and toxic effects of matrine in the development of liver injury: a systematic review and meta-analysis

  2024cites this paper
• Regulation of immunomodulatory networks by Nrf2-activation in immune cells: Redox control and therapeutic potential in inflammatory diseases

  2024cites this paper
• Minimizing Oxidative Stress in the Lens: Alternative Measures for Elevating Glutathione in the Lens to Protect against Cataract

  2024cites this paper
• Modular Nanotransporters Deliver Anti-Keap1 Monobody into Mouse Hepatocytes, Thereby Inhibiting Production of Reactive Oxygen Species

  2024cites this paper
• Ameliorative inhibition of sirtuin 6 by imidazole derivative triggers oxidative stress-mediated apoptosis associated with Nrf2/Keap1 signaling in non-small cell lung cancer cell lines

  2024cites this paper
• Engineered Cas9 variants bypass Keap1-mediated degradation in human cells and enhance epigenome editing efficiency

  2024cites this paper
• Effects of Dietary Ursolic Acid on Growth Performance and Intestinal Health of Largemouth Bass (Micropterus salmoides)

  2024cites this paper
• The application of alkaloids in ferroptosis: A review.

  2024cites this paper
• Unlocking peak performance: The role of Nrf2 in enhancing exercise outcomes and training adaptation in humans.

  2024cites this paper
• Immunological dimensions of neuroinflammation and microglial activation: exploring innovative immunomodulatory approaches to mitigate neuroinflammatory progression

  2024cites this paper
• Modulation of osteoblastogenesis by NRF2: NRF2 activation suppresses osteogenic differentiation and enhances mineralization in human bone marrow‐derived mesenchymal stromal cells

  2024cites this paper
• Sesamin Exerts an Antioxidative Effect by Activating the Nrf2 Transcription Factor in the Glial Cells of the Central Nervous System in Drosophila Larvae

  2024cites this paper
• Replacement of fish oil by palm oil in diet for juvenile greenfin horse-faced filefish (Thamnaconus septentrionalis): Effects on growth performance, fatty acid composition, antioxidant capacity and inflammatory responses

  2024cites this paper
• Ferulic Acid in Chinese Herbal Medicine: Regulating Autophagy for Oxidative Damage Reduction

  2024cites this paper
• Metabolically activated proteostasis regulators that protect against erastin-induced ferroptosis

  2024cites this paper
• Distinct Perception Mechanisms of BACH1 Quaternary Structure Degrons by Two F-box Proteins under Oxidative Stress

  2024cites this paper
• VHL synthetic lethality screens uncover CBF-β as a negative regulator of STING

  2024cites this paper
• Magnolol against enterovirus 71 by targeting Nrf2-SLC7A11-GSH pathway.

  2024cites this paper
• Regulatory factors of Nrf2 in age-related macular degeneration pathogenesis.

  2024cites this paper
• Effects of dietary astaxanthin on growth performance, immunity, and tissue composition in largemouth bass, Micropterus salmoides

  2024cites this paper
• NRF2-mediated regulation of lipid pathways in viral infection.

  2024cites this paper
• Digital manufacturing techniques and the in vitro biocompatibility of acrylic-based occlusal device materials

  2024cites this paper
• Análisis e identificación de genes expresados diferencialmente entre juveniles y adultos de la tortuga caguama (Caretta caretta) relacionados con hipoxia y sistema inmune: Primera aproximación

  2024cites this paper
• The Complex Roles of Redox and Antioxidant Biology in Cancer.

  2024cites this paper
• Flavonoids as Complementary Medicines for Therapy and Prevention of COVID-19: Part I. Experimental and Clinical Applications

  2024cites this paper
• The Role of NRF2 in Trinucleotide Repeat Expansion Disorders

  2024cites this paper
• New insights into the role of myo-inositol in regulating the skin immune response of grass carp (Ctenopharyngodon idella)

  2024cites this paper
• Acute accumulation of PIM2 and NRF2 and recovery of β5 subunit activity mitigate multiple myeloma cell susceptibility to proteasome inhibitors

  2024cites this paper
• A critical insight into the physicochemical stability of macular carotenoids with respect to their industrial production, safety profile, targeted tissue delivery, and bioavailability

  2024cites this paper
• Suitable dietary Myo-inositol supplementations improve growth, immunity and antioxidant properties of hybrid grouper (Epinephelus. fuscoguttatus♀ × E. lanceolatus♂) fed low-fishmeal diets

  2024cites this paper
• Iron chelators as mitophagy agents: Potential and limitations.

  2024cites this paper
• SN‐38, an active metabolite of irinotecan, inhibits transcription of nuclear factor erythroid 2‐related factor 2 and enhances drug sensitivity of colorectal cancer cells

  2024cites this paper
• Exercise-induced fumarate accumulation: a potential mediator of mitochondrial biogenesis in mammalian skeletal muscle

  2023cites this paper