CX3CR1-dependent renal macrophage survival promotes Candida control and host survival.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Journal of Clinical Investigation

• Publication date

  2013-12-02

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1172/JCI71307PMID 24177428PMCID PMC3859390
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Invasive Candidiasis.

  2019cited by this paper
• Candida and Host Determinants of Susceptibility to Invasive Candidiasis

  2013cited by this paper
• Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages

  2012cited by this paper
• Fractalkine: a survivor's guide: chemokines as antiapoptotic mediators.

  2012cited by this paper
• Inflammation switches the differentiation program of Ly6Chi monocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon

  2012influential reference
• Genetic Susceptibility to Fungal Infections in Humans

  2012cited by this paper
• Simple assays for measuring innate interactions with fungi.

  2012cited by this paper
• Toll-like receptor 1 polymorphisms increase susceptibility to candidemia.

  2012cited by this paper
• Chemokine Receptor Ccr1 Drives Neutrophil-Mediated Kidney Immunopathology and Mortality in Invasive Candidiasis

  2012cited by this paper
• Local Macrophage Proliferation, Rather than Recruitment from the Blood, Is a Signature of TH2 Inflammation

  2011cited by this paper
• In vivo structure/function and expression analysis of the CX3C chemokine fractalkine.

  2011cited by this paper
• Innate antifungal immunity: the key role of phagocytes.

  2011cited by this paper
• CX3CR1 regulates intestinal macrophage homeostasis, bacterial translocation and colitogenic TH17 responses in mice

  2011cited by this paper
• The fractalkine receptor CX3CR1 protects against liver fibrosis by controlling differentiation and survival of infiltrating hepatic monocytes

  2010cited by this paper
• Organ-Specific Innate Immune Responses in a Mouse Model of Invasive Candidiasis

  2010influential reference
• CX3CR1+ CD115+ CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation

  2009cited by this paper
• Integrin αvβ3 is a pleiotrophin receptor required for pleiotrophin‐induced endothelial cell migration through receptor protein tyrosine phosphatase β/ζ

  2009cited by this paper
• Epidemiology and outcomes of candidemia in 2019 patients: data from the prospective antifungal therapy alliance registry.

  2009influential reference
• CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival.

  2009cited by this paper
• Fractalkine has anti-apoptotic and proliferative effects on human vascular smooth muscle cells via epidermal growth factor receptor signalling

  2009cited by this paper
• Dynamic, Morphotype-Specific Candida albicans β-Glucan Exposure during Infection and Drug Treatment

  2008cited by this paper
• Monocyte-mediated defense against microbial pathogens.

  2008cited by this paper
• Adjuvant corticosteroid therapy for chronic disseminated candidiasis.

  2008cited by this paper
• Regulation of progenitor cell proliferation and granulocyte function by microRNA-223

  2008cited by this paper
• CX3CR1 is expressed by prostate epithelial cells and androgens regulate the levels of CX3CL1/fractalkine in the bone marrow: potential role in prostate cancer bone tropism.

  2008cited by this paper
• The chemokine receptors CCR2 and CX3CR1 mediate monocyte/macrophage trafficking in kidney ischemia-reperfusion injury.

  2008cited by this paper
• Regulation of Progenitor Cell Proliferation and Granulocyte Function by microRNA-223.

  2007cited by this paper
• Fractalkine Upregulates Intercellular Adhesion Molecule-1 in Endothelial Cells Through CX3CR1 and the Jak–Stat5 Pathway

  2007cited by this paper
• Invasive candidiasis.

  2006cited by this paper
• Mice with disseminated candidiasis die of progressive sepsis.

  2005cited by this paper
• The epidemiology and attributable outcomes of candidemia in adults and children hospitalized in the United States: a propensity analysis.

  2005cited by this paper
• International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels

  2003cited by this paper
• Decreased Atherosclerotic Lesion Formation in CX3CR1/Apolipoprotein E Double Knockout Mice

  2003cited by this paper
• Blood monocytes consist of two principal subsets with distinct migratory properties.

  2003cited by this paper
• Chemokine receptor mutant CX3CR1-M280 has impaired adhesive function and correlates with protection from cardiovascular disease in humans.

  2003cited by this paper
• Fractalkine (CX3CL1) stimulated by nuclear factor kappaB (NF-kappaB)-dependent inflammatory signals induces aortic smooth muscle cell proliferation through an autocrine pathway.

  2003cited by this paper
• The direct cost and incidence of systemic fungal infections.

  2002cited by this paper
• Estimating the cost of nosocomial candidemia in the united states.

  2001cited by this paper
• Analysis of Fractalkine Receptor CX3CR1 Function by Targeted Deletion and Green Fluorescent Protein Reporter Gene Insertion

  2000cited by this paper
• The Chemokine Fractalkine Inhibits Fas-Mediated Cell Death of Brain Microglia

  2000cited by this paper
• International union of pharmacology. XXII. Nomenclature for chemokine receptors.

  2000cited by this paper
• Fractalkine and CX3CR1 Mediate a Novel Mechanism of Leukocyte Capture, Firm Adhesion, and Activation under Physiologic Flow

  1998cited by this paper
• An immunoregulatory role for neutrophils in CD4+ T helper subset selection in mice with candidiasis.

  1997cited by this paper
• Nonfilamentous C. albicans mutants are avirulent.

  1997cited by this paper
• Germ tube growth of Candida albicans.

  1997cited by this paper
• Germ tube growth of Candida albicans.

  1997cited by this paper
• Elimination of mouse splenic macrophages correlates with increased susceptibility to experimental disseminated candidiasis.

  1994cited by this paper
• Isogenic strain construction and gene mapping in Candida albicans.

  1993cited by this paper
• Renal failure and disseminated candidiasis.

  1962cited by this paper
• Disseminated moniliasis In the Adult.

  1962cited by this paper

• Genetic Polymorphisms in Human CX3CR1-Mediated Macrophage Dysregulation are Associated with the Worsening of Hearing Loss and Cochlear Degeneration After Noise Trauma: A Study in a Humanized Mouse Model

  2025cites this paper
• Candida albicans infection suppresses Lipopolysaccharide or Pseudomonas aeruginosa stimulated murine bone marrow derived macrophage (BMDM) responses

  2025cites this paper
• Genetic polymorphisms in human CX3CR1-mediated macrophage dysregulation are associated with the worsening of hearing loss and cochlear degeneration after noise trauma: a study in a humanized mouse model

  2025cites this paper
• Of Tingible Bodies and Starry Skies: Control of Normal and Malignant Tissues Through Apoptotic Cell-Dependent Communication (ACDC).

  2025cites this paper
• Breaking Boundaries: Chronic Diseases and the Frontiers of Immune Microenvironments

  2025cites this paper
• IRE1α promotes phagosomal calcium flux to enhance macrophage fungicidal activity

  2025cites this paper
• Kidney immunology from pathophysiology to clinical translation

  2025cites this paper
• Essential role of hepcidin in host resistance to disseminated candidiasis

  2025cites this paper
• Pathophysiological Roles of the CX3CL1-CX3CR1 Axis in Renal Disease, Cardiovascular Disease, and Cancer

  2025cites this paper
• Progression of Kidney Fibrosis after Sepsis: The Underestimated Role of Resident Macrophages and Recruited Monocytes.

  2025cites this paper
• Piezo1 senses hyphae and initiates host defense against pathogenic fungi.

  2025cites this paper
• IL-1 protects from fatal systemic candidiasis in mice by inhibiting oxidative phosphorylation and hypoxia

  2025cites this paper
• An overview of the role of chemokine CX3CL1 (Fractalkine) and CX3C chemokine receptor 1 in systemic sclerosis

  2024cites this paper
• BLNK negatively regulates innate antifungal immunity through inhibiting c-Cbl-mediated macrophage migration

  2024cites this paper
• HDAC1 fine-tunes Th17 polarization in vivo to restrain tissue damage in fungal infections.

  2024cites this paper
• Essential role of Hepcidin in host resistance to disseminated candidiasis

  2024cites this paper
• A human commensal-pathogenic fungus suppresses host immunity via targeting TBK1.

  2024cites this paper
• Tissue-Resident Macrophages in Solid Organ Transplantation: Harmful or Protective?

  2024cites this paper
• Macrophage SREBP1 regulates skeletal muscle regeneration

  2024cites this paper
• The Laws of Attraction: Chemokines as Critical Mediators in Cancer Progression and Immunotherapy Response in Bladder Cancer

  2024cites this paper
• Kidney macrophages keep the stones rolling.

  2024cites this paper
• Development of an immune-related diagnostic predictive model for oral lichen planus

  2024cites this paper
• Controlling Candida: immune regulation of commensal fungi in the gut

  2024cites this paper
• Invasive candidiasis

  2024cites this paper
• Pravastatin prevents colitis-associated carcinogenesis by reducing CX3CR1high M2-like fibrocyte counts in the inflamed colon

  2024cites this paper
• Residual Kidney Function in Hemodialysis: Its Importance and Contribution to Improved Patient Outcomes

  2024cites this paper
• Early ART reduces viral seeding and innate immunity in liver and lungs of SIV-infected macaques

  2023cites this paper
• C5‐C5aR1‐mediated immune responses during fungal infection: Clinical and translational implications

  2023cites this paper
• Cx43-mediated hyphal folding counteracts phagosome integrity loss during fungal infection

  2023cites this paper
• C5a-licensed phagocytes drive sterilizing immunity during systemic fungal infection.

  2023cites this paper
• Quantitative live-cell imaging of Candida albicans escape from immune phagocytes

  2023cites this paper
• Dual wave of neutrophil recruitment determines the outcome of C. albicans infection

  2023cites this paper
• The yeast-human coevolution: Fungal transition from passengers, colonizers, and invaders.

  2023cites this paper
• Exploiting antifungal immunity in the clinical context.

  2023cites this paper
• Farnesol remodels the peritoneal cavity immune environment influencing Candida albicans pathogenesis during intra-abdominal infection

  2023cites this paper
• Proline catabolism is a key factor facilitating Candida albicans pathogenicity

  2023cites this paper
• Immune responses to human fungal pathogens and therapeutic prospects

  2023cites this paper
• Non-canonical activation of IRE1α during Candida albicans infection enhances macrophage fungicidal activity

  2023cites this paper
• The F1Fo-ATP synthase α subunit of Candida albicans induces inflammatory responses by controlling amino acid catabolism

  2023cites this paper
• Evaluation of murine renal phagocyte-fungal interactions using intravital confocal microscopy and flow cytometry

  2023cites this paper
• Analysis of Mononuclear Phagocytes Disclosed the Establishment Processes of Two Macrophage Subsets in the Adult Murine Kidney

  2022cites this paper
• Induction and analysis of systemic C. albicans infections in mice.

  2022cites this paper
• A kidney resident macrophage subset is a candidate biomarker for renal cystic disease in preclinical models

  2022cites this paper
• The characteristic of resident macrophages and their therapeutic potential for myocardial infarction.

  2022cites this paper
• Transfusable neutrophil progenitors as cellular therapy for the prevention of invasive fungal infections

  2022cites this paper
• Fungal Infections in Critically Ill COVID-19 Patients: Inevitabile Malum

  2022cites this paper
• The escape of Candida albicans from macrophages is enabled by the fungal toxin candidalysin and two host cell death pathways.

  2022cites this paper
• The histone chaperone HIR maintains chromatin states to control nitrogen assimilation and fungal virulence

  2021cites this paper
• The Role of the CX3CL1-CX3CR1 Axis in Renal Disease.

  2021cites this paper
• A Mouse Model of Candidiasis.

  2021cites this paper
• Fractalkine (CX3CL1) and Its Receptor CX3CR1: A Promising Therapeutic Target in Chronic Kidney Disease?

  2021cites this paper
• Candida tropicalis Systemic Infection Redirects Leukocyte Infiltration to the Kidneys Attenuating Encephalomyelitis

  2021cites this paper
• Intestinal mycobiota in health and diseases: from a disrupted equilibrium to clinical opportunities

  2021cites this paper
• Macrophages and Stem Cells—Two to Tango for Tissue Repair?

  2021cites this paper
• Immunity to Fungal Infections

  2021cites this paper
• Deletion of the ATP2 Gene in Candida albicans Blocks Its Escape From Macrophage Clearance

  2021cites this paper
• Candida albicans Infection by Fungal Pathogen TSC1 Suppresses Macrophage Necroptosis for the Control of

  2021cites this paper
• Challenges and Opportunities in Understanding Genetics of Fungal Diseases: Towards a Functional Genomics Approach

  2021cites this paper
• Local antifungal immunity in the kidney in disseminated candidiasis.

  2021cites this paper
• Renal CD169++ resident macrophages are crucial for protection against acute systemic candidiasis

  2021influential citation
• Regulation and function of CX3CR1 and its ligand CX3CL1 in kidney disease

  2021cites this paper
• Immune System Disequilibrium—Neutrophils, Their Extracellular Traps, and COVID-19-Induced Sepsis

  2021cites this paper
• The renal inflammatory network of nephronophthisis

  2021cites this paper
• Vaccine-Induced Immunological Memory in Invasive Fungal Infections – A Dream so Close yet so Far

  2021cites this paper
• CX3CR1 Depletion Promotes the Formation of Platelet–Neutrophil Complexes and Aggravates Acute Peritonitis

  2021cites this paper
• Pathogenesis of Respiratory Viral and Fungal Coinfections

  2021cites this paper
• Macrophage Heterogeneity in Kidney Injury and Fibrosis

  2021cites this paper
• IL-23 signaling prevents ferroptosis-driven renal immunopathology during candidiasis

  2021cites this paper
• Pathogenesis and virulence of Candida albicans

  2021cites this paper
• In vitro infection models to study fungal–host interactions

  2021cites this paper
• I want to break free - macrophage strategies to recognize and kill Candida albicans, and fungal counter-strategies to escape.

  2020cites this paper
• The Dual Function of the Fungal Toxin Candidalysin during Candida albicans—Macrophage Interaction and Virulence

  2020cites this paper
• Chronic mucocutaneous candidiasis and invasive fungal infection susceptibility

  2020cites this paper
• Immunometabolism in fungal infections: the need to eat to compete.

  2020cites this paper
• Fungal Cardiac Infections

  2020cites this paper
• Kidney dendritic cells: fundamental biology and functional roles in health and disease

  2020cites this paper
• Distinct fate, dynamics and niches of renal macrophages of bone marrow or embryonic origins

  2020cites this paper
• Rationale for and clinical development of anti-fractalkine antibody in rheumatic diseases

  2020cites this paper
• SWL-1 Reverses Fluconazole Resistance in Candida albicans by Regulating the Glycolytic Pathway

  2020cites this paper
• The mycobiota of the human body: a spark can start a prairie fire

  2020cites this paper
• Polymorphisms within the ARNT2 and CX3CR1 Genes Are Associated with the Risk of Developing Invasive Aspergillosis

  2020influential citation
• Mechanisms of Pathogenic Candida Species to Evade the Host Complement Attack

  2020cites this paper
• Advances in Understanding Human Genetic Variations That Influence Innate Immunity to Fungi

  2020cites this paper
• Development of a novel (cid:2) -1,6-glucan–specific detection system using functionally-modified recombinant endo- (cid:2) -1,6-glucanase

  2020cites this paper
• Development of a novel β-1,6-glucan–specific detection system using functionally-modified recombinant endo-β-1,6-glucanase

  2020cites this paper
• The Kidney Contains Ontogenetically Distinct Dendritic Cell and Macrophage Subtypes throughout Development That Differ in Their Inflammatory Properties.

  2020cites this paper
• CCR5-mediated Recruitment of NK Cells to the Kidney Is a Critical Step for Host Defense to Systemic Candida albicans Infection

  2020cites this paper
• Emerging Role of Fractalkine in the Treatment of Rheumatic Diseases

  2020cites this paper
• The impact of the Fungus-Host-Microbiota interplay upon Candida albicans infections: current knowledge and new perspectives

  2020cites this paper
• Murine model of colonization with fungal pathogen Candida auris to explore skin tropism, host risk factors and therapeutic strategies.

  2020influential citation
• Neutrophil-Macrophage Imbalance Drives the Development of Renal Scarring during Experimental Pyelonephritis.

  2020cites this paper
• Intravital imaging of eosinophils: Unwrapping the enigma

  2020cites this paper
• Immune Mechanisms in Arterial Homeostasis and Disease

  2019cites this paper
• Title Autophagy-Inducing Factor Atg 1 Is Required for Virulence in thePathogenic Fungus Candida glabrata

  2019cites this paper
• Intravital Imaging in a Zebrafish Model Elucidates Interactions Between Mucosal Immunity and Pathogenic Fungi

  2019cites this paper
• Interleukin-35 Promotes Macrophage Survival and Improves Wound Healing After Myocardial Infarction in Mice

  2019cites this paper
• Autophagy-Inducing Factor Atg1 Is Required for Virulence in the Pathogenic Fungus Candida glabrata

  2019cites this paper
• Microglia and Neutrophils to the Rescue.

  2019cites this paper
• Gut Mycobiota in Immunity and Inflammatory Disease.

  2019cites this paper
• Intravital Imaging Reveals Divergent Cytokine and Cellular Immune Responses to Candida albicans and Candida parapsilosis

  2019cites this paper