Transcriptional activation by EBV nuclear antigen 1 is essential for the expression of EBV's transforming genes

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2006-09-19

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1073/pnas.0605985103PMID 16966603PMCID PMC1599932
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Essential Elements of a Licensed, Mammalian Plasmid Origin of DNA Synthesis

  2006cited by this paper
• DNA replication and human disease

  2006cited by this paper
• Epstein-Barr Virus Provides a New Paradigm: A Requirement for the Immediate Inhibition of Apoptosis

  2005cited by this paper
• Molecular genetics of DNA viruses: recombinant virus technology.

  2005cited by this paper
• Latent membrane protein 1 of Epstein–Barr virus coordinately regulates proliferation with control of apoptosis

  2005cited by this paper
• Epstein-Barr virus sustains Burkitt's lymphomas and Hodgkin's disease.

  2004cited by this paper
• EBNA-1, a Bifunctional Transcriptional Activator

  2003cited by this paper
• Functional Interaction of Nuclear Factor Y and Sp1 Is Required for Activation of the Epstein-Barr Virus C Promoter

  2003cited by this paper
• Latent membrane protein 1 is critical for efficient growth transformation of human B cells by epstein-barr virus.

  2003cited by this paper
• The EBV nuclear antigen 1 (EBNA1) enhances B cell immortalization several thousandfold

  2003cited by this paper
• Glycoprotein gp110 of Epstein–Barr virus determines viral tropism and efficiency of infection

  2002cited by this paper
• Promoter-Proximal Regulatory Elements Involved in oriP-EBNA1-Independent and -Dependent Activation of the Epstein-Barr Virus C Promoter in B-Lymphoid Cell Lines

  2001cited by this paper
• Maintenance of Epstein-Barr virus (EBV) oriP-based episomes requires EBV-encoded nuclear antigen-1 chromosome-binding domains, which can be replaced by high-mobility group-I or histone H1.

  2001cited by this paper
• EBNA‐1: a protein pivotal to latent infection by Epstein–Barr virus

  2000cited by this paper
• Determining the Role of the Epstein-Barr Virus Cp EBNA2-Dependent Enhancer during the Establishment of Latency by Using Mutant and Wild-Type Viruses Recovered from Cottontop Marmoset Lymphoblastoid Cell Lines

  2000cited by this paper
• The activity of the Epstein-Barr virus BamHI W promoter in B cells is dependent on the binding of CREB/ATF factors.

  2000cited by this paper
• The Linking Regions of EBNA1 Are Essential for Its Support of Replication and Transcription

  1999cited by this paper
• Up to 100-Fold Increase of Apparent Gene Expression in the Presence of Epstein-Barr Virus oriP Sequences and EBNA1: Implications of the Nuclear Import of Plasmids

  1998cited by this paper
• Propagation and recovery of intact, infectious Epstein-Barr virus from prokaryotic to human cells.

  1998cited by this paper
• oriP is essential for EBNA gene promoter activity in Epstein-Barr virus-immortalized lymphoblastoid cell lines

  1996cited by this paper
• Latent Marek's disease virus can be activated from its chromosomally integrated state in herpesvirus‐transformed lymphoma cells.

  1993cited by this paper
• The Epstein-Barr virus nuclear protein 1 promoter active in type I latency is autoregulated

  1992cited by this paper
• Role for the Epstein-Barr virus nuclear antigen 2 in viral promoter switching during initial stages of infection.

  1991cited by this paper
• Promoter switching in Epstein-Barr virus during the initial stages of infection of B lymphocytes.

  1990cited by this paper
• Construction of large DNA segments in Escherichia coli.

  1989cited by this paper
• Mutually exclusive use of viral promoters in Epstein-Barr virus latently infected lymphocytes.

  1989cited by this paper
• A promoter of Epstein-Barr virus that can function during latent infection can be transactivated by EBNA-1, a viral protein required for viral DNA replication during latent infection

  1989cited by this paper
• Identification and characterization of oriLyt, a lytic origin of DNA replication of Epstein-Barr virus

  1988cited by this paper
• Detection of circular and linear herpesvirus DNA molecules in mammalian cells by gel electrophoresis

  1984cited by this paper

• EBV INFECTION OUTCOMES DETERMINED BY MONOCYTE AND TREG-DRIVEN IMMUNE DYNAMICS IN AN EX VIVO PBMC MODEL

  2025cites this paper
• Viral oncogenesis and immune remodeling: Decoding the therapeutic potential of immune checkpoint inhibitors in virus-associated cancers.

  2025cites this paper
• Transcriptional regulation of gene modules in Epstein-Barr virus

  2025cites this paper
• Burkitt's Lymphoma and Early B Cell Transformation as Paradigms of How Epstein-Barr Virus Overcomes Apoptosis and Ferroptosis.

  2025cites this paper
• Causal association between EBV and gastritis, gastric cancer, and gastric ulcer: a two-sample Mendelian randomization study

  2025cites this paper
• EBNA1.

  2025cites this paper
• A direct RNA-seq-based EBV latency transcriptome offers insights into the biogenesis of EBV gene products

  2025cites this paper
• USP7 Inhibitors Destabilize EBNA1 and Suppress Epstein‐Barr Virus Tumorigenesis

  2025cites this paper
• Activation of Epstein–Barr Virus’ Lytic Cycle in Nasopharyngeal Carcinoma Cells by NEO212, a Conjugate of Perillyl Alcohol and Temozolomide

  2024cites this paper
• Carcinogenic mechanisms of virus-associated lymphoma

  2024cites this paper
• Pathogenesis and therapeutic implications of EBV-associated epithelial cancers

  2023cites this paper
• Chromosomal fragile site breakage by EBV-encoded EBNA1 at clustered repeats

  2023cites this paper
• Epstein–Barr Virus B Cell Growth Transformation: The Nuclear Events

  2023cites this paper
• THE POTENTIAL ROLE OF EPSTEIN BARR VIRUS IN MULTIPLE SCLEROSIS MOLECULAR AND SEROLOGICAL STUDY.

  2022cites this paper
• Time-resolved transcriptomes reveal diverse B cell fate trajectories in the early response to Epstein-Barr virus infection.

  2022cites this paper
• Fate-resolved gene regulatory signatures of individual B lymphocytes in the early stages of Epstein-Barr Virus infection

  2022cites this paper
• Burkitt Lymphomas Evolve to Escape Dependencies on Epstein-Barr Virus

  2021cites this paper
• A multi-omics approach to Epstein-Barr virus immortalization of B-cells reveals EBNA1 chromatin pioneering activities targeting nucleotide metabolism.

  2021influential citation
• Activation of DNA methyltransferase 3a by Epstein-Barr nuclear antigen 1 in gastric carcinoma.

  2021cites this paper
• The Epstein-Barr Virus Oncogene EBNA1 Suppresses Natural Killer Cell Responses and Apoptosis Early after Infection of Peripheral B Cells

  2021cites this paper
• Epstein-Barr Virus Infection in the Development of Neurological Disorders.

  2020cites this paper
• The Critical Role of Genome Maintenance Proteins in Immune Evasion During Gammaherpesvirus Latency

  2019cites this paper
• First Days in the Life of Naive Human B Lymphocytes Infected with Epstein-Barr Virus

  2019cites this paper
• BZLF1 interacts with chromatin remodelers promoting escape from latent infections with EBV

  2019cites this paper
• Structure-based design of small-molecule inhibitors of EBNA1 DNA binding blocks Epstein-Barr virus latent infection and tumor growth

  2019cites this paper
• CRISPRa mediated pluripotency reprogramming of biobanked lymphoblastoid cell lines

  2018cites this paper
• Epstein Barr Virus genome variation and functional analysis of the IR-1 internal repeat

  2018influential citation
• Increased Epstein-Barr virus C-promoter activity with CTCF-binding site deletion is associated with elevated EBNA2 recruitment

  2018cites this paper
• BZLF1 interacts with the chromatin remodeler INO80 promoting escape from latent infections with Epstein-Barr virus

  2018cites this paper
• Epstein-Barr virus nuclear antigen EBNA-LP is essential for transforming naïve B cells, and facilitates recruitment of transcription factors to the viral genome

  2018cites this paper
• EBNA1: Oncogenic Activity, Immune Evasion and Biochemical Functions Provide Targets for Novel Therapeutic Strategies against Epstein-Barr Virus- Associated Cancers

  2018cites this paper
• Séquençage du génome complet du virus d’Epstein-Barr dans des prélèvements issus de lymphomes T angio-immunoblastiques

  2017cites this paper
• Epstein-Barr virus nuclear antigen EBNA-LP is essential for transforming naive B cells, and facilitates recruitment of transcription factors to the viral genome

  2017cites this paper
• Serological profiling of the EBV immune response in Chronic Fatigue Syndrome using a peptide microarray

  2017cites this paper
• Analysis of Epstein-Barr Virus Genomes and Expression Profiles in Gastric Adenocarcinoma

  2017cites this paper
• Etude des homologies phénotypiques et fonctionnelles des lymphocytes B en latence III de l'EBV avec les cellules B régulatrices, implication de l'axe PD-1/PD-L1

  2017cites this paper
• Epigenetics of Virus-Induced Tumors: Perspectives for Therapeutic Targeting.

  2017cites this paper
• High-elevation plants have reduced plasticity in flowering time in response to warming compared to low-elevation congeners

  2017cites this paper
• The Role of Gammaherpesviruses in Cancer Pathogenesis

  2016cites this paper
• Modeling neurological diseases with induced pluripotent cells reprogrammed from immortalized lymphoblastoid cell lines

  2016cites this paper
• Oxidative stress enables Epstein–Barr virus-induced B-cell transformation by posttranscriptional regulation of viral and cellular growth-promoting factors

  2016cites this paper
• HCF1 and OCT2 Cooperate with EBNA1 To Enhance OriP-Dependent Transcription and Episome Maintenance of Latent Epstein-Barr Virus

  2016influential citation
• Nasopharyngeal Carcinoma: An Evolving Role for the Epstein-Barr Virus.

  2015cites this paper
• Chromatin Structure of Epstein-Barr Virus Latent Episomes.

  2015cites this paper
• Contribution of the Epstein-Barr Virus to the Pathogenesis of Hodgkin Lymphoma.

  2015cites this paper
• The Epstein-Barr virus BCL-2 homologues : interactions with cellular BCL-2 proteins and their role in apoptosis

  2015cites this paper
• The V-val subtype Epstein-Barr virus nuclear antigen 1 promotes cell survival after serum withdrawal.

  2015cites this paper
• The Epstein-Barr Virus BamHI C Promoter Is Not Essential for B Cell Immortalization In Vitro, but It Greatly Enhances B Cell Growth Transformation

  2014cites this paper
• Dynamic Epstein-Barr virus gene expression on the path to B-cell transformation.

  2014cites this paper
• A new version of targeted minicircle producer system for EBV-positive human nasopharyngeal carcinoma.

  2014cites this paper
• EBNA1 binding and epigenetic regulation of gastrokine tumor suppressor genes in gastric carcinoma cells

  2014cites this paper
• The Epstein-Barr Virus-Encoded MicroRNA MiR-BART9 Promotes Tumor Metastasis by Targeting E-Cadherin in Nasopharyngeal Carcinoma

  2014cites this paper
• Deficient EBV-Specific B- and T-Cell Response in Patients with Chronic Fatigue Syndrome

  2014cites this paper
• Mechanism of superior B cell immortalisation activity of type 1 Epstein-Barr virus

  2014cites this paper
• Epstein–Barr Virus and Nasopharyngeal Carcinoma

  2014cites this paper
• Epigenetic regulation of EBV persistence and oncogenesis.

  2014cites this paper
• ReliableGenerationofInducedPluripotentStemCells From Human Lymphoblastoid Cell Lines

  2014cites this paper
• Upregulation of TFAM and mitochondria copy number in human lymphoblastoid cells.

  2014cites this paper
• Investigation of Epstein-Barr Virus-Host Interactions during Latent and Lytic Infection

  2014cites this paper
• Reliable Generation of Induced Pluripotent Stem Cells From Human Lymphoblastoid Cell Lines

  2014cites this paper
• Replication of Epstein-Barr viral DNA.

  2013cites this paper
• The Effect of Epstein-Barr Virus Latent Membrane Protein 2 Expression on the Kinetics of Early B Cell Infection

  2013cites this paper
• EBNA1 and Epstein-Barr Virus Associated Tumours

  2013influential citation
• Keeping it quiet: chromatin control of gammaherpesvirus latency

  2013cites this paper
• Potential Cellular Functions of Epstein-Barr Nuclear Antigen 1 (EBNA1) of Epstein-Barr Virus

  2013cites this paper
• Epstein-Barr Virus Induces Global Changes in Cellular mRNA Isoform Usage That Are Important for the Maintenance of Latency

  2013cites this paper
• Nucleolin is important for Epstein–Barr virus nuclear antigen 1-mediated episome binding, maintenance, and transcription

  2013cites this paper
• Mechanisms of Regulation of Promyelocytic Leukemia (PML) Proteins by Epstein-Barr Nuclear Antigen 1 (EBNA1) and Ubiquitin Specific Protease 7 (USP7)

  2013cites this paper
• Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells

  2013cites this paper
• Epstein-Barr Virus and the Pathogenesis of Nasopharyngeal Carcinomas

  2013cites this paper
• EBNA1 Contributions to EBV-Associated Tumours

  2013cites this paper
• Interaction between Basic Residues of Epstein-Barr Virus EBNA1 Protein and Cellular Chromatin Mediates Viral Plasmid Maintenance*

  2013cites this paper
• Epstein-Barr virus and host cell methylation: regulation of latency, replication and virus reactivation.

  2013cites this paper
• Roles of EBNA1 at EBV Episomes

  2013cites this paper
• Epigenetic regulation of EBV and KSHV latency.

  2013cites this paper
• Contributions of Epstein–Barr Nuclear Antigen 1 (EBNA1) to Cell Immortalization and Survival

  2012cites this paper
• Similarities between the Epstein-Barr Virus (EBV) Nuclear Protein EBNA1 and the Pioneer Transcription Factor FoxA: Is EBNA1 a “Bookmarking” Oncoprotein that Alters the Host Cell Epigenotype?

  2012cites this paper
• Options for Change in the Australian Energy Profile

  2012cites this paper
• Shutoff of BZLF1 Gene Expression Is Necessary for Immortalization of Primary B Cells by Epstein-Barr Virus

  2012cites this paper
• BZLF1 Governs CpG-Methylated Chromatin of Epstein-Barr Virus Reversing Epigenetic Repression

  2012influential citation
• The Epstein-Barr Virus EBNA1 Protein

  2012cites this paper
• Analysis of Epstein-Barr Virus-Regulated Host Gene Expression Changes through Primary B-Cell Outgrowth Reveals Delayed Kinetics of Latent Membrane Protein 1-Mediated NF-κB Activation

  2012cites this paper
• Live-Cell Imaging Reveals Multiple Interactions between Epstein-Barr Virus Nuclear Antigen 1 and Cellular Chromatin during Interphase and Mitosis

  2012cites this paper
• Human B cells on their route to latent infection--early but transient expression of lytic genes of Epstein-Barr virus.

  2012cites this paper
• Contributions of Epstein-Barr Nuclear Antigen 1 (EBNA1) and the Family of Repeats (FR) Region to oriP-mediated Replication and Segregation Functions in Nasopharyngeal Carcinoma

  2012cites this paper
• 4 Contributions of the EBNA 1 Protein of Epstein-Barr Virus Toward B-Cell

  2012cites this paper
• Role of EBNA1 in NPC tumourigenesis.

  2012influential citation
• Contributions of the EBNA1 Protein of Epstein-Barr Virus Toward B-Cell Immortalization and Lymphomagenesis

  2012influential citation
• Charakterystyka białek wirusa Epsteina-Barr - ich udział w zakażeniu latentnym i powiązanie z procesami nowotworzenia

  2012cites this paper
• B Activation κ 1-Mediated NF- Kinetics of Latent Membrane Protein Primary B-Cell Outgrowth Reveals Delayed Host Gene Expression Changes through Analysis of Epstein-Barr Virus-Regulated

  2012cites this paper
• Functional Interactions between Chromatin-associated Proteins and Epstein-Barr virus Nuclear Antigen 1 (EBNA1)

  2012influential citation
• Human lymphoblastoid B-cell lines reprogrammed to EBV-free induced pluripotent stem cells.

  2011cites this paper
• The ZIIR Element of the Epstein-Barr Virus BZLF1 Promoter Plays a Central Role in Establishment and Maintenance of Viral Latency

  2011cites this paper
• Hematopoietic cells as sources for patient-specific iPSCs and disease modeling

  2011cites this paper
• EBV Latency Types Adopt Alternative Chromatin Conformations

  2011cites this paper
• Minicircle-oriP-IFNγ: A Novel Targeted Gene Therapeutic System for EBV Positive Human Nasopharyngeal Carcinoma

  2011cites this paper
• The Epstein–Barr virus nuclear antigen-1 promotes telomere dysfunction via induction of oxidative stress

  2011cites this paper
• Infection of primary human tonsillar lymphoid cells by KSHV reveals frequent but abortive infection of T cells.

  2011cites this paper
• Gene Functional Studies Using Bacterial Artificial Chromosome (BACs)

  2011cites this paper
• Reprogramming of EBV-immortalized B-lymphocyte cell lines into induced pluripotent stem cells.

  2011cites this paper