Genetic and Epigenetic Abnormalities in Primary Sclerosing Cholangitis-associated Cholangiocarcinoma

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Inflammatory Bowel Diseases

• Publication date

  2013-07-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1097/MIB.0b013e318281f49aPMID 23615529
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Molecular Pathogenesis of Cholangiocarcinoma

  2014cited by this paper
• Correlation between promoter methylation of p14ARF, TMS1/ASC, and DAPK, and p53 mutation with prognosis in cholangiocarcinoma

  2012cited by this paper
• Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping.

  2012cited by this paper
• Genomic and genetic characterization of cholangiocarcinoma identifies therapeutic targets for tyrosine kinase inhibitors.

  2012cited by this paper
• Novel target genes and a valid biomarker panel identified for cholangiocarcinoma

  2012cited by this paper
• Epidemiology of primary sclerosing cholangitis and primary biliary cirrhosis: a systematic review.

  2012cited by this paper
• Polysomy and p16 deletion by fluorescence in situ hybridization in the diagnosis of indeterminate biliary strictures.

  2012influential reference
• Biliary dysplasia in patients with primary sclerosing cholangitis: additional value of DNA ploidity

  2012cited by this paper
• Routine brush cytology and fluorescence in situ hybridization for assessment of pancreatobiliary strictures.

  2012cited by this paper
• Primary Sclerosing Cholangitis Patients With Serial Polysomy Fluorescence In Situ Hybridization Results Are at Increased Risk of Cholangiocarcinoma

  2011influential reference
• Tumor Suppressor RASSF1A Promoter: p53 Binding and Methylation

  2011cited by this paper
• Identification of malignant cytologic criteria in pancreatobiliary brushings with corresponding positive fluorescence in situ hybridization results.

  2011cited by this paper
• Array comparative genomic hybridization identifies novel potential therapeutic targets in cholangiocarcinoma.

  2011cited by this paper
• Loss of Rassf1a enhances p53-mediated tumor predisposition and accelerates progression to aneuploidy

  2011cited by this paper
• TPX2 and AURKA promote 20q amplicon-driven colorectal adenoma to carcinoma progression

  2011cited by this paper
• Many patients with primary sclerosing cholangitis and increased serum levels of carbohydrate antigen 19-9 do not have cholangiocarcinoma.

  2011cited by this paper
• p53 Status and Its Prognostic Role in Extrahepatic Bile Duct Cancer: A Meta-Analysis of Published Studies

  2011cited by this paper
• Update on primary sclerosing cholangitis.

  2010influential reference
• The biliary HCO3− umbrella: A unifying hypothesis on pathogenetic and therapeutic aspects of fibrosing cholangiopathies

  2010cited by this paper
• Comparison of KRAS mutation analysis and FISH for detecting pancreatobiliary tract cancer in cytology specimens collected during endoscopic retrograde cholangiopancreatography.

  2010influential reference
• Incidence and prevalence of primary sclerosing cholangitis in a defined adult population in sweden

  2010cited by this paper
• Epidermal growth factor receptor and HER-2/neu status by immunohistochemistry and fluorescence in situ hybridization in adenocarcinomas of the biliary tree and gallbladder.

  2010cited by this paper
• Precancerous Bile Duct Pathology in End-stage Primary Sclerosing Cholangitis, With and Without Cholangiocarcinoma

  2010cited by this paper
• Tumor markers as a diagnostic key for hilar cholangiocarcinoma

  2010cited by this paper
• Genome-wide association analysis in primary sclerosing cholangitis.

  2010influential reference
• DNA Mutational Differences in Cytological Specimens from Pancreatic Cancer and Cholangiocarcinoma

  2010cited by this paper
• Implications for KRAS status and EGFR-targeted therapies in metastatic CRC

  2009cited by this paper
• AUTOIMMUNE, CHOLESTATIC AND BILIARY DISEASE Long-Term Outcomes of Positive Fluorescence In Situ Hybridization Tests in Primary Sclerosing Cholangitis

  2009influential reference
• Genome wide analysis and clinical correlation of chromosomal and transcriptional mutations in cancers of the biliary tract

  2009cited by this paper
• A multivariable model using advanced cytologic methods for the evaluation of indeterminate pancreatobiliary strictures.

  2009cited by this paper
• High lifetime risk of cancer in primary sclerosing cholangitis.

  2009cited by this paper
• Prognostic molecular markers in cholangiocarcinoma: a systematic review.

  2009cited by this paper
• Pattern of chromosomal aberrations in primary liver cancers identified by comparative genomic hybridization.

  2009cited by this paper
• DNA methylation alterations in endoscopic retrograde cholangiopancreatography brush samples of patients with suspected pancreaticobiliary disease.

  2008cited by this paper
• The tumor suppressor p53: Cancer and aging

  2008cited by this paper
• Utility of serum tumor markers, imaging, and biliary cytology for detecting cholangiocarcinoma in primary sclerosing cholangitis

  2008influential reference
• Risk of Primary Sclerosing Cholangitis and Ulcerative Colitis in irst-Degree Relatives of Patients With Primary Sclerosing Cholangitis

  2008influential reference
• EGFR and HER2 expression in advanced biliary tract cancer.

  2008cited by this paper
• Prospective Evaluation of Advanced Molecular Markers and Imaging Techniques in Patients With Indeterminate Bile Duct Strictures

  2008cited by this paper
• Activation‐induced cytidine deaminase links bile duct inflammation to human cholangiocarcinoma

  2008cited by this paper
• Role of ErbB family receptor tyrosine kinases in intrahepatic cholangiocarcinoma.

  2008influential reference
• Incidence, Diagnosis, and Therapy of Cholangiocarcinoma in Patients with Primary Sclerosing Cholangitis

  2007cited by this paper
• Correlating routine cytology, quantitative nuclear morphometry by digital image analysis, and genetic alterations by fluorescence in situ hybridization to assess the sensitivity of cytology for detecting pancreatobiliary tract malignancy.

  2007cited by this paper
• The Burden of Large and Small Duct Primary Sclerosing Cholangitis in Adults and Children: A Population-Based Analysis

  2007cited by this paper
• Immunohistochemical analysis of inflammation in primary sclerosing cholangitis

  2007cited by this paper
• Ten‐year results of a prospective study on the prognostic role of ploidy in endometrial carcinoma

  2007cited by this paper
• An assessment of chromosomal alterations detected by fluorescence in situ hybridization and p16 expression in sporadic and primary sclerosing cholangitis-associated cholangiocarcinomas.

  2007cited by this paper
• Cholangiocarcinoma in primary sclerosing cholangitis is associated with NKG2D polymorphisms

  2007influential reference
• Distal Bile Duct Carcinoma: Prognostic Factors After Curative Surgery. A Series of 112 Cases

  2007influential reference
• DNA Ploidy Status and Prognosis in Colorectal Cancer: A Meta-Analysis of Published Data

  2007cited by this paper
• Diagnostic and Prognostic Implications of DNA Ploidy and S-Phase Evaluation in the Assessment of Malignancy in Biliary Strictures

  2006cited by this paper
• Advanced cytologic techniques for the detection of malignant pancreatobiliary strictures.

  2006cited by this paper
• Amplification and overexpression of c-erbB-2, epidermal growth factor receptor, and c-met in biliary tract cancers

  2006cited by this paper
• Primary Sclerosing Cholangitis and Cholangiocarcinoma

  2006cited by this paper
• Diagnostic benefit of biliary brush cytology in cholangiocarcinoma in primary sclerosing cholangitis.

  2006cited by this paper
• Advances in the diagnosis of cholangiocarcinoma in patients with primary sclerosing cholangitis

  2006cited by this paper
• Comparison of gene expression profiles between Opisthorchis viverrini and non‐Opisthorchis viverrini associated human intrahepatic cholangiocarcinoma

  2006cited by this paper
• NKG2D and cytotoxic effector function in tumor immune surveillance.

  2006cited by this paper
• Somatic Mutations of Epidermal Growth Factor Receptor in Bile Duct and Gallbladder Carcinoma

  2006cited by this paper
• A novel mutation in the tyrosine kinase domain of ERBB2 in hepatocellular carcinoma

  2006cited by this paper
• Identification of epigenetic aberrant promoter methylation in serum DNA is useful for early detection of lung cancer.

  2005cited by this paper
• Biliary brush cytology and the detection of cholangiocarcinoma in primary sclerosing cholangitis: evaluation of specific cytomorphologic features and CA19-9 levels.

  2005cited by this paper
• The tumor suppressor RASSF1A in human carcinogenesis: an update.

  2005cited by this paper
• Allele loss and epigenetic inactivation of 3p21.3 in malignant liver tumors

  2005cited by this paper
• Promoter methylation profiles of tumor suppressor genes in intrahepatic and extrahepatic cholangiocarcinoma

  2005cited by this paper
• Amplification and overexpression of c‐erbB‐2, epidermal growth factor receptor, and c‐met in biliary tract cancers

  2005cited by this paper
• Biliary brushing cytology

  2004cited by this paper
• Promoter hypermethylation of DAP‐kinase is associated with poor survival in primary biliary tract carcinoma patients

  2004cited by this paper
• A Comparison of Routine Cytology and Fluorescence in situ Hybridization for the Detection of Malignant Bile Duct Strictures

  2004cited by this paper
• Serum and bile markers for cholangiocarcinoma.

  2004cited by this paper
• Genetic Alterations in Intrahepatic Cholangiocarcinoma as revealed by Degenerate Oligonucleotide Primed PCR-Comparative Genomic Hybridization

  2004cited by this paper
• The epidemiology of cholangiocarcinoma.

  2004cited by this paper
• The molecular pathogenesis of cholangiocarcinoma.

  2004cited by this paper
• Promoter methylation of INK4a/ARF as detected in bile-significance for the differential diagnosis in biliary disease.

  2003influential reference
• Investigation of ErbB1 and ErbB2 expression for therapeutic targeting in primary liver tumours.

  2003cited by this paper
• p16INK4a promoter mutations are frequent in primary sclerosing cholangitis (PSC) and PSC-associated cholangiocarcinoma.

  2002cited by this paper
• Genetic and epigenetic alterations of the INK4a–ARF pathway in cholangiocarcinoma

  2002cited by this paper
• Frequent loss of chromosome 3p and hypermethylation of RASSF1A in cholangiocarcinoma.

  2002cited by this paper
• Gene amplification and mRNA and protein overexpression of c-erbB-2 (HER-2/neu) in human intrahepatic cholangiocarcinoma as detected by fluorescence in situ hybridization, in situ hybridization, and immunohistochemistry.

  2002cited by this paper
• Natural history of primary sclerosing cholangitis and prognostic value of cholangiography in a Dutch population

  2002cited by this paper
• Genetic alterations in hepatocellular carcinoma and intrahepatic cholangiocarcinoma.

  2001cited by this paper
• A Comparison of DNA Copy Number Changes Detected by Comparative Genomic Hybridization in Malignancies of the Liver, Biliary Tract and Pancreas

  2001cited by this paper
• Increased colorectal neoplasia in chronic ulcerative colitis complicated by primary sclerosing cholangitis: fact or fiction?

  2001cited by this paper
• K-ras mutations in the bile of patients with primary sclerosing cholangitis

  2001cited by this paper
• Primary sclerosing cholangitis is associated to an extended B8‐DR3 haplotype including particular MICA and MICB alleles

  2001influential reference
• Biliary dysplasia as a marker of cholangiocarcinoma in primary sclerosing cholangitis.

  2001cited by this paper
• Expression of p53 and PCNA in Cholangiocarcinoma and Primary Sclerosing Cholangitis

  2000cited by this paper
• Cholangiocarcinoma in primary sclerosing cholangitis: K-ras mutations and Tp53 dysfunction are implicated in the neoplastic development.

  2000cited by this paper
• Frequency of p16INK4A alterations and k-ras mutations in intrahepatic cholangiocarcinoma of the liver

  2000cited by this paper
• p53 overexpression and K-ras gene mutations in primary sclerosing cholangitis-associated biliary tract cancer.

  2000cited by this paper
• Mutations of p53 Tumor Suppressor Gene, Apoptosis, and Proliferation in Intrahepatic Cholangiocellular Carcinoma of the Liver

  2000cited by this paper
• Can DNA cytometry be used for evaluation of malignancy and premalignancy in bile duct strictures in primary sclerosing cholangitis?

  2000cited by this paper
• Chromosome 9p21 loss and p16 inactivation in primary sclerosing cholangitis-associated cholangiocarcinoma.

  1999cited by this paper
• Mutation of p53 and K-ras, and loss of heterozygosity of APC in intrahepatic cholangiocarcinoma.

  1999cited by this paper
• Genomic alterations in distal bile duct carcinoma by comparative genomic hybridization and karyotype analysis

  1999cited by this paper
• Value of brush cytology for dominant strictures in primary sclerosing cholangitis.

  1999cited by this paper
• Prognostic significance of tumor DNA content in carcinoma of the hepatic duct confluence.

  1998cited by this paper
• Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis.

  1998cited by this paper
• Value of Brush Cytology for Dominant Strictures in Primary Sclerosing Cholangitis

  1998cited by this paper
• p53 Protein overexpression in cholangiocarcinoma arising in primary sclerosing cholangitis.

  1996cited by this paper

• Clinicogenomic Characterization of Primary Sclerosing Cholangitis-Associated Biliary Tract Cancers.

  2025cites this paper
• Spatial transcriptomics profiling of gallbladder adenocarcinoma: a detailed two-case study of progression from precursor lesions to cancer

  2024cites this paper
• Genetic alterations during the neoplastic cascade towards cholangiocarcinoma in primary sclerosing cholangitis

  2022cites this paper
• Epigenetic Aspects and Prospects in Autoimmune Hepatitis

  2022cites this paper
• Review of incidence and outcomes of treatment of cholangiocarcinoma in patients with primary sclerosing cholangitis

  2021cites this paper
• The Role of Microbiota in Primary Sclerosing Cholangitis and Related Biliary Malignancies

  2021cites this paper
• Optimal tissue sampling during ERCP and emerging molecular techniques for the differentiation of benign and malignant biliary strictures

  2021cites this paper
• Serum Dickkopf-1 in Combined with CA 19-9 as a Biomarker of Intrahepatic Cholangiocarcinoma

  2021cites this paper
• Quantitative proteomic analysis of bile in extrahepatic cholangiocarcinoma patients

  2020cites this paper
• Clinical Epidemiology of Chronic Liver Diseases

  2019cites this paper
• Cholangiocarcinoma in Patients with Primary Sclerosing Cholangitis (PSC): a Comprehensive Review

  2019cites this paper
• Slit2 signaling contributes to cholestatic fibrosis in mice by activation of hepatic stellate cells.

  2019cites this paper
• Autoimmune Hepatitis and Immune-Mediated Cholestatic Liver Diseases

  2018cites this paper
• Epigenetic changes and their implications in autoimmune hepatitis

  2018cites this paper
• The Pathophysiology of Cholangiocarcinoma, a Review about Possible Involved Risk Factors

  2018cites this paper
• Let-7c inhibits cholangiocarcinoma growth but promotes tumor cell invasion and growth at extrahepatic sites

  2018cites this paper
• Pathological features of primary sclerosing cholangitis identified by bile proteomic analysis.

  2017cites this paper
• Primary Sclerosing Cholangitis

  2017cites this paper
• Malignancy and Primary Sclerosing Cholangitis: Cholangiocarcinoma, Hepatocellular Carcinoma, and Gallbladder Carcinoma

  2017cites this paper
• Bile duct ligation–induced biliary hyperplasia, hepatic injury, and fibrosis are reduced in mast cell–deficient KitW‐sh mice

  2017influential citation
• Lipids, Low-Grade Chronic Inflammation and NAFLD: A Ménage À Trois?

  2016cites this paper
• Lipids Nutrition and Epigenetic Modification in Obesity-Related Co-Morbitities**All authors equally contributed to draft the manuscript. All authors gave final approval of the version to be published. Disclosure statement: The authors declare that there are no conflicts of interest

  2016cites this paper
• Genetic Abnormalities in Biliary Brush Samples for Distinguishing Cholangiocarcinoma from Benign Strictures in Primary Sclerosing Cholangitis

  2016cites this paper
• Lipids, Low-Grade Chronic Inflammation and NAFLD

  2016cites this paper
• Epigenetics in Childhood Health and Disease

  2014cites this paper
• Update on primary sclerosing cholangitis genetics

  2014cites this paper
• Direct targeting of SUZ12/ROCK2 by miR-200b/c inhibits cholangiocarcinoma tumourigenesis and metastasis

  2013cites this paper