Central effects of tetanus and botulinum neurotoxins.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Toxicon

• Publication date

  2009-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.toxicon.2008.12.026PMID 19264088
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Axonal Transport Tracers

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• Identification of the fibroblast growth factor receptor FGFR3 as a component of the receptor complex for Botulinum Neurotoxin Type A

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• Molecular basis for tetanus toxin coreceptor interactions.

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• Novel Chimeras of Botulinum Neurotoxins A and E Unveil Contributions from the Binding, Translocation, and Protease Domains to Their Functional Characteristics*

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• Heterogeneous expression of SNAP‐25 in rat and human brain

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• Long-Distance Retrograde Effects of Botulinum Neurotoxin A

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• Botulinum neurotoxin E (BoNT/E) reduces CA1 neuron loss and granule cell dispersion, with no effects on chronic seizures, in a mouse model of temporal lobe epilepsy.

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• Assessment: Botulinum neurotoxin for the treatment of spasticity (an evidence-based review): Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of NeurologySYMBOL

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• Mechanism of botulinum neurotoxin B and G entry into hippocampal neurons

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• Association of botulinum neurotoxin serotypes a and B with synaptic vesicle protein complexes.

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• Rab5 and Rab7 control endocytic sorting along the axonal retrograde transport pathway.

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• Action of botulinum neurotoxins in the central nervous system: Antiepileptic effects

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• Characterization of the Tetanus Toxin Model of Refractory Focal Neocortical Epilepsy in the Rat

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• Central effects of botulinum toxin type A: Evidence and supposition

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• Uptake of botulinum neurotoxin into cultured neurons.

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• Physiological effects of botulinum toxin in spasticity

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• 125I-Labelled botulinum a neurotoxin: Pharmacokinetics in cats after intramuscular injection

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• Axonal transport and neuronal transcytosis of trophic factors, tracers, and pathogens.

  2004cited by this paper
• Presynaptic receptor arrays for clostridial neurotoxins.

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• Translocation of botulinum neurotoxin light chain protease through the heavy chain channel

  2003cited by this paper
• The journey of tetanus and botulinum neurotoxins in neurons.

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• Evaluation of the Therapeutic Usefulness of Botulinum Neurotoxin B, C1, E, and F Compared with the Long Lasting Type A

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• C-terminal fragment of tetanus toxin heavy chain activates Akt and MEK/ERK signalling pathways in a Trk receptor-dependent manner in cultured cortical neurons.

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• Synaptotagmins I and II mediate entry of botulinum neurotoxin B into cells

  2003cited by this paper
• Two carbohydrate binding sites in the H(CC)-domain of tetanus neurotoxin are required for toxicity.

  2003cited by this paper
• Fragment C tetanus toxin: a putative activity-dependent neuroanatomical tracer.

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• Retargeted clostridial endopeptidases: Inhibition of nociceptive neurotransmitter release in vitro, and antinociceptive activity in in vivo models of pain

  2002cited by this paper
• Botulinum neurotoxins: from paralysis to recovery of functional neuromuscular transmission.

  2002cited by this paper
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• When should temporal-lobe epilepsy be treated surgically?

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• Botulinum and tetanus neurotoxins: structure, function and therapeutic utility.

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  2002cited by this paper
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  2001cited by this paper
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  2001cited by this paper
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  2000cited by this paper
• Membrane fusion and exocytosis.

  1999cited by this paper
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  1998cited by this paper
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  1998cited by this paper
• Mechanisms of Deafferentation-Induced Plasticity in Human Motor Cortex

  1998cited by this paper
• Dose-dependent, central effects of botulinum neurotoxin type A

  1997cited by this paper
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• Effects of botulinum neurotoxin type A on abducens motoneurons in the cat: ultrastructural and synaptic alterations.

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• Clostridial Neurotoxins and Substrate Proteolysis in Intact Neurons

  1996cited by this paper
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  1996cited by this paper
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  1995cited by this paper
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  1995cited by this paper
• Botulinum neurotoxin alters the discharge characteristics of abducens motoneurons in the alert cat.

  1994cited by this paper
• Botulinum A toxin effects on rat jaw muscle spindles.

  1993cited by this paper
• Time course of distant effects of local injections of botulinum toxin

  1993cited by this paper
• Chronic Epileptic Foci in Neocortex: In Vivo and In Vitro Effects of Tetanus Toxin

  1991cited by this paper
• Characterization of the Inhibitory Action of Botulinum Neurotoxin Type A on the Release of Several Transmitters from Rat Cerebrocortical Synaptosomes

  1988cited by this paper
• How do tetanus and botulinum toxins bind to neuronal membranes

  1986cited by this paper
• Use of the B-IIb tetanus toxin derived fragment as a specific neuropharmacological transport agent.

  1980cited by this paper
• On the question of permeability of the blood-brain barrier to botulinum toxin.

  1975cited by this paper
• Botulinum Toxin, Type A: Effects on Central Nervous System

  1965cited by this paper
• Botulinus toxin: effect on the central nervous system of man.

  1963cited by this paper
• Botulinus Toxin: Effect on the Central Nervous System of Man

  1963cited by this paper
• Influence of nerve‐ending activity and of drugs on the rate of paralysis of rat diaphragm preparation by Cl. botulinum type A toxin

  1962cited by this paper

• BoNT/Action beyond Neurons.

  2025cites this paper
• Local tetanus begins with a VAMP cleavage-associated neuromuscular junction paralysis around the site of tetanus neurotoxin release.

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• Pathogenicity and virulence of Clostridium botulinum

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• Successful treatment of idiopathic tetanus using metronidazole, magnesium, and acepromazine in Hanwoo (Korean indigenous cattle) yearling bull

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• A look at the future-new BoNTs and delivery systems in development: What it could mean in the clinic.

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• Pain control due to botulinum toxin therapy in cervical dystonia relates to the sensorimotor integration process

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• Toxicology and pharmacology of botulinum and tetanus neurotoxins: an update

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• Botulinum toxin therapy of dystonia.

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• Tetanus

  2020cites this paper
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  2019cites this paper
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  2019cites this paper
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  2018cites this paper
• Intrastriatally injected botulinum neurotoxin-A differently effects cholinergic and dopaminergic fibers in C57BL/6 mice.

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  2017cites this paper
• The Molecular Basis of Toxins’ Interactions with Intracellular Signaling via Discrete Portals

  2017cites this paper
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  2017cites this paper
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  2017cites this paper
• Uptake of Clostridial Neurotoxins into Cells and Dissemination.

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• Refractory focal motor seizures controlled with intramuscular botulinum toxin.

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• Clostridial neurotoxins as a drug delivery vehicle targeting nervous system.

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• [Botulinum neurotoxin].

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