Noninvasive quantification of ascorbate and glutathione concentration in the elderly human brain

No abstract is available for this paper.

• Publication year

  2011

• Venue

  NMR in Biomedicine

• Publication date

  2011-08-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1002/nbm.1646PMID 21834011PMCID PMC3118919
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2008cited by this paper
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  2008cited by this paper
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  2007cited by this paper
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  2007cited by this paper
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  2007cited by this paper
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  2006cited by this paper
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  2006cited by this paper
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  2006cited by this paper
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  2006cited by this paper
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  2005cited by this paper
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  2005cited by this paper
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  2005cited by this paper
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  2005cited by this paper
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  2003cited by this paper
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  2003cited by this paper
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  2002cited by this paper
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  2002cited by this paper
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  2002cited by this paper
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  2002cited by this paper
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  2001cited by this paper
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  2001influential reference
• Field mapping without reference scan using asymmetric echo‐planar techniques

  2000cited by this paper
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  2000cited by this paper
• Ascorbate regulation and its neuroprotective role in the brain.

  2000cited by this paper
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  1999cited by this paper
• In vivo 1H NMR spectroscopy of rat brain at 1 ms echo time

  1999cited by this paper
• Homonuclear J coupling effects in volume localized NMR spectroscopy: Pitfalls and solutions

  1998cited by this paper
• A half-volume coil for efficient proton decoupling in humans at 4 tesla.

  1997cited by this paper
• Differential compartmentalization of brain ascorbate and glutathione between neurons and glia.

  1997influential reference
• Alterations in the activities of cerebral antioxidant enzymes of rat are related to aging

  1997cited by this paper
• In vivo proton magnetic resonance spectroscopy of the normal aging human brain.

  1996cited by this paper
• Oxidative Stress, Caloric Restriction, and Aging

  1996cited by this paper
• Absolute Quantitation of Water and Metabolites in the Human Brain. I. Compartments and Water

  1993cited by this paper
• Automatic, localized in Vivo adjustment of all first‐and second‐order shim coils

  1993cited by this paper
• Estimation of metabolite concentrations from localized in vivo proton NMR spectra

  1993cited by this paper
• Effect of ageing on extracellular ascorbate concentration in rat brain.

  1993cited by this paper
• Relationship between antioxidant defenses and longevity in different mammalian species.

  1990cited by this paper
• Basic Neurochemistry: Molecular, Cellular and Medical Aspects

  1989cited by this paper
• Effect of aging on aqueous-phase antioxidants in tissues of male Fischer rats.

  1988cited by this paper
• Amino acid transport across the human blood-CSF barrier. An evaluation graph for amino acid concentrations in cerebrospinal fluid.

  1985cited by this paper
• Glutathione biosynthesis in the aging adult yellow-fever mosquito [Aedes aegypti (Louisville)].

  1983cited by this paper
• Glutathione contents of tissues in the aging mouse.

  1980cited by this paper
• The ascorbic acid content of human pituitary, cerebral cortex, heart, and skeletal muscle and its relation to age.

  1957cited by this paper
• Article Reference

  year unknowncited by this paper

• Consequences of iron exposure and glutathione depletion on redox balance, lipidome, and neurotransmission in C. elegans

  2026cites this paper
• Brain Glutathione Levels Associate With Cognitive Performance in Older Adults

  2026cites this paper
• The role of glutathione in cognition, cognitive effort, and cognitive endurance in young and older adults

  2026cites this paper
• Ferroptosis-related stress during aging and its relevance to disease.

  2025cites this paper
• Sulforaphane and Brain Health: From Pathways of Action to Effects on Specific Disorders

  2025influential citation
• Transcriptomic signatures of oxytosis/ferroptosis are enriched in Alzheimer’s disease

  2025cites this paper
• GABA, Glx, and GSH in the cerebellum: their role in motor performance and learning across age groups

  2025cites this paper
• Sinomenine Hydrochloride Impedes Memory Impairments via Nrf2/HO-1-Mediated Inhibition of Oxidative Stress, Neuroinflammation and Apoptosis in Mice Brain

  2025cites this paper
• The links among age, sex, and glutathione: A cross-sectional magnetic resonance spectroscopy study.

  2024cites this paper
• Using Redox Proteomics to Gain New Insights into Neurodegenerative Disease and Protein Modification

  2024cites this paper
• Estimating the synaptic density deficit in Alzheimer’s disease using multi-contrast CEST imaging

  2024cites this paper
• Brain extended and closed forms glutathione levels decrease with age and extended glutathione is associated with visuospatial memory

  2024influential citation
• Neuronal glutathione depletion elevates the Aβ42/Aβ40 ratio and tau aggregation in Alzheimer's disease mice

  2024cites this paper
• Neuronal glutathione loss leads to neurodegeneration involving gasdermin activation

  2023cites this paper
• Prefrontal Glutathione Levels in Major Depressive Disorder Are Linked to a Lack of Positive Affect

  2023cites this paper
• Changes in levels of the antioxidant glutathione in brain and blood across the age span of healthy adults: A systematic review

  2023cites this paper
• Reduced brain glutathione levels during normal aging are associated with visuospatial memory

  2023cites this paper
• Perturbed neurochemical and microstructural organization in a mouse model of prenatal opioid exposure: a multi-modal magnetic resonance study

  2023cites this paper
• Sex hormones as correlates of oxidative stress in the adult brain.

  2023cites this paper
• Astrocytes in Ageing.

  2023cites this paper
• Multinuclear Magnetic Resonance Spectroscopy at Ultra-High-Field: Assessing Human Cerebral Metabolism in Healthy and Diseased States

  2023cites this paper
• Perturbed neurochemical and microstructural organization in a mouse model of prenatal opioid exposure: A multi-modal magnetic resonance study

  2023cites this paper
• Microglia and Astrocyte Function and Communication: What Do We Know in Humans?

  2022cites this paper
• Do glutathione and copper interact to modify Alzheimer's disease pathogenesis?

  2022cites this paper
• The Role of AMP-activated Protein Kinase in Oxytosis/Ferroptosis: Protector or Potentiator?

  2022cites this paper
• Importance of Linear Combination Modeling for Quantification of Glutathione and γ-Aminobutyric Acid Levels Using Hadamard-Edited Magnetic Resonance Spectroscopy

  2022cites this paper
• MR Spectroscopy in Health and Disease

  2021cites this paper
• In Vivo Brain GSH: MRS Methods and Clinical Applications

  2021influential citation
• Astroglia in ageing

  2021cites this paper
• Assessment of the Precision in Measuring Glutathione at 3 T With a MEGA‐PRESS Sequence in Primary Motor Cortex and Occipital Cortex

  2021cites this paper
• Milk intake enhances cerebral antioxidant (glutathione) concentration in older adults: A randomized controlled intervention study

  2021cites this paper
• In Vivo Brain Glutathione is Higher in Older Age and Correlates with Mobility.

  2021cites this paper
• Brain Energy Deficit as a Source of Oxidative Stress in Migraine: A Molecular Basis for Migraine Susceptibility

  2021cites this paper
• The search for anti‐oxytotic/ferroptotic compounds in the plant world

  2021cites this paper
• Bidirectional Association Between Sleep and Brain Atrophy in Aging

  2021cites this paper
• Neuroprotective effects of dexpanthenol on streptozotocin-induced neuronal damage in rats

  2021cites this paper
• The cross‐sectional interplay between neurochemical profile and brain connectivity

  2021cites this paper
• Physiological and Pathological Ageing of Astrocytes in the Human Brain

  2021cites this paper
• Importance of linear combination modeling for quantification of Glutathione and GABA levels using Hadamard-edited MRS

  2021cites this paper
• ROS networks: designs, aging, Parkinson’s disease and precision therapies

  2020cites this paper
• Using the Oxytosis/Ferroptosis Pathway to Understand and Treat Age-Associated Neurodegenerative Diseases.

  2020cites this paper
• Modulation of the Neuroprotective and Anti-inflammatory Activities of the Flavonol Fisetin by the Transition Metals Iron and Copper

  2020cites this paper
• Supplementation with a putative calorie restriction mimetic micronutrient blend increases glutathione concentrations and improves neuroenergetics in brain of healthy middle-aged men and women.

  2020cites this paper
• Longitudinal Quantification of Metabolites and Macromolecules Reveals Age- and Sex-Related Changes in the Healthy Fischer 344 Rat Brain

  2020cites this paper
• Effect of Age on GABA+ and Glutathione in a Pediatric Sample

  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
• In Vivo Brain Glutathione is Higher in Older Age and Correlates with Mobility

  2020influential citation
• Metabolic Dysregulation Contributes to the Progression of Alzheimer’s Disease

  2020cites this paper
• Neuroglia in Ageing.

  2019cites this paper
• The Lifespan Human Connectome Project in Aging: An overview

  2019cites this paper
• Biochemical deficits and cognitive decline in brain aging: Intervention by dietary supplements.

  2019cites this paper
• Redox Mechanisms in Neurodegeneration: From Disease Outcomes to Therapeutic Opportunities

  2019cites this paper
• Iron, Ferritin, Hereditary Ferritinopathy, and Neurodegeneration

  2019cites this paper
• Advanced Hadamard‐encoded editing of seven low‐concentration brain metabolites: Principles of HERCULES

  2019cites this paper
• MEGA-PRESS and PRESS measure oxidation of glutathione in a phantom.

  2019cites this paper
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  2019cites this paper
• Magnetic resonance spectroscopy as part of a comprehensive neuroimaging assessment tool

  2018cites this paper
• From fetus to older age: A review of brain metabolic changes across the lifespan.

  2018cites this paper
• Potentiation of glutathione loss and nerve cell death by the transition metals iron and copper: Implications for age‐related neurodegenerative diseases

  2018cites this paper
• The use of magnetic resonance spectroscopy for assessing the effect of diet on cognition

  2018cites this paper
• Cysteine Metabolism in Neuronal Redox Homeostasis.

  2018cites this paper
• Metabolomic Assays of Postmortem Brain Extracts: Pitfalls in Extrapolation of Concentrations of Glucose and Amino Acids to Metabolic Dysregulation In Vivo in Neurological Diseases

  2018cites this paper
• Conditional Human Immunodeficiency Virus Transactivator of Transcription Protein Expression Induces Depression-like Effects and Oxidative Stress.

  2017cites this paper
• Redox Signaling in Neurotransmission and Cognition During Aging

  2017cites this paper
• Effect of age and the APOE gene on metabolite concentrations in the posterior cingulate cortex

  2017influential citation
• Edited 1H magnetic resonance spectroscopy in vivo: Methods and metabolites

  2017cites this paper
• Fatty Acids, Antioxidants and Physical Activity in Brain Aging

  2017cites this paper
• Vitamin C, Aging and Alzheimer’s Disease

  2017cites this paper
• Gclc deficiency in mouse CNS causes mitochondrial damage and neurodegeneration

  2017cites this paper
• Echo time optimization for J‐difference editing of glutathione at 3T

  2017cites this paper
• Neurochemical responses to chromatic and achromatic stimuli in the human visual cortex

  2017influential citation
• Glutathione in the human brain: Review of its roles and measurement by magnetic resonance spectroscopy.

  2017cites this paper
• 1 Fatty acids , antioxidants and physical activity in 2 brain aging 3

  2017cites this paper
• Effect of repetition time on metabolite quantification in the human brain in 1H MR spectroscopy at 3 tesla

  2017cites this paper
• University of Birmingham A pilot study to assess the effect of acute exercise on brain glutathione

  2017cites this paper
• Energy metabolism and inflammation in brain aging and Alzheimer's disease.

  2016cites this paper
• 1H-NMR chemical shifts and coupling constants for brain metabolites

  2016cites this paper
• Sensitivity and specificity of human brain glutathione concentrations measured using short‐TE 1H MRS at 7 T

  2016cites this paper
• Aging is associated with dimerization and inactivation of the brain-enriched tyrosine phosphatase STEP.

  2016influential citation
• Prospective frequency correction for macromolecule‐suppressed GABA editing at 3T

  2016cites this paper
• Selected Micronutrients in Cognitive Decline Prevention and Therapy

  2016cites this paper
• Combined treatment with pantothenic acid derivatives and memantine alleviates scopolamine-induced amnesia in rats: The involvement of the thiol redox state and coenzyme A

  2016cites this paper
• Central nervous system uptake of intranasal glutathione in Parkinson’s disease

  2016cites this paper
• Preclinical Magnetic Resonance Imaging and Spectroscopy Studies of Memory, Aging, and Cognitive Decline

  2016influential citation
• Quantification of glutathione in the human brain by MR spectroscopy at 3 Tesla: Comparison of PRESS and MEGA‐PRESS

  2016cites this paper
• Metabolomic analysis of exercise effects in the POLG mitochondrial DNA mutator mouse brain.

  2015cites this paper
• Neurochemical and BOLD Responses during Neuronal Activation Measured in the Human Visual Cortex at 7 Tesla

  2015cites this paper
• How fisetin reduces the impact of age and disease on CNS function.

  2015cites this paper
• Oxidative stress response and Nrf2 signaling in aging.

  2015cites this paper
• Probing astrocyte metabolism in vivo: proton magnetic resonance spectroscopy in the injured and aging brain

  2015cites this paper
• Age-related changes in the central auditory system

  2015cites this paper
• Regional metabolite concentrations in the brain of healthy dogs measured by use of short echo time, single voxel proton magnetic resonance spectroscopy at 3.0 Tesla.

  2015cites this paper
• Redox modulation of oxidatively induced DNA damage by ascorbate enhances melanoma cancer cell DNA damage formation & cell killing

  2015cites this paper
• Ascorbic Acid and the Brain: Rationale for the Use against Cognitive Decline

  2014cites this paper
• High-field proton magnetic resonance spectroscopy reveals metabolic effects of normal brain aging.

  2014cites this paper
• Basis of Magnetic Resonance

  2014cites this paper
• Advances in High-Field Magnetic Resonance Spectroscopy in Alzheimer’s Disease

  2014influential citation
• Metabolic changes in the auditory cortex in presbycusis demonstrated by MR spectroscopy.

  2013cites this paper