Calprotectin protects against experimental colonic inflammation in mice

Calprotectin is a heterodimer composed of two myeloid‐related proteins, S100A8 and S100A9, that is abundant in neutrophils and monocytes/macrophages. Faecal levels of calprotectin are used routinely to monitor inflammatory bowel disease activity.

• Publication year

  2018

• Venue

  British Journal of Pharmacology

• Publication date

  2018-09-02

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/bph.14449PMID 30007036PMCID PMC6135788
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Experimental design and analysis and their reporting II: updated and simplified guidance for authors and peer reviewers

  2018cited by this paper
• Calprotectin protects against experimental colonic inflammation in mice

  2018cited by this paper
• THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Transporters

  2017cited by this paper
• THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview

  2017cited by this paper
• THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Other ion channels

  2017cited by this paper
• The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY

  2017cited by this paper
• THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Catalytic receptors

  2017cited by this paper
• THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Enzymes

  2017cited by this paper
• Accelerated dysbiosis of gut microbiota during aggravation of DSS-induced colitis by a butyrate-producing bacterium

  2016cited by this paper
• Genetic polymorphisms of RAGE and risk of ulcerative colitis in a Chinese population.

  2016cited by this paper
• Implementing guidelines on reporting research using animals (ARRIVE etc.): new requirements for publication in BJP

  2015cited by this paper
• The calcium-binding protein complex S100A8/A9 has a crucial role in controlling macrophage-mediated renal repair following ischemia/reperfusion.

  2015cited by this paper
• Akkermansia muciniphila Adheres to Enterocytes and Strengthens the Integrity of the Epithelial Cell Layer

  2015cited by this paper
• Longitudinal study of murine microbiota activity and interactions with the host during acute inflammation and recovery

  2014cited by this paper
• Fecal level of calprotectin identifies histologic inflammation in patients with ulcerative colitis in clinical and endoscopic remission.

  2014influential reference
• Role and species–specific expression of colon T cell homing receptor GPR15 in colitis

  2014cited by this paper
• Intestinal Inflammation and Mucosal Barrier Function

  2014cited by this paper
• Calgranulins may contribute vascular protection in atherogenesis.

  2014cited by this paper
• Nondigestible oligosaccharides exert nonprebiotic effects on intestinal epithelial cells enhancing the immune response via activation of TLR4-NFκB.

  2014cited by this paper
• S100A8 Induces IL-10 and Protects against Acute Lung Injury

  2014cited by this paper
• Predictive validity and immune cell involvement in the pathogenesis of piroxicam-accelerated colitis in interleukin-10 knockout mice.

  2014cited by this paper
• High Levels of S100A8/A9 Proteins Aggravate Ventilator-Induced Lung Injury via TLR4 Signaling

  2013cited by this paper
• Validation of bovine glycomacropeptide as an intestinal anti-inflammatory nutraceutical in the lymphocyte-transfer model of colitis

  2013cited by this paper
• IL-22–producing neutrophils contribute to antimicrobial defense and restitution of colonic epithelial integrity during colitis

  2013influential reference
• Impact of Neutrophil-Secreted Myeloid Related Proteins 8 and 14 (MRP 8/14) on Leishmaniasis Progression

  2013cited by this paper
• Interleukin-6 Induces S100A9 Expression in Colonic Epithelial Cells through STAT3 Activation in Experimental Ulcerative Colitis

  2012influential reference
• Dextran Sodium Sulfate Inhibition of Real‐Time Polymerase Chain Reaction Amplification: A Poly‐A Purification Solution

  2012cited by this paper
• Myosin light chain kinase: pulling the strings of epithelial tight junction function

  2012cited by this paper
• The functional -374T/A polymorphism of the receptor for advanced glycation end products may modulate Crohn's disease.

  2011cited by this paper
• Tissue‐nonspecific alkaline phosphatase is activated in enterocytes by oxidative stress via changes in glycosylation

  2011cited by this paper
• S100A9 Differentially Modifies Phenotypic States of Neutrophils, Macrophages, and Dendritic Cells: Implications for Atherosclerosis and Adipose Tissue Inflammation

  2011cited by this paper
• Septic Shock Is Associated with Receptor for Advanced Glycation End Products Ligation of LPS

  2011cited by this paper
• Oxidative Modifications of DAMPs Suppress Inflammation: The Case for S100A8 and S100A9

  2011cited by this paper
• Nutrient metal sequestration by calprotectin inhibits bacterial superoxide defense, enhancing neutrophil killing of Staphylococcus aureus.

  2011cited by this paper
• Fecal Calprotectin Excretion in Preterm Infants during the Neonatal Period

  2010cited by this paper
• Animal Research: Reporting In Vivo Experiments: The ARRIVE Guidelines

  2010cited by this paper
• The Toll-like receptor 4 ligands Mrp8 and Mrp14 are crucial in the development of autoreactive CD8+ T cells

  2010influential reference
• Global patterns of 16S rRNA diversity at a depth of millions of sequences per sample

  2010cited by this paper
• S100A8/A9 Is Not Involved in Host Defense against Murine Urinary Tract Infection

  2010cited by this paper
• The endogenous Toll–like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer

  2009cited by this paper
• Short-Chain Inulin-Like Fructans Reduce Endotoxin and Bacterial Translocations and Attenuate Development of TNBS-Induced Colitis in Rats

  2009cited by this paper
• Disturbances in metabolic, transport and structural genes in experimental colonic inflammation in the rat: a longitudinal genomic analysis

  2008cited by this paper
• Mice deficient in the CXCR2 ligand, CXCL1 (KC/GRO-α), exhibit increased susceptibility to dextran sodium sulfate (DSS)-induced colitis

  2008cited by this paper
• Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock

  2007influential reference
• Interactions of intestinal epithelial cells with bacteria and immune cells: methods to characterize microflora and functional consequences.

  2006cited by this paper
• Disturbances in epithelial ionic secretion in different experimental models of colitis.

  2005cited by this paper
• Calprotectin - a pleiotropic molecule in acute and chronic inflammation.

  2004cited by this paper
• Myeloid Cell Function in MRP-14 (S100A9) Null Mice

  2003cited by this paper
• Loss of S100A9 (MRP14) Results in Reduced Interleukin-8-Induced CD11b Surface Expression, a Polarized Microfilament System, and Diminished Responsiveness to Chemoattractants In Vitro

  2003cited by this paper
• Non-invasive investigation of inflammatory bowel disease.

  2001cited by this paper
• Correlation between faecal excretion of indium-111-labelled granulocytes and calprotectin, a granulocyte marker protein, in patients with inflammatory bowel disease.

  1999cited by this paper
• A null mutation in the inflammation-associated S100 protein S100A8 causes early resorption of the mouse embryo.

  1999cited by this paper
• High Level Expression and Dimer Characterization of the S100 EF-hand Proteins, Migration Inhibitory Factor-related Proteins 8 and 14*

  1998cited by this paper
• Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity: Assessment of inflammation in rat and hamster models

  1984cited by this paper
• Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity. Assessment of inflammation in rat and hamster models.

  1984cited by this paper

• S100A8 regulated by estrogen improves injured endometrial epithelium reconstruction by promoting tight junction formation and stromal cell transformation

  2025cites this paper
• Fecal Detection of Calprotectin Subunits Links Inflammatory Bowel Disease Activity With Chronicity of Intestinal Inflammation.

  2025cites this paper
• Source of dietary protein alters the abundance of proteases, intestinal epithelial and immune proteins both directly and via interactions with the gut microbiota

  2025cites this paper
• Intestinal inflammation marker calprotectin regulates epithelial intestinal zinc metabolism and proliferation in mouse jejunal organoids

  2024influential citation
• Targeted Transcriptional Analysis of IgA Vasculitis, IgA Nephropathy, and IgA-Dominant Infection-Related Glomerulonephritis Reveals Both Distinct and Overlapping Immune Signatures

  2023cites this paper
• Exploring the ameliorative potential of Bacopa monnieri in acetic acid induced ulcerative colitis in mice

  2023cites this paper
• Calprotectin in Parkinsonian Disease: Anticipation and Dedication.

  2023cites this paper
• Patterned Duplex Fabric Based on Genetically Modified Spidroin for Smart Wound Management

  2022cites this paper
• Multi-Strain-Probiotic-Loaded Nanoparticles Reduced Colon Inflammation and Orchestrated the Expressions of Tight Junction, NLRP3 Inflammasome and Caspase-1 Genes in DSS-Induced Colitis Model

  2022cites this paper
• Protection against ulcerative colitis and colorectal cancer by evodiamine via anti-inflammatory effects

  2022cites this paper
• Mice carrying an epithelial deletion of the glucocorticoid receptor NR3C1 develop a higher tumor load in experimental colitis associated cancer.

  2021cites this paper
• Long-Term Iron Deficiency and Dietary Iron Excess Exacerbate Acute Dextran Sodium Sulphate-Induced Colitis and Are Associated with Significant Dysbiosis

  2021cites this paper
• Leptin resistant Zucker rats with trinitrobenzene sulfonic acid colitis present a reduced inflammatory response but enhanced epithelial damage.

  2021cites this paper
• Serum and Fecal Markers of Intestinal Inflammation and Intestinal Barrier Permeability Are Elevated in Parkinson’s Disease

  2021cites this paper
• Calprotectin: from biomarker to biological function

  2021cites this paper
• Estrogen Receptor β as a Candidate Regulator of Sex Differences in the Maternal Immune Activation Model of ASD

  2021cites this paper
• S100A8/S100A9 deficiency increases neutrophil activation and protective immune responses against invading infective L3 larvae of the filarial nematode Litomosoides sigmodontis

  2020influential citation
• MK2 Is Required for Neutrophil-Derived ROS Production and Inflammatory Bowel Disease

  2020cites this paper
• Ecotoxicity of a novel biopesticide from Artemisia absinthium on non-target aquatic organisms.

  2019cites this paper
• Differential Expression of Soluble Receptor for Advanced Glycation End-products in Mice Susceptible or Resistant to Chronic Colitis

  2019cites this paper
• MMI-0100 Ameliorates Dextran Sulfate Sodium-Induced Colitis in Mice through Targeting MK2 Pathway

  2019cites this paper
• Differential expression of soluble receptor for advanced glycation end-products (sRAGE) in mice susceptible or resistant to chronic colitis

  2019cites this paper
• Calprotectin protects against experimental colonic inflammation in mice

  2018cites this paper