Diagnostic Accuracy of Measurement Methods to Assess Non‐Adherence to Immunosuppressive Drugs in Kidney Transplant Recipients

Valid assessment of immunosuppressive therapy non‐adherence (NAH) is vital: NAH is associated with negative transplantation outcomes. We studied the diagnostic accuracy of assay, patient self‐reports and clinicians' collateral reports and composite adherence scores using electronic monitoring (EM) as a reference standard.

• Publication year

  2008

• Venue

  American Journal of Transplantation

• Publication date

  2008-03-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1111/j.1600-6143.2007.02127.xPMID 18294158
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The economic implications of non-adherence after renal transplantation

  2012cited by this paper
• Measuring Medication Adherence

  2009cited by this paper
• Bmc Medical Research Methodology Open Access Examining Assumptions regarding Valid Electronic Monitoring of Medication Therapy: Development of a Validation Framework and Its Application on a European Sample of Kidney Transplant Patients

  2008cited by this paper
• Prevalence and Risk Factors of Non‐Adherence with Immunosuppressive Medication in Kidney Transplant Patients

  2007influential reference
• Supporting medication adherence in renal transplantation--the SMART study.

  2007cited by this paper
• How well do clinicians estimate patients’ adherence to combination antiretroviral therapy?

  2007cited by this paper
• Towards complete and accurate reporting of studies of diagnostic accuracy: The STARD Initiative.

  2007cited by this paper
• A Retrospective Analysis of Immunosuppression Compliance, Dose Reduction and Discontinuation in Kidney Transplant Recipients

  2007cited by this paper
• Supporting medication adherence in renal transplantation (SMART): a pilot RCT to improve adherence to immunosuppressive regimens

  2006cited by this paper
• Medication adherence patterns in adult renal transplant recipients.

  2006cited by this paper
• Adherence to medication after liver transplantation in Scotland: A pilot study

  2006cited by this paper
• Use of electronic monitoring induces a 40-day intervention effect in HIV patients.

  2006cited by this paper
• Impact of stress, distress and feelings of indebtedness on adherence to immunosuppressants following kidney transplantation

  2006cited by this paper
• Subclinical noncompliance with immunosuppressive therapy in heart transplant recipients. A cluster analytic study

  2006cited by this paper
• Medication adherence after heart transplantation: adolescents and their issues.

  2006cited by this paper
• Measuring therapy adherence in Parkinson’s disease: a comparison of methods

  2006cited by this paper
• Prevalence, consequences, and determinants of nonadherence in adult renal transplant patients: a literature review

  2005influential reference
• Adherence to medication.

  2005influential reference
• Race and electronically measured adherence to immunosuppressive medications after deceased donor renal transplantation.

  2005cited by this paper
• Factors contributing to acute rejection in renal transplantation: the role of noncompliance.

  2005cited by this paper
• Adherence to medication.

  2005cited by this paper
• Medication adherence in pediatric and adolescent liver transplant recipients.

  2004cited by this paper
• Measuring compliance with drug regimens after renal transplantation: comparison of self-report and clinician rating with electronic monitoring

  2004influential reference
• Prospective Study on Late Consequences of Subclinical Non‐Compliance with Immunosuppressive Therapy in Renal Transplant Patients

  2004cited by this paper
• Effect of late medication non-compliance on outcome after heart transplantation: a 5-year follow-up.

  2004cited by this paper
• Psychological Distress and Adherence to the Medical Regimen Among Adolescent Renal Transplant Recipients

  2003cited by this paper
• Assessment of Adherence to Triple Antiretroviral Treatment Including Indinavir: Role of the Determination of Plasma Levels of Indinavir

  2003cited by this paper
• Patterns of adherence to antiretroviral medications: the value of electronic monitoring

  2003cited by this paper
• Towards complete and accurate reporting of studies of diagnostic accuracy: the STARD initiative

  2003cited by this paper
• Life satisfaction among kidney transplant recipients: demographic and biological factors.

  2002cited by this paper
• Why do kidney grafts fail?

  2002cited by this paper
• Electronic Monitoring of Medication Adherence: When Is High-Tech Best?

  2002cited by this paper
• Assessment of Adherence to HIV Protease Inhibitors: Comparison and Combination of Various Methods, Including MEMS (Electronic Monitoring), Patient and Nurse Report, and Therapeutic Drug Monitoring

  2002cited by this paper
• The development and role of predictive instruments in acute coronary events: improving diagnosis and management.

  2002cited by this paper
• The natural history of azathioprine compliance after renal transplantation.

  2001cited by this paper
• Compliance in Healthcare and Research

  2001cited by this paper
• A Comparison Study of Multiple Measures of Adherence to HIV Protease Inhibitors

  2001cited by this paper
• Profiles of Patients Who Experienced a Late Acute Rejection Due to Nonadherence with Immunosuppressive Therapy

  2001cited by this paper
• Clinical risk associated with appointment noncompliance in heart transplant recipients.

  2000cited by this paper
• Increased morbidity and high variability of cyclosporine levels in pediatric heart transplant recipients.

  2000cited by this paper
• RENAL TRANSPLANT PATIENT COMPLIANCE WITH FREE IMMUNOSUPPRESSIVE MEDICATIONS1

  2000cited by this paper
• Compliance with tricyclic antidepressants: the value of four different methods of assessment.

  2000cited by this paper
• Methodological issues in transplant compliance research.

  1999cited by this paper
• Early post-transplant medical compliance and mental health predict physical morbidity and mortality one to three years after heart transplantation.

  1999cited by this paper
• Medication nonadherence and its relation to financial restriction.

  1999cited by this paper
• Methods for measuring and monitoring medication regimen adherence in clinical trials and clinical practice.

  1999influential reference
• Compliance and noncompliance in patients with a functioning renal transplant: a multicenter study.

  1998cited by this paper
• Late acute rejection and subclinical noncompliance with cyclosporine therapy in heart transplant recipients.

  1998cited by this paper
• Medication compliance following renal transplantation.

  1998cited by this paper
• The assessment of refill compliance using pharmacy records: methods, validity, and applications.

  1997cited by this paper
• Noncompliance in children and adolescents after renal transplantation.

  1996cited by this paper
• INCIDENCE, DETERMINANTS, AND CONSEQUENCES OF SUBCLINICAL NONCOMPLIANCE WITH IMMUNOSUPPRESSIVE THERAPY IN RENAL TRANSPLANT RECIPIENTS

  1995cited by this paper
• MEDICATION COMPLIANCE AFTER RENAL TRANSPLANTATION

  1995cited by this paper
• Retransplantation after renal allograft loss due to noncompliance. Indications, outcome, and ethical concerns.

  1995cited by this paper
• Microelectronic Systems for Monitoring and Enhancing Patient Compliance With Medication Regimens

  1995cited by this paper
• Correlates of noncompliance among renal transplant recipients

  1994cited by this paper
• Postrenal transplant compliance: report of 519 responses to a self-report questionnaire.

  1993cited by this paper
• A STUDY OF TREATMENT COMPLIANCE FOLLOWING KIDNEY TRANSPLANTATION

  1993cited by this paper
• On white-coat effects and the electronic monitoring of compliance.

  1990cited by this paper
• Accuracy of self-reported measures of compliance.

  1985cited by this paper

• CNI Trough Variability Does Not Reliably Reflect Medication Adherence: Insights From a 3-Year Follow-Up Study

  2026cites this paper
• Effectiveness of eHealth for Medication Adherence in Renal Transplant Recipients: Systematic Review and Meta-Analysis

  2025cites this paper
• Intrapatient tacrolimus variability is associated with medical nonadherence among pediatric kidney transplant recipients

  2025cites this paper
• Tocilizumab in chronic active antibody-mediated rejection: rationale and protocol of an in-progress randomized controlled open-label multi-center trial (INTERCEPT study)

  2024cites this paper
• Nonadherence to Immunosuppressive Medications in Kidney Transplant Recipients: A Systematic Scoping Review

  2024cites this paper
• Betreuung von Patienten nach Nierentransplantation

  2024cites this paper
• Impact of text message reminders on immunosuppressive medication adherence among kidney transplant recipients: A randomized controlled study

  2024cites this paper
• EASL Clinical Practice Guidelines on liver transplantation.

  2024cites this paper
• Nonadherence to Immunosuppressant Therapy of Kidney Transplant Candidate Patients: External Validation of the KATITA-25 Scale

  2024cites this paper
• Immunosuppressant nonadherence profile in kidney transplant recipients and the impact of medication adherence on transplant outcomes

  2024cites this paper
• Electronic Health Record-Enabled Routine Assessment of Medication Adherence after Solid Organ Transplantation: The time is now.

  2024cites this paper
• Prevalence and Patient-Level Correlates of Intentional Non-Adherence to Immunosuppressive Medication After Heart-Transplantation—Findings From the International BRIGHT Study

  2023cites this paper
• Psychometric Properties of the BAASIS: A Meta-analysis of Individual Participant Data

  2023cites this paper
• Reliability and Validity of the Japanese Version of the Basel Assessment of Adherence to Immunosuppressive Medications Scale in Kidney Transplant Recipients

  2023cites this paper
• Development and Internal Validation of a Questionnaire Assessing Predisposition to Nonadherence to Immunosuppressive Medication in Kidney Pretransplant Patients

  2023cites this paper
• Nonadherence to Immunosuppressants Among Transplant Recipients: Emotional Intelligence as a Predictive Factor During COVID-19 Pandemic

  2023cites this paper
• Self‐management skills in a UK sample of young people with chronic liver disease

  2023cites this paper
• Optimizing medication adherence with home‐monitoring – A feasibility study using capillary microsampling and mHealth in solid organ‐transplanted adolescents

  2023cites this paper
• Clinical Practice Guideline: Psychosocial Diagnosis and Treatment Before and After Organ Transplantation.

  2023cites this paper
• Long-term outcomes in pediatric patients who underwent living donor liver transplantation for biliary atresia.

  2022cites this paper
• Pro-adherence complementary audiovisual educational intervention model for chronic myeloid leukemia patients treated with imatinib mesylate

  2022cites this paper
• Ethical considerations in pediatric chronic illness: The relationship between psychological factors, treatment adherence, and health outcomes.

  2021cites this paper
• Prevalence of Non-Adherence to Immunosuppressive Medications in Kidney Transplant Recipients: Barriers and Predictors

  2021cites this paper
• Use of an electronic medication monitoring device to estimate medication adherence in kidney transplant patients.

  2021cites this paper
• Adherence management in transplantation

  2021cites this paper
• Post-transplant Medication Challenges

  2021cites this paper
• Adherence to immunosuppression in adult heart transplant recipients: A systematic review.

  2021cites this paper
• Ethical Challenges in Pediatric Kidney Transplantation

  2021cites this paper
• Depression, Quantified Medication Adherence, and Quality of Life in Renal Transplant Candidates and Recipients

  2021cites this paper
• Prospective Measures of Adherence by Questionnaire, Low Immunosuppression and Graft Outcome in Kidney Transplantation

  2021cites this paper
• Association between medication adherence and intrapatient variability in tacrolimus concentration among stable kidney transplant recipients

  2021cites this paper
• Medication nonadherence monitoring and management in adult kidney transplantation: A survey of practices and perceptions at US‐based transplant programs

  2021cites this paper
• Mobile Health to Improve Adherence and Patient Experience in Heart Transplantation Recipients: The mHeart Trial

  2021cites this paper
• Immunosuppressive Medication Adherence in Kidney Transplant Recipients During the COVID-19 Pandemic: A Cross-Sectional Study in Hong Kong

  2021cites this paper
• Accuracy and concordance of measurement methods to assess non-adherence after renal transplantation - a prospective study

  2020cites this paper
• Utility of single‐item questions to assess physical inactivity in patients with chronic heart failure

  2020cites this paper
• Prospective single-centre clinical observational study on electronically monitored medication non-adherence, its psychosocial risk factors and lifestyle behaviours after heart transplantation: a study protocol

  2020cites this paper
• Theory-driven development of a medication adherence intervention delivered by eHealth and transplant team in allogeneic stem cell transplantation: the SMILe implementation science project

  2020influential citation
• Comparison of a home-based (multi) systemic intervention to promoting Medication AdheRence and Self-management among kidney transplant recipients with care-as-usual: the MARS randomized controlled trial protocol

  2020cites this paper
• Depression, Immunosuppressant Levels, and Clinical Outcomes in Postlung Transplant Recipients

  2020cites this paper
• No Apparent Influence of Non-Adherence on Tacrolimus Intra-Patient Variability in Stable Kidney Transplant Recipients.

  2020cites this paper
• Studies Exploring Non-Adherence in Adult Renal Transplant Recipients

  2020influential citation
• Optimization of Electronically Monitored Non-Adherence in Highly Adherent Renal Transplant Recipients by Reducing the Dosing Frequency – A Prospective Single-Center Observational Study

  2020cites this paper
• Optimization of Electronically Monitored Non-Adherence in Highly Adherent Renal Transplant Recipients by Reducing the Dosing Frequency – A Prospective Single-Center Observational Study

  2020cites this paper
• Remote Therapy to Improve Outcomes in Lung Transplant Recipients: Design of the INSPIRE-III Randomized Clinical Trial

  2020cites this paper
• Die Urologie

  2020cites this paper
• Mobile medication manager application to improve adherence with immunosuppressive therapy in renal transplant recipients: A randomized controlled trial

  2019influential citation
• Adherence Behavior in Subjects on Hemodialysis Is Not a Clear Predictor of Posttransplantation Adherence

  2019cites this paper
• Factors Associated With Adherence To Immunosuppressive Therapy And Barriers In Asian Kidney Transplant Recipients

  2019cites this paper
• Predictors of neuropsychological functioning and medication adherence in pediatric heart transplant recipients referred for neuropsychological evaluation

  2019cites this paper
• Results of Renal Transplantation

  2019cites this paper
• Evaluation of tools for annual capture of adherence to immunosuppressive medications after renal transplantation – a single‐centre open prospective trial

  2019cites this paper
• Adherence is associated with a favorable outcome after lung transplantation

  2019cites this paper
• Beliefs of Immunosuppressive Medication Among Chinese Renal Transplant Recipients, as Assessed in a Cross-Sectional Study With the Basel Assessment of Adherence to Immunosuppressive Medications Scale.

  2019cites this paper
• Diagnosis and Therapy of Graft Dysfunction

  2019cites this paper
• Medication non-adherence after kidney transplantation: A critical appraisal and systematic review.

  2019cites this paper
• Non-adherence to Immunosuppressant after Lung Transplantation – A Common Risk Behavior

  2019influential citation
• Impact of Once- Versus Twice-Daily Tacrolimus Dosing on Medication Adherence in Stable Renal Transplant Recipients: A Canadian Single-Center Randomized Controlled Trial

  2019cites this paper
• The Medication Level Variability Index (MLVI) as a potential predictive biomarker of graft‐versus‐host disease in pediatric hematopoietic stem cell transplant patients

  2019cites this paper
• Post-transplant Psychosocial and Mental Health Care of the Renal Recipient

  2018cites this paper
• Depressive Symptoms, Exercise Capacity, and Clinical Outcomes After Lung Transplantation

  2018cites this paper
• Self-Reported Non-adherence to Medication in Japanese Patients with Cardiovascular Diseases

  2018cites this paper
• The multidimensional kidney transplant self-management scale : development and psychometric testing

  2018cites this paper
• Assessment of tacrolimus intrapatient variability in stable adherent transplant recipients: Establishing baseline values

  2018cites this paper
• Identifying Tyrosine Kinase Inhibitor Nonadherence in Chronic Myeloid Leukemia: Subanalysis of TAKE‐IT Pilot Study

  2018cites this paper
• A Randomized Trial of a Multicomponent Intervention to Promote Medication Adherence: The Teen Adherence in Kidney Transplant Effectiveness of Intervention Trial (TAKE-IT).

  2018cites this paper
• Modélisation conjointe pour données longitudinales et données de survie : analyse des facteurs prédictifs du devenir de la greffe rénale

  2018influential citation
• Einfluss von Emotionsregulation und emotionaler Erregung auf Lebensqualität und Adhärenz bei Paaren nach Nierentransplantation

  2018influential citation
• Prevalence and correlates of non-adherence to immunosuppressants and to health behaviours in patients after kidney transplantation in Brazil – the ADHERE BRAZIL multicentre study: a cross-sectional study protocol

  2018cites this paper
• Rationale and design of TransplantLines: a prospective cohort study and biobank of solid organ transplant recipients

  2018cites this paper
• Post-transplant Psychosocial and Mental Health Care of the Liver Recipient

  2018cites this paper
• Posttransplant Medical Adherence: What Have We Learned and Can We Do Better?

  2018cites this paper
• Medication adherence in resistant hypertension: An investigation of prevalence, psychological predictors and patient perspectives

  2018cites this paper
• Medication adherence for resistant hypertension: Assessing theoretical predictors of adherence using direct and indirect adherence measures

  2018cites this paper
• Joint modelling of longitudinal and time-to-event data : analysis of predictive factors of graft outcomes in kidney transplant recipients

  2018influential citation
• Pediatric Outcomes in Transplant: PersOnaliSing Immunosuppression To ImproVe Efficacy (POSITIVE Study): The Collaboration and Design of a National Transplant Precision Medicine Program

  2018cites this paper
• Practice patterns to improve pre and post-transplant medication adherence in heart transplant centres: a secondary data analysis of the international BRIGHT study

  2018cites this paper
• Immunsuppressiva-Adhärenz nach Transplantation

  2018influential citation
• University of Birmingham Practical Recommendations for Long-term Management of Modifiable Risks in Kidney and Liver Transplant Recipients

  2017cites this paper
• Adherence to fingolimod in multiple sclerosis: an investigator-initiated, prospective, observational, single-center cohort study

  2017cites this paper
• Telemedically Supported Case Management of Living‐Donor Renal Transplant Recipients to Optimize Routine Evidence‐Based Aftercare: A Single‐Center Randomized Controlled Trial

  2017cites this paper
• Advancing Transplantation: New Questions, New Possibilities in Kidney and Liver Transplantation

  2017cites this paper
• Non-adherence to immunosuppressants following renal transplantation: a protocol for a systematic review

  2017cites this paper
• Adherence to medication and characteristics of Japanese patients with non-valvular atrial fibrillation.

  2017cites this paper
• Practical Recommendations for Long-term Management of Modifiable Risks in Kidney and Liver Transplant Recipients: A Guidance Report and Clinical Checklist by the Consensus on Managing Modifiable Risk in Transplantation (COMMIT) Group

  2017cites this paper
• The efficacy and stability of an information and communication technology-based centralized monitoring system of adherence to immunosuppressive medication in kidney transplant recipients: study protocol for a randomized controlled trial

  2017cites this paper
• Patient-reported non-adherence and immunosuppressant trough levels are associated with rejection after renal transplantation

  2017cites this paper
• High Intrapatient Variability of Tacrolimus Levels and Outpatient Clinic Nonattendance Are Associated With Inferior Outcomes in Renal Transplant Patients

  2017cites this paper
• [Manualized psychotherapy for the optimization of immunosuppressant adherence following kidney transplantation: Results of a feasibility study].

  2017cites this paper
• Factors that determine self‐reported immunosuppressant adherence in kidney transplant recipients: a correlational study

  2017cites this paper
• A Pilot Randomized Controlled Trial to Promote Immunosuppressant Adherence in Adult Kidney Transplant Recipients

  2016cites this paper
• [Chronic kidney disease and kidney transplantation].

  2016cites this paper
• Immunosuppressant Therapy Adherence Scale for Transplant Recipients: The Study of Validity and Reliability

  2016cites this paper
• A scoping review of studies comparing the medication event monitoring system (MEMS) with alternative methods for measuring medication adherence.

  2016cites this paper
• Toward appropriate criteria in medication adherence assessment in older persons: Position Paper

  2016cites this paper
• Sirolimus and tacrolimus coefficient of variation is associated with rejection, donor-specific antibodies, and nonadherence

  2016cites this paper
• Adherence to and Acceptance of Once-Daily Tacrolimus After Kidney and Liver Transplant: Results From OSIRIS, a French Observational Study

  2016cites this paper
• Clinical Management of Transplant Recipients

  2016cites this paper
• Nonadherence to immunosuppressive therapy in kidney transplant recipients: can technology help?

  2016cites this paper
• Étude multicentrique, française comparant les résultats à long terme de la transplantation rénale selon l’adhérence des patients aux immunosuppresseurs mesurée de façon prospective et répétée

  2016cites this paper